Development Level

Tdark 58 | 7,003
Tbio 46 | 10,625
Tchem 25 | 1,890
Tclin 7 | 602

Collection

Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 4 | 633
decreased lean body mass 2 | 195
abnormal bone structure 1 | 131
abnormal cornea morphology 1 | 24
abnormal lens morphology 1 | 73
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal skin condition 1 | 6
abnormal testis morphology 1 | 30
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased circulating amylase ... 1 | 24
decreased circulating sodium l... 1 | 18
decreased mean corpuscular hem... 1 | 19
decreased thermal nociceptive ... 1 | 4
embryonic lethality prior to t... 1 | 187
increased circulating alkaline... 1 | 119
increased circulating free fat... 1 | 17
increased fasted circulating g... 1 | 68
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular vol... 1 | 91
increased thermal nociceptive ... 1 | 9
male infertility 1 | 62
polydactyly 1 | 22
preweaning lethality, incomple... 1 | 260
small testis 1 | 37

Disease

ovarian cancer 55 | 8,491
osteosarcoma 41 | 7,933
lung cancer 39 | 4,473
psoriasis 37 | 6,685
Multiple myeloma 36 | 1,327
glioblastoma 29 | 5,572
Cancer 20 | 2,346
medulloblastoma, large-cell 19 | 6,234
atypical teratoid / rhabdoid tumor 17 | 4,369
HIV Infections 15 | 99
dermatomyositis 15 | 966
interstitial cystitis 14 | 2,299
non-small cell lung cancer 14 | 2,798
lung adenocarcinoma 13 | 2,714
malignant mesothelioma 13 | 3,163
oligodendroglioma 13 | 2,849
ulcerative colitis 13 | 2,087
ependymoma 12 | 2,514
Waldenstrons macroglobulinemia 11 | 764
astrocytic glioma 11 | 2,241
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,289
subependymal giant cell astrocytoma 11 | 2,287
Breast cancer 10 | 3,098
Pick disease 10 | 1,893
astrocytoma 10 | 1,493
diabetes mellitus 10 | 1,663
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
pancreatic cancer 10 | 2,300
pediatric high grade glioma 10 | 2,712
primary pancreatic ductal adenocarcinoma 10 | 1,271
tuberculosis 10 | 1,563
cutaneous lupus erythematosus 9 | 1,056
lung carcinoma 9 | 2,844
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,795
periodontitis 9 | 269
Lymphoma 8 | 57
invasive ductal carcinoma 8 | 2,950
Mantle cell lymphoma 7 | 20
chronic lymphosyte leukemia 7 | 232
non primary Sjogren syndrome sicca 7 | 840
pilocytic astrocytoma 7 | 3,086
primary Sjogren syndrome 7 | 788
acute myeloid leukemia 6 | 785
colon cancer 6 | 1,475
group 4 medulloblastoma 6 | 1,875
juvenile dermatomyositis 6 | 1,189
medulloblastoma 6 | 1,524
posterior fossa group A ependymoma 6 | 1,511
primitive neuroectodermal tumor 6 | 3,031
Amebiasis 5 | 22
Leukemia 5 | 88
Rheumatoid Arthritis 5 | 1,170
cystic fibrosis 5 | 1,670
esophageal adenocarcinoma 5 | 737
group 3 medulloblastoma 5 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
Carcinoma 4 | 2,147
Diabetes Mellitus, Non-Insulin-Dependent 4 | 161
IGA Glomerulonephritis 4 | 454
active Crohn's disease 4 | 918
acute quadriplegic myopathy 4 | 1,157
cystic fibrosis and chronic rhinosinusitis 4 | 213
mucosa-associated lymphoid tissue lymphoma 4 | 480
Arthritis 3 | 248
Brain Ischemia 3 | 87
Chronic obstructive pulmonary disease 3 | 147
Crohn's disease 3 | 304
Diffuse large B-cell lymphoma 3 | 42
Hypohidrotic ectodermal dysplasia 3 | 14
Osteoporosis 3 | 259
Peripheral Neuropathy 3 | 303
adult high grade glioma 3 | 2,148
gastric carcinoma 3 | 832
non-small cell lung carcinoma 3 | 413
progressive supranuclear palsy 3 | 674
sarcoidosis 3 | 368
tuberculosis and treatment for 6 months 3 | 686
Acquired metabolic disease 2 | 267
Alzheimer's disease 2 | 644
Asthma 2 | 349
Barrett's esophagus 2 | 185
Cleft palate 2 | 125
Colonic Neoplasms 2 | 126
Duchenne muscular dystrophy 2 | 602
Edwards syndrome 2 | 15
Gaucher disease type 3 2 | 76
Inflammatory bowel disease 2 | 142
Lymphoma, T-Cell, Cutaneous 2 | 21
Mammary Neoplasms 2 | 410
Myocardial Ischemia 2 | 169
Osteopetrosis 2 | 40
Parkinson's disease 2 | 364
Renal Cell Carcinoma 2 | 199
Sezary Syndrome 2 | 26
Squamous cell carcinoma of esophagus 2 | 82
Stevens-Johnson syndrome 2 | 91
adrenocortical carcinoma 2 | 1,427
chronic kidney disease 2 | 90
hepatocellular carcinoma 2 | 550
pituitary cancer 2 | 1,972

Tissue

Blood and immune system 122 | 17,994
Digestive Tract 122 | 18,472
Female tissues 122 | 18,646
Liver and Pancreas 121 | 18,135
Respiratory system 121 | 17,483
Urinary Tract 121 | 18,443
Skin and soft tissues 120 | 18,114
Cardiovascular System 118 | 17,957
Endocrine System 118 | 18,511
Nervous System 118 | 18,560
Male tissues 116 | 17,968

Target Family

Non-IDG 84 | 11,969
Enzyme 42 | 4,146
Kinase 8 | 634
Transcription Factor 2 | 1,400

Reactome Pathway

FCERI mediated NF-kB activatio... 136 | 136
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ig lambda-6 chain C region IGLC6 Tdark Non-IDG -1.81183 228.7 0
Caspase recruitment domain-containing protein 11 CARD11 Tbio Enzyme -2.12968 129.2 231
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TAB2 Tbio Enzyme -1.87718 69.0 145
26S proteasome non-ATPase regulatory subunit 13 PSMD13 Tchem Enzyme -1.05639 9.70 94
S-phase kinase-associated protein 1 SKP1 Tbio Enzyme -2.54884 305.8 337
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.41371 28.0 678
26S proteasome non-ATPase regulatory subunit 3 PSMD3 Tbio Enzyme -1.21151 15.4 162
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 TAB3 Tbio Enzyme -1.37963 22.0 191
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 TAB1 Tbio Kinase -1.90358 73.6 452
Tyrosine-protein kinase Lyn LYN Tclin Kinase -2.82112 659.3 521