Development Level

Tbio 238 | 11,445
Tchem 71 | 1,598
Tclin 50 | 613
Tdark 8 | 6,588

Collection

Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 37 | 979
embryonic lethality prior to t... 10 | 278
decreased body weight 8 | 161
preweaning lethality, incomple... 8 | 499
abnormal embryo size 7 | 220
decreased total body fat amoun... 7 | 207
abnormal bone structure 6 | 187
decreased bone mineral content 6 | 151
enlarged heart 6 | 210
increased startle reflex 6 | 112
increased total body fat amoun... 6 | 134
cataract 5 | 92
decreased lean body mass 5 | 135
increased circulating choleste... 5 | 66
abnormal behavior 4 | 298
abnormal heart morphology 4 | 162
abnormal lens morphology 4 | 81
abnormal retinal vasculature m... 4 | 27
decreased bone mineral density 4 | 126
decreased vertical activity 4 | 208
embryonic lethality prior to o... 4 | 239
increased circulating HDL chol... 4 | 80
increased circulating alkaline... 4 | 122
increased mean corpuscular hem... 4 | 96
short tibia 4 | 97
abnormal retina morphology 3 | 71
abnormal retinal blood vessel ... 3 | 26
abnormal seminal vesicle morph... 3 | 114
decreased circulating LDL chol... 3 | 38
decreased circulating choleste... 3 | 93
decreased prepulse inhibition 3 | 82
hemorrhage 3 | 23
hypoactivity 3 | 132
increased hemoglobin content 3 | 45
male infertility 3 | 123
thrombocytopenia 3 | 56
abnormal bone mineralization 2 | 38
abnormal epididymis morphology 2 | 42
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal hair growth 2 | 10
abnormal head morphology 2 | 10
abnormal tail morphology 2 | 25
cardiovascular system phenotyp... 2 | 36
decreased blood urea nitrogen ... 2 | 51
decreased body length 2 | 101
decreased caudal vertebrae num... 2 | 53
decreased circulating creatini... 2 | 39
decreased circulating total pr... 2 | 49
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
decreased heart left ventricle... 2 | 28
decreased neutrophil cell numb... 2 | 42
enlarged lymph nodes 2 | 37
impaired pupillary reflex 2 | 26
impaired righting response 2 | 26
increased circulating LDL chol... 2 | 13
increased circulating total pr... 2 | 28
increased grip strength 2 | 41
increased lean body mass 2 | 172
increased leukocyte cell numbe... 2 | 47
increased lymphocyte cell numb... 2 | 32
increased mean corpuscular vol... 2 | 92
increased neutrophil cell numb... 2 | 46
limb grasping 2 | 41
pale yolk sac 2 | 25
pallor 2 | 34
prenatal lethality prior to he... 2 | 87
unresponsive to tactile stimul... 2 | 8
vertebral fusion 2 | 23
abnormal behavioral response t... 1 | 66
abnormal body wall morphology 1 | 9
abnormal cornea morphology 1 | 31
abnormal embryo turning 1 | 31
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal vertebrae morphology 1 | 18
abnormal whole-body plethysmog... 1 | 4
absent pinna reflex 1 | 23
decreased T cell number 1 | 15
decreased circulating amylase ... 1 | 28
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased mean corpuscular hem... 1 | 31
enlarged spleen 1 | 41
hydrometra 1 | 53
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
iris synechia 1 | 3
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24

