Development Level

Tbio 4 | 11,445
Tclin 4 | 613
Tchem 3 | 1,598

IMPC Phenotype

abnormal bone mineralization 1 | 38
abnormal lens morphology 1 | 81
abnormal response to tactile s... 1 | 17
abnormal startle reflex 1 | 15
abnormal vocalization 1 | 21
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating total pr... 1 | 49

Disease

Alcohol dependence 10 | 107
Alcoholic Intoxication, Chronic 9 | 289
Carcinoma 9 | 11,493
psoriasis 9 | 6,694
Alcohol abuse 7 | 50
Liver disease 5 | 237
ductal carcinoma in situ 5 | 1,745
invasive ductal carcinoma 5 | 2,951
lung adenocarcinoma 5 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
Alcoholic Intoxication 4 | 34
Cancer 4 | 2,499
Liver Cirrhosis, Experimental 4 | 769
Pancreatitis 4 | 123
esophageal cancer 4 | 22
fibroadenoma 4 | 559
lung cancer 4 | 4,740
lung carcinoma 4 | 2,843
nasopharyngeal carcinoma 4 | 1,058
ovarian cancer 4 | 8,520
Accidental poisoning by methyl alcohol 3 | 3
Alcoholism 3 | 45
Breast cancer 3 | 3,578
Esophageal Neoplasms 3 | 69
Ethylene Glycol Toxicity 3 | 3
Genetic Predisposition to Disease 3 | 27
Mouth Neoplasms 3 | 55
Organ system cancer 3 | 18
Substance abuse 3 | 59
Succinic semialdehyde dehydrogenase deficiency 3 | 16
acute myeloid leukemia 3 | 783
breast carcinoma 3 | 1,638
colon cancer 3 | 1,478
esophageal adenocarcinoma 3 | 737
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
non-small cell lung cancer 3 | 2,890
pituitary cancer 3 | 1,972
substance-related disorder 3 | 162
ulcerative colitis 3 | 1,819
Alcoholic neuropathy 2 | 3
Atopic dermatitis 2 | 952
Attention deficit hyperactivity disorder 2 | 278
Colorectal Neoplasms 2 | 243
Esophageal Squamous Cell Carcinoma 2 | 77
Essential Hypertension 2 | 94
Hangover from alcohol 2 | 2
Laryngeal Neoplasms 2 | 2
Laryngeal neoplasm 2 | 2
Pharyngeal Neoplasms 2 | 2
Retinitis pigmentosa 23 2 | 27
Squamous cell carcinoma of esophagus 2 | 77
Wernicke-Korsakoff syndrome 2 | 10
adrenocortical carcinoma 2 | 1,428
atypical teratoid / rhabdoid tumor 2 | 5,112
chronic rhinosinusitis 2 | 512
glioblastoma 2 | 5,792
group 3 medulloblastoma 2 | 4,104
medulloblastoma, large-cell 2 | 6,241
non-small cell lung carcinoma 2 | 317
osteosarcoma 2 | 7,950
primitive neuroectodermal tumor 2 | 3,035
Bipolar Disorder 1 | 666
Brain infarction 1 | 22
Carcinoma, Renal Cell 1 | 124
Cholestasis 1 | 155
Colonic Neoplasms 1 | 142
Coronary artery disease 1 | 268
Creutzfeldt-Jakob Syndrome 1 | 10
Creutzfeldt-Jakob disease 1 | 21
Cyclothymic disorder 1 | 8
Familial encephalopathy with neuroserpin inclusion bodies 1 | 10
Fetal alcohol spectrum disorder 1 | 7
Flushing 1 | 60
Hepatomegaly 1 | 285
Heroin dependence 1 | 30
Infertility, Male 1 | 46
Intracranial aneurysm 1 | 24
Kidney disease 1 | 430
Male infertility 1 | 206
Parkinsonian Disorders 1 | 56
Psychotic Disorders 1 | 151
Renal Cell Carcinoma 1 | 214
Vascular Diseases 1 | 16
Waldenstrons macroglobulinemia 1 | 765
acute quadriplegic myopathy 1 | 1,158
adrenocortical adenoma 1 | 131
aldosterone-producing adenoma 1 | 665
chronic lymphosyte leukemia 1 | 204
cystic fibrosis and chronic rhinosinusitis 1 | 214
head and neck cancer 1 | 271
head and neck cancer and chronic obstructive pulmonary disease 1 | 239
hereditary spastic paraplegia 1 | 318
limb girdle muscular dystrophy 2B 1 | 40
nephrosclerosis 1 | 333
pediatric high grade glioma 1 | 1,064
tuberculosis 1 | 2,010
tuberculosis and treatment for 6 months 1 | 409
urothelial carcinoma 1 | 318

Tissue

Blood and immune system 11 | 16,909
Digestive Tract 11 | 17,369
Female tissues 11 | 17,400
Liver and Pancreas 11 | 16,750
Respiratory system 11 | 16,393
Skin and soft tissues 11 | 17,230
Urinary Tract 11 | 16,678
Endocrine System 10 | 18,159
Male tissues 10 | 17,142
Cardiovascular System 9 | 15,192
Nervous System 9 | 16,725

Target Family

Enzyme 11 | 4,145

Reactome Pathway

Ethanol oxidation 11 | 11
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Alcohol dehydrogenase class 4 mu/sigma chain ADH7 Tchem Enzyme -2.18765 159.0 243
Alcohol dehydrogenase 6 ADH6 Tbio Enzyme -1.84121 71.7 117
Alcohol dehydrogenase 4 ADH4 Tbio Enzyme -2.30746 247.9 210
Retinal dehydrogenase 1 ALDH1A1 Tchem Enzyme -2.81062 648.3 725
Alcohol dehydrogenase class-3 ADH5 Tchem Enzyme -2.37411 239.5 283
Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 Tbio Enzyme -2.25828 174.5 264
Aldehyde dehydrogenase X, mitochondrial ALDH1B1 Tbio Enzyme -1.73034 52.5 194
Alcohol dehydrogenase 1B ADH1B Tclin Enzyme -2.42307 381.5 160
Alcohol dehydrogenase 1C ADH1C Tclin Enzyme -2.42307 381.5 97
Aldehyde dehydrogenase, mitochondrial ALDH2 Tclin Enzyme -2.97865 1004.9 470