Development Level

Tbio 51 | 11,445
Tclin 10 | 613
Tchem 6 | 1,598
Tdark 3 | 6,588

IMPC Phenotype

preweaning lethality, complete... 7 | 979
decreased fasted circulating g... 2 | 65
increased circulating total pr... 2 | 28
vertebral fusion 2 | 23
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal hair growth 1 | 10
abnormal kidney morphology 1 | 65
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating choleste... 1 | 93
decreased circulating total pr... 1 | 49
decreased large unstained cell... 1 | 11
decreased neutrophil cell numb... 1 | 42
decreased vertical activity 1 | 208
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased lymphocyte cell numb... 1 | 32
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

ovarian cancer 45 | 8,520
psoriasis 30 | 6,694
Carcinoma 29 | 11,493
Multiple myeloma 29 | 1,332
lung cancer 26 | 4,740
osteosarcoma 24 | 7,950
glioblastoma 20 | 5,792
HIV Infections 16 | 102
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
Cancer 12 | 2,499
Breast cancer 11 | 3,578
Waldenstrons macroglobulinemia 11 | 765
diabetes mellitus 11 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
dermatomyositis 10 | 966
ependymoma 10 | 4,679
medulloblastoma, large-cell 10 | 6,241
astrocytoma 9 | 1,146
atypical teratoid / rhabdoid tumor 9 | 5,112
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
malignant mesothelioma 9 | 3,232
pancreatic cancer 8 | 2,398
non-small cell lung cancer 7 | 2,890
Liver Cirrhosis, Experimental 6 | 769
Pick disease 6 | 1,894
group 3 medulloblastoma 6 | 4,104
interstitial cystitis 6 | 2,312
invasive ductal carcinoma 6 | 2,951
non primary Sjogren syndrome sicca 6 | 891
Anemia 5 | 365
Astrocytoma, Pilocytic 5 | 3,081
Autosomal recessive predisposition 5 | 1,442
Diarrhea 5 | 253
Epilepsy 5 | 792
Failure to gain weight 5 | 365
Intellectual disability 5 | 1,016
Mantle cell lymphoma 5 | 23
Muscle Weakness 5 | 170
Osteoporosis 5 | 363
Pediatric failure to thrive 5 | 365
adult high grade glioma 5 | 3,801
lung adenocarcinoma 5 | 2,716
lung carcinoma 5 | 2,843
oligodendroglioma 5 | 2,850
primitive neuroectodermal tumor 5 | 3,035
subependymal giant cell astrocytoma 5 | 2,287
tuberculosis 5 | 2,010
Congestive heart failure 4 | 113
Diabetes Mellitus, Non-Insulin-Dependent 4 | 145
Diabetes Mellitus, Type 2 4 | 142
Heart failure 4 | 162
Hypoglycemia 4 | 152
Kidney disease 4 | 430
Neuropathy 4 | 261
Rheumatoid arthritis 4 | 1,191
Seizures 4 | 596
Stevens-Johnson syndrome 4 | 92
astrocytic glioma 4 | 2,597
cystic fibrosis 4 | 1,696
juvenile dermatomyositis 4 | 1,187
maturity-onset diabetes of the young 4 | 32
primary Sjogren syndrome 4 | 735
progressive supranuclear palsy 4 | 676
ulcerative colitis 4 | 1,819
Acquired metabolic disease 3 | 336
Alzheimer's disease 3 | 658
Arthrogryposis 3 | 54
Asthma 3 | 385
Dehydration 3 | 40
Dull intelligence 3 | 645
Fatty liver disease 3 | 103
Hyperglycemia 3 | 137
Hypothyroidism 3 | 122
Kidney cancer 3 | 2,613
Liver Cirrhosis 3 | 181
Long philtrum 3 | 137
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Myopathy 3 | 185
Neurodegenerative disease 3 | 414
Neurogenic Muscular Atrophy 3 | 139
Neurogenic muscle atrophy, especially in the lower limbs 3 | 139
Obesity 3 | 678
Pain 3 | 103
Peripheral Neuropathy 3 | 134
Poor school performance 3 | 645
Short nose 3 | 132
Skeletal muscle atrophy 3 | 139
Small nose 3 | 132
Type 2 diabetes mellitus 3 | 272
Vascular disease 3 | 319
Vomiting 3 | 116
Weight decreased 3 | 103
acute myeloid leukemia 3 | 783
cutaneous lupus erythematosus 3 | 1,057
esophageal adenocarcinoma 3 | 737
muscle degeneration 3 | 139
primary pancreatic ductal adenocarcinoma 3 | 1,109

Tissue

Endocrine System 69 | 18,159
Urinary Tract 68 | 16,678
Blood and immune system 67 | 16,909
Digestive Tract 67 | 17,369
Skin and soft tissues 67 | 17,230
Female tissues 66 | 17,400
Male tissues 66 | 17,142
Nervous System 66 | 16,725
Respiratory system 66 | 16,393
Liver and Pancreas 65 | 16,750
Cardiovascular System 64 | 15,192

Target Family

Enzyme 43 | 4,145
Non-IDG 21 | 12,091
GPCR 3 | 408
Ion Channel 2 | 344
Kinase 1 | 634

Reactome Pathway

Disorders of transmembrane tra... 70 | 70
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Derlin-3 DERL3 Tbio Non-IDG -1.46252 25.1 60
Derlin-1 DERL1 Tbio Non-IDG -1.88253 69.7 178
Serum albumin ALB Tchem Non-IDG -5.01233 98804.9 2101
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Proteasome activator complex subunit 4 PSME4 Tdark Non-IDG -1.60128 39.3 43
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139