Development Level

Tbio 20 | 11,445
Tchem 5 | 1,598
Tclin 3 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 8 | 979
embryonic lethality prior to o... 5 | 239
decreased circulating triglyce... 2 | 79
embryonic lethality prior to t... 2 | 278
increased mean corpuscular vol... 2 | 92
prenatal lethality prior to he... 2 | 87
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal pharyngeal arch morph... 1 | 8
decreased body weight 1 | 161
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased erythrocyte cell num... 1 | 62
decreased mean corpuscular hem... 1 | 31
embryonic growth retardation 1 | 106
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating fructosa... 1 | 13
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
increased red blood cell distr... 1 | 34

Disease

group 3 medulloblastoma 19 | 4,104
malignant mesothelioma 17 | 3,232
ovarian cancer 17 | 8,520
lung cancer 15 | 4,740
medulloblastoma, large-cell 15 | 6,241
non-small cell lung cancer 14 | 2,890
Carcinoma 13 | 11,493
primitive neuroectodermal tumor 12 | 3,035
psoriasis 12 | 6,694
osteosarcoma 11 | 7,950
atypical teratoid / rhabdoid tumor 9 | 5,112
glioblastoma 9 | 5,792
Breast cancer 7 | 3,578
Short stature 7 | 531
colon cancer 7 | 1,478
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
Cancer 6 | 2,499
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Mental and motor retardation 6 | 608
Waldenstrons macroglobulinemia 6 | 765
adrenocortical carcinoma 6 | 1,428
adult high grade glioma 6 | 3,801
ependymoma 6 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
nasopharyngeal carcinoma 6 | 1,058
Autosomal recessive predisposition 5 | 1,442
Dull intelligence 5 | 645
Intellectual disability 5 | 1,016
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Poor school performance 5 | 645
diabetes mellitus 5 | 1,728
Abnormality of the fingernails 4 | 51
Colorectal Neoplasms 4 | 243
Hypodontia 4 | 81
Kidney cancer 4 | 2,613
Recurrent respiratory infections 4 | 141
Small head 4 | 374
Urethral Stricture 4 | 18
Xeroderma pigmentosum 4 | 43
ductal carcinoma in situ 4 | 1,745
invasive ductal carcinoma 4 | 2,951
lung adenocarcinoma 4 | 2,716
non primary Sjogren syndrome sicca 4 | 891
oligodendroglioma 4 | 2,850
Abnormal blistering of the skin 3 | 54
Abnormality of female internal genitalia 3 | 13
Abnormality of the pharynx 3 | 19
Acute myeloid leukemia, disease 3 | 30
Anemia 3 | 365
Anorectal Malformations 3 | 8
Aplasia/Hypoplasia of the skin 3 | 16
Blister of skin 3 | 54
Blood Coagulation Disorders 3 | 42
Bone marrow hypocellularity 3 | 20
Cellular immunodeficiency 3 | 17
Coagulation abnormalities 3 | 27
Decreased platelet count 3 | 111
Dental caries 3 | 164
Dyskeratosis congenita 3 | 24
Dystrophia unguium 3 | 53
Esophageal Stenosis 3 | 15
Frequent fractures 3 | 53
Gingival Diseases 3 | 19
Hemoglobin low 3 | 124
Hemorrhagic Disorders 3 | 30
Hyperhidrosis disorder 3 | 81
Hyperpigmented macules 3 | 42
Hypoplastic mandible condyle 3 | 275
Hypoplastic-absent toenails 3 | 11
Increased fracture rate 3 | 53
Increased sweating 3 | 81
Intrauterine retardation 3 | 176
Leukokeratosis 3 | 19
Leukoplakia, Oral 3 | 20
Malabsorption 3 | 82
Malignant tumor of ovary 3 | 25
Mandibular hypoplasia 3 | 275
Micrognathism 3 | 275
Multiple myeloma 3 | 1,332
Neutrophil abnormality 3 | 20
Osteoporosis 3 | 363
Periodontal Diseases 3 | 21
Rough bone trabeculation 3 | 11
Seckel syndrome 3 | 34
Skin Ulcer 3 | 48
Skin bulla 3 | 54
Sparse hair 3 | 59
Sweating 3 | 81
Taurodontism 3 | 14
Telangiectasia of the skin 3 | 39
Thin, sparse hair 3 | 59
Thrombocytopenia 3 | 197
Tracheoesophageal Fistula 3 | 36
Varying degree of multiple fractures 3 | 53
hypopigmented skin patch 3 | 59
pediatric high grade glioma 3 | 1,064
periodontitis 3 | 293

Tissue

Blood and immune system 29 | 16,909
Digestive Tract 29 | 17,369
Endocrine System 29 | 18,159
Cardiovascular System 28 | 15,192
Female tissues 28 | 17,400
Liver and Pancreas 28 | 16,750
Male tissues 28 | 17,142
Nervous System 28 | 16,725
Respiratory system 28 | 16,393
Skin and soft tissues 28 | 17,230
Urinary Tract 28 | 16,678

Target Family

Enzyme 17 | 4,145
Non-IDG 12 | 12,091

Reactome Pathway

Extension of Telomeres 29 | 29
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta subunit 4 POLD4 Tbio Enzyme -0.84887 7.32 24
H/ACA ribonucleoprotein complex subunit 2 NHP2 Tbio Non-IDG -1.51951 28.7 54
Replication factor C subunit 2 RFC2 Tbio Non-IDG -1.36589 20.3 293
Replication factor C subunit 1 RFC1 Tbio Non-IDG -1.43459 26.5 198
Replication factor C subunit 3 RFC3 Tbio Non-IDG -1.30866 19.7 176
Replication protein A 14 kDa subunit RPA3 Tbio Non-IDG -1.85941 67.1 171
DNA primase large subunit PRIM2 Tbio Enzyme 0.00000 89
Telomerase reverse transcriptase TERT Tchem Enzyme -3.56910 3506.4 643
DNA polymerase delta subunit 2 POLD2 Tbio Enzyme -0.95222 8.52 115
Replication protein A 70 kDa DNA-binding subunit RPA1 Tchem Non-IDG -2.48277 297.9 350