Disease

Carcinoma 259 | 11,493
ovarian cancer 219 | 8,520
osteosarcoma 197 | 7,950
Cancer 179 | 2,499
psoriasis 156 | 6,694
lung cancer 148 | 4,740
glioblastoma 146 | 5,792
medulloblastoma, large-cell 130 | 6,241
atypical teratoid / rhabdoid tumor 121 | 5,112
Breast cancer 109 | 3,578
ependymoma 108 | 4,679
Kidney cancer 93 | 2,613
malignant mesothelioma 89 | 3,232
group 3 medulloblastoma 88 | 4,104
adult high grade glioma 80 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 79 | 3,291
Multiple myeloma 77 | 1,332
invasive ductal carcinoma 73 | 2,951
Astrocytoma, Pilocytic 71 | 3,081
oligodendroglioma 69 | 2,850
astrocytic glioma 66 | 2,597
interstitial cystitis 66 | 2,312
lung adenocarcinoma 66 | 2,716
pancreatic cancer 66 | 2,398
subependymal giant cell astrocytoma 65 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 64 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 61 | 2,989
non-small cell lung cancer 61 | 2,890
primitive neuroectodermal tumor 60 | 3,035
diabetes mellitus 59 | 1,728
Schizophrenia 56 | 1,160
lung carcinoma 55 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 53 | 1,962
tuberculosis 53 | 2,010
astrocytoma 49 | 1,146
ulcerative colitis 48 | 1,819
Mammary Neoplasms 46 | 425
breast carcinoma 46 | 1,638
pituitary cancer 46 | 1,972
Breast Neoplasms 45 | 445
Pick disease 45 | 1,894
Rheumatoid arthritis 44 | 1,191
ductal carcinoma in situ 44 | 1,745
juvenile dermatomyositis 42 | 1,187
Autosomal recessive predisposition 41 | 1,442
group 4 medulloblastoma 41 | 1,855
cystic fibrosis 38 | 1,696
Intellectual disability 37 | 1,016
Liver Cirrhosis, Experimental 34 | 769
Lung Neoplasms 34 | 232
Prostatic Neoplasms 33 | 495
dermatomyositis 33 | 966
Bipolar Disorder 32 | 666
Orbital separation excessive 32 | 244
Osteoporosis 32 | 363
Stomach Neoplasms 32 | 300
pediatric high grade glioma 32 | 1,064
Epilepsy 31 | 792
Short stature 31 | 531
acute quadriplegic myopathy 31 | 1,158
Alzheimer's disease 30 | 658
Seizures 30 | 596
adrenocortical carcinoma 30 | 1,428
primary pancreatic ductal adenocarcinoma 30 | 1,109
Depressive disorder 29 | 409
Obesity 29 | 678
Liver carcinoma 28 | 240
Strabismus 28 | 270
Vascular disease 28 | 319
Carcinoma, Hepatocellular 27 | 228
Dull intelligence 27 | 645
Low intelligence 27 | 645
Mental Retardation 27 | 645
Mental deficiency 27 | 645
Poor school performance 27 | 645
Waldenstrons macroglobulinemia 27 | 765
gastric carcinoma 27 | 807
Cognitive delay 26 | 608
Global developmental delay 26 | 608
Mental and motor retardation 26 | 608
cutaneous lupus erythematosus 26 | 1,057
Acquired scoliosis 25 | 281
Byzanthine arch palate 25 | 194
Cleft Palate 25 | 271
Curvature of spine 25 | 282
Hypoplastic mandible condyle 25 | 275
Mandibular hypoplasia 25 | 275
Micrognathism 25 | 275
colon cancer 25 | 1,478
Blepharoptosis 24 | 231
Downward slant of palpebral fissure 24 | 158
Muscle hypotonia 24 | 571
Renal Cell Carcinoma 23 | 214
Carcinoma, Squamous Cell 22 | 110
Cryptorchidism 22 | 296
Melanoma 22 | 711
Small head 22 | 374
acute myeloid leukemia 22 | 783
non primary Sjogren syndrome sicca 21 | 891
spina bifida 21 | 1,074

Tissue

Endocrine System 361 | 18,159
Digestive Tract 360 | 17,369
Male tissues 358 | 17,142
Female tissues 357 | 17,400
Skin and soft tissues 357 | 17,230
Urinary Tract 355 | 16,678
Blood and immune system 354 | 16,909
Liver and Pancreas 354 | 16,750
Nervous System 354 | 16,725
Respiratory system 353 | 16,393
Cardiovascular System 341 | 15,192

Target Family

Non-IDG 159 | 12,091
Enzyme 112 | 4,145
Kinase 45 | 634
Transcription Factor 22 | 1,400
Epigenetic 18 | 242
GPCR 7 | 408
Nuclear Receptor 3 | 48
Ion Channel 1 | 344

Reactome Pathway

Diseases of signal transductio... 367 | 367
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Connector enhancer of kinase suppressor of ras 2 CNKSR2 Tbio Enzyme -1.11551 14.5 71
Histone deacetylase 9 HDAC9 Tclin Epigenetic -2.27309 185.2 431
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.49730 299.8 149
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Staphylococcal nuclease domain-containing protein 1 SND1 Tbio Epigenetic -2.35812 225.9 175
Ras/Rap GTPase-activating protein SynGAP SYNGAP1 Tbio Enzyme -1.91757 81.2 178
Ras GTPase-activating protein nGAP RASAL2 Tbio Enzyme -1.51440 33.0 99
Hairy/enhancer-of-split related with YRPW motif protein 1 HEY1 Tbio Transcription Factor -2.28398 163.4 335
Rapamycin-insensitive companion of mTOR RICTOR Tbio Non-IDG -2.79454 597.0 440