Development Level

Tbio 18 | 11,445
Tchem 3 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, incomple... 3 | 499
hypoactivity 2 | 132
preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal eyelid morphology 1 | 7
abnormal head size 1 | 6
abnormal iris morphology 1 | 13
abnormal placement of pupils 1 | 6
abnormal retina morphology 1 | 71
abnormal retinal inner nuclear... 1 | 8
absent startle reflex 1 | 24
corneal opacity 1 | 32
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating calcium ... 1 | 36
decreased fasted circulating g... 1 | 65
decreased hemoglobin content 1 | 68
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased total retina thickne... 1 | 17
increased body weight 1 | 25
increased circulating glycerol... 1 | 9
increased heart weight 1 | 62
increased lymphocyte cell numb... 1 | 32
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
irregularly shaped pupil 1 | 7
limb grasping 1 | 41
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
thrombocytopenia 1 | 56

Disease

ovarian cancer 18 | 8,520
Carcinoma 16 | 11,493
Cancer 12 | 2,499
glioblastoma 11 | 5,792
lung cancer 9 | 4,740
medulloblastoma, large-cell 9 | 6,241
osteosarcoma 9 | 7,950
psoriasis 9 | 6,694
Breast cancer 8 | 3,578
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
atypical teratoid / rhabdoid tumor 7 | 5,112
ependymoma 7 | 4,679
Kidney cancer 6 | 2,613
Multiple myeloma 6 | 1,332
Pick disease 6 | 1,894
malignant mesothelioma 6 | 3,232
pituitary cancer 6 | 1,972
Astrocytoma, Pilocytic 5 | 3,081
astrocytic glioma 5 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
pancreatic cancer 5 | 2,398
subependymal giant cell astrocytoma 5 | 2,287
tuberculosis 5 | 2,010
Anemia 4 | 365
Craniofacial Abnormalities 4 | 151
Intellectual disability 4 | 1,016
Pulmonary Fibrosis 4 | 106
Ureteral obstruction 4 | 33
acute myeloid leukemia 4 | 783
acute quadriplegic myopathy 4 | 1,158
adult high grade glioma 4 | 3,801
astrocytoma 4 | 1,146
diabetes mellitus 4 | 1,728
group 3 medulloblastoma 4 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
invasive ductal carcinoma 4 | 2,951
non-small cell lung cancer 4 | 2,890
oligodendroglioma 4 | 2,850
primitive neuroectodermal tumor 4 | 3,035
progressive supranuclear palsy 4 | 676
ulcerative colitis 4 | 1,819
Arts syndrome 3 | 26
Congenital Camptodactyly 3 | 40
Dull intelligence 3 | 645
Epilepsy 3 | 792
Hypertensive disease 3 | 292
Liver Cirrhosis, Experimental 3 | 769
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Orbital separation excessive 3 | 244
Pneumonia 3 | 174
Poor school performance 3 | 645
Renal fibrosis 3 | 6
Rheumatoid arthritis 3 | 1,191
Seizures 3 | 596
colon cancer 3 | 1,478
dermatomyositis 3 | 966
group 4 medulloblastoma 3 | 1,855
juvenile dermatomyositis 3 | 1,187
lung adenocarcinoma 3 | 2,716
lung carcinoma 3 | 2,843
pediatric high grade glioma 3 | 1,064
spina bifida 3 | 1,074
Acquired scoliosis 2 | 281
Arachnodactyly 2 | 49
Autistic Disorder 2 | 364
Blepharoptosis 2 | 231
Brachydactyly 2 | 156
Breast Neoplasms 2 | 445
Colorectal Neoplasms 2 | 243
Concave bridge of nose 2 | 195
Curvature of spine 2 | 282
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Endometriosis 2 | 540
Enophthalmos 2 | 75
Failure to gain weight 2 | 365
Holoprosencephaly 2 | 56
Hypertension 2 | 396
Hypoplasia of the maxilla 2 | 66
Kidney disease 2 | 430
Liver disease 2 | 237
Mammary Neoplasms 2 | 425
Maxillary retrognathia 2 | 66
Microstomia 2 | 78
Osteoarthritis 2 | 184
Pediatric failure to thrive 2 | 365
Peripheral T-cell lymphoma 2 | 25
Primary cutaneous T-cell lymphoma 2 | 29
Strabismus 2 | 270
Sunken eyes 2 | 63
Umbilical hernia 2 | 93
Vascular disease 2 | 319
Waldenstrons macroglobulinemia 2 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
medulloblastoma 2 | 720
primary pancreatic ductal adenocarcinoma 2 | 1,109
sarcoidosis 2 | 370

Tissue

Blood and immune system 22 | 16,909
Cardiovascular System 22 | 15,192
Digestive Tract 22 | 17,369
Endocrine System 22 | 18,159
Female tissues 22 | 17,400
Liver and Pancreas 22 | 16,750
Male tissues 22 | 17,142
Nervous System 22 | 16,725
Respiratory system 22 | 16,393
Skin and soft tissues 22 | 17,230
Urinary Tract 22 | 16,678

Target Family

Non-IDG 8 | 12,091
Transcription Factor 7 | 1,400
Enzyme 6 | 4,145
Epigenetic 1 | 242

Reactome Pathway

Downregulation of SMAD2/3:SMAD... 22 | 22
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
E3 ubiquitin-protein ligase TRIM33 TRIM33 Tbio Epigenetic -3.10754 1197.2 297
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139
Mothers against decapentaplegic homolog 4 SMAD4 Tbio Transcription Factor -3.16129 1349.8 605
E3 ubiquitin-protein ligase Arkadia RNF111 Tbio Enzyme -1.40857 30.7 98
E3 ubiquitin-protein ligase NEDD4-like NEDD4L Tbio Enzyme -2.52486 353.9 144
Nuclear receptor corepressor 2 NCOR2 Tchem Transcription Factor -2.83392 645.1 189
Ubiquitin-conjugating enzyme E2 D3 UBE2D3 Tbio Non-IDG -1.33082 20.0 161