Development Level

Tbio 180 | 10,625
Tchem 104 | 1,890
Tclin 53 | 602
Tdark 7 | 7,003

Collection

Eligible Kinase Proteins 5 | 134
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 15 | 633
decreased body weight 11 | 174
decreased total body fat amoun... 9 | 186
decreased lean body mass 7 | 195
decreased circulating choleste... 6 | 85
embryonic lethality prior to t... 6 | 187
abnormal behavior 5 | 226
abnormal embryo size 5 | 112
decreased bone mineral content 5 | 157
decreased circulating HDL chol... 5 | 77
decreased lumbar vertebrae num... 5 | 62
enlarged heart 5 | 111
abnormal bone structure 4 | 131
abnormal retina morphology 4 | 100
abnormal retinal pigmentation 4 | 61
decreased body length 4 | 108
decreased circulating LDL chol... 4 | 37
decreased circulating alanine ... 4 | 53
decreased circulating glucose ... 4 | 121
increased mean corpuscular hem... 4 | 93
thrombocytopenia 4 | 46
abnormal cornea morphology 3 | 24
decreased circulating total pr... 3 | 41
decreased circulating triglyce... 3 | 83
decreased grip strength 3 | 123
decreased kidney weight 3 | 7
decreased rib number 3 | 59
increased circulating alkaline... 3 | 119
increased lean body mass 3 | 107
abnormal bone mineralization 2 | 55
abnormal coat/hair pigmentatio... 2 | 54
abnormal forebrain development 2 | 18
abnormal hindbrain development 2 | 24
abnormal lens morphology 2 | 73
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
abnormal seminal vesicle morph... 2 | 47
cataract 2 | 26
decreased bone mineral density 2 | 126
decreased circulating chloride... 2 | 32
decreased circulating creatini... 2 | 31
decreased circulating serum al... 2 | 79
decreased circulating sodium l... 2 | 18
decreased heart weight 2 | 44
decreased lactate dehydrogenas... 2 | 14
decreased neutrophil cell numb... 2 | 37
decreased prepulse inhibition 2 | 52
decreased spleen weight 2 | 13
decreased thoracic vertebrae n... 2 | 7
dilated heart left ventricle 2 | 10
enlarged lymph nodes 2 | 27
hypoactivity 2 | 89
impaired pupillary reflex 2 | 14
increased bone mineral content 2 | 92
increased circulating HDL chol... 2 | 63
increased circulating LDL chol... 2 | 15
increased circulating phosphat... 2 | 24
increased grip strength 2 | 83
increased mean corpuscular vol... 2 | 91
increased sacral vertebrae num... 2 | 62
increased startle reflex 2 | 38
male infertility 2 | 62
prenatal lethality prior to he... 2 | 64
abnormal behavioral response t... 1 | 52
abnormal body wall morphology 1 | 7
abnormal gait 1 | 51
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 51
abnormal respiratory quotient 1 | 9
abnormal rib morphology 1 | 28
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
absent pinna reflex 1 | 21
corneal opacity 1 | 25
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased caudal vertebrae num... 1 | 49
decreased circulating bilirubi... 1 | 14
decreased circulating calcium ... 1 | 33
decreased circulating potassiu... 1 | 17
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased total retina thickne... 1 | 20
enlarged spleen 1 | 26
female infertility 1 | 34
impaired righting response 1 | 19
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased body weight 1 | 42
increased circulating choleste... 1 | 53
increased circulating fructosa... 1 | 11
increased mean platelet volume 1 | 19
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
short tibia 1 | 82
thrombocytosis 1 | 23
tremors 1 | 34
vertebral fusion 1 | 23

