Development Level

Tbio 22 | 10,625
Tchem 21 | 1,890
Tclin 5 | 602

IMPC Phenotype

abnormal behavior 2 | 226
decreased lumbar vertebrae num... 2 | 62
increased sacral vertebrae num... 2 | 62
abnormal epididymis morphology 1 | 31
abnormal femur morphology 1 | 14
abnormal kidney morphology 1 | 30
abnormal seminal vesicle morph... 1 | 47
abnormal skin morphology 1 | 23
abnormal spleen morphology 1 | 36
abnormal vocalization 1 | 21
absent pinna reflex 1 | 21
corneal opacity 1 | 25
decreased circulating fructosa... 1 | 31
decreased circulating serum al... 1 | 79
decreased heart weight 1 | 44
decreased mean corpuscular vol... 1 | 50
enlarged adrenal glands 1 | 3
enlarged epididymis 1 | 27
enlarged kidney 1 | 7
enlarged uterus 1 | 3
female infertility 1 | 34
hydrometra 1 | 13
impaired righting response 1 | 19
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating alkaline... 1 | 119
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased fasted circulating g... 1 | 68
irregularly shaped pupil 1 | 7
male infertility 1 | 62
polycystic kidney 1 | 9
preweaning lethality, complete... 1 | 633
short tibia 1 | 82

Disease

ovarian cancer 29 | 8,491
psoriasis 24 | 6,685
glioblastoma 22 | 5,572
medulloblastoma, large-cell 20 | 6,234
osteosarcoma 20 | 7,933
atypical teratoid / rhabdoid tumor 19 | 4,369
malignant mesothelioma 19 | 3,163
Cancer 18 | 2,346
oligodendroglioma 16 | 2,849
Blastic phase chronic myeloid leukemia 15 | 58
Carcinoma 15 | 2,147
Chronic Myelocytic Leukemia Accelerated Phase 15 | 59
lung cancer 15 | 4,473
pancreatic cancer 15 | 2,300
pilocytic astrocytoma 15 | 3,086
Breast cancer 14 | 3,098
Chronic phase chronic myeloid leukemia 14 | 45
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 14 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 14 | 47
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
lung carcinoma 14 | 2,844
pediatric high grade glioma 14 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,988
pituitary cancer 12 | 1,972
astrocytic glioma 11 | 2,241
primitive neuroectodermal tumor 11 | 3,031
Alzheimer's disease 10 | 644
cystic fibrosis 10 | 1,670
ependymoma 10 | 2,514
cutaneous lupus erythematosus 9 | 1,056
diabetes mellitus 9 | 1,663
invasive ductal carcinoma 9 | 2,950
esophageal adenocarcinoma 8 | 737
interstitial cystitis 8 | 2,299
non-small cell lung cancer 8 | 2,798
astrocytoma 7 | 1,493
breast carcinoma 7 | 1,614
ductal carcinoma in situ 7 | 1,745
group 4 medulloblastoma 7 | 1,875
lung adenocarcinoma 7 | 2,714
primary pancreatic ductal adenocarcinoma 7 | 1,271
subependymal giant cell astrocytoma 7 | 2,287
Craniofrontonasal syndrome 6 | 13
Mammary Neoplasms 6 | 410
Multiple myeloma 6 | 1,327
adult high grade glioma 6 | 2,148
colon cancer 6 | 1,475
group 3 medulloblastoma 6 | 2,254
sonic hedgehog group medulloblastoma 6 | 1,482
spina bifida 6 | 1,064
ulcerative colitis 6 | 2,087
Pick disease 5 | 1,893
Waldenstrons macroglobulinemia 5 | 764
juvenile dermatomyositis 5 | 1,189
medulloblastoma 5 | 1,524
posterior fossa group A ependymoma 5 | 1,511
Down syndrome 4 | 548
IGA Glomerulonephritis 4 | 454
Kidney disease 4 | 397
active Crohn's disease 4 | 918
adrenocortical carcinoma 4 | 1,427
interstitial lung disease 4 | 292
posterior fossa group B ependymoma 4 | 1,530
primary Sjogren syndrome 4 | 788
Amyotrophic Lateral Sclerosis 3 | 432
Arthritis 3 | 248
Hidradenitis suppurativa 3 | 12
Inflammation 3 | 109
Liver carcinoma 3 | 217
Multiple Sclerosis 3 | 498
Neoplasm Invasiveness 3 | 127
Neoplasm Metastasis 3 | 138
Reperfusion Injury 3 | 84
Rheumatoid Arthritis 3 | 1,170
acute quadriplegic myopathy 3 | 1,157
dermatomyositis 3 | 966
head and neck cancer and chronic obstructive pulmonary disease 3 | 237
nephrosclerosis 3 | 329
non primary Sjogren syndrome sicca 3 | 840
tuberculosis 3 | 1,563
Atopic dermatitis 2 | 944
Colonic Neoplasms 2 | 126
Craniosynostosis 2 | 47
Disease Progression 2 | 125
Endometriosis 2 | 535
Eye disease 2 | 55
Heart disease 2 | 279
Hypertension 2 | 293
Hypertensive disease 2 | 193
Lung disease 2 | 136
Vascular disease 2 | 281
aldosterone-producing adenoma 2 | 664
fibroadenoma 2 | 557
glioblastoma multiforme 2 | 347
mucosa-associated lymphoid tissue lymphoma 2 | 480
nasopharyngeal carcinoma 2 | 1,056
non-small cell lung carcinoma 2 | 413
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
progressive supranuclear palsy 2 | 674

Tissue

Blood and immune system 48 | 17,994
Cardiovascular System 48 | 17,957
Digestive Tract 48 | 18,472
Endocrine System 48 | 18,511
Female tissues 48 | 18,646
Liver and Pancreas 48 | 18,135
Male tissues 48 | 17,968
Nervous System 48 | 18,560
Respiratory system 48 | 17,483
Skin and soft tissues 48 | 18,114
Urinary Tract 48 | 18,443

Target Family

Non-IDG 21 | 11,969
Kinase 19 | 634
Enzyme 8 | 4,146

Reactome Pathway

EPH-ephrin mediated repulsion ... 48 | 48
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Guanine nucleotide exchange factor VAV2 VAV2 Tbio Non-IDG -1.78476 58.3 173
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.87449 73.5 395
AP-2 complex subunit beta AP2B1 Tbio Non-IDG -1.90682 75.1 192
AP-2 complex subunit sigma AP2S1 Tbio Non-IDG -1.39116 24.9 96
Clathrin heavy chain 1 CLTC Tbio Non-IDG -1.63705 36.3 159
Gamma-secretase subunit PEN-2 PSENEN Tchem Enzyme -2.84368 678.2 177
AP-2 complex subunit alpha-2 AP2A2 Tbio Non-IDG -0.63932 4.63 109
Ephrin type-A receptor 6 EPHA6 Tchem Kinase -1.33373 29.2 223
Ephrin type-A receptor 2 EPHA2 Tclin Kinase -2.87482 785.1 704
Ephrin-B3 EFNB3 Tbio Non-IDG -1.77671 61.7 149