Development Level

Tbio 54 | 11,651
Tchem 6 | 1,388
Tdark 3 | 6,593
Tclin 2 | 612

IMPC Phenotype

preweaning lethality, complete... 8 | 979
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 3 | 278
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal pharyngeal arch morph... 1 | 8
abnormal retina morphology 1 | 71
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased circulating glucose ... 1 | 126
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
embryonic growth retardation 1 | 106
increased anti-nuclear antigen... 1 | 19
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating potassiu... 1 | 29
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
prenatal lethality prior to he... 1 | 87

Disease

ovarian cancer 39 | 8,520
Carcinoma 34 | 11,493
osteosarcoma 28 | 7,950
Cockayne syndrome 27 | 60
lung cancer 25 | 4,740
group 3 medulloblastoma 17 | 4,104
psoriasis 17 | 6,694
Cancer 15 | 2,499
malignant mesothelioma 15 | 3,232
Photosensitive trichothiodystrophy 14 | 30
Xeroderma pigmentosum 14 | 43
glioblastoma 12 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
medulloblastoma, large-cell 12 | 6,241
Intellectual disability 11 | 1,016
Short stature 11 | 531
primitive neuroectodermal tumor 11 | 3,035
Autosomal recessive predisposition 10 | 1,442
Cataract 10 | 297
Cryptorchidism 10 | 296
Dull intelligence 10 | 645
Hypogonadism 10 | 173
Kidney cancer 10 | 2,613
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Poor school performance 10 | 645
Sensorineural Hearing Loss (disorder) 10 | 284
Small head 10 | 374
atypical teratoid / rhabdoid tumor 10 | 5,112
diabetes mellitus 10 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
Lens Opacities 9 | 231
Photosensitivity of skin 9 | 51
Strabismus 9 | 270
Xeroderma pigmentosum group B 9 | 20
acute myeloid leukemia 9 | 783
ependymoma 9 | 4,679
non-small cell lung cancer 9 | 2,890
Breast cancer 8 | 3,578
Cerebellar Ataxia 8 | 304
Epilepsy 8 | 792
Hypoplastic mandible condyle 8 | 275
Mandibular hypoplasia 8 | 275
Micrognathism 8 | 275
Seizures 8 | 596
Atrophic condition of skin 7 | 25
Dry skin 7 | 75
Electroencephalogram abnormal 7 | 101
Failure to gain weight 7 | 365
Freckles 7 | 33
Melanoma 7 | 711
Multiple myeloma 7 | 1,332
Muscle Spasticity 7 | 195
Muscle hypotonia 7 | 571
Optic Atrophy 7 | 242
Pediatric failure to thrive 7 | 365
Waldenstrons macroglobulinemia 7 | 765
Xeroderma pigmentosum group D 7 | 33
Xerosis 7 | 75
adult high grade glioma 7 | 3,801
Arthralgia 6 | 90
Broad flat nasal bridge 6 | 236
Cognitive delay 6 | 608
Conjunctival telangiectasis 6 | 14
Deafness 6 | 198
Global developmental delay 6 | 608
Keratitis 6 | 62
Low Vision 6 | 174
Mental and motor retardation 6 | 608
Nasal bridge wide 6 | 236
Poikiloderma 6 | 14
UV-sensitive syndrome 6 | 10
Visual Impairment 6 | 174
Xeroderma pigmentosum group G 6 | 16
astrocytoma 6 | 1,146
hearing impairment 6 | 199
nasopharyngeal carcinoma 6 | 1,058
oligodendroglioma 6 | 2,850
pituitary cancer 6 | 1,972
Abnormally small eyeball 5 | 97
Cerebral atrophy 5 | 178
Congenital deafness 5 | 185
Decreased size of eyeball 5 | 97
Developmental regression 5 | 95
Fever 5 | 138
Hearing Loss, Partial 5 | 185
Impaired cognition 5 | 96
Loss of developmental milestones 5 | 95
Mental deterioration in childhood 5 | 95
Mental impairment 5 | 95
Neurodevelopmental regression 5 | 95
Pick disease 5 | 1,894
Psychomotor regression 5 | 95
Psychomotor regression beginning in infancy 5 | 95
Psychomotor regression in infants 5 | 95
Psychomotor regression, progressive 5 | 95
Stomach Neoplasms 5 | 300
Thin skin 5 | 47
astrocytic glioma 5 | 2,597

Tissue

Blood and immune system 64 | 16,909
Cardiovascular System 64 | 15,192
Digestive Tract 64 | 17,369
Endocrine System 64 | 18,159
Female tissues 64 | 17,400
Liver and Pancreas 64 | 16,750
Male tissues 64 | 17,142
Nervous System 64 | 16,725
Respiratory system 64 | 16,393
Skin and soft tissues 64 | 17,230
Urinary Tract 64 | 16,678

Target Family

Non-IDG 34 | 12,091
Enzyme 29 | 4,145
Epigenetic 1 | 242
Kinase 1 | 634

Reactome Pathway

Dual incision in TC-NER 65 | 65
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
General transcription factor IIH subunit 1 GTF2H1 Tbio Non-IDG -1.65323 46.0 231
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.06760 110.4 225
Pre-mRNA-processing factor 19 PRPF19 Tbio Non-IDG -1.71524 54.2 234
Peptidyl-prolyl cis-trans isomerase E PPIE Tbio Enzyme -1.36546 21.0 185
Ubiquitin carboxyl-terminal hydrolase 7 USP7 Tchem Enzyme -2.26799 196.6 427
DNA-directed RNA polymerase II subunit RPB11-a POLR2J Tbio Enzyme -1.43224 29.3 213
DNA-directed RNA polymerase II subunit RPB7 POLR2G Tbio Enzyme -1.77350 60.4 174
General transcription factor IIH subunit 3 GTF2H3 Tbio Non-IDG -0.87291 7.21 78
Cullin-4A CUL4A Tbio Non-IDG -1.92199 80.1 276
Cullin-4B CUL4B Tbio Non-IDG -1.68710 54.9 251