Development Level

Tdark 70 | 6,569
Tchem 19 | 1,885
Tbio 11 | 11,178
Tclin 2 | 612

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal bone structure 2 | 187
decreased hemoglobin content 2 | 68
increased blood urea nitrogen ... 2 | 48
increased erythrocyte cell num... 2 | 39
increased total body fat amoun... 2 | 134
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal digit morphology 1 | 10
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
abnormal retina morphology 1 | 71
abnormal startle reflex 1 | 15
cataract 1 | 92
decreased IgG3 level 1 | 1
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating fructosa... 1 | 30
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mature B cell number 1 | 7
decreased neutrophil cell numb... 1 | 42
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased circulating triglyce... 1 | 42
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56

Disease

osteosarcoma 29 | 7,766
Carcinoma 25 | 11,192
Cancer 23 | 2,388
ovarian cancer 22 | 8,297
lung cancer 19 | 4,607
psoriasis 17 | 6,514
glioblastoma 16 | 5,635
interstitial cystitis 15 | 2,237
medulloblastoma, large-cell 15 | 6,086
Multiple myeloma 12 | 1,296
atypical teratoid / rhabdoid tumor 12 | 4,971
pancreatic cancer 11 | 2,322
subependymal giant cell astrocytoma 11 | 2,230
tuberculosis 11 | 1,963
ulcerative colitis 11 | 1,765
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,902
lung carcinoma 10 | 2,755
non-small cell lung cancer 10 | 2,799
periodontitis 10 | 280
Breast cancer 9 | 3,469
Kidney cancer 9 | 2,548
adult high grade glioma 9 | 3,701
group 3 medulloblastoma 9 | 4,002
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,204
lung adenocarcinoma 9 | 2,627
Astrocytoma, Pilocytic 8 | 3,006
Schizophrenia 8 | 1,136
chronic lymphosyte leukemia 8 | 199
juvenile dermatomyositis 8 | 1,147
primitive neuroectodermal tumor 8 | 2,957
Stomach Neoplasms 7 | 287
colon cancer 7 | 1,428
diabetes mellitus 7 | 1,683
ependymoma 7 | 4,559
group 4 medulloblastoma 7 | 1,806
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,872
invasive ductal carcinoma 7 | 2,867
primary pancreatic ductal adenocarcinoma 7 | 1,071
Breast Neoplasms 6 | 423
Lung Neoplasms 6 | 217
Mammary Neoplasms 6 | 403
Melanoma 6 | 689
Pick disease 6 | 1,856
Vascular disease 6 | 294
Waldenstrons macroglobulinemia 6 | 742
astrocytic glioma 6 | 2,530
astrocytoma 6 | 1,113
cutaneous lupus erythematosus 6 | 1,016
Arthritis 5 | 276
Asthma 5 | 370
Cell Transformation, Neoplastic 5 | 90
Cholestasis, Extrahepatic 5 | 20
Cryptorchidism 5 | 287
Disease Models, Animal 5 | 148
Dull intelligence 5 | 634
Intellectual disability 5 | 998
Low intelligence 5 | 634
Lymphoma 5 | 75
Mental Retardation 5 | 634
Mental deficiency 5 | 634
Neoplasm Metastasis 5 | 160
Neoplastic Cell Transformation 5 | 83
Noonan syndrome 5 | 34
Parkinson's disease 5 | 378
Poor school performance 5 | 634
Short stature 5 | 514
breast carcinoma 5 | 1,589
cystic fibrosis and chronic rhinosinusitis 5 | 211
malignant mesothelioma 5 | 3,135
non-small cell lung carcinoma 5 | 302
oligodendroglioma 5 | 2,768
pediatric high grade glioma 5 | 1,035
primary Sjogren syndrome 5 | 710
Adenocarcinoma of lung 4 | 140
Alzheimer's disease 4 | 640
Blepharoptosis 4 | 229
Brain Ischemia 4 | 107
Byzanthine arch palate 4 | 194
Carcinoma, Hepatocellular 4 | 217
Cardiac Arrhythmia 4 | 101
Cardiac conduction abnormalities 4 | 78
Conduction disorder of the heart 4 | 79
Delayed bone age 4 | 132
Depressive disorder 4 | 401
Downward slant of palpebral fissure 4 | 158
EKG abnormalities 4 | 78
Electrocardiogram abnormal 4 | 81
Electrocardiogram change 4 | 78
Epilepsy 4 | 775
Heart disease 4 | 288
Hepatomegaly 4 | 280
Hyperalgesia 4 | 80
Joint hyperflexibility 4 | 76
Leukemia 4 | 103
Liver carcinoma 4 | 229
Rheumatoid arthritis 4 | 1,156
Strabismus 4 | 265
Toxic encephalopathy 4 | 139
cystic fibrosis 4 | 1,629
pituitary cancer 4 | 1,915

Tissue

Blood and immune system 28 | 16,909
Cardiovascular System 28 | 15,192
Digestive Tract 28 | 17,369
Endocrine System 28 | 18,159
Female tissues 28 | 17,400
Liver and Pancreas 28 | 16,750
Male tissues 28 | 17,142
Nervous System 28 | 16,725
Respiratory system 28 | 16,393
Skin and soft tissues 28 | 17,230
Urinary Tract 28 | 16,678

Target Family

Non-IDG 83 | 12,091
Kinase 12 | 634
Enzyme 6 | 4,145
Transcription Factor 1 | 1,400

Reactome Pathway

FCERI mediated MAPK activation 102 | 102
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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