Development Level

Tbio 94 | 10,625
Tchem 23 | 1,890
Tdark 16 | 7,003
Tclin 4 | 602

Collection

Eligible Kinase Proteins 3 | 134

IMPC Term

preweaning lethality, complete... 10 | 633
abnormal embryo size 3 | 112
embryonic lethality prior to t... 3 | 187
preweaning lethality, incomple... 3 | 260
abnormal behavior 2 | 226
abnormal sleep behavior 2 | 63
decreased circulating aspartat... 2 | 27
decreased circulating serum al... 2 | 79
decreased grip strength 2 | 123
decreased lumbar vertebrae num... 2 | 62
enlarged heart 2 | 111
hyperactivity 2 | 108
increased circulating chloride... 2 | 43
increased circulating sodium l... 2 | 71
increased grip strength 2 | 83
increased or absent threshold ... 2 | 128
increased sacral vertebrae num... 2 | 62
vertebral transformation 2 | 12
abnormal QRS complex 1 | 25
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
abnormal epididymis morphology 1 | 31
abnormal eyelid aperture 1 | 3
abnormal facial morphology 1 | 9
abnormal head shape 1 | 4
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal lens morphology 1 | 73
abnormal limb morphology 1 | 7
abnormal liver size 1 | 4
abnormal outer ear morphology 1 | 1
abnormal ovary morphology 1 | 3
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal seminal vesicle morph... 1 | 47
abnormal thoracic vertebrae mo... 1 | 16
absent epididymis 1 | 2
absent pinna reflex 1 | 21
anophthalmia 1 | 20
craniofacial phenotype 1 | 9
cyanosis 1 | 6
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 53
decreased circulating free fat... 1 | 39
decreased circulating glucose ... 1 | 121
decreased circulating total pr... 1 | 41
decreased circulating triglyce... 1 | 83
decreased hemoglobin content 1 | 53
decreased lean body mass 1 | 195
decreased red blood cell distr... 1 | 11
decreased rib number 1 | 59
decreased startle reflex 1 | 48
embryonic lethality prior to o... 1 | 148
fusion of vertebral arches 1 | 7
hemorrhage 1 | 12
impaired glucose tolerance 1 | 52
increased bone mineral content 1 | 92
increased circulating HDL chol... 1 | 63
increased circulating glucose ... 1 | 16
increased circulating potassiu... 1 | 31
increased erythrocyte cell num... 1 | 26
increased fasted circulating g... 1 | 68
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
mydriasis 1 | 9
prenatal lethality prior to he... 1 | 64
small heart 1 | 8
small kidney 1 | 10
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 11
vertebral fusion 1 | 23

