Development Level

Tbio 30 | 11,445
Tchem 4 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

embryonic lethality prior to o... 3 | 239
preweaning lethality, complete... 3 | 979
anophthalmia 2 | 33
corneal opacity 2 | 32
decreased circulating glucose ... 2 | 126
embryonic lethality prior to t... 2 | 278
preweaning lethality, incomple... 2 | 499
abnormal blood vessel morpholo... 1 | 5
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal iris transilluminatio... 1 | 2
abnormal lens morphology 1 | 81
abnormal placement of pupils 1 | 6
abnormal spinal cord morpholog... 1 | 9
abnormal spleen morphology 1 | 55
abnormal vitreous body morphol... 1 | 10
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
cornea ulcer 1 | 1
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased fasted circulating g... 1 | 65
decreased heart rate variabili... 1 | 13
fused cornea and lens 1 | 5
increased bone mineral density 1 | 72
increased circulating sodium l... 1 | 71
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
iris synechia 1 | 3
narrow eye opening 1 | 12

Disease

Carcinoma 23 | 11,493
ovarian cancer 22 | 8,520
Fanconi anemia 21 | 56
osteosarcoma 18 | 7,950
Anemia 15 | 365
group 3 medulloblastoma 15 | 4,104
medulloblastoma, large-cell 14 | 6,241
Short stature 13 | 531
Small head 13 | 374
Acquired scoliosis 12 | 281
Cancer 12 | 2,499
Cognitive delay 12 | 608
Curvature of spine 12 | 282
Dull intelligence 12 | 645
Esophageal atresia with or without tracheoesophageal fistula 12 | 21
Global developmental delay 12 | 608
Intellectual disability 12 | 1,016
Low intelligence 12 | 645
Mental Retardation 12 | 645
Mental and motor retardation 12 | 608
Mental deficiency 12 | 645
Poor school performance 12 | 645
esophageal atresia/tracheoesophageal fistula 12 | 22
Almond-shaped eyes 11 | 23
Breast cancer 11 | 3,578
Chromosome Breakage 11 | 36
Decreased platelet count 11 | 111
Increased chromosomal breakage 11 | 27
Irregular hyperpigmentation 11 | 33
Leukopenia 11 | 72
Pyridoxine-responsive sideroblastic anemia 11 | 17
Radial aplasia/hypoplasia 11 | 29
Short palpebral fissure 11 | 38
Thrombocytopenia 11 | 197
glioblastoma 11 | 5,792
hypopigmented skin patch 11 | 59
lung cancer 11 | 4,740
Autosomal recessive predisposition 10 | 1,442
Esophageal atresia 10 | 43
Tracheoesophageal Fistula 10 | 36
atypical teratoid / rhabdoid tumor 10 | 5,112
psoriasis 10 | 6,694
Xeroderma pigmentosum group F 9 | 22
malignant mesothelioma 9 | 3,232
primitive neuroectodermal tumor 9 | 3,035
Hemoglobin low 8 | 124
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
Fanconi Anemia, Complementation Group a 7 | 9
Bloom syndrome 6 | 29
Cryptorchidism 6 | 296
Kidney cancer 6 | 2,613
Pancytopenia 6 | 45
Strabismus 6 | 270
Thumb aplasia 6 | 16
pancreatic cancer 6 | 2,398
Abnormally small eyeball 5 | 97
Absence of radius and ulna 5 | 15
Absent radius 5 | 15
Birthmark 5 | 35
Cafe-au-Lait Spots 5 | 37
Congenital absence of kidney 5 | 31
Congenital deafness 5 | 185
Deafness 5 | 198
Decreased size of eyeball 5 | 97
Hearing Loss, Partial 5 | 185
Hematologic Neoplasms 5 | 22
Hypoplasia of thumb 5 | 26
Leukemia 5 | 104
Microphthalmos 5 | 100
Neutrophil count decreased 5 | 47
Radial aplasia 5 | 15
Xeroderma pigmentosum 5 | 43
hearing impairment 5 | 199
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
invasive ductal carcinoma 5 | 2,951
non-small cell lung cancer 5 | 2,890
Abnormal pigmentation 4 | 25
Allergic hypersensitivity disease 4 | 126
Chromosomal breakage induced by crosslinking agents 4 | 5
Congenital Heart Defects 4 | 58
Congenital heart disease 4 | 93
Digitalization of thumbs 4 | 6
Duplicated collecting system 4 | 7
Ecchymosis 4 | 66
Ectopic kidney 4 | 11
Epilepsy 4 | 792
Horseshoe Kidney 4 | 16
Increased tendency to bruise 4 | 66
Low Birth Weights 4 | 69
Pick disease 4 | 1,894
Primary hypogonadism 4 | 37
Prolonged G2 phase of cell cycle 4 | 4
Reticulocytopenia 4 | 10
Seizures 4 | 596
Small for gestational age (disorder) 4 | 69
adult high grade glioma 4 | 3,801
dermatomyositis 4 | 966
ductal carcinoma in situ 4 | 1,745
ependymoma 4 | 4,679
lung adenocarcinoma 4 | 2,716

Tissue

Blood and immune system 35 | 16,909
Digestive Tract 35 | 17,369
Endocrine System 35 | 18,159
Female tissues 35 | 17,400
Male tissues 35 | 17,142
Nervous System 35 | 16,725
Respiratory system 35 | 16,393
Skin and soft tissues 35 | 17,230
Urinary Tract 35 | 16,678
Liver and Pancreas 34 | 16,750
Cardiovascular System 33 | 15,192

Target Family

Non-IDG 24 | 12,091
Enzyme 10 | 4,145
Kinase 1 | 634

Reactome Pathway

Fanconi Anemia Pathway 35 | 35
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase FANCL FANCL Tbio Enzyme -2.46302 286.2 146
Fanconi-associated nuclease 1 FAN1 Tbio Enzyme -2.06970 115.9 85
Serine/threonine-protein kinase ATR ATR Tchem Kinase -2.80362 549.6 376
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Fanconi anemia group C protein FANCC Tbio Non-IDG -2.85516 703.4 348
Fanconi anemia group B protein FANCB Tbio Non-IDG -2.33079 210.0 96
Replication protein A 14 kDa subunit RPA3 Tbio Non-IDG -1.85941 67.1 171
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139