Development Level

Tbio 196 | 10,625
Tchem 110 | 1,890
Tdark 64 | 7,003
Tclin 53 | 602

Collection

Kinase: IDG Consortium (Targets) 4 | 125
Kinase: IDG Consortium (Complete/Control) 2 | 37

IMPC Phenotype

preweaning lethality, complete... 19 | 633
decreased body weight 13 | 174
decreased lean body mass 9 | 195
decreased total body fat amoun... 9 | 186
decreased circulating choleste... 7 | 85
embryonic lethality prior to t... 7 | 187
abnormal bone structure 6 | 131
decreased bone mineral content 6 | 157
abnormal embryo size 5 | 112
abnormal retina morphology 5 | 100
abnormal retinal pigmentation 5 | 61
decreased circulating HDL chol... 5 | 77
decreased lumbar vertebrae num... 5 | 62
enlarged heart 5 | 111
abnormal behavior 4 | 226
decreased body length 4 | 108
decreased circulating LDL chol... 4 | 37
decreased circulating alanine ... 4 | 53
decreased circulating sodium l... 4 | 18
decreased circulating triglyce... 4 | 83
increased mean corpuscular hem... 4 | 93
thrombocytopenia 4 | 46
abnormal bone mineralization 3 | 55
abnormal cornea morphology 3 | 24
abnormal lens morphology 3 | 73
decreased bone mineral density 3 | 126
decreased circulating creatini... 3 | 31
decreased circulating glucose ... 3 | 121
decreased circulating total pr... 3 | 41
decreased grip strength 3 | 123
decreased kidney weight 3 | 7
increased bone mineral content 3 | 92
increased circulating alkaline... 3 | 119
increased mean corpuscular vol... 3 | 91
increased startle reflex 3 | 38
male infertility 3 | 62
preweaning lethality, incomple... 3 | 260
abnormal coat-hair pigmentatio... 2 | 54
abnormal forebrain development 2 | 18
abnormal hindbrain development 2 | 24
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
abnormal seminal vesicle morph... 2 | 47
abnormal testis morphology 2 | 30
cataract 2 | 26
decreased circulating fructosa... 2 | 31
decreased circulating serum al... 2 | 79
decreased heart weight 2 | 44
decreased lactate dehydrogenas... 2 | 14
decreased mean corpuscular hem... 2 | 19
decreased neutrophil cell numb... 2 | 37
decreased prepulse inhibition 2 | 52
decreased rib number 2 | 59
decreased spleen weight 2 | 13
decreased thoracic vertebrae n... 2 | 7
dilated heart left ventricle 2 | 10
hypoactivity 2 | 89
impaired pupillary reflex 2 | 14
increased CD4-positive, alpha ... 2 | 15
increased blood urea nitrogen ... 2 | 44
increased circulating HDL chol... 2 | 63
increased circulating LDL chol... 2 | 15
increased circulating choleste... 2 | 53
increased circulating phosphat... 2 | 24
increased erythrocyte cell num... 2 | 26
increased grip strength 2 | 83
increased lean body mass 2 | 107
increased leukocyte cell numbe... 2 | 37
increased sacral vertebrae num... 2 | 62
prenatal lethality prior to he... 2 | 64
small testis 2 | 37
abnormal behavioral response t... 1 | 52
abnormal body wall morphology 1 | 7
abnormal gait 1 | 51
abnormal heart morphology 1 | 51
abnormal rib morphology 1 | 28
abnormal spleen morphology 1 | 36
absent pinna reflex 1 | 21
corneal opacity 1 | 25
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased caudal vertebrae num... 1 | 49
decreased circulating bilirubi... 1 | 14
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating magnesiu... 1 | 11
decreased circulating potassiu... 1 | 17
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased total retina thickne... 1 | 20
enlarged spleen 1 | 26
female infertility 1 | 34
impaired righting response 1 | 19
increased body length 1 | 20
increased bone mineral density 1 | 52
increased mean platelet volume 1 | 19
limb grasping 1 | 35
short tibia 1 | 82
tremors 1 | 34
vertebral fusion 1 | 23

