Development Level

Tbio 30 | 10,625
Tdark 6 | 7,003
Tchem 2 | 1,890

IMPC Term

preweaning lethality, complete... 4 | 633
embryonic lethality prior to o... 2 | 148
prenatal lethality prior to he... 2 | 64
abnormal behavior 1 | 226
abnormal coat appearance 1 | 25
abnormal embryo size 1 | 112
abnormal gait 1 | 51
abnormal iris morphology 1 | 12
abnormal retinal pigmentation 1 | 61
decreased bone mineral content 1 | 157
decreased circulating triglyce... 1 | 83
decreased effector memory CD8-... 1 | 24
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
enlarged heart 1 | 111
hypoactivity 1 | 89
increased circulating triglyce... 1 | 24
increased or absent threshold ... 1 | 128
limb grasping 1 | 35
preweaning lethality, incomple... 1 | 260

Disease

ovarian cancer 23 | 8,484
lung cancer 14 | 4,466
Multiple myeloma 10 | 1,327
osteosarcoma 10 | 7,933
atypical teratoid / rhabdoid tumor 9 | 4,369
glioblastoma 9 | 5,572
Breast cancer 8 | 3,094
psoriasis 8 | 6,685
acute quadriplegic myopathy 7 | 1,157
astrocytic glioma 7 | 2,241
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,289
lung adenocarcinoma 7 | 2,713
medulloblastoma, large-cell 7 | 6,234
pancreatic cancer 7 | 2,300
Cancer 5 | 2,346
ependymoma 5 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,988
oligodendroglioma 5 | 2,849
Carcinoma 4 | 2,147
breast carcinoma 4 | 1,614
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
invasive ductal carcinoma 4 | 2,950
malignant mesothelioma 4 | 3,162
non-small cell lung cancer 4 | 2,798
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
Male infertility 3 | 170
Rheumatoid Arthritis 3 | 1,160
Waldenstrons macroglobulinemia 3 | 765
acute myeloid leukemia 3 | 780
astrocytoma 3 | 1,493
cutaneous lupus erythematosus 3 | 1,056
cystic fibrosis 3 | 1,665
ductal carcinoma in situ 3 | 1,745
lung carcinoma 3 | 2,844
primary pancreatic ductal adenocarcinoma 3 | 1,271
progressive supranuclear palsy 3 | 674
sonic hedgehog group medulloblastoma 3 | 1,482
subependymal giant cell astrocytoma 3 | 2,287
Down syndrome 2 | 548
Exophthalmos 2 | 16
Mammary Neoplasms 2 | 410
Myofibrillar myopathy 1 2 | 5
Myofibrillar myopathy 3 2 | 4
Parathyroid carcinoma 2 | 5
Pick disease 2 | 1,893
Pick's disease 2 | 14
adult high grade glioma 2 | 2,148
colon cancer 2 | 1,475
diabetes mellitus 2 | 1,663
gastric cancer 2 | 430
group 4 medulloblastoma 2 | 1,875
juvenile dermatomyositis 2 | 1,189
limb girdle muscular dystrophy 2B 2 | 74
non-small cell lung carcinoma 2 | 413
pancreatic carcinoma 2 | 567
pediatric high grade glioma 2 | 2,712
pituitary cancer 2 | 1,972
spina bifida 2 | 1,064
ulcerative colitis 2 | 2,087
Adenoid Cystic Carcinoma 1 | 99
Adenoma 1 | 165
Alzheimer's disease 1 | 644
Amyotrophic Lateral Sclerosis 1 | 431
Ankylosing spondylitis 1 | 138
Arsenic Poisoning 1 | 59
Autistic Disorder 1 | 320
Bipolar Disorder 1 | 266
Cleft Lip 1 | 91
Cleft palate 1 | 125
Crohn Disease 1 | 97
Dermatologic disorders 1 | 65
Drug-Induced Liver Injury 1 | 118
Edwards syndrome 1 | 15
Hepatic encephalopathy 1 | 25
Hepatitis B 1 | 103
Hyperparathyroidism 1 | 43
IGA Glomerulonephritis 1 | 454
Inflammatory Bowel Diseases 1 | 87
Lung diseases 1 | 48
Lymphoma 1 | 56
Lymphoma, Follicular 1 | 20
Malaria 1 | 140
Malignant neoplasm of testis 1 | 5
Mesothelioma 1 | 40
Nijmegen breakage syndrome 1 | 23
Peripheral vascular disease 1 | 90
Primary ciliary dyskinesia 1 | 73
Severe Combined Immunodeficiency 1 | 46
Squamous cell carcinoma of esophagus 1 | 82
Testicular cancer 1 | 24
active Crohn's disease 1 | 918
autosomal dominant Emery-Dreifuss muscular dystrophy 1 | 499
glioblastoma multiforme 1 | 347
inflammatory breast cancer 1 | 404
nasopharyngeal carcinoma 1 | 1,056
sarcoidosis 1 | 358
systemic lupus erythematosus 1 | 156
tuberculosis 1 | 1,557
tuberculosis and treatment for 3 months 1 | 327
tuberculosis and treatment for 6 months 1 | 686

Tissue

Blood and immune system 38 | 17,995
Cardiovascular System 38 | 17,958
Digestive Tract 38 | 18,473
Endocrine System 38 | 18,512
Female tissues 38 | 18,647
Liver and Pancreas 38 | 18,136
Male tissues 38 | 17,969
Nervous System 38 | 18,561
Respiratory system 38 | 17,484
Urinary Tract 38 | 18,444
Skin and soft tissues 34 | 18,115

Target Family

Non-IDG 28 | 11,971
Enzyme 9 | 4,146
Kinase 1 | 634

Reactome Pathway

E3 ubiquitin ligases ubiquitin... 38 | 38
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin-conjugating enzyme E2 A UBE2A Tbio Non-IDG -1.50248 30.7 117
Ubiquitin-conjugating enzyme E2 B UBE2B Tbio Non-IDG -1.56439 38.8 140
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Ubiquitin-conjugating enzyme E2 E1 UBE2E1 Tbio Non-IDG -1.18305 12.0 72
Histone H2B type 1-C/E/F/G/I HIST1H2BC Tbio Non-IDG -1.35785 22.1 103
E3 ubiquitin-protein ligase BRE1B RNF40 Tbio Enzyme -0.78876 5.67 173
Ubiquitin-conjugating enzyme E2 D2 UBE2D2 Tbio Non-IDG -2.06903 107.6 211
E3 ubiquitin-protein ligase RNF144A RNF144A Tbio Enzyme -0.50601 3.76 142
Ubiquitin-conjugating enzyme E2 N UBE2N Tchem Non-IDG -2.02460 99.0 237