Development Level

Tbio 161 | 10,625
Tchem 53 | 1,890
Tdark 20 | 7,003
Tclin 10 | 602

Collection

Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 15 | 633
preweaning lethality, incomple... 9 | 260
decreased total body fat amoun... 5 | 186
embryonic lethality prior to t... 5 | 187
increased or absent threshold ... 5 | 128
abnormal embryo size 4 | 112
decreased body length 4 | 108
decreased circulating glucose ... 4 | 121
decreased lean body mass 4 | 195
increased mean corpuscular hem... 4 | 93
abnormal behavior 3 | 226
abnormal bone structure 3 | 131
decreased body weight 3 | 174
decreased circulating alkaline... 3 | 41
abnormal retina morphology 2 | 100
abnormal retinal pigmentation 2 | 61
abnormal seminal vesicle morph... 2 | 47
decreased Ly6C low monocyte nu... 2 | 23
decreased bone mineral content 2 | 157
decreased caudal vertebrae num... 2 | 49
decreased circulating HDL chol... 2 | 77
decreased circulating calcium ... 2 | 33
decreased circulating choleste... 2 | 85
decreased circulating serum al... 2 | 79
decreased circulating total pr... 2 | 41
decreased eosinophil cell numb... 2 | 41
decreased fasted circulating g... 2 | 49
decreased grip strength 2 | 123
decreased leukocyte cell numbe... 2 | 54
decreased threshold for audito... 2 | 32
embryonic lethality prior to o... 2 | 148
hypoactivity 2 | 89
increased Ly6C high monocyte n... 2 | 12
increased body weight 2 | 42
increased circulating alkaline... 2 | 119
increased circulating bilirubi... 2 | 16
increased fasted circulating g... 2 | 68
increased mean corpuscular hem... 2 | 25
increased total body fat amoun... 2 | 57
prenatal lethality prior to he... 2 | 64
abnormal behavioral response t... 1 | 52
abnormal coping response 1 | 12
abnormal embryo turning 1 | 15
abnormal eye morphology 1 | 38
abnormal gait 1 | 51
abnormal head morphology 1 | 10
abnormal kidney morphology 1 | 30
abnormal locomotor activation 1 | 26
abnormal motor capabilities-co... 1 | 4
abnormal respiratory quotient 1 | 9
abnormal rib morphology 1 | 28
abnormal sleep behavior 1 | 63
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 14
abnormal vocalization 1 | 21
corneal opacity 1 | 25
decreased KLRG1+ CD4 alpha bet... 1 | 2
decreased anxiety-related resp... 1 | 12
decreased bone mineral density 1 | 126
decreased circulating triglyce... 1 | 83
decreased gamma-delta T cell n... 1 | 18
decreased heart weight 1 | 44
decreased hemoglobin content 1 | 53
decreased vertical activity 1 | 22
embryonic growth retardation 1 | 28
enlarged lymph nodes 1 | 27
enlarged spleen 1 | 26
hemorrhage 1 | 12
hydrometra 1 | 13
impaired glucose tolerance 1 | 52
increased bone mineral content 1 | 92
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating choleste... 1 | 53
increased circulating fructosa... 1 | 11
increased circulating glycerol... 1 | 11
increased circulating iron lev... 1 | 25
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased erythrocyte cell num... 1 | 26
increased grip strength 1 | 83
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased lactate dehydrogenas... 1 | 3
increased lean body mass 1 | 107
increased mean platelet volume 1 | 19
increased rib number 1 | 41
limb grasping 1 | 35
long tibia 1 | 13
microphthalmia 1 | 15
persistence of hyaloid vascula... 1 | 22
short tibia 1 | 82
small testis 1 | 37
straub tail 1 | 26
thin ventricular wall 1 | 5
thrombocytopenia 1 | 46
thrombocytosis 1 | 23

