Development Level

Tbio 110 | 11,651
Tchem 14 | 1,388
Tdark 11 | 6,593
Tclin 3 | 612

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 16 | 979
abnormal embryo size 7 | 220
preweaning lethality, incomple... 7 | 499
embryonic lethality prior to t... 6 | 278
abnormal behavior 3 | 298
decreased vertical activity 3 | 208
embryonic growth retardation 3 | 106
hyperactivity 3 | 148
prenatal lethality prior to he... 3 | 87
abnormal bone structure 2 | 187
abnormal eye morphology 2 | 68
abnormal retina morphology 2 | 71
abnormal seminal vesicle morph... 2 | 114
abnormal sleep behavior 2 | 70
cataract 2 | 92
cyanosis 2 | 7
decreased circulating aspartat... 2 | 34
decreased circulating serum al... 2 | 82
decreased mean corpuscular hem... 2 | 50
embryonic lethality prior to o... 2 | 239
enlarged heart 2 | 210
hypoactivity 2 | 132
increased circulating chloride... 2 | 41
increased circulating choleste... 2 | 66
increased circulating sodium l... 2 | 71
increased lean body mass 2 | 172
increased or absent threshold ... 2 | 101
prolonged QT interval 2 | 38
vertebral transformation 2 | 12
abnormal behavioral response t... 1 | 66
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal epididymis morphology 1 | 42
abnormal facial morphology 1 | 17
abnormal gait 1 | 69
abnormal head shape 1 | 10
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal liver size 1 | 5
abnormal outer ear morphology 1 | 3
abnormal ovary morphology 1 | 7
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal skin coloration 1 | 25
absent epididymis 1 | 3
absent pinna reflex 1 | 23
aorta dilation 1 | 3
cardiovascular system phenotyp... 1 | 36
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 47
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased granulocyte number 1 | 6
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased lean body mass 1 | 135
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
enlarged kidney 1 | 14
fusion of vertebral arches 1 | 7
hemorrhage 1 | 23
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating glucose ... 1 | 24
increased circulating potassiu... 1 | 29
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
mydriasis 1 | 6
prolonged ST segment 1 | 36
short tibia 1 | 97
shortened QT interval 1 | 4
small heart 1 | 10
small kidney 1 | 16
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 19
vertebral fusion 1 | 23