Disease

ovarian cancer 76 | 8,484
osteosarcoma 69 | 7,933
medulloblastoma, large-cell 67 | 6,234
glioblastoma 59 | 5,572
psoriasis 52 | 6,685
lung cancer 48 | 4,466
atypical teratoid / rhabdoid tumor 44 | 4,369
pediatric high grade glioma 38 | 2,712
Breast cancer 36 | 3,094
malignant mesothelioma 36 | 3,162
primitive neuroectodermal tumor 36 | 3,031
non-small cell lung cancer 35 | 2,798
Cancer 34 | 2,346
invasive ductal carcinoma 33 | 2,950
pilocytic astrocytoma 31 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 29 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 29 | 3,289
oligodendroglioma 29 | 2,849
Carcinoma 28 | 2,147
group 3 medulloblastoma 26 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 26 | 2,956
subependymal giant cell astrocytoma 25 | 2,287
ductal carcinoma in situ 24 | 1,745
pancreatic cancer 24 | 2,300
lung carcinoma 23 | 2,844
adrenocortical carcinoma 20 | 1,427
group 4 medulloblastoma 20 | 1,875
lung adenocarcinoma 20 | 2,713
sonic hedgehog group medulloblastoma 20 | 1,482
ependymoma 19 | 2,514
ulcerative colitis 19 | 2,087
astrocytoma 18 | 1,493
colon cancer 18 | 1,475
pituitary cancer 18 | 1,972
posterior fossa group A ependymoma 18 | 1,511
breast carcinoma 17 | 1,614
interstitial cystitis 17 | 2,299
Atopic dermatitis 15 | 944
Pick disease 15 | 1,893
adult high grade glioma 15 | 2,148
astrocytic glioma 15 | 2,241
nasopharyngeal carcinoma 15 | 1,056
juvenile dermatomyositis 14 | 1,189
tuberculosis 14 | 1,557
Endometriosis 13 | 535
atypical teratoid/rhabdoid tumor 13 | 1,095
posterior fossa group B ependymoma 13 | 1,530
Anemia 12 | 252
IGA Glomerulonephritis 12 | 454
cutaneous lupus erythematosus 12 | 1,056
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
primary Sjogren syndrome 12 | 789
primary pancreatic ductal adenocarcinoma 12 | 1,271
spina bifida 12 | 1,064
Rheumatoid Arthritis 11 | 1,160
dermatomyositis 11 | 933
Multiple myeloma 10 | 1,327
Neurodegenerative disease 10 | 383
Amyotrophic Lateral Sclerosis 9 | 431
Hemolytic anemia 9 | 66
Waldenstrons macroglobulinemia 9 | 765
acute myeloid leukemia 9 | 780
cystic fibrosis 9 | 1,665
gastric carcinoma 9 | 832
Melanoma 8 | 261
active Crohn's disease 8 | 918
diabetes mellitus 8 | 1,663
medulloblastoma 8 | 1,524
Down syndrome 7 | 548
acute quadriplegic myopathy 7 | 1,157
aldosterone-producing adenoma 7 | 664
hepatocellular carcinoma 7 | 532
pancreatic carcinoma 7 | 567
Asthma 6 | 349
Carney complex 6 | 23
Colorectal Neoplasms 6 | 217
Crohn's disease 6 | 304
Intellectual disability 6 | 573
Mammary Neoplasms 6 | 410
Neuropathy 6 | 210
Prostatic Neoplasms 6 | 471
Thalassemia 6 | 46
esophageal adenocarcinoma 6 | 737
fibroadenoma 6 | 557
tuberculosis and treatment for 6 months 6 | 686
Adenoid Cystic Carcinoma 5 | 99
Hepatitis B 5 | 103
Immune system cancer 5 | 38
Malaria 5 | 140
Multiple Sclerosis 5 | 498
Obesity 5 | 616
Paraplegia 5 | 71
Parkinson's disease 5 | 364
Polycystic Ovary Syndrome 5 | 332
Polycythemia Vera 5 | 24
Sickle cell anemia 5 | 35
Thrombocytopenia 5 | 105
hereditary spastic paraplegia 5 | 313
non primary Sjogren syndrome sicca 5 | 840
progressive supranuclear palsy 5 | 674

Tissue

Nervous System 136 | 18,561
Female tissues 134 | 18,647
Digestive Tract 133 | 18,473
Urinary Tract 133 | 18,444
Skin and soft tissues 132 | 18,115
Blood and immune system 130 | 17,995
Endocrine System 129 | 18,512
Liver and Pancreas 129 | 18,136
Cardiovascular System 128 | 17,958
Male tissues 125 | 17,969
Respiratory system 125 | 17,484

Target Family

Non-IDG 89 | 11,971
Transcription Factor 20 | 1,400
Kinase 10 | 634
Enzyme 9 | 4,146
Epigenetic 9 | 242

Reactome Pathway

Factors involved in megakaryoc... 137 | 137
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
SH2B adapter protein 3 SH2B3 Tbio Non-IDG -2.46631 317.6 137
Kinesin-like protein KIF1C KIF1C Tbio Non-IDG -1.21884 20.0 95
F-actin-capping protein subunit alpha-1 CAPZA1 Tbio Non-IDG -1.28182 20.1 139
Erythroid transcription factor GATA1 Tbio Transcription Factor -2.97791 941.1 675
Zinc finger protein ZFPM1 ZFPM1 Tbio Transcription Factor -2.48522 310.9 77
Mitofusin-1 MFN1 Tbio Non-IDG -1.99234 91.2 0
Kinesin-like protein KIF3B KIF3B Tbio Non-IDG -1.33400 20.0 84
Transcription factor MafG MAFG Tbio Transcription Factor -1.76701 56.9 92
Dedicator of cytokinesis protein 3 DOCK3 Tbio Non-IDG -1.43918 28.2 44
cAMP-dependent protein kinase type II-alpha regulatory subunit PRKAR2A Tbio Enzyme -0.84292 6.74 237