Development Level

Tbio 116 | 11,651
Tchem 39 | 1,388
Tdark 17 | 6,593
Tclin 8 | 612

IMPC Phenotype

preweaning lethality, incomple... 6 | 499
abnormal heart morphology 4 | 162
preweaning lethality, complete... 4 | 979
decreased mean corpuscular vol... 3 | 79
decreased mean platelet volume 3 | 25
enlarged heart 3 | 210
increased monocyte cell number 3 | 63
abnormal bone structure 2 | 187
abnormal lens morphology 2 | 81
abnormal seminal vesicle morph... 2 | 114
abnormal testis morphology 2 | 43
cataract 2 | 92
decreased body length 2 | 101
decreased bone mineral content 2 | 151
decreased circulating triglyce... 2 | 79
embryonic lethality prior to t... 2 | 278
hydrometra 2 | 53
hypoactivity 2 | 132
increased mean corpuscular hem... 2 | 96
small testis 2 | 58
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal clavicle morphology 1 | 6
abnormal epididymis morphology 1 | 42
abnormal joint morphology 1 | 23
abnormal optic disc morphology 1 | 10
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal tibia morphology 1 | 14
abnormal vertebrae morphology 1 | 18
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
enlarged spleen 1 | 41
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased body length 1 | 32
increased circulating bilirubi... 1 | 16
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased heart rate 1 | 23
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
prenatal lethality prior to he... 1 | 87
small superior vagus ganglion 1 | 74
thrombocytopenia 1 | 56

Disease

Carcinoma 111 | 11,493
ovarian cancer 88 | 8,520
psoriasis 86 | 6,694
osteosarcoma 81 | 7,950
pancreatic ductal adenocarcinoma liver metastasis 63 | 1,962
medulloblastoma, large-cell 62 | 6,241
lung cancer 57 | 4,740
interstitial cystitis 46 | 2,312
glioblastoma 43 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 42 | 3,291
malignant mesothelioma 42 | 3,232
lung carcinoma 39 | 2,843
intraductal papillary-mucinous carcinoma (IPMC) 38 | 2,989
ependymoma 37 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 37 | 2,955
atypical teratoid / rhabdoid tumor 35 | 5,112
non-small cell lung cancer 35 | 2,890
Autosomal recessive predisposition 34 | 1,442
pancreatic cancer 34 | 2,398
ulcerative colitis 34 | 1,819
group 3 medulloblastoma 32 | 4,104
invasive ductal carcinoma 32 | 2,951
Cancer 31 | 2,499
lung adenocarcinoma 31 | 2,716
oligodendroglioma 30 | 2,850
tuberculosis 29 | 2,010
Breast cancer 28 | 3,578
astrocytoma 27 | 1,146
adrenocortical carcinoma 26 | 1,428
adult high grade glioma 26 | 3,801
Obesity 25 | 678
Schizophrenia 24 | 1,160
cystic fibrosis 24 | 1,696
Astrocytoma, Pilocytic 23 | 3,081
ductal carcinoma in situ 23 | 1,745
Muscle hypotonia 22 | 571
diabetes mellitus 22 | 1,728
Atopic dermatitis 21 | 952
colon cancer 21 | 1,478
primitive neuroectodermal tumor 21 | 3,035
Epilepsy 20 | 792
subependymal giant cell astrocytoma 20 | 2,287
Multiple myeloma 19 | 1,332
Prostatic Neoplasms 18 | 495
active Crohn's disease 18 | 922
astrocytic glioma 18 | 2,597
pituitary cancer 18 | 1,972
Hepatomegaly 17 | 285
Pick disease 17 | 1,894
Liver Cirrhosis, Experimental 16 | 769
Rheumatoid arthritis 16 | 1,191
Seizures 16 | 596
group 4 medulloblastoma 16 | 1,855
Chemical and Drug Induced Liver Injury 15 | 195
Cardiomyopathies 14 | 110
Cognitive delay 14 | 608
Global developmental delay 14 | 608
Heart failure 14 | 162
Hypertension 14 | 396
Kidney cancer 14 | 2,613
Mental and motor retardation 14 | 608
primary pancreatic ductal adenocarcinoma 14 | 1,109
Breast Neoplasms 13 | 445
Intellectual disability 13 | 1,016
Mammary Neoplasms 13 | 425
active ulcerative colitis 13 | 764
Atherosclerosis 12 | 291
Bipolar Disorder 12 | 666
Coronary artery disease 12 | 268
Hypoglycemia 12 | 152
acute myeloid leukemia 12 | 783
acute quadriplegic myopathy 12 | 1,158
Asthma 11 | 385
Carcinoma, Hepatocellular 11 | 228
Cardiomegaly 11 | 116
Cerebrovascular disease 11 | 238
Depressive disorder 11 | 409
Failure to gain weight 11 | 365
Liver carcinoma 11 | 240
Liver disease 11 | 237
Pediatric failure to thrive 11 | 365
Waldenstrons macroglobulinemia 11 | 765
aldosterone-producing adenoma 11 | 665
cutaneous lupus erythematosus 11 | 1,057
progressive supranuclear palsy 11 | 676
Adrenoleukodystrophy 10 | 29
Cholestasis 10 | 155
Elevated hepatic transaminases 10 | 81
Hepatic enzyme increased 10 | 81
Lethargy 10 | 77
Liver Dysfunction 10 | 99
Liver enzymes abnormal 10 | 81
Liver function test increased 10 | 81
Liver function tests abnormal finding 10 | 81
Neurodegenerative disease 10 | 414
Subclinical abnormal liver function tests 10 | 81
Transaminases increased 10 | 81
breast carcinoma 10 | 1,638
non primary Sjogren syndrome sicca 10 | 891
pancreatic carcinoma 10 | 562

Tissue

Digestive Tract 178 | 17,369
Female tissues 178 | 17,400
Skin and soft tissues 178 | 17,230
Endocrine System 175 | 18,159
Liver and Pancreas 175 | 16,750
Male tissues 175 | 17,142
Urinary Tract 175 | 16,678
Blood and immune system 170 | 16,909
Nervous System 170 | 16,725
Respiratory system 167 | 16,393
Cardiovascular System 154 | 15,192

Target Family

Enzyme 132 | 4,145
Non-IDG 37 | 12,091
Transporter 7 | 473
Kinase 2 | 634
Nuclear Receptor 2 | 48

Reactome Pathway

Fatty acid metabolism 180 | 180
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Carbonyl reductase family member 4 CBR4 Tbio Enzyme -1.69083 48.5 128
Fatty-acid amide hydrolase 2 FAAH2 Tbio Enzyme -0.82593 5.68 104
Enoyl-CoA delta isomerase 1, mitochondrial ECI1 Tbio Enzyme -2.67168 459.1 229
Acyl-coenzyme A thioesterase 11 ACOT11 Tbio Enzyme -2.32299 204.5 165
Phosphatidylcholine transfer protein PCTP Tbio Non-IDG -1.72354 56.3 156
Peroxisomal carnitine O-octanoyltransferase CROT Tbio Enzyme -1.33388 20.1 252
5'-AMP-activated protein kinase catalytic subunit alpha-2 PRKAA2 Tchem Kinase -1.42705 21.1 603
Long-chain specific acyl-CoA dehydrogenase, mitochondrial ACADL Tbio Enzyme -1.52646 31.4 231
Long-chain-fatty-acid--CoA ligase ACSBG2 ACSBG2 Tdark Enzyme -0.38371 2.13 98