Development Level

Tbio 33 | 11,651
Tchem 4 | 1,388
Tclin 2 | 612
Tdark 1 | 6,593

IMPC Phenotype

preweaning lethality, complete... 4 | 979
decreased body length 2 | 101
increased leukocyte cell numbe... 2 | 47
preweaning lethality, incomple... 2 | 499
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal incisor morphology 1 | 4
abnormal radius morphology 1 | 8
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal ulna morphology 1 | 8
abnormal vibrissa morphology 1 | 25
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
convulsive seizures 1 | 13
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased neutrophil cell numb... 1 | 42
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 34 | 11,493
psoriasis 25 | 6,694
glioblastoma 24 | 5,792
atypical teratoid / rhabdoid tumor 22 | 5,112
ovarian cancer 22 | 8,520
ependymoma 21 | 4,679
lung carcinoma 21 | 2,843
osteosarcoma 21 | 7,950
Astrocytoma, Pilocytic 20 | 3,081
Breast cancer 19 | 3,578
pancreatic cancer 19 | 2,398
malignant mesothelioma 18 | 3,232
Cancer 17 | 2,499
medulloblastoma, large-cell 17 | 6,241
primary pancreatic ductal adenocarcinoma 17 | 1,109
non-small cell lung cancer 16 | 2,890
lung cancer 15 | 4,740
adult high grade glioma 14 | 3,801
invasive ductal carcinoma 14 | 2,951
lung adenocarcinoma 14 | 2,716
group 3 medulloblastoma 13 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
cystic fibrosis 12 | 1,696
interstitial cystitis 12 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
Liver Cirrhosis, Experimental 11 | 769
Atopic dermatitis 10 | 952
Duchenne muscular dystrophy 10 | 601
colon cancer 10 | 1,478
ductal carcinoma in situ 10 | 1,745
Autosomal recessive predisposition 9 | 1,442
Orbital separation excessive 9 | 244
Short stature 9 | 531
pituitary cancer 9 | 1,972
primitive neuroectodermal tumor 9 | 3,035
Hypertensive disease 8 | 292
Kidney cancer 8 | 2,613
adrenocortical carcinoma 8 | 1,428
breast carcinoma 8 | 1,638
cutaneous lupus erythematosus 8 | 1,057
ulcerative colitis 8 | 1,819
Aortic Valve Insufficiency 7 | 40
Aortic aneurysm 7 | 38
Brachydactyly 7 | 156
Coronary artery disease 7 | 268
Endometriosis 7 | 540
Pulmonary emphysema 7 | 48
diabetes mellitus 7 | 1,728
gastric carcinoma 7 | 807
pediatric high grade glioma 7 | 1,064
tuberculosis 7 | 2,010
Arachnodactyly 6 | 49
Cleft Palate 6 | 271
Cutis Laxa 6 | 39
Hernia, Inguinal 6 | 89
Increase in blood pressure 6 | 119
Osteoarthritis 6 | 184
Osteoporosis 6 | 363
Prostatic Neoplasms 6 | 495
Schizophrenia 6 | 1,160
astrocytic glioma 6 | 2,597
limb girdle muscular dystrophy 2A 6 | 213
medulloblastoma 6 | 720
oligodendroglioma 6 | 2,850
Acquired flat foot 5 | 72
Acquired metabolic disease 5 | 336
Acquired scoliosis 5 | 281
Aortic aneurysm, familial thoracic 3 5 | 13
Ascending aortic dissection 5 | 13
Byzanthine arch palate 5 | 194
Cardiomegaly 5 | 116
Chest Pain 5 | 38
Colorectal Neoplasms 5 | 243
Curvature of spine 5 | 282
Cutis marmorata 5 | 32
Cystic medial necrosis of aorta 5 | 13
Dyspnea on exertion 5 | 24
Dyspnea, Paroxysmal 5 | 13
Flatfoot 5 | 73
Generalized elastolysis 5 | 24
Glaucoma 5 | 239
Hanging skin 5 | 24
Hypoplastic mandible condyle 5 | 275
Impaired left ventricular function 5 | 16
Joint stiffness 5 | 84
Left-Sided Heart Failure 5 | 16
Loeys-Dietz Aortic Aneurysm Syndrome 5 | 13
Mandibular hypoplasia 5 | 275
Micrognathism 5 | 275
Mitral Valve Prolapse Syndrome 5 | 39
Mitral regurgitation, mild 5 | 32
Mitral valve insufficiency 5 | 49
Muscle hypotonia 5 | 571
Myopia 5 | 176
Pectus excavatum 5 | 100
Retrognathia 5 | 54
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
fascioscapulohumeral muscular dystrophy 5 | 100
subependymal giant cell astrocytoma 5 | 2,287

Tissue

Digestive Tract 40 | 17,369
Endocrine System 40 | 18,159
Female tissues 40 | 17,400
Male tissues 40 | 17,142
Nervous System 40 | 16,725
Respiratory system 40 | 16,393
Skin and soft tissues 40 | 17,230
Urinary Tract 40 | 16,678
Liver and Pancreas 39 | 16,750
Blood and immune system 38 | 16,909
Cardiovascular System 38 | 15,192

Target Family

Non-IDG 33 | 12,091
Enzyme 6 | 4,145
Transcription Factor 1 | 1,400

Reactome Pathway

Elastic fibre formation 40 | 40
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Integrin beta-8 ITGB8 Tbio Non-IDG -1.47947 27.7 99
Protein-lysine 6-oxidase LOX Tbio Enzyme -3.36257 2227.1 513
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.24186 173.0 274
Transforming growth factor beta-1 TGFB1 Tchem Non-IDG -3.84680 5672.0 1222
Fibulin-2 FBLN2 Tbio Non-IDG -1.72650 54.6 170
EGF-containing fibulin-like extracellular matrix protein 1 EFEMP1 Tbio Non-IDG -2.17305 162.6 259
Bone morphogenetic protein 4 BMP4 Tchem Non-IDG -3.21660 1658.5 540
Lysyl oxidase homolog 3 LOXL3 Tbio Enzyme -1.24444 16.8 108
Furin FURIN Tchem Enzyme -3.10213 1183.5 260
Integrin beta-3 ITGB3 Tclin Non-IDG -3.04475 986.9 1517