Development Level

Tbio 79 | 10,625
Tdark 15 | 7,003
Tchem 14 | 1,890
Tclin 5 | 602

IMPC Phenotype

preweaning lethality, complete... 6 | 633
decreased body weight 3 | 174
embryonic lethality prior to o... 3 | 148
increased sacral vertebrae num... 3 | 62
preweaning lethality, incomple... 3 | 260
abnormal behavior 2 | 226
abnormal maxilla morphology 2 | 16
abnormal tooth morphology 2 | 24
decreased circulating HDL chol... 2 | 77
decreased lumbar vertebrae num... 2 | 62
decreased rib number 2 | 59
embryonic lethality prior to t... 2 | 187
increased circulating creatini... 2 | 29
increased circulating triglyce... 2 | 24
abnormal bone mineralization 1 | 55
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal iris morphology 1 | 12
abnormal placement of pupils 1 | 4
abnormal retina morphology 1 | 100
abnormal snout morphology 1 | 18
decreased B cell number 1 | 30
decreased CD4-positive, alpha ... 1 | 19
decreased CD8-positive, alpha-... 1 | 26
decreased Ly6C high monocyte n... 1 | 18
decreased Ly6C low monocyte nu... 1 | 23
decreased NK cell number 1 | 16
decreased T cell number 1 | 31
decreased alpha-beta T cell nu... 1 | 12
decreased caudal vertebrae num... 1 | 49
decreased circulating LDL chol... 1 | 37
decreased circulating choleste... 1 | 85
decreased circulating glucose ... 1 | 121
decreased circulating sodium l... 1 | 18
decreased circulating total pr... 1 | 41
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased heart left ventricle... 1 | 2
decreased hemoglobin content 1 | 53
decreased lean body mass 1 | 195
decreased leukocyte cell numbe... 1 | 54
decreased mature B cell number 1 | 25
decreased respiratory quotient 1 | 12
enlarged epididymis 1 | 27
female infertility 1 | 34
hypoactivity 1 | 89
increased CD4-positive, CD25-p... 1 | 18
increased Ly6C low monocyte nu... 1 | 8
increased body length 1 | 20
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating chloride... 1 | 43
increased circulating free fat... 1 | 17
increased circulating potassiu... 1 | 31
increased effector memory CD4-... 1 | 15
increased grip strength 1 | 83
increased heart rate 1 | 17
increased mean corpuscular hem... 1 | 93
increased or absent threshold ... 1 | 128
increased plasma cell number 1 | 5
increased total body fat amoun... 1 | 57
irregularly shaped pupil 1 | 7
male infertility 1 | 62
narrow eye opening 1 | 15
prolonged PR interval 1 | 4
shortened PR interval 1 | 5
shortened RR interval 1 | 19
thick ventricular wall 1 | 7
thin ventricular wall 1 | 5
thrombocytopenia 1 | 46
trunk curl 1 | 15

