Development Level

Tbio 161 | 10,625
Tchem 53 | 1,890
Tdark 20 | 7,003
Tclin 10 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 15 | 633
preweaning lethality, incomple... 9 | 260
decreased total body fat amoun... 5 | 186
embryonic lethality prior to t... 5 | 187
increased or absent threshold ... 5 | 128
abnormal embryo size 4 | 112
decreased body length 4 | 108
decreased circulating glucose ... 4 | 121
decreased lean body mass 4 | 195
increased mean corpuscular hem... 4 | 93
abnormal behavior 3 | 226
abnormal bone structure 3 | 131
decreased body weight 3 | 174
decreased circulating alkaline... 3 | 41
abnormal retina morphology 2 | 100
abnormal retinal pigmentation 2 | 61
abnormal seminal vesicle morph... 2 | 47
decreased Ly6C low monocyte nu... 2 | 23
decreased bone mineral content 2 | 157
decreased caudal vertebrae num... 2 | 49
decreased circulating HDL chol... 2 | 77
decreased circulating calcium ... 2 | 33
decreased circulating choleste... 2 | 85
decreased circulating serum al... 2 | 79
decreased circulating total pr... 2 | 41
decreased eosinophil cell numb... 2 | 41
decreased fasted circulating g... 2 | 49
decreased grip strength 2 | 123
decreased leukocyte cell numbe... 2 | 54
decreased threshold for audito... 2 | 32
embryonic lethality prior to o... 2 | 148
hypoactivity 2 | 89
increased Ly6C high monocyte n... 2 | 12
increased body weight 2 | 42
increased circulating alkaline... 2 | 119
increased circulating bilirubi... 2 | 16
increased fasted circulating g... 2 | 68
increased mean corpuscular hem... 2 | 25
increased total body fat amoun... 2 | 57
prenatal lethality prior to he... 2 | 64
abnormal behavioral response t... 1 | 52
abnormal coping response 1 | 12
abnormal embryo turning 1 | 15
abnormal eye morphology 1 | 38
abnormal gait 1 | 51
abnormal head morphology 1 | 10
abnormal kidney morphology 1 | 30
abnormal locomotor activation 1 | 26
abnormal motor capabilities/co... 1 | 4
abnormal respiratory quotient 1 | 9
abnormal rib morphology 1 | 28
abnormal sleep behavior 1 | 63
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 14
abnormal vocalization 1 | 21
corneal opacity 1 | 25
decreased KLRG1+ CD4 alpha bet... 1 | 2
decreased anxiety-related resp... 1 | 12
decreased bone mineral density 1 | 126
decreased circulating triglyce... 1 | 83
decreased gamma-delta T cell n... 1 | 18
decreased heart weight 1 | 44
decreased hemoglobin content 1 | 53
decreased vertical activity 1 | 22
embryonic growth retardation 1 | 28
enlarged lymph nodes 1 | 27
enlarged spleen 1 | 26
hemorrhage 1 | 12
hydrometra 1 | 13
impaired glucose tolerance 1 | 52
increased bone mineral content 1 | 92
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating choleste... 1 | 53
increased circulating fructosa... 1 | 11
increased circulating glycerol... 1 | 11
increased circulating iron lev... 1 | 25
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased erythrocyte cell num... 1 | 26
increased grip strength 1 | 83
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased lactate dehydrogenas... 1 | 3
increased lean body mass 1 | 107
increased mean platelet volume 1 | 19
increased rib number 1 | 41
limb grasping 1 | 35
long tibia 1 | 13
microphthalmia 1 | 15
persistence of hyaloid vascula... 1 | 22
short tibia 1 | 82
small testis 1 | 37
straub tail 1 | 26
thin ventricular wall 1 | 5
thrombocytopenia 1 | 46
thrombocytosis 1 | 23

