Development Level

Tdark 70 | 6,593
Tbio 15 | 11,651
Tchem 11 | 1,388
Tclin 4 | 612

IMPC Phenotype

preweaning lethality, complete... 3 | 979
decreased body weight 2 | 161
decreased heart left ventricle... 2 | 28
decreased hemoglobin content 2 | 68
decreased lymphocyte cell numb... 2 | 83
increased monocyte cell number 2 | 63
increased total body fat amoun... 2 | 134
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal digit morphology 1 | 10
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
abnormal seminal vesicle morph... 1 | 114
cataract 1 | 92
decreased IgG3 level 1 | 1
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating magnesiu... 1 | 13
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mature B cell number 1 | 7
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
increased CD4-positive, alpha ... 1 | 4
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased blood urea nitrogen ... 1 | 48
increased erythrocyte cell num... 1 | 39
increased lean body mass 1 | 172
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
preweaning lethality, incomple... 1 | 499
small epididymis 1 | 3
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56

Disease

osteosarcoma 25 | 7,950
Carcinoma 23 | 11,493
lung cancer 20 | 4,740
interstitial cystitis 19 | 2,312
psoriasis 19 | 6,694
Cancer 17 | 2,499
ovarian cancer 16 | 8,520
ulcerative colitis 15 | 1,819
subependymal giant cell astrocytoma 14 | 2,287
lung carcinoma 13 | 2,843
Kidney cancer 11 | 2,613
Multiple myeloma 11 | 1,332
medulloblastoma, large-cell 11 | 6,241
periodontitis 11 | 293
glioblastoma 10 | 5,792
lung adenocarcinoma 10 | 2,716
non-small cell lung cancer 10 | 2,890
tuberculosis 10 | 2,010
cutaneous lupus erythematosus 9 | 1,057
pancreatic cancer 9 | 2,398
Astrocytoma, Pilocytic 8 | 3,081
Breast cancer 8 | 3,578
colon cancer 8 | 1,478
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
malignant mesothelioma 8 | 3,232
adult high grade glioma 7 | 3,801
chronic lymphosyte leukemia 7 | 204
ependymoma 7 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
invasive ductal carcinoma 7 | 2,951
primary Sjogren syndrome 7 | 735
astrocytic glioma 6 | 2,597
atypical teratoid / rhabdoid tumor 6 | 5,112
primary pancreatic ductal adenocarcinoma 6 | 1,109
Pick disease 5 | 1,894
Rheumatoid arthritis 5 | 1,191
Waldenstrons macroglobulinemia 5 | 765
cystic fibrosis and chronic rhinosinusitis 5 | 214
group 3 medulloblastoma 5 | 4,104
group 4 medulloblastoma 5 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
oligodendroglioma 5 | 2,850
primitive neuroectodermal tumor 5 | 3,035
Agammaglobulinemia 4 | 34
Autosomal recessive predisposition 4 | 1,442
Cherubism 4 | 13
Chronic obstructive pulmonary disease 4 | 184
Isolated growth hormone deficiency 4 | 30
Lymphoma 4 | 81
astrocytoma 4 | 1,146
cystic fibrosis 4 | 1,696
non-small cell lung carcinoma 4 | 317
pituitary cancer 4 | 1,972
spina bifida 4 | 1,074
Adenocarcinoma of lung 3 | 142
Adenocarcinoma of lung (disorder) 3 | 60
Amebiasis 3 | 21
Arthritis 3 | 290
Asthma 3 | 385
Blastic phase chronic myeloid leukemia 3 | 58
Chronic Myelocytic Leukemia Accelerated Phase 3 | 59
Chronic graft-versus-host disease 3 | 6
Chronic lymphoid leukemia, disease 3 | 13
Hepatomegaly 3 | 285
Leukemia 3 | 104
Liver cancer 3 | 604
Mantle cell lymphoma 3 | 23
Prostatic Neoplasms 3 | 495
Waldenström macroglobulinemia 3 | 6
diabetes mellitus 3 | 1,728
esophageal adenocarcinoma 3 | 737
gastric carcinoma 3 | 807
juvenile dermatomyositis 3 | 1,187
medulloblastoma 3 | 720
mucosa-associated lymphoid tissue lymphoma 3 | 484
pediatric high grade glioma 3 | 1,064
AMYOTROPHIC LATERAL SCLEROSIS 1 2 | 49
Adult T-Cell Lymphoma/Leukemia 2 | 30
Allergic hypersensitivity disease 2 | 126
Anemia 2 | 365
Atopic dermatitis 2 | 952
Barrett's esophagus 2 | 182
Bipolar Disorder 2 | 666
Chronic Lymphocytic Leukemia 2 | 262
Congenital heart disease 2 | 93
Delayed bone age 2 | 136
Hepatitis C 2 | 94
Hypertrophy, Left Ventricular 2 | 24
Left Ventricular Hypertrophy 2 | 47
Leukemia-Lymphoma, Adult T-Cell 2 | 30
Liver Cirrhosis, Experimental 2 | 769
Melanoma 2 | 711
Multiple Sclerosis 2 | 540
Schizophrenia 2 | 1,160
Type 2 diabetes mellitus 2 | 272
active ulcerative colitis 2 | 764
breast carcinoma 2 | 1,638
ductal carcinoma in situ 2 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
posterior fossa group A ependymoma 2 | 468

Tissue

Blood and immune system 26 | 16,909
Cardiovascular System 26 | 15,192
Digestive Tract 26 | 17,369
Endocrine System 26 | 18,159
Female tissues 26 | 17,400
Liver and Pancreas 26 | 16,750
Male tissues 26 | 17,142
Respiratory system 26 | 16,393
Skin and soft tissues 26 | 17,230
Urinary Tract 26 | 16,678
Nervous System 24 | 16,725

Target Family

Non-IDG 84 | 12,091
Kinase 6 | 634
Enzyme 4 | 4,145
Ion Channel 3 | 344
Transcription Factor 3 | 1,400

Reactome Pathway

FCERI mediated Ca+2 mobilizati... 100 | 100
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
Guanine nucleotide exchange factor VAV3 VAV3 Tbio Non-IDG -1.82116 74.0 249
Guanine nucleotide exchange factor VAV2 VAV2 Tbio Non-IDG -1.81793 64.6 227
Proto-oncogene vav VAV1 Tchem Non-IDG -2.66356 489.1 548
Tyrosine-protein kinase Tec TEC Tchem Kinase -0.75690 9.25 247
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -3.02404 981.4 501
Tyrosine-protein kinase BTK BTK Tclin Kinase -3.07545 1199.5 810
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA Tchem Enzyme -3.00226 997.7 359
Nuclear factor of activated T-cells, cytoplasmic 3 NFATC3 Tbio Transcription Factor -2.05694 111.0 184
Son of sevenless homolog 1 SOS1 Tbio Non-IDG -2.69482 466.2 147