Development Level

Tbio 3 | 11,445
Tchem 1 | 1,598

IMPC Phenotype

abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
decreased bone mineral content 1 | 151
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
preweaning lethality, complete... 1 | 979
small superior vagus ganglion 1 | 74

Disease

Autoimmune lymphoproliferative syndrome 4 | 11
Cancer 4 | 2,499
psoriasis 4 | 6,694
Lung Neoplasms 3 | 232
Splenomegaly 3 | 190
glioblastoma 3 | 5,792
lung cancer 3 | 4,740
ovarian cancer 3 | 8,520
Acute Lung Injury 2 | 22
Anti-nuclear factor positive 2 | 18
Antiphospholipid antibody positivity 2 | 4
Arthritis 2 | 290
Astrocytoma, Pilocytic 2 | 3,081
Autoimmune hemolytic anemia 2 | 31
Autoimmune neutropenia 2 | 5
Autoimmune thrombocytopenia 2 | 22
Autosomal recessive predisposition 2 | 1,442
Breast cancer 2 | 3,578
Carcinoma 2 | 11,493
Carcinoma, Non-Small-Cell Lung 2 | 107
Cardiomyopathies 2 | 110
Cardiomyopathy, Dilated 2 | 83
Chronic noninfectious lymphadenopathy 2 | 6
Coombs positive hemolytic anemia 2 | 4
Defective lymphocyte apoptosis 2 | 4
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Elevated serum IgA 2 | 5
Eosinophilia 2 | 28
Follicular hyperplasia 2 | 4
Hepatomegaly 2 | 285
Human immunodeficiency virus infectious disease 2 | 138
Hypersensitivity reaction type II disease 2 | 253
Idiopathic thrombocytopenia 2 | 22
Immune thrombocytopenic purpura 2 | 24
Increased IgM levels 2 | 16
Increased levels of IgG 2 | 4
Increased number of CD4-/CD8- T cells expressing alpha/beta T-cell receptors 2 | 3
Increased number of peripheral CD3+ T cells 2 | 3
Increased proportion of HLA DR+ and CD57+ T cells 2 | 3
Iron deficiency anemia 2 | 12
Liver Failure, Acute 2 | 29
Lymphoproliferative syndrome 2 | 58
Melanoma 2 | 711
Multiple Sclerosis 2 | 540
Neutrophil antibody positive 2 | 3
Platelet antibody positive 2 | 4
Reduced delayed hypersensitivity 2 | 4
Rheumatoid arthritis 2 | 1,191
Rheumatoid factor positive (finding) 2 | 3
Sensorineural Hearing Loss (disorder) 2 | 284
Short stature 2 | 531
Smooth muscle antibodies positive 2 | 3
Urticaria 2 | 67
Vascular disease 2 | 319
Vasculitis 2 | 80
atypical teratoid / rhabdoid tumor 2 | 5,112
cutaneous lupus erythematosus 2 | 1,057
ependymoma 2 | 4,679
hepatocellular carcinoma 2 | 547
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
lung carcinoma 2 | 2,843
non-small cell lung carcinoma 2 | 317
osteosarcoma 2 | 7,950
primary Sjogren syndrome 2 | 735
subependymal giant cell astrocytoma 2 | 2,287
Acne 1 | 52
Angle class 2 malocclusion 1 | 57
Angle class 3 malocclusion 1 | 57
Apraxias 1 | 27
Autoimmune lymphoproliferative syndrome type 2B 1 | 9
Behcet's syndrome 1 | 50
Carcinoma, squamous cell of head and neck 1 | 31
Carotid Artery Diseases 1 | 11
Confusion 1 | 21
Decreased T cell activation 1 | 4
Diffuse large B-cell lymphoma 1 | 39
Drug allergy 1 | 36
Edema 1 | 81
Gaucher disease type 3 1 | 67
Hemiparesis 1 | 34
Hepatitis 1 | 67
Increased hepatocellular carcinoma risk 1 | 27
Increased incidence of hepatocellular carcinoma 1 | 27
Juvenile rheumatoid arthritis 1 | 111
Lymphoma, Large B-Cell, Diffuse 1 | 34
Malaria, Falciparum 1 | 3
Malocclusion 1 | 57
Micronodular cirrhosis 1 | 12
Myasthenia gravis 1 | 23
Myocardial Reperfusion Injury 1 | 37
Nephritis 1 | 51
Premature canities 1 | 24
Skin Neoplasms 1 | 69
Sparse scalp hair 1 | 42
Squamous cell carcinoma of the head and neck 1 | 29
Stomach cancer 1 | 30
Subacute progressive viral hepatitis 1 | 9
Ventricular Dysfunction, Left 1 | 22
esophageal cancer 1 | 22

Tissue

Blood and immune system 4 | 16,909
Cardiovascular System 4 | 15,192
Digestive Tract 4 | 17,369
Endocrine System 4 | 18,159
Female tissues 4 | 17,400
Liver and Pancreas 4 | 16,750
Male tissues 4 | 17,142
Nervous System 4 | 16,725
Respiratory system 4 | 16,393
Skin and soft tissues 4 | 17,230
Urinary Tract 4 | 16,678

Target Family

Non-IDG 3 | 12,091
Enzyme 1 | 4,145

Reactome Pathway

FasL/ CD95L signaling 4 | 4
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Caspase-8 CASP8 Tchem Enzyme -3.54224 3121.4 1045
Tumor necrosis factor receptor superfamily member 6 FAS Tbio Non-IDG -3.32299 2090.2 2060
Tumor necrosis factor ligand superfamily member 6 FASLG Tbio Non-IDG -3.53551 3585.2 953
FAS-associated death domain protein FADD Tbio Non-IDG -2.70083 469.8 708