Development Level

Tbio 24 | 11,445
Tchem 1 | 1,598

IMPC Phenotype

preweaning lethality, complete... 4 | 979
decreased circulating sodium l... 1 | 22
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
increased circulating free fat... 1 | 20
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45

Disease

ovarian cancer 16 | 8,520
Carcinoma 13 | 11,493
osteosarcoma 11 | 7,950
ependymoma 8 | 4,679
group 3 medulloblastoma 8 | 4,104
lung cancer 8 | 4,740
Multiple myeloma 7 | 1,332
glioblastoma 7 | 5,792
psoriasis 7 | 6,694
Kidney cancer 6 | 2,613
acute quadriplegic myopathy 6 | 1,158
medulloblastoma, large-cell 6 | 6,241
adult high grade glioma 5 | 3,801
astrocytoma 5 | 1,146
dermatomyositis 5 | 966
diabetes mellitus 5 | 1,728
invasive ductal carcinoma 5 | 2,951
Hereditary spherocytosis type 5 4 | 12
Waldenstrons macroglobulinemia 4 | 765
atypical teratoid / rhabdoid tumor 4 | 5,112
breast carcinoma 4 | 1,638
lung adenocarcinoma 4 | 2,716
primitive neuroectodermal tumor 4 | 3,035
subependymal giant cell astrocytoma 4 | 2,287
Breast cancer 3 | 3,578
Pick disease 3 | 1,894
acute myeloid leukemia 3 | 783
astrocytic glioma 3 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
non-small cell lung cancer 3 | 2,890
oligodendroglioma 3 | 2,850
pancreatic cancer 3 | 2,398
progressive supranuclear palsy 3 | 676
relapsing-remitting multiple sclerosis 3 | 18
Amyotrophic lateral sclerosis 2 | 451
Animal Mammary Neoplasms 2 | 136
Astrocytoma, Pilocytic 2 | 3,081
Atopic dermatitis 2 | 952
Cancer 2 | 2,499
Cockayne syndrome 2 | 60
Congenital myasthenic syndrome 5 2 | 11
Mammary Neoplasms, Animal 2 | 136
Mammary Neoplasms, Experimental 2 | 154
Mildly increased creatine kinase 2 | 20
Mixed connective tissue disease 2 | 16
Myopathy 2 | 185
Rheumatoid arthritis 2 | 1,191
Rimmed vacuoles on biopsy 2 | 15
Xeroderma pigmentosum group B 2 | 20
aldosterone-producing adenoma 2 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
colon cancer 2 | 1,478
ductal carcinoma in situ 2 | 1,745
group 4 medulloblastoma 2 | 1,855
juvenile dermatomyositis 2 | 1,187
malignant mesothelioma 2 | 3,232
nasopharyngeal carcinoma 2 | 1,058
non primary Sjogren syndrome sicca 2 | 891
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
primary pancreatic ductal adenocarcinoma 2 | 1,109
spina bifida 2 | 1,074
Adenocarcinoma of lung 1 | 142
Adenoid Cystic Carcinoma 1 | 99
Adult onset 1 | 82
Anxiety 1 | 136
Anxiety disease 1 | 113
Carcinoma, Adenoid Cystic 1 | 99
Disease Models, Animal 1 | 155
Distal amyotrophy 1 | 51
Distal limb muscle weakness due to peripheral neuropathy 1 | 62
Distal muscle weakness 1 | 62
Eumycotic mycetoma 1 | 3
Fatigue 1 | 182
Frontotemporal dementia 1 | 51
Fusariosis 1 | 6
Generalized muscle weakness 1 | 57
Liver Cirrhosis, Experimental 1 | 769
Lymphoma 1 | 81
Megaloblastic anemia 1 | 18
Mood swings 1 | 77
Muscle Spasticity 1 | 195
Muscle biopsy shows dystrophic changes 1 | 39
Muscle fiber inclusion bodies 1 | 4
Muscular dystrophy 1 | 75
Nerve Degeneration 1 | 121
Neurodegenerative disease 1 | 414
Neurogenic Muscular Atrophy 1 | 139
Neurogenic muscle atrophy, especially in the lower limbs 1 | 139
Proximal muscle weakness 1 | 47
Proximal neurogenic muscle weakness 1 | 47
Respiratory Failure 1 | 104
Skeletal muscle atrophy 1 | 139
Slow progression 1 | 89
Subcutaneous mycosis 1 | 2
Tinea pedis 1 | 29
atypical teratoid/rhabdoid tumor 1 | 357
medulloblastoma 1 | 720
muscle degeneration 1 | 139

Tissue

Blood and immune system 25 | 16,909
Cardiovascular System 25 | 15,192
Digestive Tract 25 | 17,369
Endocrine System 25 | 18,159
Female tissues 25 | 17,400
Liver and Pancreas 25 | 16,750
Male tissues 25 | 17,142
Nervous System 25 | 16,725
Respiratory system 25 | 16,393
Skin and soft tissues 25 | 17,230
Urinary Tract 25 | 16,678

Target Family

Non-IDG 13 | 12,091
Enzyme 12 | 4,145

Reactome Pathway

FGFR2 alternative splicing 25 | 25
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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