Development Level

Tdark 57 | 7,003
Tchem 15 | 1,890
Tbio 11 | 10,625
Tclin 4 | 602

Collection

Eligible Ion Channel Proteins 1 | 117

IMPC Term

decreased body weight 2 | 174
decreased circulating choleste... 2 | 85
abnormal bone mineralization 1 | 55
abnormal cornea morphology 1 | 24
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
decreased B cell number 1 | 30
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating alkaline... 1 | 41
decreased circulating bilirubi... 1 | 14
decreased circulating free fat... 1 | 39
decreased circulating magnesiu... 1 | 11
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased lean body mass 1 | 195
decreased macrophage cell numb... 1 | 4
decreased mature B cell number 1 | 25
decreased total body fat amoun... 1 | 186
embryonic lethality prior to t... 1 | 187
increased CD4-positive, alpha ... 1 | 15
increased IgG1 level 1 | 1
increased T cell number 1 | 15
increased bone mineral content 1 | 92
increased mean platelet volume 1 | 19
increased startle reflex 1 | 38
preweaning lethality, complete... 1 | 633
small epididymis 1 | 3

Disease

osteosarcoma 25 | 7,933
lung cancer 18 | 4,466
interstitial cystitis 17 | 2,299
ovarian cancer 17 | 8,484
psoriasis 17 | 6,685
ulcerative colitis 16 | 2,087
Cancer 15 | 2,346
subependymal giant cell astrocytoma 15 | 2,287
lung carcinoma 13 | 2,844
Carcinoma 12 | 2,147
medulloblastoma, large-cell 12 | 6,234
glioblastoma 11 | 5,572
Multiple myeloma 10 | 1,327
lung adenocarcinoma 10 | 2,713
periodontitis 10 | 269
cutaneous lupus erythematosus 9 | 1,056
non-small cell lung cancer 9 | 2,798
pancreatic cancer 9 | 2,300
tuberculosis 9 | 1,557
colon cancer 8 | 1,475
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
malignant mesothelioma 8 | 3,162
pilocytic astrocytoma 8 | 3,086
atypical teratoid / rhabdoid tumor 7 | 4,369
chronic lymphosyte leukemia 7 | 232
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,289
invasive ductal carcinoma 7 | 2,950
primary Sjogren syndrome 7 | 789
Breast cancer 6 | 3,094
adult high grade glioma 6 | 2,148
primary pancreatic ductal adenocarcinoma 6 | 1,271
primitive neuroectodermal tumor 6 | 3,031
Agammaglobulinemia 5 | 24
Amebiasis 5 | 22
Leukemia 5 | 88
Lymphoma 5 | 56
Pick disease 5 | 1,893
Rheumatoid Arthritis 5 | 1,160
Waldenstrons macroglobulinemia 5 | 765
astrocytic glioma 5 | 2,241
astrocytoma 5 | 1,493
cystic fibrosis and chronic rhinosinusitis 5 | 213
ependymoma 5 | 2,514
group 4 medulloblastoma 5 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
medulloblastoma 5 | 1,524
oligodendroglioma 5 | 2,849
Asthma 4 | 349
Cherubism 4 | 14
pediatric high grade glioma 4 | 2,712
pituitary cancer 4 | 1,972
spina bifida 4 | 1,064
Blastic phase chronic myeloid leukemia 3 | 58
Chronic Myelocytic Leukemia Accelerated Phase 3 | 59
Chronic obstructive pulmonary disease 3 | 146
IGA Glomerulonephritis 3 | 454
Obesity 3 | 616
Prostatic Neoplasms 3 | 471
cystic fibrosis 3 | 1,665
diabetes mellitus 3 | 1,663
esophageal adenocarcinoma 3 | 737
gastric carcinoma 3 | 832
juvenile dermatomyositis 3 | 1,189
non-small cell lung carcinoma 3 | 413
posterior fossa group A ependymoma 3 | 1,511
sonic hedgehog group medulloblastoma 3 | 1,482
AMYOTROPHIC LATERAL SCLEROSIS 1 2 | 49
Adult T-Cell Lymphoma/Leukemia 2 | 30
Allergic hypersensitivity disease 2 | 123
Arthritis 2 | 248
Atopic dermatitis 2 | 944
Barrett's esophagus 2 | 183
Brain Hypoxia 2 | 2
Cardiomegaly 2 | 66
Chronic Lymphocytic Leukemia 2 | 242
Chronic phase chronic myeloid leukemia 2 | 45
Hepatitis C 2 | 90
Hepatolenticular Degeneration 2 | 24
Left Ventricular Hypertrophy 2 | 24
Lupus erythematosus 2 | 80
Multiple Sclerosis 2 | 498
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 2 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 2 | 47
X-linked agammaglobulinemia 2 | 7
breast carcinoma 2 | 1,614
ductal carcinoma in situ 2 | 1,745
group 3 medulloblastoma 2 | 2,254
mucosa-associated lymphoid tissue lymphoma 2 | 480
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
tuberculosis and treatment for 6 months 2 | 686
Common variable immunodeficiency 1 | 72
Congenital heart disease 1 | 63
Generalized anxiety disorder 1 | 29
Kidney cancer 1 | 118
Liver Cirrhosis 1 | 101
Progressive multifocal leukoencephalopathy 1 | 24
Pulmonary valve stenosis 1 | 10
Renal Cell Carcinoma 1 | 199
Silver-Russell syndrome 1 | 37
chorea-acanthocytosis 1 | 11

Tissue

Blood and immune system 73 | 17,995
Digestive Tract 73 | 18,473
Female tissues 73 | 18,647
Respiratory system 73 | 17,484
Skin and soft tissues 73 | 18,115
Liver and Pancreas 72 | 18,136
Urinary Tract 72 | 18,444
Cardiovascular System 70 | 17,958
Endocrine System 69 | 18,512
Nervous System 69 | 18,561
Male tissues 67 | 17,969

Target Family

Non-IDG 70 | 11,971
Kinase 6 | 634
Enzyme 5 | 4,146
Ion Channel 3 | 341
Transcription Factor 3 | 1,400

Reactome Pathway

FCERI mediated Ca+2 mobilizati... 87 | 87
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Immunoglobulin kappa variable 3-11 IGKV3-11 Tdark Non-IDG 0.00000 0
Adenosylhomocysteinase 2 AHCYL1 Tchem Enzyme -1.57893 43.2 102
Ig lambda-7 chain C region IGLC7 Tdark Non-IDG 228.7 0
Immunoglobulin lambda variable 1-44 IGLV1-44 Tdark Non-IDG 0.00000 0
Immunoglobulin heavy variable 1-2 IGHV1-2 Tdark Non-IDG 0.00000 0
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -2.99303 933.5 424
Immunoglobulin kappa variable 3-15 IGKV3-15 Tdark Non-IDG 0.00000 0
Immunoglobulin kappa variable 2-28 IGKV2-28 Tdark Non-IDG 0.00000 0
Immunoglobulin kappa variable 2D-30 IGKV2D-30 Tdark Non-IDG 0.00000 0
Ig epsilon chain C region IGHE Tclin Non-IDG 0.00000 0