Development Level

Tbio 26 | 11,445
Tchem 7 | 1,598
Tdark 3 | 6,588

IMPC Phenotype

preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal lens morphology 1 | 81
abnormal tibia morphology 1 | 14
corneal opacity 1 | 32
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
increased circulating bilirubi... 1 | 16
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased heart weight 1 | 62
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
limb grasping 1 | 41
thrombocytopenia 1 | 56

Disease

Carcinoma 22 | 11,493
osteosarcoma 21 | 7,950
ovarian cancer 19 | 8,520
psoriasis 17 | 6,694
atypical teratoid / rhabdoid tumor 14 | 5,112
group 3 medulloblastoma 14 | 4,104
medulloblastoma, large-cell 14 | 6,241
ependymoma 12 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
pancreatic cancer 12 | 2,398
glioblastoma 11 | 5,792
lung cancer 11 | 4,740
tuberculosis 11 | 2,010
Breast cancer 10 | 3,578
adult high grade glioma 10 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
malignant mesothelioma 10 | 3,232
non-small cell lung cancer 10 | 2,890
oligodendroglioma 10 | 2,850
Pick disease 9 | 1,894
cystic fibrosis 9 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
lung carcinoma 9 | 2,843
Astrocytoma, Pilocytic 8 | 3,081
acute quadriplegic myopathy 8 | 1,158
interstitial cystitis 8 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
primitive neuroectodermal tumor 8 | 3,035
progressive supranuclear palsy 8 | 676
active Crohn's disease 7 | 922
astrocytic glioma 7 | 2,597
Multiple myeloma 6 | 1,332
astrocytoma 6 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
invasive ductal carcinoma 6 | 2,951
Alzheimer's disease 5 | 658
Atopic dermatitis 5 | 952
Intellectual disability 5 | 1,016
Kidney cancer 5 | 2,613
Obesity 5 | 678
active ulcerative colitis 5 | 764
aldosterone-producing adenoma 5 | 665
ductal carcinoma in situ 5 | 1,745
gastric cancer 5 | 459
lung adenocarcinoma 5 | 2,716
pituitary cancer 5 | 1,972
subependymal giant cell astrocytoma 5 | 2,287
Autosomal recessive predisposition 4 | 1,442
Carcinoma, Hepatocellular 4 | 228
Down syndrome 4 | 499
Duchenne muscular dystrophy 4 | 601
Liver carcinoma 4 | 240
Muscle hypotonia 4 | 571
Neurodegenerative disease 4 | 414
Schizophrenia 4 | 1,160
Waldenstrons macroglobulinemia 4 | 765
adrenocortical carcinoma 4 | 1,428
juvenile dermatomyositis 4 | 1,187
non primary Sjogren syndrome sicca 4 | 891
pancreatic carcinoma 4 | 562
ulcerative colitis 4 | 1,819
Adrenoleukodystrophy 3 | 29
Arthritis, Experimental 3 | 39
Cancer 3 | 2,499
Dull intelligence 3 | 645
Epilepsy 3 | 792
Fatty liver disease 3 | 103
Heart failure 3 | 162
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Poor school performance 3 | 645
Rheumatoid arthritis 3 | 1,191
acute myeloid leukemia 3 | 783
colon cancer 3 | 1,478
diabetes mellitus 3 | 1,728
hepatocellular carcinoma 3 | 547
posterior fossa group A ependymoma 3 | 468
primary Sjogren syndrome 3 | 735
primary pancreatic ductal adenocarcinoma 3 | 1,109
Adenocarcinoma of lung 2 | 142
Cerebrovascular disease 2 | 238
Chronic intestinal vascular insufficiency 2 | 12
Cognitive delay 2 | 608
Coronary artery disease 2 | 268
Depressive disorder 2 | 409
Global developmental delay 2 | 608
Liver Cirrhosis, Experimental 2 | 769
Mental and motor retardation 2 | 608
Polycystic ovary syndrome 2 | 360
Prostatic Neoplasms 2 | 495
Retinal Degeneration 2 | 106
Seizures 2 | 596
chronic rhinosinusitis 2 | 512
dermatomyositis 2 | 966
hereditary spastic paraplegia 2 | 318
limb girdle muscular dystrophy 2A 2 | 213
nasopharyngeal carcinoma 2 | 1,058
non diabetic and post-ischemic heart failure 2 | 200
pediatric high grade glioma 2 | 1,064

Tissue

Blood and immune system 36 | 16,909
Digestive Tract 36 | 17,369
Endocrine System 36 | 18,159
Female tissues 36 | 17,400
Nervous System 36 | 16,725
Skin and soft tissues 36 | 17,230
Urinary Tract 36 | 16,678
Liver and Pancreas 35 | 16,750
Male tissues 35 | 17,142
Respiratory system 35 | 16,393
Cardiovascular System 34 | 15,192

Target Family

Enzyme 26 | 4,145
Non-IDG 8 | 12,091
Transporter 2 | 473

Reactome Pathway

Fatty acyl-CoA biosynthesis 36 | 36
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Long-chain-fatty-acid--CoA ligase 5 ACSL5 Tbio Enzyme -1.98202 97.3 170
S-acyl fatty acid synthase thioesterase, medium chain OLAH Tdark Enzyme -1.11894 12.1 39
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Long-chain-fatty-acid--CoA ligase 6 ACSL6 Tbio Enzyme -1.86749 73.8 139
ATP-citrate synthase ACLY Tchem Enzyme -2.82704 654.3 332
Lysosomal thioesterase PPT2 PPT2 Tbio Enzyme -2.06846 111.8 104
MORC family CW-type zinc finger protein 2 MORC2 Tbio Non-IDG -1.12323 14.2 98
Elongation of very long chain fatty acids protein 1 ELOVL1 Tbio Non-IDG -1.29305 16.7 156
Hydroxyacyl-thioester dehydratase type 2, mitochondrial HTD2 Tdark Enzyme 0.00000 16
Elongation of very long chain fatty acids protein 5 ELOVL5 Tbio Non-IDG -1.90493 83.7 237