Development Level

Tbio 19 | 11,445
Tchem 1 | 1,598

IMPC Phenotype

preweaning lethality, complete... 2 | 979
vertebral fusion 2 | 23
increased circulating total pr... 1 | 28

Disease

ovarian cancer 14 | 8,520
Carcinoma 12 | 11,493
osteosarcoma 9 | 7,950
glioblastoma 8 | 5,792
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Kidney cancer 6 | 2,613
Rheumatoid arthritis 6 | 1,191
atypical teratoid / rhabdoid tumor 5 | 5,112
lung cancer 5 | 4,740
medulloblastoma, large-cell 5 | 6,241
psoriasis 5 | 6,694
Astrocytoma, Pilocytic 4 | 3,081
ependymoma 4 | 4,679
pancreatic cancer 4 | 2,398
progressive supranuclear palsy 4 | 676
Breast cancer 3 | 3,578
Multiple myeloma 3 | 1,332
adult high grade glioma 3 | 3,801
astrocytic glioma 3 | 2,597
hepatocellular carcinoma 3 | 547
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
lung adenocarcinoma 3 | 2,716
malignant mesothelioma 3 | 3,232
non primary Sjogren syndrome sicca 3 | 891
oligodendroglioma 3 | 2,850
primitive neuroectodermal tumor 3 | 3,035
subependymal giant cell astrocytoma 3 | 2,287
Acquired metabolic disease 2 | 336
Alzheimer's disease 2 | 658
Anemia 2 | 365
Epilepsy 2 | 792
Myofibrillar myopathy 1 2 | 6
Myofibrillar myopathy 3 2 | 5
Pick disease 2 | 1,894
Pick's disease 2 | 15
Seizures 2 | 596
acute myeloid leukemia 2 | 783
astrocytoma 2 | 1,146
cystic fibrosis 2 | 1,696
diabetes mellitus 2 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
lung carcinoma 2 | 2,843
medulloblastoma 2 | 720
non-small cell lung cancer 2 | 2,890
pancreatic carcinoma 2 | 562
tuberculosis 2 | 2,010
Aggressive behavior 1 | 75
Aggressive reaction 1 | 75
Alpha 1-antitrypsin deficiency 1 | 11
Arthritis, Juvenile 1 | 126
Broad eyebrows 1 | 4
Broad flat nasal bridge 1 | 236
Cardiovascular system disease 1 | 246
Chemical and Drug Induced Liver Injury 1 | 195
Congenital disorder of glycosylation 1 | 54
Downward slant of palpebral fissure 1 | 158
Dysgerminoma 1 | 11
Familial encephalopathy with neuroserpin inclusion bodies 1 | 10
Gaucher disease type 1 1 | 180
Gingival Hyperplasia 1 | 34
Gingival Hypertrophy 1 | 34
Gingival Overgrowth 1 | 36
Hyperplasia of nose 1 | 23
Hypersensitivity reaction type II disease 1 | 253
Hypertrophy of nose 1 | 23
Hypotrophic malar bone 1 | 129
Isolated cases 1 | 72
Large nose 1 | 23
Liver cancer 1 | 604
Long eyebrows 1 | 2
Long narrow head 1 | 75
MENTAL RETARDATION, AUTOSOMAL RECESSIVE 15 1 | 1
Major Depressive Disorder 1 | 301
Malar flattening 1 | 129
Moderate mental retardation (I.Q. 35-49) 1 | 28
Narrow cranium shape 1 | 75
Narrow head shape 1 | 75
Narrow skull shape 1 | 75
Nasal bridge wide 1 | 236
Neuroblastoma 1 | 80
Nevoid basal cell carcinoma syndrome 1 | 16
Pain agnosia 1 | 104
Physical aggression 1 | 76
Pointed chin 1 | 33
Profound Mental Retardation 1 | 31
Profound intellectual disabilities 1 | 31
Short philtrum 1 | 53
Smooth philtrum 1 | 43
Syringomyelia 1 | 15
Thin upper lip vermilion 1 | 67
Turridolichocephaly 1 | 75
Unipolar Depression 1 | 250
Vitiligo 1 | 73
breast carcinoma 1 | 1,638
pediatric high grade glioma 1 | 1,064
permanent atrial fibrillation 1 | 45
sarcoidosis 1 | 370
tuberculosis and treatment for 3 months 1 | 179
tuberculosis and treatment for 6 months 1 | 409

Tissue

Blood and immune system 20 | 16,909
Cardiovascular System 20 | 15,192
Digestive Tract 20 | 17,369
Endocrine System 20 | 18,159
Female tissues 20 | 17,400
Liver and Pancreas 20 | 16,750
Male tissues 20 | 17,142
Nervous System 20 | 16,725
Respiratory system 20 | 16,393
Skin and soft tissues 20 | 17,230
Urinary Tract 20 | 16,678

Target Family

Enzyme 13 | 4,145
Non-IDG 7 | 12,091

Reactome Pathway

ER Quality Control Compartment... 20 | 20
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 Tchem Enzyme -1.80418 63.8 91
E3 ubiquitin-protein ligase RNF139 RNF139 Tbio Enzyme -1.17169 16.6 133
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
UDP-glucose:glycoprotein glucosyltransferase 1 UGGT1 Tbio Enzyme -1.60583 43.0 80
ER degradation-enhancing alpha-mannosidase-like protein 3 EDEM3 Tbio Enzyme -0.60839 3.23 88
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139
E3 ubiquitin-protein ligase RNF103 RNF103 Tbio Enzyme -1.95102 35.6 76
E3 ubiquitin-protein ligase MARCH6 MARCH6 Tbio Enzyme -1.67925 45.8 121