Development Level

Tbio 21 | 10,625
Tchem 13 | 1,890
Tclin 8 | 602

IMPC Phenotype

preweaning lethality, complete... 3 | 633
abnormal bone structure 2 | 131
abnormal coat-hair pigmentatio... 2 | 54
decreased circulating fructosa... 2 | 31
abnormal behavior 1 | 226
abnormal femur morphology 1 | 14
abnormal hair texture 1 | 4
abnormal lens morphology 1 | 73
abnormal locomotor activation 1 | 26
abnormal retina morphology 1 | 100
abnormal rib morphology 1 | 28
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased circulating alanine ... 1 | 53
decreased circulating serum al... 1 | 79
decreased circulating total pr... 1 | 41
decreased hematocrit 1 | 25
decreased lean body mass 1 | 195
decreased total body fat amoun... 1 | 186
embryonic lethality prior to t... 1 | 187
enlarged heart 1 | 111
fusion of vertebral arches 1 | 7
hydrops fetalis 1 | 22
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased body weight 1 | 42
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased red blood cell distr... 1 | 21
increased startle reflex 1 | 38
long tibia 1 | 13
preweaning lethality, incomple... 1 | 260
thrombocytopenia 1 | 46
vertebral fusion 1 | 23

Disease

ovarian cancer 30 | 8,491
osteosarcoma 27 | 7,933
Cancer 23 | 2,346
medulloblastoma, large-cell 22 | 6,234
psoriasis 21 | 6,685
glioblastoma 20 | 5,572
atypical teratoid / rhabdoid tumor 16 | 4,369
Breast cancer 15 | 3,098
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
oligodendroglioma 14 | 2,849
pancreatic cancer 14 | 2,300
Carcinoma 13 | 2,147
lung cancer 13 | 4,473
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,988
pediatric high grade glioma 12 | 2,712
pilocytic astrocytoma 12 | 3,086
primary pancreatic ductal adenocarcinoma 12 | 1,271
primitive neuroectodermal tumor 11 | 3,031
Pick disease 10 | 1,893
astrocytic glioma 10 | 2,241
ependymoma 10 | 2,514
juvenile dermatomyositis 10 | 1,189
malignant mesothelioma 10 | 3,163
subependymal giant cell astrocytoma 10 | 2,287
Blastic phase chronic myeloid leukemia 9 | 58
Chronic Myelocytic Leukemia Accelerated Phase 9 | 59
Waldenstrons macroglobulinemia 9 | 764
cystic fibrosis 9 | 1,670
invasive ductal carcinoma 9 | 2,950
lung carcinoma 9 | 2,844
medulloblastoma 9 | 1,524
Chronic phase chronic myeloid leukemia 8 | 45
Multiple myeloma 8 | 1,327
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 8 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 8 | 47
astrocytoma 8 | 1,493
diabetes mellitus 8 | 1,663
lung adenocarcinoma 8 | 2,714
non-small cell lung cancer 8 | 2,798
Down syndrome 7 | 548
Intellectual disability 7 | 573
cutaneous lupus erythematosus 7 | 1,056
group 4 medulloblastoma 7 | 1,875
non primary Sjogren syndrome sicca 7 | 840
pituitary cancer 7 | 1,972
posterior fossa group A ependymoma 7 | 1,511
primary Sjogren syndrome 7 | 788
spina bifida 7 | 1,064
Neoplasm Invasiveness 6 | 127
Rheumatoid Arthritis 6 | 1,170
adult high grade glioma 6 | 2,148
breast carcinoma 6 | 1,614
ductal carcinoma in situ 6 | 1,745
esophageal adenocarcinoma 6 | 737
Alzheimer's disease 5 | 644
Animal Mammary Neoplasms 5 | 135
Mammary Neoplasms 5 | 410
Mammary Neoplasms, Experimental 5 | 149
Schizophrenia 5 | 503
dermatomyositis 5 | 966
interstitial cystitis 5 | 2,299
Amyotrophic Lateral Sclerosis 4 | 432
Duchenne muscular dystrophy 4 | 602
IGA Glomerulonephritis 4 | 454
Kidney disease 4 | 397
Liver carcinoma 4 | 217
Parkinson's disease 4 | 364
Wiskott-Aldrich syndrome 4 | 27
acute quadriplegic myopathy 4 | 1,157
group 3 medulloblastoma 4 | 2,254
mucosa-associated lymphoid tissue lymphoma 4 | 480
sonic hedgehog group medulloblastoma 4 | 1,482
tuberculosis 4 | 1,563
Barrett's esophagus 3 | 185
Bladder Neoplasm 3 | 109
Craniofrontonasal syndrome 3 | 13
Heart disease 3 | 279
Hypertension 3 | 293
Impotence 3 | 45
Neoplastic Cell Transformation 3 | 81
Noonan Syndrome 3 | 33
Precancerous Conditions 3 | 69
Stomach Neoplasms 3 | 282
Vascular disease 3 | 281
adrenocortical carcinoma 3 | 1,427
aldosterone-producing adenoma 3 | 664
atypical teratoid/rhabdoid tumor 3 | 1,095
colon cancer 3 | 1,475
hereditary spastic paraplegia 3 | 313
nephrosclerosis 3 | 329
pancreatic carcinoma 3 | 567
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
posterior fossa group B ependymoma 3 | 1,530
ulcerative colitis 3 | 2,087
active Crohn's disease 2 | 918
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
fibroadenoma 2 | 557
progressive supranuclear palsy 2 | 674
tuberculosis and treatment for 6 months 2 | 686

Tissue

Blood and immune system 42 | 17,994
Cardiovascular System 42 | 17,957
Digestive Tract 42 | 18,472
Endocrine System 42 | 18,511
Female tissues 42 | 18,646
Liver and Pancreas 42 | 18,135
Male tissues 42 | 17,968
Nervous System 42 | 18,560
Respiratory system 42 | 17,483
Skin and soft tissues 42 | 18,114
Urinary Tract 42 | 18,443

Target Family

Non-IDG 19 | 11,969
Kinase 16 | 634
Enzyme 5 | 4,146
Ion Channel 2 | 341

Reactome Pathway

EPHB-mediated forward signalin... 42 | 42
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase HRas HRAS Tchem Enzyme -3.99319 9497.9 312
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.87449 73.5 395
Ras GTPase-activating protein 1 RASA1 Tbio Enzyme -2.58603 375.1 340
Ephrin-B3 EFNB3 Tbio Non-IDG -1.77671 61.7 149
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.27458 228.6 993
Tyrosine-protein kinase Yes YES1 Tclin Kinase -2.02315 100.2 381
Tyrosine-protein kinase Lyn LYN Tclin Kinase -2.82112 659.3 521
T-lymphoma invasion and metastasis-inducing protein 1 TIAM1 Tchem Non-IDG -2.22446 174.7 122
Ephrin type-B receptor 2 EPHB2 Tchem Kinase -2.66552 472.2 420
Cofilin-1 CFL1 Tbio Non-IDG -3.08440 1212.2 597