Development Level

Tbio 26 | 11,651
Tchem 17 | 1,388
Tclin 5 | 612

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal behavior 3 | 298
abnormal seminal vesicle morph... 2 | 114
decreased vertical activity 2 | 208
embryonic lethality prior to t... 2 | 278
hydrometra 2 | 53
preweaning lethality, incomple... 2 | 499
abnormal cecum morphology 1 | 7
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal heart shape 1 | 5
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal maxilla morphology 1 | 17
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal tail morphology 1 | 25
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
cataract 1 | 92
cyanosis 1 | 7
decreased basophil cell number 1 | 16
decreased circulating aspartat... 1 | 34
decreased heart left ventricle... 1 | 28
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased startle reflex 1 | 75
edema 1 | 59
enlarged adrenal glands 1 | 3
enlarged cecum 1 | 5
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged kidney 1 | 14
enlarged seminal vesicle 1 | 10
enlarged uterus 1 | 11
hemorrhage 1 | 23
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased circulating free fat... 1 | 20
increased fasted circulating g... 1 | 76
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
irregularly shaped pupil 1 | 7
pale yolk sac 1 | 25
pallor 1 | 34
polycystic kidney 1 | 15
prenatal lethality prior to he... 1 | 87
respiratory system phenotype 1 | 2
short tibia 1 | 97
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 34 | 11,493
ovarian cancer 29 | 8,520
psoriasis 24 | 6,694
glioblastoma 22 | 5,792
osteosarcoma 21 | 7,950
Cancer 20 | 2,499
Kidney cancer 19 | 2,613
atypical teratoid / rhabdoid tumor 19 | 5,112
malignant mesothelioma 19 | 3,232
medulloblastoma, large-cell 19 | 6,241
Breast cancer 16 | 3,578
ependymoma 16 | 4,679
oligodendroglioma 16 | 2,850
Blastic phase chronic myeloid leukemia 15 | 58
Chronic Myelocytic Leukemia Accelerated Phase 15 | 59
lung cancer 15 | 4,740
Astrocytoma, Pilocytic 14 | 3,081
Chronic phase chronic myeloid leukemia 14 | 45
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 14 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 14 | 47
lung carcinoma 14 | 2,843
pancreatic cancer 14 | 2,398
astrocytic glioma 13 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
adult high grade glioma 12 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
pituitary cancer 12 | 1,972
cystic fibrosis 11 | 1,696
Alzheimer's disease 10 | 658
group 3 medulloblastoma 10 | 4,104
group 4 medulloblastoma 10 | 1,855
primitive neuroectodermal tumor 10 | 3,035
cutaneous lupus erythematosus 9 | 1,057
diabetes mellitus 9 | 1,728
esophageal adenocarcinoma 8 | 737
interstitial cystitis 8 | 2,312
invasive ductal carcinoma 8 | 2,951
non-small cell lung cancer 8 | 2,890
subependymal giant cell astrocytoma 8 | 2,287
breast carcinoma 7 | 1,638
ductal carcinoma in situ 7 | 1,745
lung adenocarcinoma 7 | 2,716
pediatric high grade glioma 7 | 1,064
Craniofrontonasal syndrome 6 | 13
Liver cancer 6 | 604
colon cancer 6 | 1,478
primary pancreatic ductal adenocarcinoma 6 | 1,109
spina bifida 6 | 1,074
ulcerative colitis 6 | 1,819
Breast Neoplasms 5 | 445
Mammary Neoplasms 5 | 425
Multiple myeloma 5 | 1,332
Schizophrenia 5 | 1,160
Waldenstrons macroglobulinemia 5 | 765
astrocytoma 5 | 1,146
interstitial lung disease 5 | 298
juvenile dermatomyositis 5 | 1,187
tuberculosis 5 | 2,010
Alcoholic Intoxication, Chronic 4 | 289
Alzheimer Disease 4 | 83
Amyotrophic lateral sclerosis 4 | 451
Cataract 8 multiple types 4 | 33
Down syndrome 4 | 499
Hypertension 4 | 396
Kidney disease 4 | 430
Pick disease 4 | 1,894
Skin cancer 4 | 469
active Crohn's disease 4 | 922
primary Sjogren syndrome 4 | 735
Arthritis 3 | 290
Bipolar Disorder 3 | 666
Carcinoma, Hepatocellular 3 | 228
Cardiomyopathy, Dilated 3 | 83
Colorectal Neoplasms 3 | 243
Depressive disorder 3 | 409
Heart disease 3 | 306
Heart failure 3 | 162
Hidradenitis suppurativa 3 | 13
Hidradenitis suppurativa, familial 3 | 3
Hypertensive disease 3 | 292
Inflammation 3 | 120
Liver Cirrhosis, Experimental 3 | 769
Liver carcinoma 3 | 240
Melanoma 3 | 711
Multiple Sclerosis 3 | 540
Neoplasm Invasiveness 3 | 161
Neoplasm Metastasis 3 | 168
Osteoporosis 3 | 363
Reperfusion Injury 3 | 86
Rheumatoid arthritis 3 | 1,191
Short stature 3 | 531
adrenocortical carcinoma 3 | 1,428
aldosterone-producing adenoma 3 | 665
head and neck cancer and chronic obstructive pulmonary disease 3 | 239
nephrosclerosis 3 | 333
non primary Sjogren syndrome sicca 3 | 891
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
Disease Progression 2 | 136
Stomach Neoplasms 2 | 300

Tissue

Digestive Tract 48 | 17,369
Endocrine System 48 | 18,159
Female tissues 47 | 17,400
Liver and Pancreas 47 | 16,750
Nervous System 47 | 16,725
Skin and soft tissues 47 | 17,230
Blood and immune system 46 | 16,909
Male tissues 46 | 17,142
Respiratory system 45 | 16,393
Urinary Tract 45 | 16,678
Cardiovascular System 44 | 15,192

Target Family

Non-IDG 21 | 12,091
Kinase 19 | 634
Enzyme 8 | 4,145

Reactome Pathway

EPH-ephrin mediated repulsion ... 48 | 48
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ephrin type-A receptor 6 EPHA6 Tchem Kinase -1.34848 21.8 266
Guanine nucleotide exchange factor VAV3 VAV3 Tbio Non-IDG -1.82116 74.0 249
Gamma-secretase subunit APH-1B APH1B Tbio Enzyme -1.17035 13.6 56
AP-2 complex subunit sigma AP2S1 Tbio Non-IDG -1.42073 25.5 108
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452
AP-2 complex subunit beta AP2B1 Tbio Non-IDG -1.59767 34.8 212
Guanine nucleotide exchange factor VAV2 VAV2 Tbio Non-IDG -1.81793 64.6 227
Matrix metalloproteinase-9 MMP9 Tchem Enzyme -3.96102 8811.6 1442
AP-2 complex subunit alpha-2 AP2A2 Tbio Non-IDG -0.65996 4.74 124
Ephrin-B2 EFNB2 Tbio Non-IDG -2.45068 288.9 381