Development Level

Tbio 20 | 11,445
Tchem 5 | 1,598

IMPC Phenotype

abnormal behavior 2 | 298
decreased startle reflex 2 | 75
hypoactivity 2 | 132
preweaning lethality, complete... 2 | 979
preweaning lethality, incomple... 2 | 499
abnormal eyelid morphology 1 | 7
abnormal head size 1 | 6
abnormal iris morphology 1 | 13
abnormal placement of pupils 1 | 6
abnormal retina morphology 1 | 71
absent startle reflex 1 | 24
corneal opacity 1 | 32
decreased hemoglobin content 1 | 68
decreased prepulse inhibition 1 | 82
female infertility 1 | 60
increased heart weight 1 | 62
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
irregularly shaped pupil 1 | 7
male infertility 1 | 123
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
thrombocytopenia 1 | 56
trunk curl 1 | 16

Disease

ovarian cancer 18 | 8,520
Carcinoma 16 | 11,493
Cancer 13 | 2,499
lung cancer 13 | 4,740
osteosarcoma 11 | 7,950
Multiple myeloma 10 | 1,332
atypical teratoid / rhabdoid tumor 9 | 5,112
glioblastoma 8 | 5,792
malignant mesothelioma 8 | 3,232
medulloblastoma, large-cell 8 | 6,241
tuberculosis 8 | 2,010
Astrocytoma, Pilocytic 7 | 3,081
Breast cancer 7 | 3,578
Waldenstrons macroglobulinemia 7 | 765
adult high grade glioma 7 | 3,801
ependymoma 7 | 4,679
lung adenocarcinoma 7 | 2,716
pancreatic cancer 7 | 2,398
primitive neuroectodermal tumor 7 | 3,035
Kidney cancer 6 | 2,613
astrocytic glioma 6 | 2,597
lung carcinoma 6 | 2,843
non-small cell lung cancer 6 | 2,890
psoriasis 6 | 6,694
Cleft Palate 5 | 271
Hypertensive disease 5 | 292
Pulmonary Fibrosis 5 | 106
Ureteral obstruction 5 | 33
diabetes mellitus 5 | 1,728
invasive ductal carcinoma 5 | 2,951
oligodendroglioma 5 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
Acquired scoliosis 4 | 281
Aortic Valve Insufficiency 4 | 40
Colorectal Neoplasms 4 | 243
Coronary artery disease 4 | 268
Curvature of spine 4 | 282
Kidney disease 4 | 430
Liver Cirrhosis, Experimental 4 | 769
Loeys-Dietz syndrome 4 | 23
active Crohn's disease 4 | 922
acute myeloid leukemia 4 | 783
adrenocortical carcinoma 4 | 1,428
dermatomyositis 4 | 966
group 3 medulloblastoma 4 | 4,104
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
medulloblastoma 4 | 720
subependymal giant cell astrocytoma 4 | 2,287
ulcerative colitis 4 | 1,819
Abnormality of the iris 3 | 14
Acquired flat foot 3 | 72
Aneurysm, Dissecting 3 | 8
Aortic aneurysm 3 | 38
Aortic aneurysm, familial thoracic 3 3 | 13
Arachnodactyly 3 | 49
Arterial tortuosity 3 | 5
Ascending aortic dissection 3 | 13
Asthma 3 | 385
Byzanthine arch palate 3 | 194
Cardiomegaly 3 | 116
Chest Pain 3 | 38
Cleft uvula 3 | 27
Craniofacial Abnormalities 3 | 151
Cutis marmorata 3 | 32
Cystic medial necrosis of aorta 3 | 13
Dental caries 3 | 164
Descending aortic dissection 3 | 13
Dissection of aorta 3 | 9
Dyspnea on exertion 3 | 24
Dyspnea, Paroxysmal 3 | 13
Familial thoracic aortic aneurysm and aortic dissection 3 | 13
Flatfoot 3 | 73
Hypertension 3 | 396
Hypoplastic mandible condyle 3 | 275
Impaired left ventricular function 3 | 16
Increase in blood pressure 3 | 119
Inflammatory bowel disease 3 | 151
Left-Sided Heart Failure 3 | 16
Linear atrophy 3 | 15
Liver Cirrhosis 3 | 181
Liver disease 3 | 237
Loeys-Dietz Aortic Aneurysm Syndrome 3 | 13
Mandibular hypoplasia 3 | 275
Micrognathism 3 | 275
Orbital separation excessive 3 | 244
Peyronie's disease 3 | 9
Pneumonia 3 | 174
Systemic scleroderma 3 | 60
Thoracic aortic aneurysm 3 | 15
Ventricular Remodeling 3 | 5
active ulcerative colitis 3 | 764
acute quadriplegic myopathy 3 | 1,158
colon cancer 3 | 1,478
cystic fibrosis 3 | 1,696
gastric carcinoma 3 | 807
hereditary spastic paraplegia 3 | 318
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
juvenile dermatomyositis 3 | 1,187
spina bifida 3 | 1,074

Tissue

Blood and immune system 25 | 16,909
Cardiovascular System 25 | 15,192
Digestive Tract 25 | 17,369
Endocrine System 25 | 18,159
Female tissues 25 | 17,400
Liver and Pancreas 25 | 16,750
Male tissues 25 | 17,142
Nervous System 25 | 16,725
Respiratory system 25 | 16,393
Skin and soft tissues 25 | 17,230
Urinary Tract 25 | 16,678

Target Family

Enzyme 12 | 4,145
Non-IDG 8 | 12,091
Transcription Factor 3 | 1,400
Kinase 2 | 634

Reactome Pathway

Downregulation of TGF-beta rec... 25 | 25
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin carboxyl-terminal hydrolase 15 USP15 Tbio Enzyme -1.64742 41.6 242
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Myotubularin-related protein 4 MTMR4 Tbio Enzyme -0.76288 7.50 138
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139
Protein TMEPAI PMEPA1 Tbio Non-IDG -1.35527 24.8 90
TGF-beta receptor type-2 TGFBR2 Tchem Kinase -2.84120 665.1 548
Serine-threonine kinase receptor-associated protein STRAP Tbio Enzyme -1.35902 23.9 139
Serine/threonine-protein phosphatase PP1-beta catalytic subunit PPP1CB Tbio Enzyme -1.55192 33.3 377