Development Level

Tbio 11 | 11,445
Tchem 10 | 1,598

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

male infertility 2 | 123
abnormal coat appearance 1 | 31
abnormal coat-hair pigmentatio... 1 | 64
abnormal heart shape 1 | 5
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating potassiu... 1 | 20
decreased circulating sodium l... 1 | 22
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
female infertility 1 | 60
increased circulating sodium l... 1 | 71
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 17 | 11,493
osteosarcoma 15 | 7,950
glioblastoma 14 | 5,792
medulloblastoma, large-cell 13 | 6,241
atypical teratoid / rhabdoid tumor 12 | 5,112
ovarian cancer 12 | 8,520
Cancer 11 | 2,499
adult high grade glioma 9 | 3,801
subependymal giant cell astrocytoma 9 | 2,287
Breast cancer 8 | 3,578
group 3 medulloblastoma 8 | 4,104
psoriasis 8 | 6,694
ependymoma 7 | 4,679
lung cancer 7 | 4,740
Astrocytoma, Pilocytic 6 | 3,081
Intellectual disability 6 | 1,016
Kidney cancer 5 | 2,613
Vascular disease 5 | 319
malignant mesothelioma 5 | 3,232
primitive neuroectodermal tumor 5 | 3,035
Cardiomyopathies 4 | 110
Coffin-Lowry syndrome 4 | 9
Dilated ventricles (finding) 4 | 121
Dull intelligence 4 | 645
Epilepsy 4 | 792
Low intelligence 4 | 645
Lung Neoplasms 4 | 232
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Multiple myeloma 4 | 1,332
Orbital separation excessive 4 | 244
Poor school performance 4 | 645
Schizophrenia 4 | 1,160
Seizures 4 | 596
Waldenstrons macroglobulinemia 4 | 765
active ulcerative colitis 4 | 764
astrocytic glioma 4 | 2,597
esophageal adenocarcinoma 4 | 737
group 4 medulloblastoma 4 | 1,855
invasive ductal carcinoma 4 | 2,951
lung carcinoma 4 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
pituitary cancer 4 | 1,972
Anteverted nostril 3 | 191
Arthritis 3 | 290
Cocaine-Related Disorders 3 | 92
Cognitive delay 3 | 608
Depressive disorder 3 | 409
Downward slant of palpebral fissure 3 | 158
Global developmental delay 3 | 608
Hyperalgesia 3 | 83
Mental Depression 3 | 333
Mental and motor retardation 3 | 608
Muscle hypotonia 3 | 571
Myocardial Ischemia 3 | 169
Neoplasm Invasiveness 3 | 161
Neoplasm Metastasis 3 | 168
Open mouth 3 | 45
Osteoporosis 3 | 363
Renal Cell Carcinoma 3 | 214
Stomach Neoplasms 3 | 300
active Crohn's disease 3 | 922
acute quadriplegic myopathy 3 | 1,158
colon cancer 3 | 1,478
cystic fibrosis 3 | 1,696
diabetes mellitus 3 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
non-small cell lung cancer 3 | 2,890
pancreatic cancer 3 | 2,398
tuberculosis 3 | 2,010
tuberculosis and treatment for 6 months 3 | 409
Alzheimer's disease 2 | 658
Amyotrophic lateral sclerosis 2 | 451
Arthritis, Juvenile 2 | 126
Brain Ischemia 2 | 110
Concave bridge of nose 2 | 195
Delayed bone age 2 | 136
Delayed speech and language development 2 | 112
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Endometriosis 2 | 540
Gliosis 2 | 56
Heart disease 2 | 306
Juvenile arthritis 2 | 126
Language Delay 2 | 112
Liver cancer 2 | 604
Lung disease 2 | 142
Multiple Sclerosis 2 | 540
Parkinson's disease 2 | 392
Pectus excavatum 2 | 100
Speech Delay 2 | 112
Speech impairment 2 | 112
aldosterone-producing adenoma 2 | 665
astrocytoma 2 | 1,146
breast carcinoma 2 | 1,638
lung adenocarcinoma 2 | 2,716
nephrosclerosis 2 | 333
pediatric high grade glioma 2 | 1,064
posterior fossa group B ependymoma 2 | 416

Tissue

Blood and immune system 21 | 16,909
Cardiovascular System 21 | 15,192
Digestive Tract 21 | 17,369
Endocrine System 21 | 18,159
Female tissues 21 | 17,400
Liver and Pancreas 21 | 16,750
Male tissues 21 | 17,142
Nervous System 21 | 16,725
Respiratory system 21 | 16,393
Skin and soft tissues 21 | 17,230
Urinary Tract 21 | 16,678

Target Family

Kinase 10 | 634
Enzyme 8 | 4,145
Transcription Factor 3 | 1,400

Reactome Pathway

ERK/MAPK targets 21 | 21
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform PPP2R5D Tbio Enzyme -0.70843 3.59 261
Ribosomal protein S6 kinase alpha-3 RPS6KA3 Tchem Kinase -2.50143 325.4 425
Inactive serine/threonine-protein kinase VRK3 VRK3 Tbio Kinase -0.74516 7.30 63
Dual specificity protein phosphatase 6 DUSP6 Tbio Enzyme -2.22889 183.5 379
ETS domain-containing protein Elk-1 ELK1 Tbio Transcription Factor -0.51976 3.02 941
Ribosomal protein S6 kinase alpha-1 RPS6KA1 Tchem Kinase -2.57872 338.0 1158
Ribosomal protein S6 kinase alpha-2 RPS6KA2 Tchem Kinase -2.17609 136.7 406
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform PPP2R1B Tbio Enzyme -1.20793 16.9 203
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
Mitogen-activated protein kinase 3 MAPK3 Tchem Kinase -3.66226 3484.0 1440