Development Level

Tdark 57 | 7,003
Tchem 15 | 1,890
Tbio 11 | 10,625
Tclin 4 | 602

IMPC Phenotype

decreased body weight 2 | 174
decreased circulating choleste... 2 | 85
abnormal bone mineralization 1 | 55
abnormal cornea morphology 1 | 24
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
decreased B cell number 1 | 30
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating alkaline... 1 | 41
decreased circulating bilirubi... 1 | 14
decreased circulating free fat... 1 | 39
decreased circulating magnesiu... 1 | 11
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased lean body mass 1 | 195
decreased macrophage cell numb... 1 | 4
decreased mature B cell number 1 | 25
decreased total body fat amoun... 1 | 186
embryonic lethality prior to t... 1 | 187
increased CD4-positive, alpha ... 1 | 15
increased IgG1 level 1 | 1
increased T cell number 1 | 15
increased bone mineral content 1 | 92
increased mean platelet volume 1 | 19
increased startle reflex 1 | 38
preweaning lethality, complete... 1 | 633
small epididymis 1 | 3

Disease

osteosarcoma 25 | 7,933
lung cancer 18 | 4,473
interstitial cystitis 17 | 2,299
ovarian cancer 17 | 8,491
psoriasis 17 | 6,685
ulcerative colitis 16 | 2,087
Cancer 15 | 2,346
subependymal giant cell astrocytoma 15 | 2,287
lung carcinoma 13 | 2,844
Carcinoma 12 | 2,147
medulloblastoma, large-cell 12 | 6,234
glioblastoma 11 | 5,572
Multiple myeloma 10 | 1,327
lung adenocarcinoma 10 | 2,714
periodontitis 10 | 269
cutaneous lupus erythematosus 9 | 1,056
non-small cell lung cancer 9 | 2,798
pancreatic cancer 9 | 2,300
tuberculosis 9 | 1,563
colon cancer 8 | 1,475
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
malignant mesothelioma 8 | 3,163
pilocytic astrocytoma 8 | 3,086
atypical teratoid / rhabdoid tumor 7 | 4,369
chronic lymphosyte leukemia 7 | 232
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,289
invasive ductal carcinoma 7 | 2,950
primary Sjogren syndrome 7 | 788
Breast cancer 6 | 3,098
adult high grade glioma 6 | 2,148
primary pancreatic ductal adenocarcinoma 6 | 1,271
primitive neuroectodermal tumor 6 | 3,031
Agammaglobulinemia 5 | 24
Amebiasis 5 | 22
Leukemia 5 | 88
Lymphoma 5 | 57
Pick disease 5 | 1,893
Rheumatoid Arthritis 5 | 1,170
Waldenstrons macroglobulinemia 5 | 764
astrocytic glioma 5 | 2,241
astrocytoma 5 | 1,493
cystic fibrosis and chronic rhinosinusitis 5 | 213
ependymoma 5 | 2,514
group 4 medulloblastoma 5 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
medulloblastoma 5 | 1,524
oligodendroglioma 5 | 2,849
Asthma 4 | 349
Cherubism 4 | 14
pediatric high grade glioma 4 | 2,712
pituitary cancer 4 | 1,972
spina bifida 4 | 1,064
Blastic phase chronic myeloid leukemia 3 | 58
Chronic Myelocytic Leukemia Accelerated Phase 3 | 59
Chronic obstructive pulmonary disease 3 | 147
IGA Glomerulonephritis 3 | 454
Obesity 3 | 616
Prostatic Neoplasms 3 | 471
cystic fibrosis 3 | 1,670
diabetes mellitus 3 | 1,663
esophageal adenocarcinoma 3 | 737
gastric carcinoma 3 | 832
juvenile dermatomyositis 3 | 1,189
non-small cell lung carcinoma 3 | 413
posterior fossa group A ependymoma 3 | 1,511
sonic hedgehog group medulloblastoma 3 | 1,482
AMYOTROPHIC LATERAL SCLEROSIS 1 2 | 49
Adult T-Cell Lymphoma/Leukemia 2 | 30
Allergic hypersensitivity disease 2 | 123
Arthritis 2 | 248
Atopic dermatitis 2 | 944
Barrett's esophagus 2 | 185
Brain Hypoxia 2 | 2
Cardiomegaly 2 | 66
Chronic phase chronic myeloid leukemia 2 | 45
Hepatitis C 2 | 90
Hepatolenticular Degeneration 2 | 24
Left Ventricular Hypertrophy 2 | 24
Lupus erythematosus 2 | 80
Multiple Sclerosis 2 | 498
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 2 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 2 | 47
X-linked agammaglobulinemia 2 | 7
breast carcinoma 2 | 1,614
chronic lymphocytic leukemia 2 | 244
ductal carcinoma in situ 2 | 1,745
group 3 medulloblastoma 2 | 2,254
mucosa-associated lymphoid tissue lymphoma 2 | 480
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
tuberculosis and treatment for 6 months 2 | 686
Keratoconjunctivitis sicca 1 | 19
Lymphoma, T-Cell, Cutaneous 1 | 21
Pancreatitis 1 | 97
Prevention of Cardiac Transplant Rejection 1 | 14
Prevention of Kidney Transplant Rejection 1 | 16
Prevention of Liver Transplant Rejection 1 | 14
Septic arthritis 1 | 8
Severe Recalcitrant Psoriasis 1 | 11
Sezary Syndrome 1 | 26
Tear film insufficiency 1 | 14

Tissue

Blood and immune system 73 | 17,994
Digestive Tract 73 | 18,472
Female tissues 73 | 18,646
Respiratory system 73 | 17,483
Skin and soft tissues 73 | 18,114
Liver and Pancreas 72 | 18,135
Urinary Tract 72 | 18,443
Cardiovascular System 70 | 17,957
Endocrine System 69 | 18,511
Nervous System 69 | 18,560
Male tissues 67 | 17,968

Target Family

Non-IDG 70 | 11,969
Kinase 6 | 634
Enzyme 5 | 4,146
Ion Channel 3 | 341
Transcription Factor 3 | 1,400

Reactome Pathway

FCERI mediated Ca+2 mobilizati... 87 | 87
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.39396 233.2 634
Proto-oncogene vav VAV1 Tchem Non-IDG -2.64007 465.9 479
Guanine nucleotide exchange factor VAV2 VAV2 Tbio Non-IDG -1.78476 58.3 173
Ig lambda-6 chain C region IGLC6 Tdark Non-IDG -1.81183 228.7 0
Calcineurin subunit B type 1 PPP3R1 Tbio Non-IDG -2.56314 362.9 113
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.11789 1349.3 1026
Tyrosine-protein kinase Lyn LYN Tclin Kinase -2.82112 659.3 521
Lymphocyte cytosolic protein 2 LCP2 Tbio Non-IDG -2.20845 172.5 430
Immunoglobulin heavy variable 3-7 IGHV3-7 Tdark Non-IDG 0.00000 0
Immunoglobulin heavy variable 3-33 IGHV3-33 Tdark Non-IDG 0.00000 0