Development Level

Tbio 32 | 10,625
Tchem 6 | 1,890
Tclin 2 | 602
Tdark 1 | 7,003

IMPC Term

preweaning lethality, complete... 3 | 633
decreased threshold for audito... 2 | 32
increased leukocyte cell numbe... 2 | 37
abnormal QRS complex 1 | 25
abnormal cranium morphology 1 | 32
abnormal eye morphology 1 | 38
abnormal incisor morphology 1 | 3
abnormal radius morphology 1 | 8
abnormal retina morphology 1 | 100
abnormal sleep behavior 1 | 63
abnormal snout morphology 1 | 18
abnormal tooth morphology 1 | 24
abnormal ulna morphology 1 | 8
abnormal vibrissa morphology 1 | 17
brachydactyly 1 | 2
cardiovascular system phenotyp... 1 | 35
convulsive seizures 1 | 11
decreased body length 1 | 108
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating aspartat... 1 | 27
decreased circulating choleste... 1 | 85
decreased circulating creatini... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating iron lev... 1 | 25
decreased circulating serum al... 1 | 79
decreased circulating total pr... 1 | 41
decreased eosinophil cell numb... 1 | 41
decreased erythrocyte cell num... 1 | 43
decreased grip strength 1 | 123
decreased total body fat amoun... 1 | 186
embryonic lethality prior to t... 1 | 187
hydrops fetalis 1 | 22
improved glucose tolerance 1 | 56
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased circulating free fat... 1 | 17
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased fasted circulating g... 1 | 68
increased heart weight 1 | 37
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased monocyte cell number 1 | 27
preweaning lethality, incomple... 1 | 260

Disease

psoriasis 25 | 6,685
glioblastoma 22 | 5,572
ovarian cancer 22 | 8,484
lung carcinoma 21 | 2,844
osteosarcoma 21 | 7,933
pilocytic astrocytoma 20 | 3,086
atypical teratoid / rhabdoid tumor 19 | 4,369
pancreatic cancer 18 | 2,300
primary pancreatic ductal adenocarcinoma 18 | 1,271
Breast cancer 17 | 3,094
Cancer 17 | 2,346
malignant mesothelioma 17 | 3,162
medulloblastoma, large-cell 17 | 6,234
non-small cell lung cancer 16 | 2,798
pediatric high grade glioma 16 | 2,712
lung cancer 15 | 4,466
invasive ductal carcinoma 14 | 2,950
lung adenocarcinoma 14 | 2,713
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,956
posterior fossa group A ependymoma 13 | 1,511
cystic fibrosis 12 | 1,665
interstitial cystitis 12 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,289
Atopic dermatitis 10 | 944
Duchenne muscular dystrophy 10 | 602
colon cancer 10 | 1,475
ductal carcinoma in situ 10 | 1,745
sonic hedgehog group medulloblastoma 10 | 1,482
ependymoma 9 | 2,514
group 3 medulloblastoma 9 | 2,254
pituitary cancer 9 | 1,972
primitive neuroectodermal tumor 9 | 3,031
Endometriosis 8 | 535
adrenocortical carcinoma 8 | 1,427
breast carcinoma 8 | 1,614
cutaneous lupus erythematosus 8 | 1,056
tuberculosis 8 | 1,557
ulcerative colitis 8 | 2,087
Aortic aneurysm 7 | 34
Cutis laxa 7 | 28
diabetes mellitus 7 | 1,663
gastric carcinoma 7 | 832
Cleft palate 6 | 125
Glaucoma 6 | 134
Prostatic Neoplasms 6 | 471
limb girdle muscular dystrophy 2A 6 | 156
oligodendroglioma 6 | 2,849
Acquired metabolic disease 5 | 267
Carcinoma 5 | 2,147
Colorectal Neoplasms 5 | 217
Marfan Syndrome 5 | 14
Osteoporosis 5 | 257
Pulmonary emphysema 5 | 34
adult high grade glioma 5 | 2,148
astrocytic glioma 5 | 2,241
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
fascioscapulohumeral muscular dystrophy 5 | 100
subependymal giant cell astrocytoma 5 | 2,287
Aortic valve insufficiency 4 | 22
Arthritis 4 | 248
Atherosclerosis 4 | 275
Becker muscular dystrophy 4 | 187
Iris disease 4 | 9
Mammary Neoplasms 4 | 410
Neoplasm Invasiveness 4 | 127
Osteoarthritis 4 | 96
Polycystic Ovary Syndrome 4 | 332
Pulmonary Fibrosis 4 | 66
Stomach Neoplasms 4 | 282
Weill-Marchesani syndrome 4 | 14
group 4 medulloblastoma 4 | 1,875
juvenile dermatomyositis 4 | 1,189
nasopharyngeal carcinoma 4 | 1,056
Cerebrovascular accident 3 | 44
Cleft Lip 3 | 91
Degenerative polyarthritis 3 | 93
Down syndrome 3 | 548
Gaucher disease type 3 3 | 76
Hepatitis B 3 | 103
Hepatitis C 3 | 90
Hypertension 3 | 287
Liver Cirrhosis, Experimental 3 | 108
Myopia 3 | 99
Neuropathy 3 | 210
Proliferative vitreoretinopathy 3 | 17
Schizophrenia 3 | 501
Squamous cell carcinoma 3 | 94
acute quadriplegic myopathy 3 | 1,157
astrocytoma 3 | 1,493
atypical teratoid/rhabdoid tumor 3 | 1,095
dermatomyositis 3 | 933
esophageal adenocarcinoma 3 | 737
head and neck cancer 3 | 270
inflammatory breast cancer 3 | 404
interstitial lung disease 3 | 291
mucosa-associated lymphoid tissue lymphoma 3 | 480
non-small cell lung carcinoma 3 | 413
pancreatic carcinoma 3 | 567
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795

Tissue

Cardiovascular System 41 | 17,958
Digestive Tract 41 | 18,473
Endocrine System 41 | 18,512
Female tissues 41 | 18,647
Liver and Pancreas 41 | 18,136
Male tissues 41 | 17,969
Nervous System 41 | 18,561
Respiratory system 41 | 17,484
Skin and soft tissues 41 | 18,115
Urinary Tract 41 | 18,444
Blood and immune system 40 | 17,995

Target Family

Non-IDG 34 | 11,971
Enzyme 6 | 4,146
Transcription Factor 1 | 1,400

Reactome Pathway

Elastic fibre formation 41 | 41
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Lysyl oxidase homolog 1 LOXL1 Tbio Enzyme -2.51621 344.5 145
Bone morphogenetic protein 2 BMP2 Tbio Non-IDG -3.59556 4267.5 575
Bone morphogenetic protein 4 BMP4 Tchem Non-IDG -3.16723 1539.5 438
Elastin ELN Tbio Non-IDG -3.32189 2025.2 244
Integrin beta-8 ITGB8 Tbio Non-IDG -1.29874 21.7 68
EGF-containing fibulin-like extracellular matrix protein 2 EFEMP2 Tbio Non-IDG -1.58529 46.2 203
EGF-containing fibulin-like extracellular matrix protein 1 EFEMP1 Tbio Non-IDG -2.11121 148.3 205
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.11033 142.0 237
Transforming growth factor beta-1 TGFB1 Tchem Non-IDG -4.32707 20956.6 961
Fibulin-2 FBLN2 Tbio Non-IDG -1.68871 51.2 168