Development Level

Tbio 80 | 11,445
Tchem 20 | 1,598
Tdark 9 | 6,588
Tclin 5 | 613

IMPC Phenotype

preweaning lethality, complete... 10 | 979
embryonic lethality prior to t... 7 | 278
embryonic lethality prior to o... 6 | 239
decreased vertical activity 4 | 208
enlarged heart 4 | 210
preweaning lethality, incomple... 4 | 499
abnormal behavior 3 | 298
abnormal embryo size 3 | 220
abnormal eye morphology 3 | 68
abnormal heart morphology 3 | 162
abnormal skin morphology 2 | 50
abnormal tooth morphology 2 | 24
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
enlarged uterus 2 | 11
hydrometra 2 | 53
increased circulating creatini... 2 | 38
increased grip strength 2 | 41
small superior vagus ganglion 2 | 74
abnormal coat-hair pigmentatio... 1 | 64
abnormal epididymis morphology 1 | 42
abnormal forebrain development 1 | 20
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal snout morphology 1 | 23
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating choleste... 1 | 93
decreased circulating creatine... 1 | 4
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased neutrophil cell numb... 1 | 42
enlarged epididymis 1 | 31
enlarged kidney 1 | 14
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased body length 1 | 32
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating creatine... 1 | 5
increased circulating free fat... 1 | 20
increased heart rate 1 | 23
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
male infertility 1 | 123
pale yolk sac 1 | 25
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
premature death 1 | 5
prenatal lethality prior to he... 1 | 87
shortened RR interval 1 | 17
small heart 1 | 10
small kidney 1 | 16
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 19
thrombocytosis 1 | 27

Disease

ovarian cancer 72 | 8,520
Carcinoma 68 | 11,493
osteosarcoma 56 | 7,950
Cancer 53 | 2,499
lung cancer 51 | 4,740
psoriasis 51 | 6,694
Breast cancer 44 | 3,578
glioblastoma 40 | 5,792
medulloblastoma, large-cell 37 | 6,241
atypical teratoid / rhabdoid tumor 34 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 30 | 3,291
malignant mesothelioma 28 | 3,232
invasive ductal carcinoma 27 | 2,951
lung adenocarcinoma 27 | 2,716
breast carcinoma 24 | 1,638
non-small cell lung cancer 24 | 2,890
Kidney cancer 23 | 2,613
Multiple myeloma 23 | 1,332
ductal carcinoma in situ 23 | 1,745
ependymoma 22 | 4,679
group 4 medulloblastoma 22 | 1,855
group 3 medulloblastoma 21 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,989
primitive neuroectodermal tumor 21 | 3,035
Rheumatoid arthritis 20 | 1,191
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,955
Astrocytoma, Pilocytic 18 | 3,081
Breast Neoplasms 18 | 445
Mammary Neoplasms 18 | 425
Pick disease 18 | 1,894
lung carcinoma 18 | 2,843
oligodendroglioma 18 | 2,850
pancreatic cancer 18 | 2,398
subependymal giant cell astrocytoma 18 | 2,287
acute quadriplegic myopathy 17 | 1,158
astrocytoma 17 | 1,146
Waldenstrons macroglobulinemia 16 | 765
acute myeloid leukemia 16 | 783
diabetes mellitus 16 | 1,728
Prostatic Neoplasms 15 | 495
Schizophrenia 15 | 1,160
adult high grade glioma 15 | 3,801
colon cancer 15 | 1,478
interstitial cystitis 15 | 2,312
pituitary cancer 15 | 1,972
Alzheimer's disease 12 | 658
astrocytic glioma 12 | 2,597
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
Down syndrome 11 | 499
Endometriosis 11 | 540
Carcinoma, Hepatocellular 10 | 228
Liver carcinoma 10 | 240
aldosterone-producing adenoma 10 | 665
cystic fibrosis 10 | 1,696
gastric cancer 10 | 459
juvenile dermatomyositis 10 | 1,187
pediatric high grade glioma 10 | 1,064
Intellectual disability 9 | 1,016
fibroadenoma 9 | 559
hepatocellular carcinoma 9 | 547
non primary Sjogren syndrome sicca 9 | 891
non-small cell lung carcinoma 9 | 317
pancreatic carcinoma 9 | 562
ulcerative colitis 9 | 1,819
adrenocortical carcinoma 8 | 1,428
Amyotrophic lateral sclerosis 7 | 451
Bipolar Disorder 7 | 666
Cell Transformation, Neoplastic 7 | 97
Crohn's disease 7 | 321
Endometrial cancer 7 | 311
Lung Neoplasms 7 | 232
Mammary Neoplasms, Experimental 7 | 154
Vascular disease 7 | 319
cutaneous lupus erythematosus 7 | 1,057
nasopharyngeal carcinoma 7 | 1,058
tuberculosis 7 | 2,010
Bladder Neoplasm 6 | 112
Chronic Lymphocytic Leukemia 6 | 262
Cleft Palate 6 | 271
Delayed bone age 6 | 136
Disease Progression 6 | 136
Dull intelligence 6 | 645
Hypoplastic mandible condyle 6 | 275
Immune system cancer 6 | 140
Liver neoplasms 6 | 130
Low intelligence 6 | 645
Major Depressive Disorder 6 | 301
Mandibular hypoplasia 6 | 275
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Micrognathism 6 | 275
Neoplasm Metastasis 6 | 168
Obesity 6 | 678
Poor school performance 6 | 645
Small head 6 | 374
Squamous cell carcinoma 6 | 129
Urinary Bladder Neoplasms 6 | 114
dermatomyositis 6 | 966
primary pancreatic ductal adenocarcinoma 6 | 1,109
spina bifida 6 | 1,074

Tissue

Endocrine System 113 | 18,159
Blood and immune system 112 | 16,909
Digestive Tract 112 | 17,369
Female tissues 112 | 17,400
Skin and soft tissues 112 | 17,230
Liver and Pancreas 111 | 16,750
Male tissues 111 | 17,142
Respiratory system 111 | 16,393
Urinary Tract 111 | 16,678
Nervous System 110 | 16,725
Cardiovascular System 109 | 15,192

Target Family

Non-IDG 61 | 12,091
Enzyme 19 | 4,145
Transcription Factor 17 | 1,400
Epigenetic 12 | 242
Nuclear Receptor 3 | 48
Kinase 2 | 634

Reactome Pathway

Estrogen-dependent gene expres... 114 | 114
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable ATP-dependent RNA helicase DDX5 DDX5 Tbio Enzyme -2.08566 121.1 344
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.49730 299.8 149
Histone H2B type 1-N HIST1H2BN Tbio Non-IDG -1.51422 30.2 60
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 48
Histone-arginine methyltransferase CARM1 CARM1 Tchem Epigenetic -2.04034 130.8 476
Putative helicase MOV-10 MOV10 Tbio Enzyme -1.55297 38.5 121
Protein argonaute-4 AGO4 Tbio Non-IDG -1.42077 23.0 121
Cohesin subunit SA-1 STAG1 Tbio Non-IDG -2.47449 292.2 200
Glycerol-3-phosphate acyltransferase 1, mitochondrial GPAM Tbio Enzyme -1.93041 83.4 177
DNA-directed RNA polymerases I, II, and III subunit RPABC2 POLR2F Tbio Enzyme -1.13403 13.9 68