Development Level

Tbio 207 | 11,445
Tchem 61 | 1,598
Tdark 15 | 6,588
Tclin 14 | 613

IMPC Phenotype

preweaning lethality, complete... 13 | 979
preweaning lethality, incomple... 12 | 499
decreased total body fat amoun... 7 | 207
decreased vertical activity 7 | 208
abnormal seminal vesicle morph... 6 | 114
enlarged heart 6 | 210
decreased body length 5 | 101
decreased grip strength 5 | 116
impaired glucose tolerance 5 | 75
short tibia 5 | 97
cataract 4 | 92
decreased bone mineral content 4 | 151
decreased bone mineral density 4 | 126
decreased circulating choleste... 4 | 93
decreased lymphocyte cell numb... 4 | 83
increased bone mineral content 4 | 108
increased circulating alkaline... 4 | 122
increased circulating triglyce... 4 | 42
abnormal bone structure 3 | 187
abnormal coat-hair pigmentatio... 3 | 64
abnormal embryo size 3 | 220
abnormal eye morphology 3 | 68
abnormal femur morphology 3 | 14
abnormal heart morphology 3 | 162
abnormal humerus morphology 3 | 11
abnormal lens morphology 3 | 81
abnormal retina morphology 3 | 71
abnormal skin morphology 3 | 50
abnormal tail morphology 3 | 25
abnormal tooth morphology 3 | 24
decreased body weight 3 | 161
decreased circulating HDL chol... 3 | 68
decreased circulating alkaline... 3 | 46
decreased circulating serum al... 3 | 82
decreased fasted circulating g... 3 | 65
decreased lean body mass 3 | 135
edema 3 | 59
embryonic lethality prior to t... 3 | 278
improved glucose tolerance 3 | 79
increased circulating amylase ... 3 | 25
increased heart weight 3 | 62
increased red blood cell distr... 3 | 34
increased total body fat amoun... 3 | 134
tremors 3 | 39
abnormal behavior 2 | 298
abnormal kidney morphology 2 | 65
abnormal limb position 2 | 3
abnormal locomotor behavior 2 | 24
abnormal radius morphology 2 | 8
abnormal skin coloration 2 | 25
abnormal tibia morphology 2 | 14
abnormal ulna morphology 2 | 8
abnormal vibrissa morphology 2 | 25
decreased circulating aspartat... 2 | 34
decreased circulating creatini... 2 | 39
decreased circulating glucose ... 2 | 126
decreased circulating phosphat... 2 | 27
decreased circulating total pr... 2 | 49
decreased eosinophil cell numb... 2 | 24
decreased erythrocyte cell num... 2 | 62
decreased mean corpuscular hem... 2 | 31
decreased mean corpuscular vol... 2 | 79
decreased neutrophil cell numb... 2 | 42
decreased pulmonary respirator... 2 | 5
embryonic growth retardation 2 | 106
enlarged lymph nodes 2 | 37
enlarged spleen 2 | 41
enlarged stomach 2 | 2
hemorrhage 2 | 23
hypoactivity 2 | 132
increased blood urea nitrogen ... 2 | 48
increased body weight 2 | 25
increased bone mineral density 2 | 72
increased circulating HDL chol... 2 | 80
increased circulating chloride... 2 | 41
increased circulating phosphat... 2 | 26
increased fasted circulating g... 2 | 76
increased lean body mass 2 | 172
increased leukocyte cell numbe... 2 | 47
increased neutrophil cell numb... 2 | 46
increased or absent threshold ... 2 | 101
increased startle reflex 2 | 112
persistence of hyaloid vascula... 2 | 33
small thymus 2 | 16
abnormal ear morphology 1 | 9
abnormal gait 1 | 69
abnormal lung morphology 1 | 26
abnormal spleen morphology 1 | 55
decreased T cell number 1 | 15
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased hematocrit 1 | 46
decreased red blood cell distr... 1 | 41
increased circulating choleste... 1 | 66
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63

