Development Level

Tbio 20 | 11,445
Tchem 5 | 1,598
Tclin 3 | 613

IMPC Phenotype

abnormal bone mineralization 1 | 38
abnormal embryo size 1 | 220
abnormal glucose homeostasis 1 | 4
abnormal pericardium morpholog... 1 | 26
abnormal snout morphology 1 | 23
decreased body weight 1 | 161
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating triglyce... 1 | 79
decreased leukocyte cell numbe... 1 | 73
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased grip strength 1 | 41
increased lean body mass 1 | 172
increased total body fat amoun... 1 | 134
male infertility 1 | 123
preweaning lethality, complete... 1 | 979
thrombocytosis 1 | 27

Disease

Carcinoma 19 | 11,493
osteosarcoma 15 | 7,950
ovarian cancer 15 | 8,520
Cancer 14 | 2,499
lung cancer 14 | 4,740
glioblastoma 13 | 5,792
Breast cancer 12 | 3,578
medulloblastoma, large-cell 12 | 6,241
psoriasis 11 | 6,694
atypical teratoid / rhabdoid tumor 10 | 5,112
ependymoma 10 | 4,679
interstitial cystitis 9 | 2,312
pancreatic cancer 9 | 2,398
Breast Neoplasms 8 | 445
Mammary Neoplasms 8 | 425
ulcerative colitis 8 | 1,819
Kidney cancer 7 | 2,613
adult high grade glioma 7 | 3,801
diabetes mellitus 7 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
lung adenocarcinoma 7 | 2,716
Astrocytoma, Pilocytic 6 | 3,081
Autosomal recessive predisposition 6 | 1,442
Bipolar Disorder 6 | 666
Rheumatoid arthritis 6 | 1,191
Schizophrenia 6 | 1,160
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
pituitary cancer 6 | 1,972
Major Depressive Disorder 5 | 301
Neoplasm Metastasis 5 | 168
Unipolar Depression 5 | 250
group 3 medulloblastoma 5 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
malignant mesothelioma 5 | 3,232
nasopharyngeal carcinoma 5 | 1,058
primary pancreatic ductal adenocarcinoma 5 | 1,109
primitive neuroectodermal tumor 5 | 3,035
spina bifida 5 | 1,074
subependymal giant cell astrocytoma 5 | 2,287
Disease Progression 4 | 136
Gallbladder Neoplasms 4 | 10
HER2-positive carcinoma of breast 4 | 21
Lung Neoplasms 4 | 232
Multiple myeloma 4 | 1,332
Prostatic Neoplasms 4 | 495
acute myeloid leukemia 4 | 783
astrocytic glioma 4 | 2,597
colon cancer 4 | 1,478
cutaneous lupus erythematosus 4 | 1,057
cystic fibrosis 4 | 1,696
fibroadenoma 4 | 559
gallbladder neoplasm 4 | 10
group 4 medulloblastoma 4 | 1,855
invasive ductal carcinoma 4 | 2,951
lung carcinoma 4 | 2,843
non primary Sjogren syndrome sicca 4 | 891
oligodendroglioma 4 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Adenocarcinoma 3 | 122
Adenoma 3 | 167
Arthritis, Juvenile 3 | 126
Endometriosis 3 | 540
Epilepsy 3 | 792
Juvenile arthritis 3 | 126
Liver Cirrhosis, Experimental 3 | 769
Liver cancer 3 | 604
Melanoma 3 | 711
Neoplasm Invasiveness 3 | 161
Neurodegenerative disease 3 | 414
Non-small cell lung cancer, positive for epidermal growth factor receptor expression 3 | 4
Ovarian Neoplasms 3 | 102
Polycystic ovary syndrome 3 | 360
Seizures 3 | 596
Skin cancer 3 | 469
Stomach Neoplasms 3 | 300
Vascular disease 3 | 319
adrenocortical carcinoma 3 | 1,428
astrocytoma 3 | 1,146
breast carcinoma 3 | 1,638
ductal carcinoma in situ 3 | 1,745
gastric cancer 3 | 459
hepatocellular carcinoma 3 | 547
mucosa-associated lymphoid tissue lymphoma 3 | 484
non-small cell lung cancer 3 | 2,890
ovarian neoplasm 3 | 99
pancreatic carcinoma 3 | 562
progressive supranuclear palsy 3 | 676
tuberculosis 3 | 2,010
Alzheimer's disease 2 | 658
Atopic dermatitis 2 | 952
Dermatitis 2 | 157
Dermatitis, Contact 2 | 71
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Down syndrome 2 | 499
Failure to gain weight 2 | 365
Kidney disease 2 | 430
Pediatric failure to thrive 2 | 365
Waldenstrons macroglobulinemia 2 | 765
pediatric high grade glioma 2 | 1,064

Tissue

Blood and immune system 28 | 16,909
Digestive Tract 28 | 17,369
Endocrine System 28 | 18,159
Female tissues 28 | 17,400
Liver and Pancreas 28 | 16,750
Male tissues 28 | 17,142
Nervous System 28 | 16,725
Respiratory system 28 | 16,393
Skin and soft tissues 28 | 17,230
Urinary Tract 28 | 16,678
Cardiovascular System 27 | 15,192

Target Family

Non-IDG 16 | 12,091
Kinase 7 | 634
Enzyme 5 | 4,145

Reactome Pathway

Downregulation of ERBB2 signal... 28 | 28
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pro-neuregulin-4, membrane-bound isoform NRG4 Tbio Non-IDG -1.33564 24.6 137
Tyrosine-protein phosphatase non-receptor type 18 PTPN18 Tbio Enzyme -0.77241 5.46 77
Megakaryocyte-associated tyrosine-protein kinase MATK Tbio Kinase -2.98596 792.3 265
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Receptor tyrosine-protein kinase erbB-4 ERBB4 Tclin Kinase -2.78704 558.2 1072
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Pro-neuregulin-2, membrane-bound isoform NRG2 Tbio Non-IDG -1.46980 32.0 141
Hsp90 co-chaperone Cdc37 CDC37 Tbio Non-IDG -0.96438 12.8 409