Development Level

Tbio 17 | 11,445
Tchem 3 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
embryonic lethality prior to o... 2 | 239
decreased caudal vertebrae num... 1 | 53
decreased erythrocyte cell num... 1 | 62
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
embryonic lethality prior to t... 1 | 278
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499

Disease

glioblastoma 14 | 5,792
medulloblastoma, large-cell 14 | 6,241
Carcinoma 13 | 11,493
group 3 medulloblastoma 12 | 4,104
osteosarcoma 12 | 7,950
psoriasis 12 | 6,694
atypical teratoid / rhabdoid tumor 11 | 5,112
malignant mesothelioma 11 | 3,232
ovarian cancer 11 | 8,520
lung cancer 10 | 4,740
non-small cell lung cancer 10 | 2,890
primitive neuroectodermal tumor 9 | 3,035
adrenocortical carcinoma 7 | 1,428
lung adenocarcinoma 7 | 2,716
Breast cancer 6 | 3,578
Cancer 6 | 2,499
colon cancer 5 | 1,478
invasive ductal carcinoma 5 | 2,951
Autosomal recessive predisposition 4 | 1,442
Dull intelligence 4 | 645
Fetal Growth Retardation 4 | 189
Infant, Small for Gestational Age 4 | 176
Intellectual disability 4 | 1,016
Intrauterine retardation 4 | 176
Low intelligence 4 | 645
Meier-Gorlin syndrome 4 | 10
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Poor school performance 4 | 645
Small head 4 | 374
adult high grade glioma 4 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
pediatric high grade glioma 4 | 1,064
Atopic dermatitis 3 | 952
Birth length less than 3rd percentile 3 | 6
Congenital hypoplasia of breast 3 | 25
Congenital small ears 3 | 48
Cryptorchidism 3 | 296
Delayed bone age 3 | 136
EAR, PATELLA, SHORT STATURE SYNDROME 3 | 7
Endometriosis 3 | 540
Failure to gain weight 3 | 365
Hypertrophy of clitoris 3 | 40
Hypoplastic mandible condyle 3 | 275
Isolated growth hormone deficiency 3 | 30
Kidney cancer 3 | 2,613
Mandibular hypoplasia 3 | 275
Microcephaly 3 | 166
Micrognathism 3 | 275
Microstomia 3 | 78
Multiple myeloma 3 | 1,332
Pediatric failure to thrive 3 | 365
Seckel syndrome 3 | 34
Slender, gracile long tubular bones 3 | 21
Waldenstrons macroglobulinemia 3 | 765
dermatomyositis 3 | 966
ductal carcinoma in situ 3 | 1,745
ependymoma 3 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
oligodendroglioma 3 | 2,850
primary Sjogren syndrome 3 | 735
tuberculosis and treatment for 6 months 3 | 409
Abnormality of metabolism/homeostasis 2 | 134
Astrocytoma, Pilocytic 2 | 3,081
Bilateral fifth finger clinodactyly 2 | 110
Breast Neoplasms 2 | 445
Carcinoma, Hepatocellular 2 | 228
Cognitive delay 2 | 608
Congenital deafness 2 | 185
Curvature of little finger 2 | 110
Deafness 2 | 198
Decreased projection of maxilla 2 | 66
Deficiency of upper jaw bones 2 | 66
Epilepsy 2 | 792
Gastroesophageal reflux disease 2 | 110
Genu varum 2 | 29
Global developmental delay 2 | 608
Hearing Loss, Partial 2 | 185
Heartburn 2 | 78
Hypoplasia of the maxilla 2 | 66
Hypotrophic maxilla 2 | 66
Leukemia 2 | 104
Liver carcinoma 2 | 240
Lung Neoplasms 2 | 232
Mammary Neoplasms 2 | 425
Maxillary retrognathia 2 | 66
Mental and motor retardation 2 | 608
Pick disease 2 | 1,894
Range of joint movement increased 2 | 32
Retrusion of upper jaw bones 2 | 66
Rheumatoid arthritis 2 | 1,191
Seizures 2 | 596
Uranostaphyloschisis 2 | 167
astrocytic glioma 2 | 2,597
breast carcinoma 2 | 1,638
hearing impairment 2 | 199
nasopharyngeal carcinoma 2 | 1,058
pancreatic cancer 2 | 2,398
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 2,010

Tissue

Blood and immune system 21 | 16,909
Cardiovascular System 21 | 15,192
Digestive Tract 21 | 17,369
Endocrine System 21 | 18,159
Female tissues 21 | 17,400
Liver and Pancreas 21 | 16,750
Male tissues 21 | 17,142
Nervous System 21 | 16,725
Respiratory system 21 | 16,393
Skin and soft tissues 21 | 17,230
Urinary Tract 21 | 16,678

Target Family

Enzyme 10 | 4,145
Non-IDG 7 | 12,091
Transcription Factor 3 | 1,400
Kinase 1 | 634

Reactome Pathway

E2F mediated regulation of DNA... 21 | 21
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Origin recognition complex subunit 2 ORC2 Tbio Non-IDG -0.68275 4.92 168
Origin recognition complex subunit 1 ORC1 Tbio Non-IDG -1.42573 28.0 148
Origin recognition complex subunit 5 ORC5 Tbio Non-IDG -1.50983 31.3 71
DNA primase large subunit PRIM2 Tbio Enzyme 0.00000 89
Retinoblastoma-associated protein RB1 Tchem Non-IDG -3.07052 1137.4 2150
Origin recognition complex subunit 3 ORC3 Tbio Non-IDG -1.25409 17.4 192
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform PPP2R1B Tbio Enzyme -1.20793 16.9 203
DNA helicase MCM8 MCM8 Tbio Enzyme -1.42239 28.6 195
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta PPP2R3B Tbio Enzyme -1.28190 19.5 142
Origin recognition complex subunit 6 ORC6 Tbio Non-IDG -1.38268 26.3 165