Disease

Carcinoma 249 | 11,493
ovarian cancer 181 | 8,520
glioblastoma 158 | 5,792
osteosarcoma 148 | 7,950
psoriasis 144 | 6,694
Breast cancer 126 | 3,578
atypical teratoid / rhabdoid tumor 125 | 5,112
lung cancer 125 | 4,740
Astrocytoma, Pilocytic 119 | 3,081
malignant mesothelioma 118 | 3,232
pancreatic cancer 117 | 2,398
invasive ductal carcinoma 114 | 2,951
ependymoma 113 | 4,679
medulloblastoma, large-cell 111 | 6,241
non-small cell lung cancer 106 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 103 | 2,955
Kidney cancer 102 | 2,613
Cancer 99 | 2,499
lung adenocarcinoma 98 | 2,716
lung carcinoma 97 | 2,843
adult high grade glioma 92 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 92 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 90 | 2,989
interstitial cystitis 87 | 2,312
cystic fibrosis 83 | 1,696
ulcerative colitis 83 | 1,819
Autosomal recessive predisposition 79 | 1,442
primary pancreatic ductal adenocarcinoma 71 | 1,109
ductal carcinoma in situ 69 | 1,745
Duchenne muscular dystrophy 68 | 601
breast carcinoma 67 | 1,638
pituitary cancer 63 | 1,972
primitive neuroectodermal tumor 63 | 3,035
group 3 medulloblastoma 62 | 4,104
oligodendroglioma 59 | 2,850
diabetes mellitus 58 | 1,728
gastric carcinoma 57 | 807
subependymal giant cell astrocytoma 51 | 2,287
Liver Cirrhosis, Experimental 49 | 769
colon cancer 49 | 1,478
autosomal dominant Emery-Dreifuss muscular dystrophy 48 | 510
cutaneous lupus erythematosus 46 | 1,057
nasopharyngeal carcinoma 46 | 1,058
tuberculosis 46 | 2,010
juvenile dermatomyositis 45 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 45 | 1,962
adrenocortical carcinoma 44 | 1,428
Atopic dermatitis 42 | 952
astrocytic glioma 42 | 2,597
esophageal adenocarcinoma 40 | 737
group 4 medulloblastoma 38 | 1,855
pediatric high grade glioma 36 | 1,064
Liver cancer 35 | 604
Schizophrenia 35 | 1,160
Short stature 35 | 531
Osteoarthritis 34 | 184
Myopia 33 | 176
Kidney disease 32 | 430
acute quadriplegic myopathy 32 | 1,158
limb girdle muscular dystrophy 2A 32 | 213
Acquired scoliosis 31 | 281
Becker muscular dystrophy 31 | 191
Curvature of spine 31 | 282
Melanoma 31 | 711
astrocytoma 29 | 1,146
Arthritis 28 | 290
Rheumatoid arthritis 28 | 1,191
Skin cancer 28 | 469
Vascular disease 28 | 319
dermatomyositis 28 | 966
Atherosclerosis 27 | 291
Spontaneous abortion 27 | 113
interstitial lung disease 27 | 298
Hypoplastic mandible condyle 26 | 275
Mandibular hypoplasia 26 | 275
Micrognathism 26 | 275
medulloblastoma 26 | 720
Endometriosis 25 | 540
Osteoporosis 25 | 363
Pick disease 25 | 1,894
active Crohn's disease 25 | 922
Abortion, Spontaneous 24 | 109
Degenerative polyarthritis 24 | 115
fibroadenoma 24 | 559
urothelial carcinoma 24 | 318
Alzheimer's disease 23 | 658
Heart disease 23 | 306
Hypertensive disease 23 | 292
Muscle hypotonia 23 | 571
periodontitis 23 | 293
primary Sjogren syndrome 23 | 735
Down syndrome 22 | 499
Prostatic Neoplasms 22 | 495
Degenerative disc disease 21 | 35
Hypertension 21 | 396
Platyspondyly 21 | 56
Cataract 20 | 297
Coronary artery disease 20 | 268
Multiple Sclerosis 20 | 540
Orbital separation excessive 20 | 244

Tissue

Endocrine System 292 | 18,159
Female tissues 292 | 17,400
Digestive Tract 290 | 17,369
Skin and soft tissues 287 | 17,230
Male tissues 286 | 17,142
Blood and immune system 285 | 16,909
Urinary Tract 284 | 16,678
Liver and Pancreas 283 | 16,750
Respiratory system 281 | 16,393
Nervous System 274 | 16,725
Cardiovascular System 262 | 15,192

Target Family

Non-IDG 208 | 12,091
Enzyme 82 | 4,145
Kinase 6 | 634
Transcription Factor 1 | 1,400

Reactome Pathway

Extracellular matrix organizat... 297 | 297
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Collagen alpha-1(XXIII) chain COL23A1 Tbio Non-IDG -0.49550 1.85 112
Neurexin-1 NRXN1 Tbio Non-IDG -1.88807 125.1 174
Integrin alpha-11 ITGA11 Tbio Non-IDG -1.13736 14.3 76
EGF-containing fibulin-like extracellular matrix protein 2 EFEMP2 Tbio Non-IDG -1.67314 52.3 243
Junctional adhesion molecule A F11R Tbio Non-IDG -2.56739 380.0 394
Matrix metalloproteinase-24 MMP24 Tbio Enzyme -1.38282 25.8 147
Disintegrin and metalloproteinase domain-containing protein 12 ADAM12 Tchem Enzyme -2.28901 214.1 347
Calpain-14 CAPN14 Tdark Non-IDG -0.55232 4.56 19
A disintegrin and metalloproteinase with thrombospondin motifs 14 ADAMTS14 Tbio Enzyme -0.89572 7.58 29
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314