Development Level

Tbio 103 | 11,445
Tchem 3 | 1,598
Tdark 3 | 6,588

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal behavior 2 | 298
decreased red blood cell distr... 2 | 41
embryonic lethality prior to o... 2 | 239
hypoactivity 2 | 132
increased hematocrit 2 | 46
increased mean corpuscular vol... 2 | 92
prenatal lethality prior to he... 2 | 87
preweaning lethality, incomple... 2 | 499
abnormal coat appearance 1 | 31
abnormal coat- hair morphology 1 | 19
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal hair texture 1 | 4
abnormal stomach morphology 1 | 10
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating chloride... 1 | 30
decreased circulating triglyce... 1 | 79
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased total body fat amoun... 1 | 207
enlarged heart 1 | 210
increased circulating alkaline... 1 | 122
increased circulating triglyce... 1 | 42
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 36
limb grasping 1 | 41

Disease

Cancer 64 | 2,499
diabetes mellitus 58 | 1,728
Ankylosing spondylitis 57 | 140
Acquired immunodeficiency syndrome 56 | 197
Arthritis 56 | 290
Behcet's disease 56 | 89
Herpes zoster 56 | 68
Hypersensitivity reaction type II disease 56 | 253
Juvenile rheumatoid arthritis 56 | 111
Uveitis 56 | 103
psoriasis 51 | 6,694
Carcinoma 44 | 11,493
Rheumatoid arthritis 38 | 1,191
Stevens-Johnson syndrome 38 | 92
dermatomyositis 37 | 966
ovarian cancer 36 | 8,520
Behcet's syndrome 35 | 50
Congenital adrenal hyperplasia 35 | 73
Dermatitis 35 | 157
Human immunodeficiency virus infectious disease 35 | 138
Nephritis 35 | 51
Psoriatic arthritis 35 | 86
Retinal vasculitis 35 | 36
Spondyloarthropathy, Susceptibility To, 1 35 | 35
Synovitis 35 | 78
Takayasu's arteritis 35 | 53
drug-induced hepatitis 35 | 44
Anemia 24 | 365
Hemochromatosis 22 | 54
tuberculosis 22 | 2,010
Birdshot chorioretinopathy 21 | 23
Hepatitis B 21 | 108
Kidney disease 21 | 430
Leprosy 21 | 73
Liver disease 21 | 237
Multiple Sclerosis 21 | 540
Primary immunodeficiency disease 21 | 54
Skin disease 21 | 66
lung cancer 19 | 4,740
glioblastoma 16 | 5,792
osteosarcoma 16 | 7,950
Multiple myeloma 14 | 1,332
Breast cancer 12 | 3,578
atypical teratoid / rhabdoid tumor 12 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
medulloblastoma, large-cell 10 | 6,241
Epilepsy 9 | 792
Seizures 9 | 596
lung adenocarcinoma 9 | 2,716
acute quadriplegic myopathy 8 | 1,158
adult high grade glioma 8 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
Autosomal recessive predisposition 7 | 1,442
Big calvaria 7 | 147
Cataract 7 | 297
Cerebellar Ataxia 7 | 304
Chorioretinal abnormality 7 | 21
Cognitive delay 7 | 608
Concave bridge of nose 7 | 195
Depressed nasal bridge 7 | 195
Depressed nasal root/bridge 7 | 195
Global developmental delay 7 | 608
Hypoplastic mandible condyle 7 | 275
Increased head circumference 7 | 147
Increased size of cranium 7 | 147
Increased size of skull 7 | 147
Lens Opacities 7 | 231
Mandibular hypoplasia 7 | 275
Mental and motor retardation 7 | 608
Micrognathism 7 | 275
Muscle Spasticity 7 | 195
Muscle weakness, progressive 7 | 22
Short stature 7 | 531
Small head 7 | 374
Upward slant of palpebral fissure 7 | 75
astrocytic glioma 7 | 2,597
non-small cell lung cancer 7 | 2,890
Addison Disease 6 | 18
Blepharoptosis 6 | 231
Chondrodysplasia punctata 6 | 41
Clouding of corneal stroma 6 | 50
Corneal Opacity 6 | 53
Decreased to absent deep tendon reflexes 6 | 42
Hypotonia, severe 6 | 33
Impaired cognition 6 | 96
Infantile Refsum disease 6 | 23
Low Vision 6 | 174
Mental deterioration in childhood 6 | 95
Mental impairment 6 | 95
Neurodevelopmental regression 6 | 95
Peroxisomal disease 6 | 22
Polymicrogyria 6 | 48
Premature Birth 6 | 77
Premature birth of newborn 6 | 67
Psychomotor regression beginning in infancy 6 | 95
Respiratory Insufficiency 6 | 132
Respiratory function loss 6 | 121
Visual Impairment 6 | 174
Zellweger syndrome 6 | 37

Tissue

Endocrine System 55 | 18,159
Blood and immune system 54 | 16,909
Cardiovascular System 54 | 15,192
Digestive Tract 54 | 17,369
Female tissues 54 | 17,400
Liver and Pancreas 54 | 16,750
Male tissues 54 | 17,142
Nervous System 54 | 16,725
Respiratory system 54 | 16,393
Skin and soft tissues 54 | 17,230
Urinary Tract 54 | 16,678

Target Family

Non-IDG 94 | 12,091
Enzyme 13 | 4,145
Epigenetic 1 | 242
Kinase 1 | 634

Reactome Pathway

E3 ubiquitin ligases ubiquitin... 109 | 109
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase SHPRH SHPRH Tbio Epigenetic -0.99196 10.7 137
Histone H2B type 1-N HIST1H2BN Tbio Non-IDG -1.51422 30.2 60
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 48
Derlin-1 DERL1 Tbio Non-IDG -1.88253 69.7 178
HLA class I histocompatibility antigen, B-35 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
Peroxisomal targeting signal 1 receptor PEX5 Tbio Non-IDG -2.43126 272.8 138
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Ubiquitin-conjugating enzyme E2 A UBE2A Tbio Non-IDG -1.53597 32.3 117
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.17 0.33 21