Development Level

Tbio 36 | 11,445
Tclin 4 | 613
Tchem 2 | 1,598
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 3 | 979
increased total body fat amoun... 2 | 134
preweaning lethality, incomple... 2 | 499
abnormal craniofacial morpholo... 1 | 33
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal lung morphology 1 | 26
abnormal retina morphology 1 | 71
abnormal vibrissa morphology 1 | 25
anophthalmia 1 | 33
cataract 1 | 92
decreased body weight 1 | 161
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased fasted circulating g... 1 | 65
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
hypoactivity 1 | 132
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased fasted circulating g... 1 | 76
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
small kidney 1 | 16

Disease

Carcinoma 27 | 11,493
ovarian cancer 23 | 8,520
Autosomal recessive predisposition 20 | 1,442
osteosarcoma 20 | 7,950
lung cancer 18 | 4,740
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
Epilepsy 13 | 792
psoriasis 13 | 6,694
Failure to gain weight 12 | 365
Pediatric failure to thrive 12 | 365
Seizures 12 | 596
glioblastoma 12 | 5,792
lung adenocarcinoma 11 | 2,716
Anemia 10 | 365
Vitamin B12 deficiency 10 | 20
atypical teratoid / rhabdoid tumor 10 | 5,112
medulloblastoma, large-cell 10 | 6,241
Methylmalonic acidemia 9 | 37
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
non-small cell lung cancer 9 | 2,890
Cancer 8 | 2,499
Cognitive delay 8 | 608
Dull intelligence 8 | 645
Global developmental delay 8 | 608
Intellectual disability 8 | 1,016
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental and motor retardation 8 | 608
Mental deficiency 8 | 645
Poor school performance 8 | 645
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
Anemia, Megaloblastic 7 | 16
Kidney cancer 7 | 2,613
Lethargy 7 | 77
interstitial cystitis 7 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
lung carcinoma 7 | 2,843
malignant mesothelioma 7 | 3,232
Cerebral atrophy 6 | 178
Homocystinuria 6 | 21
Multiple myeloma 6 | 1,332
Muscle hypotonia 6 | 571
Pulmonary alveolar proteinosis 6 | 15
adult high grade glioma 6 | 3,801
colon cancer 6 | 1,478
pituitary cancer 6 | 1,972
Adenoma 5 | 167
Breast cancer 5 | 3,578
Cardiomyopathies 5 | 110
Congenital adrenal hyperplasia 5 | 73
Decreased platelet count 5 | 111
Glycogen storage disease 5 | 39
Hypoglycemia 5 | 152
Infantile onset 5 | 238
Methylmalonic aciduria 5 | 9
Pneumonia 5 | 174
Schizophrenia 5 | 1,160
Thrombocytopenia 5 | 197
Vomiting 5 | 116
astrocytoma 5 | 1,146
group 3 medulloblastoma 5 | 4,104
tuberculosis 5 | 2,010
ulcerative colitis 5 | 1,819
Astrocytoma, Pilocytic 4 | 3,081
Bipolar Disorder 4 | 666
Cleft Lip 4 | 141
Comatose 4 | 56
Congenital adrenal insufficiency 4 | 7
Decreased methionine synthase activity 4 | 4
Decreased methylcobalamin 4 | 4
Degenerative brain disorder 4 | 100
Dehydration 4 | 40
Dystonia 4 | 164
Dystonic disease 4 | 106
Feeding difficulties in infancy 4 | 175
Gait abnormality 4 | 135
Hepatomegaly 4 | 285
Hyperhomocysteinemia 4 | 37
Hyperhomocystinemia 4 | 6
Hypomethioninemia 4 | 4
Lung disease 4 | 142
Megaloblastic anemia 4 | 18
Metabolic acidosis 4 | 90
Neutrophil count decreased 4 | 47
Osteoporosis 4 | 363
Propionic acidemia 4 | 16
Proteinuria 4 | 144
Supratentorial atrophy 4 | 94
Tachypnea 4 | 20
adrenocortical carcinoma 4 | 1,428
breast carcinoma 4 | 1,638
invasive ductal carcinoma 4 | 2,951
pancreatic cancer 4 | 2,398
Endometrial cancer 3 | 311
Male infertility 3 | 206
Polycystic ovary syndrome 3 | 360
Waldenstrons macroglobulinemia 3 | 765
active Crohn's disease 3 | 922
progressive supranuclear palsy 3 | 676
subependymal giant cell astrocytoma 3 | 2,287

Tissue

Digestive Tract 43 | 17,369
Endocrine System 43 | 18,159
Female tissues 42 | 17,400
Blood and immune system 41 | 16,909
Male tissues 41 | 17,142
Skin and soft tissues 41 | 17,230
Liver and Pancreas 40 | 16,750
Respiratory system 40 | 16,393
Urinary Tract 40 | 16,678
Nervous System 39 | 16,725
Cardiovascular System 36 | 15,192

Target Family

Non-IDG 25 | 12,091
Enzyme 17 | 4,145
GPCR 1 | 408
Transcription Factor 1 | 1,400

Reactome Pathway

Diseases of metabolism 44 | 44
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adrenocorticotropic hormone receptor MC2R Tclin GPCR -2.22640 172.4 223
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial MCCC1 Tbio Enzyme -1.91194 82.4 102
Methylmalonic aciduria and homocystinuria type C protein MMACHC Tbio Non-IDG -1.83573 76.5 233
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 Tbio Enzyme -1.24396 15.5 189
Methionine synthase MTR Tbio Enzyme -2.56900 300.2 87
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Methylmalonic aciduria type A protein, mitochondrial MMAA Tbio Non-IDG -2.22747 160.8 90
Ferredoxin-2, mitochondrial FDX2 Tdark Non-IDG -0.85150 6.83 4
Pulmonary surfactant-associated protein A1 SFTPA1 Tbio Non-IDG -2.05283 109.3 228