Development Level

Tbio 12 | 11,445
Tchem 2 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal embryo size 3 | 220
embryonic lethality prior to t... 3 | 278
abnormal retinal vasculature m... 2 | 27
cataract 2 | 92
increased circulating choleste... 2 | 66
abnormal body wall morphology 1 | 9
abnormal cornea morphology 1 | 31
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal tail morphology 1 | 25
cleft palate 1 | 8
corneal opacity 1 | 32
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased spleen weight 1 | 10
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
fused cornea and lens 1 | 5
hemorrhage 1 | 23
impaired pupillary reflex 1 | 26
increased circulating HDL chol... 1 | 80
increased mean corpuscular hem... 1 | 36
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
iris synechia 1 | 3
limb grasping 1 | 41
narrow eye opening 1 | 12
no spontaneous movement 1 | 1
persistence of hyaloid vascula... 1 | 33

Disease

Cancer 9 | 2,499
lung cancer 7 | 4,740
Carcinoma 6 | 11,493
Cleft Lip 6 | 141
Cleft Palate 6 | 271
invasive ductal carcinoma 6 | 2,951
Depressive disorder 5 | 409
Osteoporosis 5 | 363
osteosarcoma 5 | 7,950
psoriasis 5 | 6,694
Autosomal recessive predisposition 4 | 1,442
Breast Neoplasms 4 | 445
Breast cancer 4 | 3,578
LADD syndrome 4 | 9
Mammary Neoplasms 4 | 425
diabetes mellitus 4 | 1,728
ductal carcinoma in situ 4 | 1,745
group 3 medulloblastoma 4 | 4,104
malignant mesothelioma 4 | 3,232
ovarian cancer 4 | 8,520
Abnormality of body height 3 | 13
Abnormality of the voice 3 | 46
Absence of pubertal development 3 | 17
Absence of secondary sex characteristics 3 | 22
Achondroplasia 3 | 21
Acrocephalosyndactylia 3 | 17
Anosmia 3 | 22
Anterior hypopituitarism 3 | 18
Anxiety 3 | 136
Anxiety disease 3 | 113
Bipolar Disorder 3 | 666
Congenital hypoplasia of breast 3 | 25
Congenital hypoplasia of ovary 3 | 30
Congenital hypoplasia of penis 3 | 176
Craniofacial Abnormalities 3 | 151
Craniosynostosis 3 | 74
Cryptorchidism 3 | 296
Decreased bone mineral density Z score 3 | 31
Decreased fertility 3 | 33
Decreased testosterone in males 3 | 28
Delayed Puberty 3 | 97
Delayed bone age 3 | 136
Down syndrome 3 | 499
Downward slant of palpebral fissure 3 | 158
Erectile abnormalities 3 | 16
Erectile dysfunction 3 | 32
Eunuchoid habitus 3 | 14
Female hypogonadism syndrome 3 | 25
Generalized osteopenia 3 | 99
Gynecomastia 3 | 64
Hypogonadism 3 | 173
Hypogonadism, Isolated Hypogonadotropic 3 | 71
Hypogonadotropic hypogonadism 3 | 89
Hypophosphatemia 3 | 40
Hypoplastic ovary 3 | 30
Hypothalamic gonadotropin-releasing hormone deficiency 3 | 14
Increased female libido 3 | 13
Infantile uterus 3 | 23
Kallmann Syndrome 2 (disorder) 3 | 18
Kallmann syndrome 3 | 33
Klinefelter's syndrome 3 | 56
Mental Depression 3 | 333
Non-obstructive azoospermia 3 | 21
Orbital separation excessive 3 | 244
Osteomalacia 3 | 35
Osteopenia 3 | 99
Parkinson's disease 3 | 392
Primary physiologic amenorrhea 3 | 55
Secondary physiologic amenorrhea 3 | 32
Sense of smell impaired 3 | 21
Small testicle 3 | 75
Sparse body hair 3 | 32
Synostosis 3 | 15
Testicular hypogonadism 3 | 21
Wide spaced nipples 3 | 46
atypical teratoid / rhabdoid tumor 3 | 5,112
breast carcinoma 3 | 1,638
cystic fibrosis 3 | 1,696
ependymoma 3 | 4,679
lung adenocarcinoma 3 | 2,716
medulloblastoma, large-cell 3 | 6,241
non-small cell lung cancer 3 | 2,890
pituitary cancer 3 | 1,972
Abnormality of cardiovascular system morphology 2 | 23
Alzheimer's disease 2 | 658
Atherosclerosis 2 | 291
Broad flat nasal bridge 2 | 236
Carcinoma, Hepatocellular 2 | 228
Heart disease 2 | 306
Kidney disease 2 | 430
Liver carcinoma 2 | 240
Lung Neoplasms 2 | 232
Lung disease 2 | 142
Mesothelioma 2 | 38
Myocardial Ischemia 2 | 169
Nasal bridge wide 2 | 236
Seizures 2 | 596
Skin atrophy 2 | 16
Telecanthus 2 | 62
tuberculosis 2 | 2,010

Tissue

Endocrine System 14 | 18,159
Digestive Tract 13 | 17,369
Nervous System 13 | 16,725
Blood and immune system 12 | 16,909
Female tissues 12 | 17,400
Male tissues 12 | 17,142
Skin and soft tissues 12 | 17,230
Urinary Tract 12 | 16,678
Liver and Pancreas 11 | 16,750
Respiratory system 11 | 16,393
Cardiovascular System 8 | 15,192

Target Family

Non-IDG 13 | 12,091
Enzyme 1 | 4,145
Kinase 1 | 634

Reactome Pathway

FGFR1 ligand binding and activ... 15 | 15
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Fibroblast growth factor 5 FGF5 Tbio Non-IDG -2.07061 109.8 192
Fibroblast growth factor receptor 1 FGFR1 Tclin Kinase -3.13063 1294.7 1785
Fibroblast growth factor 20 FGF20 Tbio Non-IDG -1.71980 55.3 117
Fibroblast growth factor 23 FGF23 Tbio Non-IDG -3.19500 1726.4 296
Fibroblast growth factor 4 FGF4 Tbio Non-IDG -2.60388 394.1 327
Fibroblast growth factor 6 FGF6 Tbio Non-IDG -1.56137 40.2 113
Klotho KL Tbio Enzyme -2.86543 790.6 276
Fibroblast growth factor 22 FGF22 Tbio Non-IDG -1.15836 16.5 186
Fibroblast growth factor 10 FGF10 Tbio Non-IDG -2.55166 363.0 320
Fibroblast growth factor 2 FGF2 Tchem Non-IDG -4.00542 10573.5 798