Disease

osteosarcoma 216 | 7,933
ovarian cancer 212 | 8,491
Cancer 162 | 2,346
psoriasis 160 | 6,685
glioblastoma 159 | 5,572
medulloblastoma, large-cell 149 | 6,234
lung cancer 147 | 4,473
atypical teratoid / rhabdoid tumor 110 | 4,369
malignant mesothelioma 91 | 3,163
Breast cancer 87 | 3,098
pilocytic astrocytoma 86 | 3,086
subependymal giant cell astrocytoma 86 | 2,287
oligodendroglioma 85 | 2,849
Carcinoma 81 | 2,147
invasive ductal carcinoma 81 | 2,950
ependymoma 80 | 2,514
interstitial cystitis 80 | 2,299
intraductal papillary-mucinous neoplasm (IPMN) 78 | 3,289
pediatric high grade glioma 77 | 2,712
lung adenocarcinoma 76 | 2,714
lung carcinoma 75 | 2,844
non-small cell lung cancer 74 | 2,798
ulcerative colitis 73 | 2,087
astrocytic glioma 68 | 2,241
intraductal papillary-mucinous carcinoma (IPMC) 65 | 2,988
Multiple myeloma 64 | 1,327
primitive neuroectodermal tumor 64 | 3,031
pancreatic cancer 63 | 2,300
intraductal papillary-mucinous adenoma (IPMA) 61 | 2,956
diabetes mellitus 59 | 1,663
tuberculosis 57 | 1,563
Pick disease 54 | 1,893
astrocytoma 50 | 1,493
group 4 medulloblastoma 50 | 1,875
pituitary cancer 50 | 1,972
Rheumatoid Arthritis 49 | 1,170
medulloblastoma 47 | 1,524
cystic fibrosis 46 | 1,670
group 3 medulloblastoma 45 | 2,254
adult high grade glioma 44 | 2,148
colon cancer 40 | 1,475
cutaneous lupus erythematosus 40 | 1,056
ductal carcinoma in situ 39 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 39 | 1,795
breast carcinoma 38 | 1,614
juvenile dermatomyositis 37 | 1,189
primary pancreatic ductal adenocarcinoma 37 | 1,271
Mammary Neoplasms 36 | 410
Schizophrenia 34 | 503
Waldenstrons macroglobulinemia 31 | 764
primary Sjogren syndrome 31 | 788
Parkinson's disease 30 | 364
Prostatic Neoplasms 30 | 471
dermatomyositis 29 | 966
adrenocortical carcinoma 28 | 1,427
spina bifida 28 | 1,064
Alzheimer's disease 27 | 644
Lung Neoplasms 26 | 171
Obesity 26 | 616
gastric carcinoma 26 | 832
posterior fossa group B ependymoma 26 | 1,530
Asthma 25 | 349
Vascular disease 25 | 281
non-small cell lung carcinoma 25 | 413
posterior fossa group A ependymoma 25 | 1,511
Liver carcinoma 24 | 217
atypical teratoid/rhabdoid tumor 24 | 1,095
esophageal adenocarcinoma 24 | 737
Intellectual disability 23 | 573
Renal Cell Carcinoma 23 | 199
acute quadriplegic myopathy 23 | 1,157
acute myeloid leukemia 22 | 785
non primary Sjogren syndrome sicca 22 | 840
pancreatic carcinoma 22 | 567
tuberculosis and treatment for 6 months 21 | 686
Arthritis 20 | 248
HIV Infections 20 | 99
Stomach Neoplasms 20 | 282
sonic hedgehog group medulloblastoma 20 | 1,482
Autistic Disorder 19 | 320
Kidney disease 19 | 397
Melanoma 19 | 261
Osteoporosis 19 | 259
Polycystic Ovary Syndrome 19 | 334
Toxic encephalopathy 19 | 131
hepatocellular carcinoma 19 | 550
Anemia 17 | 252
Down syndrome 17 | 548
IGA Glomerulonephritis 17 | 454
Multiple Sclerosis 17 | 498
Neoplasm Invasiveness 17 | 127
fibroadenoma 17 | 557
periodontitis 17 | 269
Atopic dermatitis 16 | 944
Kidney cancer 16 | 121
Noonan Syndrome 16 | 33
Peripheral Neuropathy 16 | 303
gastric cancer 16 | 436
mucosa-associated lymphoid tissue lymphoma 16 | 480
nasopharyngeal carcinoma 16 | 1,056

Tissue

Female tissues 409 | 18,646
Digestive Tract 408 | 18,472
Urinary Tract 407 | 18,443
Blood and immune system 406 | 17,994
Liver and Pancreas 406 | 18,135
Endocrine System 405 | 18,511
Nervous System 405 | 18,560
Skin and soft tissues 404 | 18,114
Cardiovascular System 402 | 17,957
Respiratory system 399 | 17,483
Male tissues 398 | 17,968

Target Family

Non-IDG 224 | 11,969
Enzyme 101 | 4,146
Kinase 77 | 634
Transcription Factor 12 | 1,400
Ion Channel 8 | 341
Nuclear Receptor 1 | 48

Reactome Pathway

Fc epsilon receptor (FCERI) si... 423 | 423
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.25806 19000.3 3336
Ras/Rap GTPase-activating protein SynGAP SYNGAP1 Tbio Enzyme -1.86167 72.3 167
Ras GTPase-activating protein nGAP RASAL2 Tbio Enzyme -1.50499 28.6 91
Serine/threonine-protein kinase B-raf BRAF Tclin Kinase -2.28702 199.1 1276
Trinucleotide repeat-containing gene 6B protein TNRC6B Tbio Non-IDG -0.97375 6.84 59
Fibroblast growth factor receptor substrate 3 FRS3 Tbio Non-IDG -0.89335 9.09 133
GTPase KRas KRAS Tbio Enzyme -3.77389 5694.2 421
Pro-epidermal growth factor EGF Tbio Non-IDG -3.74596 4837.7 851
Ras GTPase-activating protein 4 RASA4 Tbio Enzyme -2.46005 289.6 46