Disease

ovarian cancer 137 | 8,491
psoriasis 127 | 6,685
osteosarcoma 121 | 7,933
medulloblastoma, large-cell 99 | 6,234
glioblastoma 70 | 5,572
atypical teratoid / rhabdoid tumor 65 | 4,369
lung cancer 65 | 4,473
pancreatic ductal adenocarcinoma liver metastasis 64 | 1,795
intraductal papillary-mucinous neoplasm (IPMN) 63 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 62 | 2,956
malignant mesothelioma 59 | 3,163
intraductal papillary-mucinous carcinoma (IPMC) 54 | 2,988
ulcerative colitis 47 | 2,087
Obesity 46 | 616
primitive neuroectodermal tumor 45 | 3,031
Pick disease 44 | 1,893
interstitial cystitis 43 | 2,299
Breast cancer 42 | 3,098
lung carcinoma 42 | 2,844
oligodendroglioma 41 | 2,849
Cancer 40 | 2,346
diabetes mellitus 40 | 1,663
invasive ductal carcinoma 39 | 2,950
group 4 medulloblastoma 37 | 1,875
subependymal giant cell astrocytoma 36 | 2,287
astrocytic glioma 35 | 2,241
astrocytoma 35 | 1,493
ependymoma 35 | 2,514
pituitary cancer 35 | 1,972
pediatric high grade glioma 34 | 2,712
tuberculosis 34 | 1,563
non-small cell lung cancer 33 | 2,798
ductal carcinoma in situ 32 | 1,745
pancreatic cancer 32 | 2,300
pilocytic astrocytoma 32 | 3,086
adult high grade glioma 31 | 2,148
lung adenocarcinoma 31 | 2,714
acute quadriplegic myopathy 30 | 1,157
adrenocortical carcinoma 30 | 1,427
cystic fibrosis 27 | 1,670
Rheumatoid Arthritis 25 | 1,170
active Crohn's disease 24 | 918
colon cancer 24 | 1,475
group 3 medulloblastoma 24 | 2,254
Multiple myeloma 23 | 1,327
Carcinoma 22 | 2,147
breast carcinoma 21 | 1,614
Atopic dermatitis 20 | 944
aldosterone-producing adenoma 19 | 664
spina bifida 19 | 1,064
Fatty liver disease 18 | 86
Lipid metabolism disorder 18 | 102
Liver carcinoma 18 | 217
Waldenstrons macroglobulinemia 18 | 764
juvenile dermatomyositis 18 | 1,189
posterior fossa group B ependymoma 18 | 1,530
primary pancreatic ductal adenocarcinoma 18 | 1,271
sonic hedgehog group medulloblastoma 18 | 1,482
Metabolic syndrome X 17 | 155
gastric carcinoma 17 | 832
non primary Sjogren syndrome sicca 17 | 840
Atherosclerosis 16 | 275
Mammary Neoplasms 16 | 410
acute myeloid leukemia 16 | 785
medulloblastoma 16 | 1,524
dermatomyositis 15 | 966
Diabetes Mellitus, Experimental 14 | 106
Prostatic Neoplasms 14 | 471
autosomal dominant Emery-Dreifuss muscular dystrophy 14 | 499
posterior fossa group A ependymoma 14 | 1,511
atypical teratoid/rhabdoid tumor 13 | 1,095
tuberculosis and treatment for 6 months 13 | 686
Coronary artery disease 12 | 240
Duchenne muscular dystrophy 12 | 602
Endometriosis 12 | 535
Intellectual disability 12 | 573
Heart disease 11 | 279
Liver disease 11 | 219
active ulcerative colitis 11 | 477
cutaneous lupus erythematosus 11 | 1,056
esophageal adenocarcinoma 11 | 737
fibroadenoma 11 | 557
pancreatic carcinoma 11 | 567
Amyotrophic Lateral Sclerosis 10 | 432
Hypoglycemia 10 | 81
Kidney disease 10 | 397
Methylmalonic acidemia 10 | 39
nephrosclerosis 10 | 329
progressive supranuclear palsy 10 | 674
Alzheimer's disease 9 | 644
Drug-Induced Liver Injury 9 | 118
IGA Glomerulonephritis 9 | 454
Kidney Failure, Chronic 9 | 45
Myocardial Ischemia 9 | 169
Polycystic Ovary Syndrome 9 | 334
gastric cancer 9 | 436
nasopharyngeal carcinoma 9 | 1,056
Down syndrome 8 | 548
hepatocellular carcinoma 8 | 550
mucosa-associated lymphoid tissue lymphoma 8 | 480

Tissue

Digestive Tract 242 | 18,472
Liver and Pancreas 242 | 18,135
Urinary Tract 242 | 18,443
Blood and immune system 241 | 17,994
Endocrine System 241 | 18,511
Female tissues 241 | 18,646
Nervous System 241 | 18,560
Cardiovascular System 240 | 17,957
Skin and soft tissues 240 | 18,114
Male tissues 239 | 17,968
Respiratory system 238 | 17,483

Target Family

Enzyme 143 | 4,146
Non-IDG 51 | 11,969
Transcription Factor 21 | 1,400
Nuclear Receptor 8 | 48
Epigenetic 7 | 242
Kinase 7 | 634
Transporter 6 | 473
TF/Epigenetic 1 | 38

Reactome Pathway

Fatty acid, triacylglycerol, a... 244 | 244
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.69372 46.6 95
Long-chain-fatty-acid--CoA ligase 6 ACSL6 Tbio Enzyme -1.84683 72.3 120
Angiotensinogen AGT Tchem Non-IDG -3.23867 1673.4 609
Mediator of RNA polymerase II transcription subunit 7 MED7 Tbio Enzyme -1.04585 10.2 155
Mediator of RNA polymerase II transcription subunit 25 MED25 Tbio Enzyme -1.76765 56.0 62
Paired amphipathic helix protein Sin3a SIN3A Tbio Non-IDG -1.89468 62.9 159
Cytochrome P450 1A1 CYP1A1 Tchem Non-IDG -3.53853 3553.5 340
Trimethylguanosine synthase TGS1 Tbio Enzyme -1.36236 24.4 85
Aryl hydrocarbon receptor nuclear translocator ARNT Tbio Transcription Factor -2.51053 243.3 424