Development Level

Tbio 12 | 11,445
Tchem 6 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 5 | 979
embryonic lethality prior to t... 3 | 278
abnormal body wall morphology 1 | 9
abnormal embryo size 1 | 220
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
cataract 1 | 92
cleft palate 1 | 8
decreased hematocrit 1 | 46
decreased spleen weight 1 | 10
decreased threshold for audito... 1 | 26
enlarged heart 1 | 210
increased circulating glucose ... 1 | 24
increased mean corpuscular hem... 1 | 36
increased startle reflex 1 | 112
limb grasping 1 | 41
prenatal lethality 1 | 28
short tibia 1 | 97

Disease

Cancer 13 | 2,499
Carcinoma 11 | 11,493
osteosarcoma 9 | 7,950
ovarian cancer 9 | 8,520
Cryptorchidism 8 | 296
lung cancer 8 | 4,740
psoriasis 8 | 6,694
Breast cancer 7 | 3,578
Delayed bone age 7 | 136
Orbital separation excessive 7 | 244
Short stature 7 | 531
glioblastoma 7 | 5,792
group 3 medulloblastoma 7 | 4,104
medulloblastoma, large-cell 7 | 6,241
Blepharoptosis 6 | 231
Byzanthine arch palate 6 | 194
Downward slant of palpebral fissure 6 | 158
Hypogonadism, Isolated Hypogonadotropic 6 | 71
Hypogonadotropic hypogonadism 6 | 89
Joint hyperflexibility 6 | 78
Muscle hypotonia 6 | 571
Strabismus 6 | 270
Wide spaced nipples 6 | 46
Abnormal dermatoglyphic pattern 5 | 24
Acquired scoliosis 5 | 281
Autosomal recessive predisposition 5 | 1,442
Cardiac Arrhythmia 5 | 103
Cardiac conduction abnormalities 5 | 78
Cleft Palate 5 | 271
Conduction disorder of the heart 5 | 79
Congenital Epicanthus 5 | 177
Congenital pectus carinatum 5 | 52
Curvature of spine 5 | 282
Decreased projection of midface 5 | 105
Depressive disorder 5 | 409
EKG abnormalities 5 | 78
Electrocardiogram abnormal 5 | 81
Electrocardiogram change 5 | 78
Excess nuchal skin 5 | 30
Exophthalmos 5 | 112
Full lower lip 5 | 64
Generalized osteopenia 5 | 99
High forehead 5 | 102
Hypoplastic mandible condyle 5 | 275
Hypotrophic midface 5 | 105
Low set ears 5 | 181
Mandibular hypoplasia 5 | 275
Melanocytic nevus 5 | 43
Micrognathism 5 | 275
Midface retrusion 5 | 105
Muscle Weakness 5 | 170
Neck webbing 5 | 35
Noncancerous mole 5 | 28
Noonan syndrome 5 | 34
Osteopenia 5 | 99
Pectus excavatum 5 | 100
Prominent eyes 5 | 96
Prominent globes 5 | 96
Prominent lower lip 5 | 64
Protruding eyes 5 | 96
Seizures 5 | 596
Small midface 5 | 105
Tall forehead 5 | 102
astrocytic glioma 5 | 2,597
atypical teratoid / rhabdoid tumor 5 | 5,112
ependymoma 5 | 4,679
malignant mesothelioma 5 | 3,232
oligodendroglioma 5 | 2,850
Abnormality of pulmonary valve 4 | 23
Big calvaria 4 | 147
Bleeding tendency 4 | 37
Blood Coagulation Disorders 4 | 42
Cerebellar hypoplasia and atrophy 4 | 41
Coagulation abnormalities 4 | 27
Coarse hair 4 | 31
Concave bridge of nose 4 | 195
Depressed nasal bridge 4 | 195
Depressed nasal root/bridge 4 | 195
Dysarthria 4 | 192
Epilepsy 4 | 792
Frequent fractures 4 | 53
Frontal bossing 4 | 157
Hemorrhagic Disorders 4 | 30
Hepatomegaly 4 | 285
Increased fracture rate 4 | 53
Increased head circumference 4 | 147
Increased size of cranium 4 | 147
Increased size of skull 4 | 147
Isolated cases 4 | 72
Lymphangioma, Cystic 4 | 21
Lymphoid leukemia 4 | 160
Neuroblastoma 4 | 80
Parkinson's disease 4 | 392
Rough hair texture 4 | 31
Stomach Neoplasms 4 | 300
Telecanthus 4 | 62
Triangular face 4 | 58
Varying degree of multiple fractures 4 | 53
Ventricular Septal Defects 4 | 119
breast carcinoma 4 | 1,638

Tissue

Endocrine System 19 | 18,159
Digestive Tract 18 | 17,369
Female tissues 18 | 17,400
Liver and Pancreas 18 | 16,750
Male tissues 18 | 17,142
Nervous System 18 | 16,725
Urinary Tract 18 | 16,678
Blood and immune system 17 | 16,909
Skin and soft tissues 17 | 17,230
Respiratory system 16 | 16,393
Cardiovascular System 15 | 15,192

Target Family

Non-IDG 14 | 12,091
Enzyme 4 | 4,145
Kinase 1 | 634

Reactome Pathway

FRS-mediated FGFR3 signaling 19 | 19
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein phosphatase non-receptor type 11 PTPN11 Tchem Enzyme -3.11032 1400.0 1077
Fibroblast growth factor 2 FGF2 Tchem Non-IDG -4.00542 10573.5 798
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -3.02404 981.4 501
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Fibroblast growth factor receptor 3 FGFR3 Tclin Kinase -3.00731 1050.1 479
Fibroblast growth factor receptor substrate 2 FRS2 Tbio Non-IDG -2.37203 224.0 344
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Fibroblast growth factor 4 FGF4 Tbio Non-IDG -2.60388 394.1 327
Fibroblast growth factor 8 FGF8 Tbio Non-IDG -2.73368 532.0 299