Development Level

Tbio 7 | 11,445

IMPC Phenotype

abnormal behavior 1 | 298
abnormal vocalization 1 | 21
decreased body weight 1 | 161
decreased circulating amylase ... 1 | 28
decreased circulating insulin ... 1 | 76
decreased circulating phosphat... 1 | 27
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased prepulse inhibition 1 | 82
increased circulating calcium ... 1 | 34
increased fasted circulating g... 1 | 76
increased startle reflex 1 | 112
male infertility 1 | 123
short tibia 1 | 97
vertebral fusion 1 | 23

Disease

Carcinoma 6 | 11,493
medulloblastoma, large-cell 5 | 6,241
psoriasis 5 | 6,694
atypical teratoid / rhabdoid tumor 4 | 5,112
colon cancer 4 | 1,478
lung carcinoma 4 | 2,843
ovarian cancer 4 | 8,520
primitive neuroectodermal tumor 4 | 3,035
Cancer 3 | 2,499
Melanoma 3 | 711
Skin cancer 3 | 469
adult high grade glioma 3 | 3,801
ependymoma 3 | 4,679
group 3 medulloblastoma 3 | 4,104
lung cancer 3 | 4,740
osteosarcoma 3 | 7,950
tuberculosis 3 | 2,010
ulcerative colitis 3 | 1,819
Abnormal vision 2 | 52
Breast cancer 2 | 3,578
Charcot-Marie-Tooth disease dominant intermediate F 2 | 3
Cholera 2 | 34
Congenital Heart Defects 2 | 58
DOID:2415 2 | 5
Epilepsy 2 | 792
Fibrous dysplasia 2 | 15
Heart Defects, Congenital 2 | 37
Hyperreflexia 2 | 209
Kidney cancer 2 | 2,613
Malignant melanoma of choroid 2 | 3
Malignant melanoma of ciliary body 2 | 3
Malignant melanoma of iris 2 | 4
McCune Albright syndrome 2 | 19
Ocular cancer 2 | 7
Pertussis 2 | 20
Phakomatosis cesioflammea 2 | 2
Pick disease 2 | 1,894
Pseudohypoparathyroidism 2 | 18
Retinal Detachment 2 | 51
Schizophrenia 2 | 1,160
Uveal melanoma 2 | 20
active Crohn's disease 2 | 922
active ulcerative colitis 2 | 764
glioblastoma 2 | 5,792
non-small cell lung cancer 2 | 2,890
pancreatic cancer 2 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
subependymal giant cell astrocytoma 2 | 2,287
Abdominal Pain 1 | 98
Abnormal respiratory patterns 1 | 20
Abnormality of the fingernails 1 | 51
Alopecia 1 | 115
Anxiety 1 | 136
Anxiety disease 1 | 113
Axial hypotonia 1 | 46
Big calvaria 1 | 147
Blood Coagulation Disorders 1 | 42
Cardiac Arrhythmia 1 | 103
Cardiac conduction abnormalities 1 | 78
Cerebrovascular accident 1 | 63
Conduction disorder of the heart 1 | 79
Congestive heart failure 1 | 113
Craniofacial Abnormalities 1 | 151
Disease of anatomical entity 1 | 32
Dry skin 1 | 75
EKG abnormalities 1 | 78
Electrocardiogram abnormal 1 | 81
Electrocardiogram change 1 | 78
Electromyogram abnormal 1 | 49
Epileptic encephalopathy 1 | 26
Globe of eye large 1 | 20
Hydrophthalmos 1 | 19
Hypercalcemia 1 | 59
Hypercalciuria 1 | 27
Hyperphosphatemia (disorder) 1 | 17
Hyperpigmented macules 1 | 42
Hypocalcemia 1 | 32
Hypomagnesemia 1 | 12
Hypotension 1 | 82
Hypsarrhythmia 1 | 25
Impotence 1 | 42
Increased head circumference 1 | 147
Increased size of cranium 1 | 147
Increased size of skull 1 | 147
Isolated cases 1 | 72
Liver Cirrhosis, Experimental 1 | 769
MYELODYSPLASTIC SYNDROME 1 | 53
Meningioma 1 | 41
Mood swings 1 | 77
Myasthenias 1 | 8
Myelodysplastic Syndromes 1 | 26
Organic writer's cramp 1 | 10
Osteoporosis 1 | 363
Paresthesia 1 | 32
SERUM PHOSPHATE ELEVATED 1 | 14
West Syndrome 1 | 28
Xerosis 1 | 75
chorea-acanthocytosis 1 | 12
non-small cell lung carcinoma 1 | 317
severe Alzheimer's disease 1 | 47

Tissue

Blood and immune system 7 | 16,909
Cardiovascular System 7 | 15,192
Digestive Tract 7 | 17,369
Endocrine System 7 | 18,159
Female tissues 7 | 17,400
Liver and Pancreas 7 | 16,750
Male tissues 7 | 17,142
Nervous System 7 | 16,725
Respiratory system 7 | 16,393
Skin and soft tissues 7 | 17,230
Urinary Tract 7 | 16,678

Target Family

Non-IDG 4 | 12,091
Enzyme 3 | 4,145

Reactome Pathway

Fatty Acids bound to GPR40 (FF... 7 | 7
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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