Disease

ovarian cancer 67 | 8,491
osteosarcoma 55 | 7,933
lung cancer 43 | 4,473
psoriasis 42 | 6,685
Cancer 33 | 2,346
medulloblastoma, large-cell 32 | 6,234
glioblastoma 31 | 5,572
invasive ductal carcinoma 25 | 2,950
lung adenocarcinoma 23 | 2,714
primitive neuroectodermal tumor 23 | 3,031
Breast cancer 22 | 3,098
Multiple myeloma 21 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,289
atypical teratoid / rhabdoid tumor 19 | 4,369
non-small cell lung cancer 19 | 2,798
group 3 medulloblastoma 18 | 2,254
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,988
malignant mesothelioma 18 | 3,163
pediatric high grade glioma 18 | 2,712
Carcinoma 16 | 2,147
ductal carcinoma in situ 16 | 1,745
ependymoma 14 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,956
astrocytoma 13 | 1,493
breast carcinoma 13 | 1,614
subependymal giant cell astrocytoma 13 | 2,287
Rheumatoid Arthritis 12 | 1,170
Waldenstrons macroglobulinemia 12 | 764
atypical teratoid/rhabdoid tumor 12 | 1,095
dermatomyositis 12 | 966
group 4 medulloblastoma 12 | 1,875
oligodendroglioma 12 | 2,849
pancreatic cancer 12 | 2,300
sonic hedgehog group medulloblastoma 12 | 1,482
Pick disease 11 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,795
Mammary Neoplasms 9 | 410
Prostatic Neoplasms 9 | 471
acute myeloid leukemia 9 | 785
diabetes mellitus 9 | 1,663
pilocytic astrocytoma 9 | 3,086
Photosensitive trichothiodystrophy 8 | 24
acute quadriplegic myopathy 8 | 1,157
colon cancer 8 | 1,475
nasopharyngeal carcinoma 8 | 1,056
posterior fossa group A ependymoma 8 | 1,511
spina bifida 8 | 1,064
tuberculosis 8 | 1,563
Cockayne syndrome 7 | 54
Endometriosis 7 | 535
adrenocortical carcinoma 7 | 1,427
adult high grade glioma 7 | 2,148
astrocytic glioma 7 | 2,241
cystic fibrosis 7 | 1,670
juvenile dermatomyositis 7 | 1,189
medulloblastoma 7 | 1,524
Alzheimer's disease 6 | 644
Intellectual disability 6 | 573
Xeroderma pigmentosum 6 | 41
pituitary cancer 6 | 1,972
Dementia 5 | 129
MYELODYSPLASTIC SYNDROME 5 | 39
Melanoma 5 | 261
Schizophrenia 5 | 503
cutaneous lupus erythematosus 5 | 1,056
gastric cancer 5 | 436
non-small cell lung carcinoma 5 | 413
Craniofacial Abnormalities 4 | 147
Endometrial Neoplasms 4 | 50
Immune system cancer 4 | 38
Lung Neoplasms 4 | 171
Lupus erythematosus 4 | 80
Peripheral Neuropathy 4 | 303
Peripheral T-cell lymphoma 4 | 24
Stomach Neoplasms 4 | 282
active Crohn's disease 4 | 918
hepatocellular carcinoma 4 | 550
inflammatory breast cancer 4 | 404
interstitial cystitis 4 | 2,299
non primary Sjogren syndrome sicca 4 | 840
pancreatic carcinoma 4 | 567
posterior fossa group B ependymoma 4 | 1,530
primary Sjogren syndrome 4 | 788
primary pancreatic ductal adenocarcinoma 4 | 1,271
progressive supranuclear palsy 4 | 674
ulcerative colitis 4 | 2,087
Adenoid Cystic Carcinoma 3 | 99
Autistic Disorder 3 | 320
Bipolar Disorder 3 | 266
Chronic obstructive pulmonary disease 3 | 147
Cleft palate 3 | 125
Crohn's disease 3 | 304
Down syndrome 3 | 548
Heart disease 3 | 279
Kidney disease 3 | 397
Leishmaniasis 3 | 49
Prostate cancer 3 | 172
Vascular disease 3 | 281
gastric carcinoma 3 | 832
lung carcinoma 3 | 2,844

Tissue

Female tissues 113 | 18,646
Male tissues 113 | 17,968
Blood and immune system 112 | 17,994
Cardiovascular System 112 | 17,957
Digestive Tract 112 | 18,472
Nervous System 112 | 18,560
Endocrine System 111 | 18,511
Liver and Pancreas 111 | 18,135
Urinary Tract 111 | 18,443
Respiratory system 110 | 17,483
Skin and soft tissues 104 | 18,114

Target Family

Non-IDG 48 | 11,969
Enzyme 33 | 4,146
Epigenetic 19 | 242
Transcription Factor 8 | 1,400
TF/Epigenetic 3 | 38
Kinase 2 | 634

Reactome Pathway

Epigenetic regulation of gene ... 113 | 113
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.13212 1.19 10
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.16 0.33 20
Ribosomal RNA-processing protein 8 RRP8 Tbio Enzyme -2.24766 174.5 99
Methylcytosine dioxygenase TET3 TET3 Tbio Enzyme -1.88050 66.7 105
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 42
Histone H2B type 1-N HIST1H2BN Tdark Non-IDG -1.51554 30.2 48
Histone H2A type 1-B/E HIST1H2AB Tbio Non-IDG -1.26707 18.9 109
Histone-lysine N-methyltransferase SUV39H1 SUV39H1 Tchem Epigenetic -2.21810 149.4 267
Paired amphipathic helix protein Sin3a SIN3A Tbio Non-IDG -1.89468 62.9 159
DNA-directed RNA polymerases I, II, and III subunit RPABC3 POLR2H Tbio Enzyme -1.14104 13.5 159