Development Level

Tbio 87 | 11,651
Tdark 12 | 6,593
Tchem 11 | 1,388
Tclin 5 | 612

IMPC Phenotype

preweaning lethality, complete... 12 | 979
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 3 | 278
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
decreased body weight 2 | 161
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
decreased lean body mass 2 | 135
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased circulating HDL chol... 2 | 80
increased circulating creatini... 2 | 38
increased circulating triglyce... 2 | 42
increased total body fat amoun... 2 | 134
abnormal bone mineralization 1 | 38
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal heart left ventricle ... 1 | 16
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
abnormal posture 1 | 2
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal tooth morphology 1 | 24
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased hemoglobin content 1 | 68
decreased lumbar vertebrae num... 1 | 2
decreased mean corpuscular vol... 1 | 79
decreased respiratory quotient 1 | 16
decreased sacral vertebrae num... 1 | 1
enlarged epididymis 1 | 31
hemorrhage 1 | 23
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased anti-nuclear antigen... 1 | 19
increased body length 1 | 32
increased body temperature 1 | 9
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating potassiu... 1 | 29
increased grip strength 1 | 41
increased hemoglobin content 1 | 45
increased lumbar vertebrae num... 1 | 1
increased mean corpuscular hem... 1 | 96
increased sacral vertebrae num... 1 | 1
thrombocytopenia 1 | 56
trunk curl 1 | 16

Disease

Carcinoma 67 | 11,493
ovarian cancer 67 | 8,520
osteosarcoma 56 | 7,950
lung cancer 46 | 4,740
psoriasis 42 | 6,694
Cancer 33 | 2,499
medulloblastoma, large-cell 32 | 6,241
glioblastoma 31 | 5,792
group 3 medulloblastoma 31 | 4,104
Breast cancer 25 | 3,578
invasive ductal carcinoma 25 | 2,951
atypical teratoid / rhabdoid tumor 24 | 5,112
lung adenocarcinoma 23 | 2,716
primitive neuroectodermal tumor 23 | 3,035
Kidney cancer 22 | 2,613
Multiple myeloma 21 | 1,332
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,291
non-small cell lung cancer 20 | 2,890
ependymoma 19 | 4,679
malignant mesothelioma 19 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
Schizophrenia 17 | 1,160
ductal carcinoma in situ 16 | 1,745
Intellectual disability 15 | 1,016
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
breast carcinoma 13 | 1,638
dermatomyositis 13 | 966
pancreatic cancer 13 | 2,398
pediatric high grade glioma 13 | 1,064
subependymal giant cell astrocytoma 13 | 2,287
Cockayne syndrome 12 | 60
Rheumatoid arthritis 12 | 1,191
Waldenstrons macroglobulinemia 12 | 765
adult high grade glioma 12 | 3,801
oligodendroglioma 12 | 2,850
Photosensitive trichothiodystrophy 11 | 30
Pick disease 11 | 1,894
astrocytoma 11 | 1,146
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
Breast Neoplasms 10 | 445
Dull intelligence 10 | 645
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Poor school performance 10 | 645
group 4 medulloblastoma 10 | 1,855
Astrocytoma, Pilocytic 9 | 3,081
Hypoplastic mandible condyle 9 | 275
Mammary Neoplasms 9 | 425
Mandibular hypoplasia 9 | 275
Micrognathism 9 | 275
Prostatic Neoplasms 9 | 495
Strabismus 9 | 270
acute myeloid leukemia 9 | 783
astrocytic glioma 9 | 2,597
diabetes mellitus 9 | 1,728
tuberculosis 9 | 2,010
Broad flat nasal bridge 8 | 236
Nasal bridge wide 8 | 236
Short stature 8 | 531
Small head 8 | 374
acute quadriplegic myopathy 8 | 1,158
colon cancer 8 | 1,478
nasopharyngeal carcinoma 8 | 1,058
spina bifida 8 | 1,074
Cleft Palate 7 | 271
Cognitive delay 7 | 608
Cryptorchidism 7 | 296
Endometriosis 7 | 540
Global developmental delay 7 | 608
Mental and motor retardation 7 | 608
Mood Disorders 7 | 184
Muscle hypotonia 7 | 571
adrenocortical carcinoma 7 | 1,428
atypical teratoid/rhabdoid tumor 7 | 357
cystic fibrosis 7 | 1,696
juvenile dermatomyositis 7 | 1,187
Autism Spectrum Disorders 6 | 75
Autism spectrum disorder 6 | 101
Autistic Disorder 6 | 364
Autosomal recessive predisposition 6 | 1,442
Bipolar Disorder 6 | 666
Cataract 6 | 297
Craniofacial Abnormalities 6 | 151
Downward slant of palpebral fissure 6 | 158
Epilepsy 6 | 792
Immune system cancer 6 | 140
Lymphoid leukemia 6 | 160
Melanoma 6 | 711
Muscle Spasticity 6 | 195
Seizures 6 | 596
Sensorineural Hearing Loss (disorder) 6 | 284
Xeroderma pigmentosum 6 | 43
Xeroderma pigmentosum group B 6 | 20
hearing impairment 6 | 199
pituitary cancer 6 | 1,972
posterior fossa group A ependymoma 6 | 468
Feeding difficulties in infancy 5 | 175
Lens Opacities 5 | 231
gastric cancer 5 | 459

Tissue

Endocrine System 113 | 18,159
Blood and immune system 112 | 16,909
Digestive Tract 112 | 17,369
Female tissues 112 | 17,400
Skin and soft tissues 112 | 17,230
Liver and Pancreas 111 | 16,750
Nervous System 111 | 16,725
Urinary Tract 111 | 16,678
Cardiovascular System 110 | 15,192
Male tissues 110 | 17,142
Respiratory system 110 | 16,393

Target Family

Non-IDG 50 | 12,091
Enzyme 33 | 4,145
Epigenetic 19 | 242
Transcription Factor 8 | 1,400
TF/Epigenetic 3 | 38
Kinase 2 | 634

Reactome Pathway

Epigenetic regulation of gene ... 115 | 115
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
General transcription factor IIH subunit 1 GTF2H1 Tbio Non-IDG -1.65323 46.0 231
Chromobox protein homolog 3 CBX3 Tbio Epigenetic -2.00023 90.5 366
Transcriptional repressor p66-beta GATAD2B Tbio Transcription Factor -1.00210 9.37 215
DNA (cytosine-5)-methyltransferase 3A DNMT3A Tclin Epigenetic -2.91291 722.8 693
DNA-directed RNA polymerase I subunit RPA43 TWISTNB Tdark Enzyme -0.05799 1.13 69
DNA (cytosine-5)-methyltransferase 3-like DNMT3L Tbio Enzyme -1.95555 87.2 403
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.76808 54.0 121
Paired amphipathic helix protein Sin3a SIN3A Tbio Non-IDG -1.93639 70.1 171
E3 ubiquitin-protein ligase UHRF1 UHRF1 Tbio Epigenetic 0.00000 279
Transcriptional repressor p66-alpha GATAD2A Tbio Non-IDG -0.85553 8.21 159