Development Level

Tbio 19 | 10,625
Tchem 11 | 1,890
Tclin 4 | 602

IMPC Phenotype

preweaning lethality, complete... 7 | 633
embryonic lethality prior to o... 4 | 148
embryonic lethality prior to t... 2 | 187
decreased caudal vertebrae num... 1 | 49
decreased neutrophil cell numb... 1 | 37
increased bone mineral content 1 | 92
increased circulating sodium l... 1 | 71
increased neutrophil cell numb... 1 | 15
male infertility 1 | 62
prenatal lethality prior to he... 1 | 64
urinary bladder obstruction 1 | 2

Disease

medulloblastoma, large-cell 26 | 6,234
glioblastoma 24 | 5,572
psoriasis 24 | 6,685
ovarian cancer 23 | 8,491
non-small cell lung cancer 22 | 2,798
lung cancer 21 | 4,473
osteosarcoma 19 | 7,933
primitive neuroectodermal tumor 19 | 3,031
malignant mesothelioma 18 | 3,163
adrenocortical carcinoma 17 | 1,427
group 3 medulloblastoma 17 | 2,254
Cancer 15 | 2,346
atypical teratoid / rhabdoid tumor 15 | 4,369
lung adenocarcinoma 15 | 2,714
Breast cancer 14 | 3,098
pediatric high grade glioma 14 | 2,712
invasive ductal carcinoma 13 | 2,950
colon cancer 10 | 1,475
ductal carcinoma in situ 10 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
Atopic dermatitis 9 | 944
Endometriosis 9 | 535
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,289
nasopharyngeal carcinoma 8 | 1,056
primary Sjogren syndrome 8 | 788
Meier-Gorlin syndrome 7 | 12
breast carcinoma 7 | 1,614
oligodendroglioma 7 | 2,849
pancreatic cancer 7 | 2,300
IGA Glomerulonephritis 6 | 454
Liver carcinoma 6 | 217
atypical teratoid/rhabdoid tumor 6 | 1,095
posterior fossa group A ependymoma 6 | 1,511
EAR, PATELLA, SHORT STATURE SYNDROME 5 | 6
Mammary Neoplasms 5 | 410
Seckel syndrome 5 | 35
Waldenstrons macroglobulinemia 5 | 764
medulloblastoma 5 | 1,524
pilocytic astrocytoma 5 | 3,086
adult high grade glioma 4 | 2,148
astrocytic glioma 4 | 2,241
astrocytoma 4 | 1,493
dermatomyositis 4 | 966
pituitary cancer 4 | 1,972
sonic hedgehog group medulloblastoma 4 | 1,482
tuberculosis 4 | 1,563
ulcerative colitis 4 | 2,087
Acute lymphoid leukemia 3 | 25
Adenocarcinoma of pancreas 3 | 12
Colorectal Neoplasms 3 | 217
Lung Neoplasms 3 | 171
Metastatic Breast Carcinoma 3 | 21
Microcephaly 3 | 149
Multiple myeloma 3 | 1,327
Pick disease 3 | 1,893
Polycystic Ovary Syndrome 3 | 334
Rheumatoid Arthritis 3 | 1,170
cystic fibrosis and chronic rhinosinusitis 3 | 213
inflammatory breast cancer 3 | 404
interstitial cystitis 3 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis and treatment for 6 months 3 | 686
Adverse reaction to drug 2 | 54
Bladder Neoplasm 2 | 109
Carcinoma 2 | 2,147
Colonic Neoplasms 2 | 126
DiGeorge syndrome 2 | 46
Disease Progression 2 | 125
Malaria 2 | 140
Malignant mesothelioma of pleura 2 | 7
Malignant tumor of head and/or neck 2 | 15
Malignant tumor of ovary 2 | 25
Meningeal Leukemia 2 | 7
Menopause present (finding) 2 | 20
Pancreatic Neoplasm 2 | 79
Pulmonary emphysema 2 | 34
Stomach Neoplasms 2 | 282
Urinary bladder cancer 2 | 34
active Crohn's disease 2 | 918
acute quadriplegic myopathy 2 | 1,157
cystic fibrosis 2 | 1,670
ependymoma 2 | 2,514
esophageal adenocarcinoma 2 | 737
facioscapulohumeral dystrophy 2 | 286
fibroadenoma 2 | 557
gastric cancer 2 | 436
juvenile dermatomyositis 2 | 1,189
nervous system disorder 2 | 53
ovarian neoplasm 2 | 97
pancreatic carcinoma 2 | 567
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
Acute myeloid leukemia, disease 1 | 16
Brain Diseases 1 | 22
Burkitt's lymphoma 1 | 15
Gestational trophoblastic neoplasia 1 | 14
Malignant tumor of stomach 1 | 12
Mycosis fungoides 1 | 30
Non-Hodgkin's lymphoma 1 | 22
Squamous cell carcinoma of the head and neck 1 | 24

Tissue

Blood and immune system 34 | 17,994
Cardiovascular System 34 | 17,957
Digestive Tract 34 | 18,472
Endocrine System 34 | 18,511
Female tissues 34 | 18,646
Liver and Pancreas 34 | 18,135
Male tissues 34 | 17,968
Nervous System 34 | 18,560
Respiratory system 34 | 17,483
Skin and soft tissues 34 | 18,114
Urinary Tract 34 | 18,443

Target Family

Non-IDG 15 | 11,969
Enzyme 14 | 4,146
Transcription Factor 3 | 1,400
Kinase 2 | 634

Reactome Pathway

E2F mediated regulation of DNA... 34 | 34
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Thymidylate synthase TYMS Tclin Enzyme -2.92025 722.7 471
M-phase inducer phosphatase 1 CDC25A Tchem Enzyme -2.45436 266.0 1243
Cyclin-dependent kinase 1 CDK1 Tchem Kinase -3.25783 1710.8 1724
Transcription factor E2F1 E2F1 Tchem Transcription Factor -2.27364 187.2 928
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform PPP2R1A Tbio Enzyme -1.40388 25.3 259
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform PPP2R1B Tbio Enzyme -1.20793 17.1 179
G1/S-specific cyclin-E1 CCNE1 Tchem Non-IDG -2.43326 239.2 741
DNA replication factor Cdt1 CDT1 Tbio Non-IDG -2.17234 139.2 105
Cell division control protein 45 homolog CDC45 Tbio Non-IDG -2.08011 105.8 227
DNA primase large subunit PRIM2 Tbio Enzyme 0.00000 76