Disease

osteosarcoma 200 | 7,933
ovarian cancer 193 | 8,484
psoriasis 148 | 6,685
Cancer 144 | 2,346
glioblastoma 144 | 5,572
medulloblastoma, large-cell 144 | 6,234
lung cancer 129 | 4,466
atypical teratoid / rhabdoid tumor 104 | 4,369
Breast cancer 89 | 3,094
malignant mesothelioma 83 | 3,162
oligodendroglioma 82 | 2,849
pilocytic astrocytoma 82 | 3,086
invasive ductal carcinoma 79 | 2,950
Carcinoma 77 | 2,147
ependymoma 76 | 2,514
pediatric high grade glioma 74 | 2,712
subependymal giant cell astrocytoma 74 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 73 | 3,289
lung adenocarcinoma 69 | 2,713
astrocytic glioma 67 | 2,241
interstitial cystitis 67 | 2,299
lung carcinoma 64 | 2,844
primitive neuroectodermal tumor 63 | 3,031
ulcerative colitis 60 | 2,087
intraductal papillary-mucinous adenoma (IPMA) 58 | 2,956
non-small cell lung cancer 58 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 57 | 2,988
pancreatic cancer 55 | 2,300
Multiple myeloma 52 | 1,327
diabetes mellitus 52 | 1,663
group 4 medulloblastoma 52 | 1,875
pituitary cancer 49 | 1,972
tuberculosis 49 | 1,557
Pick disease 47 | 1,893
group 3 medulloblastoma 47 | 2,254
astrocytoma 45 | 1,493
cystic fibrosis 45 | 1,665
Rheumatoid Arthritis 44 | 1,160
medulloblastoma 43 | 1,524
ductal carcinoma in situ 42 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 40 | 1,795
adult high grade glioma 38 | 2,148
breast carcinoma 37 | 1,614
juvenile dermatomyositis 36 | 1,189
colon cancer 34 | 1,475
Mammary Neoplasms 32 | 410
Schizophrenia 31 | 501
Prostatic Neoplasms 30 | 471
cutaneous lupus erythematosus 30 | 1,056
primary pancreatic ductal adenocarcinoma 30 | 1,271
atypical teratoid/rhabdoid tumor 28 | 1,095
Parkinson's disease 27 | 364
dermatomyositis 26 | 933
posterior fossa group B ependymoma 26 | 1,530
primary Sjogren syndrome 26 | 789
spina bifida 26 | 1,064
Alzheimer's disease 25 | 644
Obesity 25 | 616
adrenocortical carcinoma 25 | 1,427
Lung Neoplasms 24 | 171
Vascular disease 24 | 281
Waldenstrons macroglobulinemia 24 | 765
gastric carcinoma 24 | 832
non-small cell lung carcinoma 24 | 413
Intellectual disability 23 | 573
pancreatic carcinoma 22 | 567
posterior fossa group A ependymoma 22 | 1,511
Asthma 21 | 349
Liver carcinoma 21 | 217
HIV Infections 20 | 100
Renal Cell Carcinoma 20 | 199
acute quadriplegic myopathy 20 | 1,157
esophageal adenocarcinoma 20 | 737
tuberculosis and treatment for 6 months 20 | 686
Anemia 19 | 252
Polycystic Ovary Syndrome 19 | 332
Stomach Neoplasms 19 | 282
non primary Sjogren syndrome sicca 19 | 840
Autistic Disorder 18 | 320
Kidney disease 18 | 396
Animal Mammary Neoplasms 17 | 136
Mammary Neoplasms, Experimental 17 | 150
nasopharyngeal carcinoma 17 | 1,056
progressive supranuclear palsy 17 | 674
sarcoidosis 17 | 358
sonic hedgehog group medulloblastoma 17 | 1,482
Adenoma 16 | 165
Down syndrome 16 | 548
Hypersensitivity reaction type II disease 16 | 235
Melanoma 16 | 261
Multiple Sclerosis 16 | 498
Myocardial Ischemia 16 | 169
Neoplasm Invasiveness 16 | 127
Osteoporosis 16 | 257
Peripheral Neuropathy 16 | 303
Atopic dermatitis 15 | 944
Heart disease 15 | 279
Noonan Syndrome 15 | 33
acute myeloid leukemia 15 | 780
gastric cancer 14 | 430

Tissue

Endocrine System 344 | 18,512
Female tissues 344 | 18,647
Nervous System 344 | 18,561
Digestive Tract 343 | 18,473
Urinary Tract 343 | 18,444
Liver and Pancreas 342 | 18,136
Blood and immune system 341 | 17,995
Cardiovascular System 340 | 17,958
Skin and soft tissues 340 | 18,115
Male tissues 339 | 17,969
Respiratory system 334 | 17,484

Target Family

Non-IDG 148 | 11,971
Enzyme 110 | 4,146
Kinase 67 | 634
Transcription Factor 10 | 1,400
Ion Channel 8 | 341
Nuclear Receptor 1 | 48

Reactome Pathway

Downstream signal transduction 344 | 344
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Fibroblast growth factor 5 FGF5 Tbio Non-IDG -2.00731 99.9 143
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Fibrinogen alpha chain FGA Tbio Non-IDG -2.84597 716.2 457
Insulin INS Tbio Non-IDG -5.14691 141255.4 1549
Adenosylhomocysteinase 2 AHCYL1 Tchem Enzyme -1.57893 43.2 102
Beta-arrestin-1 ARRB1 Tchem Non-IDG -2.54226 366.3 416