Development Level

Tbio 140 | 10,625
Tchem 72 | 1,890
Tdark 63 | 7,003
Tclin 42 | 602

IMPC Term

preweaning lethality, complete... 14 | 633
decreased body weight 8 | 174
decreased total body fat amoun... 6 | 186
abnormal bone structure 5 | 131
decreased bone mineral content 5 | 157
decreased circulating choleste... 5 | 85
decreased circulating HDL chol... 4 | 77
decreased circulating alanine ... 4 | 53
decreased lean body mass 4 | 195
embryonic lethality prior to t... 4 | 187
enlarged heart 4 | 111
abnormal behavior 3 | 226
abnormal embryo size 3 | 112
abnormal retina morphology 3 | 100
abnormal retinal pigmentation 3 | 61
decreased circulating sodium l... 3 | 18
decreased circulating triglyce... 3 | 83
decreased kidney weight 3 | 7
decreased lumbar vertebrae num... 3 | 62
thrombocytopenia 3 | 46
abnormal bone mineralization 2 | 55
abnormal coat/hair pigmentatio... 2 | 54
abnormal seminal vesicle morph... 2 | 47
cataract 2 | 26
decreased body length 2 | 108
decreased circulating LDL chol... 2 | 37
decreased circulating fructosa... 2 | 31
decreased circulating glucose ... 2 | 121
decreased circulating serum al... 2 | 79
decreased circulating total pr... 2 | 41
decreased grip strength 2 | 123
decreased heart weight 2 | 44
decreased lactate dehydrogenas... 2 | 14
decreased neutrophil cell numb... 2 | 37
decreased rib number 2 | 59
decreased spleen weight 2 | 13
decreased thoracic vertebrae n... 2 | 7
impaired pupillary reflex 2 | 14
increased blood urea nitrogen ... 2 | 44
increased bone mineral content 2 | 92
increased circulating HDL chol... 2 | 63
increased circulating phosphat... 2 | 24
increased erythrocyte cell num... 2 | 26
increased lean body mass 2 | 107
increased startle reflex 2 | 38
male infertility 2 | 62
abnormal QRS complex 1 | 25
abnormal body wall morphology 1 | 7
abnormal cornea morphology 1 | 24
abnormal gait 1 | 51
abnormal hair growth 1 | 8
abnormal head morphology 1 | 10
abnormal lens morphology 1 | 73
abnormal neural tube closure 1 | 37
abnormal rib morphology 1 | 28
abnormal startle reflex 1 | 14
absent pinna reflex 1 | 21
cardiovascular system phenotyp... 1 | 35
cleft palate 1 | 6
corneal opacity 1 | 25
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating creatini... 1 | 31
decreased circulating potassiu... 1 | 17
decreased effector memory CD8-... 1 | 24
decreased exploration in new e... 1 | 9
decreased fasted circulating g... 1 | 49
decreased threshold for audito... 1 | 32
dilated heart left ventricle 1 | 10
embryonic lethality prior to o... 1 | 148
enlarged lymph nodes 1 | 27
female infertility 1 | 34
hypoactivity 1 | 89
impaired righting response 1 | 19
increased body length 1 | 20
increased body weight 1 | 42
increased bone mineral density 1 | 52
increased circulating alkaline... 1 | 119
increased circulating chloride... 1 | 43
increased circulating choleste... 1 | 53
increased circulating fructosa... 1 | 11
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased exploration in new e... 1 | 56
increased grip strength 1 | 83
increased hematocrit 1 | 36
increased mean corpuscular vol... 1 | 91
increased respiratory quotient 1 | 12
increased sacral vertebrae num... 1 | 62
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
prenatal lethality prior to he... 1 | 64
rough coat 1 | 1
short tibia 1 | 82
sparse hair 1 | 6
tremors 1 | 34
vertebral fusion 1 | 23