Disease

Carcinoma 101 | 11,493
ovarian cancer 77 | 8,520
osteosarcoma 70 | 7,950
medulloblastoma, large-cell 68 | 6,241
glioblastoma 61 | 5,792
atypical teratoid / rhabdoid tumor 55 | 5,112
lung cancer 55 | 4,740
psoriasis 53 | 6,694
group 3 medulloblastoma 50 | 4,104
ependymoma 44 | 4,679
Breast cancer 41 | 3,578
adult high grade glioma 41 | 3,801
malignant mesothelioma 38 | 3,232
primitive neuroectodermal tumor 37 | 3,035
non-small cell lung cancer 36 | 2,890
Cancer 33 | 2,499
invasive ductal carcinoma 33 | 2,951
Astrocytoma, Pilocytic 31 | 3,081
oligodendroglioma 31 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 30 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 29 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 27 | 2,955
Kidney cancer 26 | 2,613
pancreatic cancer 25 | 2,398
subependymal giant cell astrocytoma 25 | 2,287
ductal carcinoma in situ 24 | 1,745
astrocytic glioma 23 | 2,597
lung carcinoma 23 | 2,843
adrenocortical carcinoma 20 | 1,428
lung adenocarcinoma 20 | 2,716
pituitary cancer 19 | 1,972
breast carcinoma 18 | 1,638
colon cancer 18 | 1,478
ulcerative colitis 18 | 1,819
interstitial cystitis 17 | 2,312
tuberculosis 17 | 2,010
Pick disease 16 | 1,894
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
Atopic dermatitis 15 | 952
Autosomal recessive predisposition 15 | 1,442
group 4 medulloblastoma 15 | 1,855
nasopharyngeal carcinoma 15 | 1,058
Anemia 14 | 365
Intellectual disability 14 | 1,016
Cognitive delay 13 | 608
Endometriosis 13 | 540
Global developmental delay 13 | 608
Mental and motor retardation 13 | 608
juvenile dermatomyositis 13 | 1,187
spina bifida 13 | 1,074
Epilepsy 12 | 792
Rheumatoid arthritis 12 | 1,191
cutaneous lupus erythematosus 12 | 1,057
diabetes mellitus 12 | 1,728
pediatric high grade glioma 12 | 1,064
primary Sjogren syndrome 12 | 735
Liver cancer 11 | 604
Seizures 11 | 596
Short stature 11 | 531
Small head 11 | 374
dermatomyositis 11 | 966
Amyotrophic lateral sclerosis 10 | 451
Dull intelligence 10 | 645
Low intelligence 10 | 645
Melanoma 10 | 711
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Multiple myeloma 10 | 1,332
Neurodegenerative disease 10 | 414
Poor school performance 10 | 645
Schizophrenia 10 | 1,160
acute myeloid leukemia 10 | 783
astrocytoma 10 | 1,146
Congenital Epicanthus 9 | 177
Endometrial cancer 9 | 311
Hemolytic anemia 9 | 77
Waldenstrons macroglobulinemia 9 | 765
cystic fibrosis 9 | 1,696
gastric carcinoma 9 | 807
Acquired scoliosis 8 | 281
Cryptorchidism 8 | 296
Curvature of spine 8 | 282
Neuropathy 8 | 261
Splenomegaly 8 | 190
Thrombocytopenia 8 | 197
active Crohn's disease 8 | 922
hepatocellular carcinoma 8 | 547
primary pancreatic ductal adenocarcinoma 8 | 1,109
Autistic Disorder 7 | 364
Bipolar Disorder 7 | 666
Colorectal Neoplasms 7 | 243
Fetal Growth Retardation 7 | 189
Infant, Small for Gestational Age 7 | 176
Intrauterine retardation 7 | 176
Microcephaly 7 | 166
Obesity 7 | 678
acute quadriplegic myopathy 7 | 1,158
aldosterone-producing adenoma 7 | 665
medulloblastoma 7 | 720
Immune system cancer 6 | 140

Tissue

Endocrine System 124 | 18,159
Male tissues 123 | 17,142
Blood and immune system 122 | 16,909
Female tissues 121 | 17,400
Liver and Pancreas 121 | 16,750
Respiratory system 121 | 16,393
Digestive Tract 120 | 17,369
Skin and soft tissues 120 | 17,230
Urinary Tract 119 | 16,678
Cardiovascular System 117 | 15,192
Nervous System 117 | 16,725

Target Family

Non-IDG 90 | 12,091
Transcription Factor 20 | 1,400
Enzyme 10 | 4,145
Epigenetic 9 | 242
Kinase 9 | 634

Reactome Pathway

Factors involved in megakaryoc... 138 | 138
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
REST corepressor 1 RCOR1 Tbio Transcription Factor -1.96775 81.2 0
Kinesin-like protein KIF3A KIF3A Tbio Non-IDG -2.06068 113.6 153
Kinesin-like protein KIF22 KIF22 Tbio Non-IDG -1.69996 54.3 147
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.09531 11.7 331
Paired amphipathic helix protein Sin3a SIN3A Tbio Non-IDG -1.93639 70.1 171
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452
Transcription factor MafF MAFF Tbio Transcription Factor -2.05095 108.7 94
Kinesin-like protein KIF6 KIF6 Tbio Non-IDG -1.53414 38.4 157
Cyclin-dependent-like kinase 5 CDK5 Tchem Kinase -3.06393 1238.4 694
Zinc finger protein ZFPM1 ZFPM1 Tbio Transcription Factor -2.52665 326.6 82