Development Level

Tbio 83 | 11,651
Tdark 73 | 6,593
Tchem 37 | 1,388
Tclin 11 | 612

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 13 | 979
preweaning lethality, incomple... 6 | 499
abnormal bone structure 3 | 187
decreased body weight 3 | 161
decreased circulating creatini... 3 | 39
abnormal lens morphology 2 | 81
decreased circulating choleste... 2 | 93
decreased circulating sodium l... 2 | 22
decreased heart left ventricle... 2 | 28
decreased hemoglobin content 2 | 68
decreased lymphocyte cell numb... 2 | 83
decreased vertical activity 2 | 208
embryonic lethality prior to t... 2 | 278
increased blood urea nitrogen ... 2 | 48
increased circulating free fat... 2 | 20
increased erythrocyte cell num... 2 | 39
increased monocyte cell number 2 | 63
increased total body fat amoun... 2 | 134
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal cornea morphology 1 | 31
abnormal digit morphology 1 | 10
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal kidney morphology 1 | 65
abnormal maxilla morphology 1 | 17
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
cataract 1 | 92
decreased IgG3 level 1 | 1
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating free fat... 1 | 31
decreased circulating fructosa... 1 | 30
decreased circulating magnesiu... 1 | 13
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased thermal nociceptive ... 1 | 2
embryonic growth retardation 1 | 106
increased CD4-positive, alpha ... 1 | 4
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating triglyce... 1 | 42
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
increased thermal nociceptive ... 1 | 9
male infertility 1 | 123
prenatal lethality 1 | 28
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97
small epididymis 1 | 3
small testis 1 | 58
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56

Disease

ovarian cancer 90 | 8,520
Carcinoma 80 | 11,493
osteosarcoma 73 | 7,950
lung cancer 67 | 4,740
psoriasis 61 | 6,694
glioblastoma 58 | 5,792
Cancer 54 | 2,499
Multiple myeloma 44 | 1,332
medulloblastoma, large-cell 43 | 6,241
atypical teratoid / rhabdoid tumor 37 | 5,112
subependymal giant cell astrocytoma 32 | 2,287
non-small cell lung cancer 31 | 2,890
Breast cancer 30 | 3,578
ependymoma 30 | 4,679
adult high grade glioma 29 | 3,801
interstitial cystitis 29 | 2,312
malignant mesothelioma 28 | 3,232
Kidney cancer 27 | 2,613
Astrocytoma, Pilocytic 26 | 3,081
lung carcinoma 26 | 2,843
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
invasive ductal carcinoma 24 | 2,951
oligodendroglioma 24 | 2,850
pancreatic cancer 24 | 2,398
ulcerative colitis 24 | 1,819
lung adenocarcinoma 23 | 2,716
Waldenstrons macroglobulinemia 22 | 765
astrocytic glioma 22 | 2,597
group 3 medulloblastoma 22 | 4,104
group 4 medulloblastoma 21 | 1,855
tuberculosis 21 | 2,010
Pick disease 20 | 1,894
astrocytoma 20 | 1,146
primitive neuroectodermal tumor 20 | 3,035
dermatomyositis 19 | 966
cutaneous lupus erythematosus 17 | 1,057
diabetes mellitus 17 | 1,728
HIV Infections 16 | 102
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
juvenile dermatomyositis 16 | 1,187
Rheumatoid arthritis 15 | 1,191
Schizophrenia 15 | 1,160
primary Sjogren syndrome 15 | 735
primary pancreatic ductal adenocarcinoma 15 | 1,109
Autosomal recessive predisposition 13 | 1,442
colon cancer 13 | 1,478
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
Arthritis 12 | 290
acute myeloid leukemia 12 | 783
cystic fibrosis 12 | 1,696
periodontitis 12 | 293
Breast Neoplasms 11 | 445
Liver Cirrhosis, Experimental 11 | 769
Mammary Neoplasms 11 | 425
Epilepsy 10 | 792
Intellectual disability 10 | 1,016
Mantle cell lymphoma 10 | 23
chronic lymphosyte leukemia 10 | 204
esophageal adenocarcinoma 10 | 737
non primary Sjogren syndrome sicca 10 | 891
pituitary cancer 10 | 1,972
Alzheimer's disease 9 | 658
Asthma 9 | 385
Dull intelligence 9 | 645
Low intelligence 9 | 645
Lung Neoplasms 9 | 232
Lymphoma 9 | 81
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Osteoporosis 9 | 363
Parkinson's disease 9 | 392
Poor school performance 9 | 645
Seizures 9 | 596
Stomach Neoplasms 9 | 300
breast carcinoma 9 | 1,638
Anemia 8 | 365
Cell Transformation, Neoplastic 8 | 97
Cholestasis, Extrahepatic 8 | 25
Frontal bossing 8 | 157
Hypoplastic mandible condyle 8 | 275
Mandibular hypoplasia 8 | 275
Melanoma 8 | 711
Micrognathism 8 | 275
Obesity 8 | 678
Short stature 8 | 531
mucosa-associated lymphoid tissue lymphoma 8 | 484
Agammaglobulinemia 7 | 34
Brain Ischemia 7 | 110
Carcinoma, Hepatocellular 7 | 228
Hepatomegaly 7 | 285
Immunologic Deficiency Syndromes 7 | 113
Liver cancer 7 | 604
Liver carcinoma 7 | 240
Neoplasm Metastasis 7 | 168
Neoplastic Cell Transformation 7 | 89
Orbital separation excessive 7 | 244
Renal Cell Carcinoma 7 | 214
Vascular disease 7 | 319
acute quadriplegic myopathy 7 | 1,158

Tissue

Endocrine System 129 | 18,159
Blood and immune system 128 | 16,909
Digestive Tract 128 | 17,369
Female tissues 128 | 17,400
Male tissues 128 | 17,142
Respiratory system 128 | 16,393
Urinary Tract 128 | 16,678
Cardiovascular System 127 | 15,192
Liver and Pancreas 127 | 16,750
Skin and soft tissues 127 | 17,230
Nervous System 126 | 16,725

Target Family

Non-IDG 115 | 12,091
Enzyme 52 | 4,145
Kinase 27 | 634
Transcription Factor 7 | 1,400
Ion Channel 3 | 344

Reactome Pathway

Fc epsilon receptor (FCERI) si... 204 | 204
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
B-cell lymphoma/leukemia 10 BCL10 Tbio Non-IDG -0.53932 4.30 895
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Guanine nucleotide exchange factor VAV3 VAV3 Tbio Non-IDG -1.82116 74.0 249
26S proteasome regulatory subunit 6A PSMC3 Tbio Enzyme -1.29086 19.3 302
F-box/WD repeat-containing protein 11 FBXW11 Tbio Non-IDG -0.75887 5.88 183
TNF receptor-associated factor 6 TRAF6 Tbio Non-IDG -2.74221 511.1 403
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452
S-phase kinase-associated protein 1 SKP1 Tbio Enzyme -2.57150 310.1 381