Development Level

Tchem 14 | 1,388
Tbio 10 | 11,651
Tclin 4 | 612

IMPC Phenotype

preweaning lethality, complete... 5 | 979
decreased circulating creatini... 2 | 39
enlarged heart 2 | 210
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
anophthalmia 1 | 33
decreased body weight 1 | 161
decreased circulating glucose ... 1 | 126
decreased mean corpuscular vol... 1 | 79
embryonic lethality prior to o... 1 | 239
enlarged lymph nodes 1 | 37
impaired righting response 1 | 26
increased circulating glucose ... 1 | 24
increased hemoglobin content 1 | 45
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased neutrophil cell numb... 1 | 46
prenatal lethality 1 | 28
short tibia 1 | 97

Disease

Cancer 24 | 2,499
Carcinoma 24 | 11,493
osteosarcoma 21 | 7,950
ovarian cancer 20 | 8,520
lung cancer 16 | 4,740
Breast cancer 15 | 3,578
psoriasis 14 | 6,694
medulloblastoma, large-cell 12 | 6,241
glioblastoma 11 | 5,792
Kidney cancer 10 | 2,613
group 4 medulloblastoma 10 | 1,855
invasive ductal carcinoma 10 | 2,951
atypical teratoid / rhabdoid tumor 9 | 5,112
Breast Neoplasms 8 | 445
Delayed bone age 8 | 136
Hypoplastic mandible condyle 8 | 275
Mammary Neoplasms 8 | 425
Mandibular hypoplasia 8 | 275
Micrognathism 8 | 275
Orbital separation excessive 8 | 244
Short stature 8 | 531
juvenile dermatomyositis 8 | 1,187
lung adenocarcinoma 8 | 2,716
pancreatic cancer 8 | 2,398
Blepharoptosis 7 | 231
Byzanthine arch palate 7 | 194
Downward slant of palpebral fissure 7 | 158
Epilepsy 7 | 792
Frontal bossing 7 | 157
Hepatomegaly 7 | 285
Joint hyperflexibility 7 | 78
Noonan syndrome 7 | 34
Seizures 7 | 596
Stomach Neoplasms 7 | 300
astrocytic glioma 7 | 2,597
breast carcinoma 7 | 1,638
ductal carcinoma in situ 7 | 1,745
ependymoma 7 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
malignant mesothelioma 7 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Acquired scoliosis 6 | 281
Adenocarcinoma 6 | 122
Animal Mammary Neoplasms 6 | 136
Carcinoma, Squamous Cell 6 | 110
Curvature of spine 6 | 282
Dysarthria 6 | 192
Generalized osteopenia 6 | 99
High forehead 6 | 102
Lung Neoplasms 6 | 232
Mammary Neoplasms, Animal 6 | 136
Mammary Neoplasms, Experimental 6 | 154
Muscle hypotonia 6 | 571
Osteopenia 6 | 99
Renal Cell Carcinoma 6 | 214
Squamous cell carcinoma 6 | 129
Tall forehead 6 | 102
Ventricular Septal Defects 6 | 119
group 3 medulloblastoma 6 | 4,104
oligodendroglioma 6 | 2,850
Adenocarcinoma of lung 5 | 142
Basal cell carcinoma 5 | 54
Big calvaria 5 | 147
Bleeding tendency 5 | 37
Carcinoma, Hepatocellular 5 | 228
Cardiac Arrhythmia 5 | 103
Cardiac conduction abnormalities 5 | 78
Concave bridge of nose 5 | 195
Conduction disorder of the heart 5 | 79
Congenital Epicanthus 5 | 177
Depressed nasal bridge 5 | 195
Depressed nasal root/bridge 5 | 195
Depressive disorder 5 | 409
EKG abnormalities 5 | 78
Electrocardiogram abnormal 5 | 81
Electrocardiogram change 5 | 78
Endometrial cancer 5 | 311
Exophthalmos 5 | 112
Hyperreflexia 5 | 209
Increased head circumference 5 | 147
Increased size of cranium 5 | 147
Increased size of skull 5 | 147
Isolated cases 5 | 72
Liver carcinoma 5 | 240
Melanocytic nevus 5 | 43
Midface retrusion 5 | 105
Noncancerous mole 5 | 28
Pectus excavatum 5 | 100
Prominent eyes 5 | 96
Prominent globes 5 | 96
Protruding eyes 5 | 96
Rheumatoid arthritis 5 | 1,191
Schizophrenia 5 | 1,160
Small midface 5 | 105
Strabismus 5 | 270
Telecanthus 5 | 62
Triangular face 5 | 58
cystic fibrosis 5 | 1,696
dermatomyositis 5 | 966
pancreatic carcinoma 5 | 562

Tissue

Blood and immune system 28 | 16,909
Cardiovascular System 28 | 15,192
Digestive Tract 28 | 17,369
Endocrine System 28 | 18,159
Female tissues 28 | 17,400
Liver and Pancreas 28 | 16,750
Male tissues 28 | 17,142
Nervous System 28 | 16,725
Respiratory system 28 | 16,393
Skin and soft tissues 28 | 17,230
Urinary Tract 28 | 16,678

Target Family

Non-IDG 10 | 12,091
Enzyme 7 | 4,145
Kinase 6 | 634
Transcription Factor 5 | 1,400

Reactome Pathway

Downstream signal transduction 28 | 28
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras GTPase-activating protein 1 RASA1 Tbio Enzyme -2.61637 404.4 402
Cytoplasmic protein NCK1 NCK1 Tbio Non-IDG -2.25032 186.5 398
Signal transducer and activator of transcription 3 STAT3 Tchem Transcription Factor -3.81500 6459.7 1749
Cytoplasmic protein NCK2 NCK2 Tbio Non-IDG -1.57587 36.4 241
Platelet-derived growth factor subunit B PDGFB Tchem Non-IDG -3.27151 1795.5 434
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -3.02404 981.4 501
Tyrosine-protein phosphatase non-receptor type 11 PTPN11 Tchem Enzyme -3.11032 1400.0 1077
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.51919 316.4 758
Signal transducer and activator of transcription 5B STAT5B Tchem Transcription Factor -3.02570 950.5 620
Son of sevenless homolog 1 SOS1 Tbio Non-IDG -2.69482 466.2 147