Development Level

Tchem 16 | 1,885
Tbio 8 | 11,178
Tclin 4 | 612

IMPC Phenotype

preweaning lethality, complete... 5 | 979
decreased circulating creatini... 2 | 39
enlarged heart 2 | 210
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
anophthalmia 1 | 33
decreased body weight 1 | 161
decreased circulating glucose ... 1 | 126
decreased mean corpuscular vol... 1 | 79
embryonic lethality prior to o... 1 | 239
enlarged lymph nodes 1 | 37
impaired righting response 1 | 26
increased circulating glucose ... 1 | 24
increased hemoglobin content 1 | 45
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased neutrophil cell numb... 1 | 46
prenatal lethality 1 | 28
short tibia 1 | 97

Disease

Cancer 24 | 2,388
Carcinoma 24 | 11,192
osteosarcoma 21 | 7,766
ovarian cancer 20 | 8,297
lung cancer 16 | 4,607
Breast cancer 15 | 3,469
psoriasis 14 | 6,514
medulloblastoma, large-cell 12 | 6,086
glioblastoma 11 | 5,635
Kidney cancer 10 | 2,548
group 4 medulloblastoma 10 | 1,806
invasive ductal carcinoma 10 | 2,867
atypical teratoid / rhabdoid tumor 9 | 4,971
Breast Neoplasms 8 | 423
Delayed bone age 8 | 132
Hypoplastic mandible condyle 8 | 273
Mammary Neoplasms 8 | 403
Mandibular hypoplasia 8 | 273
Micrognathism 8 | 273
Orbital separation excessive 8 | 240
Short stature 8 | 514
juvenile dermatomyositis 8 | 1,147
lung adenocarcinoma 8 | 2,627
pancreatic cancer 8 | 2,322
Blepharoptosis 7 | 229
Byzanthine arch palate 7 | 194
Downward slant of palpebral fissure 7 | 158
Epilepsy 7 | 775
Frontal bossing 7 | 154
Hepatomegaly 7 | 280
Joint hyperflexibility 7 | 76
Noonan syndrome 7 | 34
Seizures 7 | 584
Stomach Neoplasms 7 | 287
astrocytic glioma 7 | 2,530
breast carcinoma 7 | 1,589
ductal carcinoma in situ 7 | 1,686
ependymoma 7 | 4,559
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,204
malignant mesothelioma 7 | 3,135
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,911
Acquired scoliosis 6 | 274
Adenocarcinoma 6 | 116
Animal Mammary Neoplasms 6 | 130
Carcinoma, Squamous Cell 6 | 107
Curvature of spine 6 | 275
Dysarthria 6 | 190
Generalized osteopenia 6 | 94
High forehead 6 | 101
Lung Neoplasms 6 | 217
Mammary Neoplasms, Animal 6 | 130
Mammary Neoplasms, Experimental 6 | 147
Muscle hypotonia 6 | 562
Osteopenia 6 | 94
Renal Cell Carcinoma 6 | 211
Squamous cell carcinoma 6 | 125
Tall forehead 6 | 101
Ventricular Septal Defects 6 | 113
group 3 medulloblastoma 6 | 4,002
oligodendroglioma 6 | 2,768
Adenocarcinoma of lung 5 | 140
Basal cell carcinoma 5 | 54
Big calvaria 5 | 147
Bleeding tendency 5 | 35
Carcinoma, Hepatocellular 5 | 217
Cardiac Arrhythmia 5 | 101
Cardiac conduction abnormalities 5 | 78
Concave bridge of nose 5 | 191
Conduction disorder of the heart 5 | 79
Congenital Epicanthus 5 | 175
Depressed nasal bridge 5 | 191
Depressed nasal root/bridge 5 | 191
Depressive disorder 5 | 401
EKG abnormalities 5 | 78
Electrocardiogram abnormal 5 | 81
Electrocardiogram change 5 | 78
Endometrial cancer 5 | 301
Exophthalmos 5 | 110
Hyperreflexia 5 | 208
Increased head circumference 5 | 147
Increased size of cranium 5 | 147
Increased size of skull 5 | 147
Isolated cases 5 | 70
Liver carcinoma 5 | 229
Melanocytic nevus 5 | 43
Midface retrusion 5 | 104
Noncancerous mole 5 | 28
Pectus excavatum 5 | 100
Prominent eyes 5 | 95
Prominent globes 5 | 95
Protruding eyes 5 | 95
Rheumatoid arthritis 5 | 1,156
Schizophrenia 5 | 1,136
Small midface 5 | 104
Strabismus 5 | 265
Telecanthus 5 | 62
Triangular face 5 | 57
cystic fibrosis 5 | 1,629
dermatomyositis 5 | 941
pancreatic carcinoma 5 | 555

Tissue

Blood and immune system 28 | 16,909
Cardiovascular System 28 | 15,192
Digestive Tract 28 | 17,369
Endocrine System 28 | 18,159
Female tissues 28 | 17,400
Liver and Pancreas 28 | 16,750
Male tissues 28 | 17,142
Nervous System 28 | 16,725
Respiratory system 28 | 16,393
Skin and soft tissues 28 | 17,230
Urinary Tract 28 | 16,678

Target Family

Non-IDG 10 | 12,091
Enzyme 7 | 4,145
Kinase 6 | 634
Transcription Factor 5 | 1,400

Reactome Pathway

Downstream signal transduction 28 | 28
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Platelet-derived growth factor subunit A PDGFA Tchem Non-IDG -2.74845 537.8 341
Ras GTPase-activating protein 1 RASA1 Tbio Enzyme -2.61637 404.4 402
GTPase KRas KRAS Tbio Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Rap guanine nucleotide exchange factor 1 RAPGEF1 Tbio Non-IDG -2.41980 281.2 167
Signal transducer and activator of transcription 6 STAT6 Tchem Transcription Factor -2.91382 803.7 1033
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.51919 316.4 758
Signal transducer and activator of transcription 5B STAT5B Tchem Transcription Factor -3.02570 950.5 620
Growth factor receptor-bound protein 7 GRB7 Tbio Non-IDG -2.09785 134.5 252