Disease

ovarian cancer 149 | 8,484
osteosarcoma 147 | 7,933
glioblastoma 115 | 5,572
Cancer 111 | 2,346
psoriasis 110 | 6,685
lung cancer 106 | 4,466
medulloblastoma, large-cell 105 | 6,234
atypical teratoid / rhabdoid tumor 74 | 4,369
pilocytic astrocytoma 66 | 3,086
malignant mesothelioma 65 | 3,162
Breast cancer 64 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 61 | 3,289
oligodendroglioma 60 | 2,849
Carcinoma 59 | 2,147
interstitial cystitis 58 | 2,299
invasive ductal carcinoma 58 | 2,950
pediatric high grade glioma 58 | 2,712
lung adenocarcinoma 57 | 2,713
ependymoma 56 | 2,514
lung carcinoma 56 | 2,844
Multiple myeloma 55 | 1,327
non-small cell lung cancer 53 | 2,798
subependymal giant cell astrocytoma 53 | 2,287
ulcerative colitis 50 | 2,087
astrocytic glioma 49 | 2,241
pancreatic cancer 48 | 2,300
intraductal papillary-mucinous adenoma (IPMA) 45 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 45 | 2,988
primitive neuroectodermal tumor 45 | 3,031
tuberculosis 41 | 1,557
diabetes mellitus 39 | 1,663
astrocytoma 36 | 1,493
pituitary cancer 35 | 1,972
cystic fibrosis 34 | 1,665
Pick disease 33 | 1,893
breast carcinoma 33 | 1,614
group 3 medulloblastoma 33 | 2,254
group 4 medulloblastoma 33 | 1,875
medulloblastoma 33 | 1,524
Rheumatoid Arthritis 31 | 1,160
colon cancer 31 | 1,475
ductal carcinoma in situ 29 | 1,745
primary pancreatic ductal adenocarcinoma 28 | 1,271
adult high grade glioma 27 | 2,148
pancreatic ductal adenocarcinoma liver metastasis 27 | 1,795
Mammary Neoplasms 26 | 410
Waldenstrons macroglobulinemia 26 | 765
cutaneous lupus erythematosus 23 | 1,056
Parkinson's disease 22 | 364
juvenile dermatomyositis 22 | 1,189
Schizophrenia 21 | 501
posterior fossa group B ependymoma 21 | 1,530
gastric carcinoma 20 | 832
non-small cell lung carcinoma 20 | 413
Lung Neoplasms 19 | 171
adrenocortical carcinoma 19 | 1,427
dermatomyositis 19 | 933
spina bifida 19 | 1,064
HIV Infections 18 | 100
Intellectual disability 18 | 573
Liver carcinoma 18 | 217
esophageal adenocarcinoma 18 | 737
primary Sjogren syndrome 18 | 789
atypical teratoid/rhabdoid tumor 17 | 1,095
non primary Sjogren syndrome sicca 17 | 840
posterior fossa group A ependymoma 17 | 1,511
Alzheimer's disease 16 | 644
Asthma 16 | 349
Stomach Neoplasms 16 | 282
Vascular disease 16 | 281
Osteoporosis 15 | 257
Prostatic Neoplasms 15 | 471
Renal Cell Carcinoma 15 | 199
Autistic Disorder 14 | 320
Mammary Neoplasms, Experimental 14 | 150
Melanoma 14 | 261
Neoplasm Invasiveness 14 | 127
Noonan Syndrome 14 | 33
Toxic encephalopathy 14 | 131
fibroadenoma 14 | 557
hepatocellular carcinoma 14 | 532
periodontitis 14 | 269
tuberculosis and treatment for 6 months 14 | 686
Animal Mammary Neoplasms 13 | 136
Arthritis 13 | 248
Heart disease 13 | 279
Obesity 13 | 616
Peripheral Neuropathy 13 | 303
acute myeloid leukemia 13 | 780
inflammatory breast cancer 13 | 404
pancreatic carcinoma 13 | 567
sonic hedgehog group medulloblastoma 13 | 1,482
Anemia 12 | 252
Down syndrome 12 | 548
Kidney disease 12 | 396
Multiple Sclerosis 12 | 498
Myocardial Ischemia 12 | 169
mucosa-associated lymphoid tissue lymphoma 12 | 480
Juvenile arthritis 11 | 124
gastric cancer 11 | 430

Tissue

Female tissues 303 | 18,647
Digestive Tract 302 | 18,473
Urinary Tract 301 | 18,444
Blood and immune system 300 | 17,995
Liver and Pancreas 300 | 18,136
Skin and soft tissues 300 | 18,115
Endocrine System 299 | 18,512
Nervous System 299 | 18,561
Cardiovascular System 296 | 17,958
Respiratory system 294 | 17,484
Male tissues 292 | 17,969

Target Family

Non-IDG 182 | 11,971
Enzyme 82 | 4,146
Kinase 46 | 634
Ion Channel 5 | 341
Transcription Factor 2 | 1,400

Reactome Pathway

FCERI mediated MAPK activation 317 | 317
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Immunoglobulin kappa variable 3-11 IGKV3-11 Tdark Non-IDG 0.00000 0
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Fibroblast growth factor 5 FGF5 Tbio Non-IDG -2.00731 99.9 143
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Fibrinogen alpha chain FGA Tbio Non-IDG -2.84597 716.2 457
Beta-arrestin-1 ARRB1 Tchem Non-IDG -2.54226 366.3 416
Interleukin-2 receptor subunit beta IL2RB Tclin Non-IDG -2.08442 120.9 537
Beta-klotho KLB Tbio Enzyme -1.89423 69.9 47