Disease

ovarian cancer 137 | 8,484
psoriasis 127 | 6,685
osteosarcoma 121 | 7,933
medulloblastoma, large-cell 99 | 6,234
glioblastoma 70 | 5,572
atypical teratoid / rhabdoid tumor 65 | 4,369
lung cancer 65 | 4,466
pancreatic ductal adenocarcinoma liver metastasis 64 | 1,795
intraductal papillary-mucinous neoplasm (IPMN) 63 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 62 | 2,956
malignant mesothelioma 59 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 54 | 2,988
ulcerative colitis 47 | 2,087
Obesity 46 | 616
primitive neuroectodermal tumor 45 | 3,031
Pick disease 44 | 1,893
interstitial cystitis 43 | 2,299
Breast cancer 42 | 3,094
lung carcinoma 42 | 2,844
oligodendroglioma 41 | 2,849
Cancer 40 | 2,346
diabetes mellitus 40 | 1,663
invasive ductal carcinoma 39 | 2,950
group 4 medulloblastoma 37 | 1,875
subependymal giant cell astrocytoma 36 | 2,287
astrocytic glioma 35 | 2,241
astrocytoma 35 | 1,493
ependymoma 35 | 2,514
pituitary cancer 35 | 1,972
pediatric high grade glioma 34 | 2,712
non-small cell lung cancer 33 | 2,798
tuberculosis 33 | 1,557
ductal carcinoma in situ 32 | 1,745
pancreatic cancer 32 | 2,300
pilocytic astrocytoma 32 | 3,086
adult high grade glioma 31 | 2,148
lung adenocarcinoma 31 | 2,713
acute quadriplegic myopathy 30 | 1,157
adrenocortical carcinoma 30 | 1,427
cystic fibrosis 27 | 1,665
Rheumatoid Arthritis 25 | 1,160
active Crohn's disease 24 | 918
colon cancer 24 | 1,475
group 3 medulloblastoma 24 | 2,254
Multiple myeloma 23 | 1,327
Carcinoma 22 | 2,147
breast carcinoma 21 | 1,614
Atopic dermatitis 20 | 944
aldosterone-producing adenoma 19 | 664
spina bifida 19 | 1,064
Fatty liver disease 18 | 84
Lipid metabolism disorder 18 | 102
Liver carcinoma 18 | 217
Waldenstrons macroglobulinemia 18 | 765
juvenile dermatomyositis 18 | 1,189
posterior fossa group B ependymoma 18 | 1,530
primary pancreatic ductal adenocarcinoma 18 | 1,271
sonic hedgehog group medulloblastoma 18 | 1,482
Metabolic syndrome X 17 | 155
gastric carcinoma 17 | 832
non primary Sjogren syndrome sicca 17 | 840
Atherosclerosis 16 | 275
Mammary Neoplasms 16 | 410
acute myeloid leukemia 16 | 780
medulloblastoma 16 | 1,524
dermatomyositis 15 | 933
Diabetes Mellitus, Experimental 14 | 106
Prostatic Neoplasms 14 | 471
autosomal dominant Emery-Dreifuss muscular dystrophy 14 | 499
posterior fossa group A ependymoma 14 | 1,511
atypical teratoid/rhabdoid tumor 13 | 1,095
tuberculosis and treatment for 6 months 13 | 686
Coronary artery disease 12 | 240
Duchenne muscular dystrophy 12 | 602
Endometriosis 12 | 535
Intellectual disability 12 | 573
Heart disease 11 | 279
Liver disease 11 | 219
active ulcerative colitis 11 | 477
cutaneous lupus erythematosus 11 | 1,056
esophageal adenocarcinoma 11 | 737
fibroadenoma 11 | 557
pancreatic carcinoma 11 | 567
Amyotrophic Lateral Sclerosis 10 | 431
Hypoglycemia 10 | 81
Kidney disease 10 | 396
Methylmalonic acidemia 10 | 39
nephrosclerosis 10 | 329
progressive supranuclear palsy 10 | 674
Alzheimer's disease 9 | 644
Drug-Induced Liver Injury 9 | 118
IGA Glomerulonephritis 9 | 454
Kidney Failure, Chronic 9 | 45
Myocardial Ischemia 9 | 169
Polycystic Ovary Syndrome 9 | 332
gastric cancer 9 | 430
nasopharyngeal carcinoma 9 | 1,056
Down syndrome 8 | 548
hepatocellular carcinoma 8 | 532
mucosa-associated lymphoid tissue lymphoma 8 | 480

Tissue

Digestive Tract 242 | 18,473
Liver and Pancreas 242 | 18,136
Urinary Tract 242 | 18,444
Blood and immune system 241 | 17,995
Endocrine System 241 | 18,512
Female tissues 241 | 18,647
Nervous System 241 | 18,561
Cardiovascular System 240 | 17,958
Skin and soft tissues 240 | 18,115
Male tissues 239 | 17,969
Respiratory system 238 | 17,484

Target Family

Enzyme 143 | 4,146
Non-IDG 51 | 11,971
Transcription Factor 21 | 1,400
Nuclear Receptor 8 | 48
Epigenetic 7 | 242
Kinase 7 | 634
Transporter 6 | 473
TF/Epigenetic 1 | 38

Reactome Pathway

Fatty acid, triacylglycerol, a... 244 | 244
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cyclin-dependent kinase 8 CDK8 Tchem Kinase -1.96301 102.7 307
Trifunctional enzyme subunit alpha, mitochondrial HADHA Tbio Non-IDG -2.96515 948.2 132
Fatty acid synthase FASN Tchem Enzyme -2.49948 348.5 388
Apolipoprotein A-I APOA1 Tchem Non-IDG -3.60439 3516.7 901
Apolipoprotein A-II APOA2 Tbio Non-IDG -2.80284 593.9 352
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 HACD1 Tbio Enzyme -1.46870 28.7 59
Very-long-chain enoyl-CoA reductase TECR Tbio Enzyme -2.58601 380.5 85
Acyl-coenzyme A thioesterase 12 ACOT12 Tbio Enzyme -0.94659 8.55 79
Peroxisome proliferator-activated receptor gamma coactivator 1-beta PPARGC1B Tbio Non-IDG -2.61803 420.9 51
Elongation of very long chain fatty acids protein 5 ELOVL5 Tchem Non-IDG -1.81279 72.3 189