Development Level

Tbio 19 | 11,651
Tclin 8 | 612
Tchem 6 | 1,388

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal bone structure 2 | 187
abnormal coat-hair pigmentatio... 2 | 64
abnormal retina morphology 2 | 71
decreased circulating fructosa... 2 | 30
decreased circulating serum al... 2 | 82
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
increased blood urea nitrogen ... 2 | 48
increased circulating triglyce... 2 | 42
increased neutrophil cell numb... 2 | 46
increased spleen weight 2 | 10
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal cranium morphology 1 | 36
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal hair texture 1 | 4
abnormal locomotor activation 1 | 16
abnormal maxilla morphology 1 | 17
cataract 1 | 92
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating total pr... 1 | 49
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
decreased total body fat amoun... 1 | 207
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged kidney 1 | 14
fusion of vertebral arches 1 | 7
hypoactivity 1 | 132
increased circulating alkaline... 1 | 122
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
long tibia 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
prolonged PR interval 1 | 15
short tibia 1 | 97
thrombocytopenia 1 | 56
vertebral fusion 1 | 23

Disease

Carcinoma 27 | 11,493
ovarian cancer 25 | 8,520
osteosarcoma 22 | 7,950
Cancer 18 | 2,499
medulloblastoma, large-cell 18 | 6,241
glioblastoma 16 | 5,792
psoriasis 15 | 6,694
atypical teratoid / rhabdoid tumor 14 | 5,112
Breast cancer 13 | 3,578
ependymoma 13 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
lung cancer 11 | 4,740
pancreatic cancer 11 | 2,398
Astrocytoma, Pilocytic 10 | 3,081
Kidney cancer 10 | 2,613
group 4 medulloblastoma 10 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
oligodendroglioma 10 | 2,850
Pick disease 9 | 1,894
Waldenstrons macroglobulinemia 9 | 765
adult high grade glioma 9 | 3,801
juvenile dermatomyositis 9 | 1,187
subependymal giant cell astrocytoma 9 | 2,287
astrocytic glioma 8 | 2,597
diabetes mellitus 8 | 1,728
invasive ductal carcinoma 8 | 2,951
Intellectual disability 7 | 1,016
Multiple myeloma 7 | 1,332
Schizophrenia 7 | 1,160
cystic fibrosis 7 | 1,696
primary Sjogren syndrome 7 | 735
primary pancreatic ductal adenocarcinoma 7 | 1,109
primitive neuroectodermal tumor 7 | 3,035
astrocytoma 6 | 1,146
ductal carcinoma in situ 6 | 1,745
group 3 medulloblastoma 6 | 4,104
malignant mesothelioma 6 | 3,232
non primary Sjogren syndrome sicca 6 | 891
Down syndrome 5 | 499
Mammary Neoplasms, Experimental 5 | 154
Neoplasm Invasiveness 5 | 161
Rheumatoid arthritis 5 | 1,191
Wiskott-Aldrich syndrome 5 | 30
esophageal adenocarcinoma 5 | 737
interstitial cystitis 5 | 2,312
lung carcinoma 5 | 2,843
pediatric high grade glioma 5 | 1,064
spina bifida 5 | 1,074
tuberculosis 5 | 2,010
Alzheimer's disease 4 | 658
Amyotrophic lateral sclerosis 4 | 451
Animal Mammary Neoplasms 4 | 136
Blastic phase chronic myeloid leukemia 4 | 58
Breast Neoplasms 4 | 445
Carcinoma, Squamous Cell 4 | 110
Cell Transformation, Neoplastic 4 | 97
Chronic Myelocytic Leukemia Accelerated Phase 4 | 59
Duchenne muscular dystrophy 4 | 601
Dull intelligence 4 | 645
Endometrial cancer 4 | 311
Heart disease 4 | 306
Low intelligence 4 | 645
Mammary Neoplasms 4 | 425
Mammary Neoplasms, Animal 4 | 136
Melanoma 4 | 711
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Neoplastic Cell Transformation 4 | 89
Parkinson's disease 4 | 392
Poor school performance 4 | 645
Stomach Neoplasms 4 | 300
acute quadriplegic myopathy 4 | 1,158
cutaneous lupus erythematosus 4 | 1,057
dermatomyositis 4 | 966
lung adenocarcinoma 4 | 2,716
non-small cell lung cancer 4 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
pituitary cancer 4 | 1,972
Alcoholic Intoxication, Chronic 3 | 289
Bipolar Disorder 3 | 666
Bladder Neoplasm 3 | 112
Carcinoma, Hepatocellular 3 | 228
Chronic Lymphocytic Leukemia 3 | 262
Depressive disorder 3 | 409
Epilepsy 3 | 792
Hypertension 3 | 396
Kidney disease 3 | 430
Liver Cirrhosis, Experimental 3 | 769
Liver carcinoma 3 | 240
Mouth Neoplasms 3 | 55
Proteinuria 3 | 144
Skin cancer 3 | 469
Urinary Bladder Neoplasms 3 | 114
adrenocortical carcinoma 3 | 1,428
breast carcinoma 3 | 1,638
hereditary spastic paraplegia 3 | 318
mucosa-associated lymphoid tissue lymphoma 3 | 484
pancreatic carcinoma 3 | 562
ulcerative colitis 3 | 1,819

Tissue

Blood and immune system 33 | 16,909
Digestive Tract 33 | 17,369
Endocrine System 33 | 18,159
Liver and Pancreas 33 | 16,750
Nervous System 33 | 16,725
Skin and soft tissues 33 | 17,230
Cardiovascular System 32 | 15,192
Female tissues 32 | 17,400
Male tissues 32 | 17,142
Respiratory system 32 | 16,393
Urinary Tract 32 | 16,678

Target Family

Non-IDG 15 | 12,091
Kinase 11 | 634
Enzyme 5 | 4,145
Ion Channel 2 | 344

Reactome Pathway

EPHB-mediated forward signalin... 33 | 33
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras GTPase-activating protein 1 RASA1 Tbio Enzyme -2.61637 404.4 402
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
LIM domain kinase 2 LIMK2 Tchem Kinase -1.65006 41.3 405
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452
Actin-related protein 3 ACTR3 Tbio Non-IDG -1.28334 17.7 202
LIM domain kinase 1 LIMK1 Tchem Kinase -2.28919 187.7 664
Actin-related protein 2/3 complex subunit 5 ARPC5 Tbio Non-IDG -1.08599 11.7 94
Transforming protein RhoA RHOA Tbio Enzyme -3.54095 3332.7 501
Actin-related protein 2/3 complex subunit 3 ARPC3 Tbio Non-IDG -1.30200 16.5 182
Actin-related protein 2/3 complex subunit 1B ARPC1B Tbio Non-IDG -1.16868 14.7 136