Development Level

Tbio 21 | 10,625
Tchem 13 | 1,890
Tclin 8 | 602

IMPC Term

preweaning lethality, complete... 3 | 633
abnormal bone structure 2 | 131
abnormal coat/hair pigmentatio... 2 | 54
decreased circulating fructosa... 2 | 31
abnormal behavior 1 | 226
abnormal femur morphology 1 | 14
abnormal hair texture 1 | 4
abnormal lens morphology 1 | 73
abnormal locomotor activation 1 | 26
abnormal retina morphology 1 | 100
abnormal rib morphology 1 | 28
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased circulating alanine ... 1 | 53
decreased circulating serum al... 1 | 79
decreased circulating total pr... 1 | 41
decreased hematocrit 1 | 25
decreased lean body mass 1 | 195
decreased total body fat amoun... 1 | 186
embryonic lethality prior to t... 1 | 187
enlarged heart 1 | 111
fusion of vertebral arches 1 | 7
hydrops fetalis 1 | 22
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased body weight 1 | 42
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased red blood cell distr... 1 | 21
increased startle reflex 1 | 38
long tibia 1 | 13
preweaning lethality, incomple... 1 | 260
thrombocytopenia 1 | 46
vertebral fusion 1 | 23

Disease

ovarian cancer 30 | 8,484
osteosarcoma 27 | 7,933
Cancer 23 | 2,346
medulloblastoma, large-cell 22 | 6,234
psoriasis 21 | 6,685
glioblastoma 20 | 5,572
atypical teratoid / rhabdoid tumor 16 | 4,369
Breast cancer 15 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
oligodendroglioma 14 | 2,849
pancreatic cancer 14 | 2,300
Carcinoma 13 | 2,147
lung cancer 13 | 4,466
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,988
pediatric high grade glioma 12 | 2,712
pilocytic astrocytoma 12 | 3,086
primary pancreatic ductal adenocarcinoma 12 | 1,271
primitive neuroectodermal tumor 11 | 3,031
Pick disease 10 | 1,893
astrocytic glioma 10 | 2,241
ependymoma 10 | 2,514
juvenile dermatomyositis 10 | 1,189
malignant mesothelioma 10 | 3,162
subependymal giant cell astrocytoma 10 | 2,287
Blastic phase chronic myeloid leukemia 9 | 58
Chronic Myelocytic Leukemia Accelerated Phase 9 | 59
Waldenstrons macroglobulinemia 9 | 765
cystic fibrosis 9 | 1,665
invasive ductal carcinoma 9 | 2,950
lung carcinoma 9 | 2,844
medulloblastoma 9 | 1,524
Chronic phase chronic myeloid leukemia 8 | 45
Multiple myeloma 8 | 1,327
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 8 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 8 | 47
astrocytoma 8 | 1,493
diabetes mellitus 8 | 1,663
lung adenocarcinoma 8 | 2,713
non-small cell lung cancer 8 | 2,798
Down syndrome 7 | 548
Intellectual disability 7 | 573
cutaneous lupus erythematosus 7 | 1,056
group 4 medulloblastoma 7 | 1,875
non primary Sjogren syndrome sicca 7 | 840
pituitary cancer 7 | 1,972
posterior fossa group A ependymoma 7 | 1,511
primary Sjogren syndrome 7 | 789
spina bifida 7 | 1,064
Neoplasm Invasiveness 6 | 127
Rheumatoid Arthritis 6 | 1,160
adult high grade glioma 6 | 2,148
breast carcinoma 6 | 1,614
ductal carcinoma in situ 6 | 1,745
esophageal adenocarcinoma 6 | 737
Alzheimer's disease 5 | 644
Animal Mammary Neoplasms 5 | 136
Mammary Neoplasms 5 | 410
Mammary Neoplasms, Experimental 5 | 150
Schizophrenia 5 | 501
dermatomyositis 5 | 933
interstitial cystitis 5 | 2,299
Amyotrophic Lateral Sclerosis 4 | 431
Duchenne muscular dystrophy 4 | 602
IGA Glomerulonephritis 4 | 454
Kidney disease 4 | 396
Liver carcinoma 4 | 217
Parkinson's disease 4 | 364
Wiskott-Aldrich syndrome 4 | 27
acute quadriplegic myopathy 4 | 1,157
group 3 medulloblastoma 4 | 2,254
mucosa-associated lymphoid tissue lymphoma 4 | 480
sonic hedgehog group medulloblastoma 4 | 1,482
tuberculosis 4 | 1,557
Barrett's esophagus 3 | 183
Bladder Neoplasm 3 | 109
Craniofrontonasal syndrome 3 | 13
Heart disease 3 | 279
Hypertension 3 | 287
Impotence 3 | 45
Neoplastic Cell Transformation 3 | 81
Noonan Syndrome 3 | 33
Precancerous Conditions 3 | 69
Stomach Neoplasms 3 | 282
Vascular disease 3 | 281
adrenocortical carcinoma 3 | 1,427
aldosterone-producing adenoma 3 | 664
atypical teratoid/rhabdoid tumor 3 | 1,095
colon cancer 3 | 1,475
hereditary spastic paraplegia 3 | 313
nephrosclerosis 3 | 329
pancreatic carcinoma 3 | 567
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
posterior fossa group B ependymoma 3 | 1,530
ulcerative colitis 3 | 2,087
active Crohn's disease 2 | 918
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
fibroadenoma 2 | 557
progressive supranuclear palsy 2 | 674
tuberculosis and treatment for 6 months 2 | 686

Tissue

Blood and immune system 42 | 17,995
Cardiovascular System 42 | 17,958
Digestive Tract 42 | 18,473
Endocrine System 42 | 18,512
Female tissues 42 | 18,647
Liver and Pancreas 42 | 18,136
Male tissues 42 | 17,969
Nervous System 42 | 18,561
Respiratory system 42 | 17,484
Skin and soft tissues 42 | 18,115
Urinary Tract 42 | 18,444

Target Family

Non-IDG 19 | 11,971
Kinase 16 | 634
Enzyme 5 | 4,146
Ion Channel 2 | 341

Reactome Pathway

EPHB-mediated forward signalin... 42 | 42
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Actin-related protein 2 ACTR2 Tchem Non-IDG -1.84526 72.5 184
Actin-related protein 3 ACTR3 Tbio Non-IDG -1.25542 16.8 169
Transforming protein RhoA RHOA Tbio Enzyme -3.48838 3096.5 467
Actin-related protein 2/3 complex subunit 5 ARPC5 Tbio Non-IDG -1.07398 11.5 63
Rho-associated protein kinase 2 ROCK2 Tclin Kinase -2.39656 248.3 472
LIM domain kinase 2 LIMK2 Tchem Kinase -1.59273 39.0 382
LIM domain kinase 1 LIMK1 Tchem Kinase -2.22441 175.4 612
Ephrin type-B receptor 6 EPHB6 Tchem Kinase -1.37176 32.3 0
Actin-related protein 2/3 complex subunit 2 ARPC2 Tbio Non-IDG -1.21087 14.8 213
Actin-related protein 2/3 complex subunit 3 ARPC3 Tbio Non-IDG -1.26003 15.9 153