Development Level

Tbio 56 | 11,445
Tchem 26 | 1,598
Tclin 9 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 12 | 979
embryonic lethality prior to t... 4 | 278
abnormal behavior 3 | 298
edema 3 | 59
prenatal lethality prior to he... 3 | 87
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
abnormal coat-hair pigmentatio... 2 | 64
abnormal retina morphology 2 | 71
abnormal seminal vesicle morph... 2 | 114
cataract 2 | 92
decreased circulating fructosa... 2 | 30
decreased circulating serum al... 2 | 82
decreased vertical activity 2 | 208
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
enlarged kidney 2 | 14
hemorrhage 2 | 23
hydrometra 2 | 53
increased blood urea nitrogen ... 2 | 48
increased circulating triglyce... 2 | 42
increased neutrophil cell numb... 2 | 46
increased spleen weight 2 | 10
pallor 2 | 34
short tibia 2 | 97
abnormal cecum morphology 1 | 7
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal hair texture 1 | 4
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal locomotor activation 1 | 16
abnormal maxilla morphology 1 | 17
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal skin coloration 1 | 25
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal tail morphology 1 | 25
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
cardiovascular system phenotyp... 1 | 36
cyanosis 1 | 7
decreased basophil cell number 1 | 16
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating aspartat... 1 | 34
decreased circulating total pr... 1 | 49
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
enlarged adrenal glands 1 | 3
enlarged cecum 1 | 5
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged seminal vesicle 1 | 10
enlarged uterus 1 | 11
fusion of vertebral arches 1 | 7
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating free fat... 1 | 20
increased fasted circulating g... 1 | 76
increased heart rate variabili... 1 | 7
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
irregularly shaped pupil 1 | 7
long tibia 1 | 25
pale yolk sac 1 | 25
polycystic kidney 1 | 15
prolonged PR interval 1 | 15
respiratory system phenotype 1 | 2
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56
unresponsive to tactile stimul... 1 | 8
vertebral fusion 1 | 23

Disease

Carcinoma 66 | 11,493
ovarian cancer 61 | 8,520
osteosarcoma 49 | 7,950
glioblastoma 46 | 5,792
psoriasis 44 | 6,694
medulloblastoma, large-cell 42 | 6,241
atypical teratoid / rhabdoid tumor 39 | 5,112
Cancer 36 | 2,499
Kidney cancer 33 | 2,613
Breast cancer 32 | 3,578
ependymoma 31 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 30 | 3,291
lung cancer 29 | 4,740
Astrocytoma, Pilocytic 28 | 3,081
adult high grade glioma 27 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 27 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,989
malignant mesothelioma 27 | 3,232
oligodendroglioma 27 | 2,850
pancreatic cancer 26 | 2,398
astrocytic glioma 24 | 2,597
lung carcinoma 23 | 2,843
primitive neuroectodermal tumor 21 | 3,035
group 4 medulloblastoma 20 | 1,855
cystic fibrosis 19 | 1,696
invasive ductal carcinoma 19 | 2,951
group 3 medulloblastoma 18 | 4,104
subependymal giant cell astrocytoma 18 | 2,287
diabetes mellitus 17 | 1,728
pituitary cancer 17 | 1,972
Pick disease 16 | 1,894
non-small cell lung cancer 16 | 2,890
Alzheimer's disease 15 | 658
Blastic phase chronic myeloid leukemia 15 | 58
Chronic Myelocytic Leukemia Accelerated Phase 15 | 59
lung adenocarcinoma 15 | 2,716
primary pancreatic ductal adenocarcinoma 15 | 1,109
Chronic phase chronic myeloid leukemia 14 | 45
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 14 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 14 | 47
Waldenstrons macroglobulinemia 14 | 765
juvenile dermatomyositis 14 | 1,187
Schizophrenia 13 | 1,160
breast carcinoma 13 | 1,638
cutaneous lupus erythematosus 13 | 1,057
ductal carcinoma in situ 13 | 1,745
spina bifida 12 | 1,074
Intellectual disability 11 | 1,016
Multiple myeloma 11 | 1,332
interstitial cystitis 11 | 2,312
Breast Neoplasms 10 | 445
astrocytoma 10 | 1,146
esophageal adenocarcinoma 10 | 737
pediatric high grade glioma 10 | 1,064
ulcerative colitis 10 | 1,819
Duchenne muscular dystrophy 9 | 601
Mammary Neoplasms 9 | 425
colon cancer 9 | 1,478
tuberculosis 9 | 2,010
Liver cancer 8 | 604
Neoplasm Invasiveness 8 | 161
Rheumatoid arthritis 8 | 1,191
acute quadriplegic myopathy 8 | 1,158
adrenocortical carcinoma 8 | 1,428
non primary Sjogren syndrome sicca 8 | 891
primary Sjogren syndrome 8 | 735
Amyotrophic lateral sclerosis 7 | 451
Craniofrontonasal syndrome 7 | 13
Down syndrome 7 | 499
Dull intelligence 7 | 645
Hypertension 7 | 396
Kidney disease 7 | 430
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
Proteinuria 7 | 144
Skin cancer 7 | 469
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Alcoholic Intoxication, Chronic 6 | 289
Cell Transformation, Neoplastic 6 | 97
Epilepsy 6 | 792
Heart disease 6 | 306
Liver Cirrhosis, Experimental 6 | 769
Mammary Neoplasms, Experimental 6 | 154
Melanoma 6 | 711
Parkinson's disease 6 | 392
aldosterone-producing adenoma 6 | 665
dermatomyositis 6 | 966
interstitial lung disease 6 | 298
Atopic dermatitis 5 | 952
Bipolar Disorder 5 | 666
Depressive disorder 5 | 409
Hypertensive disease 5 | 292
Muscle hypotonia 5 | 571
Seizures 5 | 596
Short stature 5 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
mucosa-associated lymphoid tissue lymphoma 5 | 484
progressive supranuclear palsy 5 | 676

Tissue

Digestive Tract 91 | 17,369
Endocrine System 91 | 18,159
Liver and Pancreas 90 | 16,750
Nervous System 90 | 16,725
Skin and soft tissues 90 | 17,230
Blood and immune system 89 | 16,909
Female tissues 89 | 17,400
Male tissues 88 | 17,142
Respiratory system 87 | 16,393
Urinary Tract 87 | 16,678
Cardiovascular System 86 | 15,192

Target Family

Non-IDG 47 | 12,091
Kinase 28 | 634
Enzyme 14 | 4,145
Ion Channel 2 | 344

Reactome Pathway

EPH-Ephrin signaling 91 | 91
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Clathrin heavy chain 2 CLTCL1 Tbio Non-IDG -1.29555 21.3 39
ARF GTPase-activating protein GIT1 GIT1 Tbio Enzyme -1.84352 75.7 358
Ephrin type-B receptor 3 EPHB3 Tchem Kinase -1.68968 47.7 409
Ephrin type-A receptor 5 EPHA5 Tchem Kinase -2.28294 191.7 407
Ephrin type-B receptor 4 EPHB4 Tchem Kinase -2.26622 206.3 514
Ephrin type-B receptor 1 EPHB1 Tchem Kinase -1.70013 52.0 389
Ephrin-A2 EFNA2 Tbio Non-IDG -1.78296 60.7 253
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461
Ephrin-A3 EFNA3 Tbio Non-IDG -1.53049 26.8 219