Development Level

Tbio 35 | 10,625
Tclin 4 | 602
Tchem 3 | 1,890
Tdark 3 | 7,003

IMPC Term

preweaning lethality, complete... 2 | 633
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal heart left ventricle ... 1 | 20
abnormal jejunum morphology 1 | 1
abnormal lens morphology 1 | 73
abnormal lung morphology 1 | 15
abnormal retina morphology 1 | 100
abnormal skin appearance 1 | 8
abnormal testis morphology 1 | 30
abnormal vibrissa morphology 1 | 17
anophthalmia 1 | 20
craniofacial phenotype 1 | 9
decreased circulating alkaline... 1 | 41
decreased circulating calcium ... 1 | 33
decreased circulating glucose ... 1 | 121
decreased circulating glycerol... 1 | 19
decreased lean body mass 1 | 195
embryonic lethality prior to t... 1 | 187
enlarged lymph nodes 1 | 27
hydrops fetalis 1 | 22
increased circulating calcium ... 1 | 32
increased circulating chloride... 1 | 43
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 20
increased mean corpuscular hem... 1 | 93
microphthalmia 1 | 15
polycystic kidney 1 | 9
prenatal lethality prior to he... 1 | 64
small kidney 1 | 10

Disease

ovarian cancer 23 | 8,484
osteosarcoma 20 | 7,933
lung cancer 19 | 4,466
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,795
psoriasis 13 | 6,685
glioblastoma 12 | 5,572
lung adenocarcinoma 11 | 2,713
medulloblastoma, large-cell 11 | 6,234
Vitamin B12 deficiency 10 | 20
Methylmalonic acidemia 9 | 39
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,956
non-small cell lung cancer 9 | 2,798
Cancer 8 | 2,346
interstitial cystitis 8 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
malignant mesothelioma 8 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,289
lung carcinoma 7 | 2,844
pituitary cancer 7 | 1,972
Homocystinuria 6 | 23
Multiple myeloma 6 | 1,327
astrocytoma 6 | 1,493
atypical teratoid / rhabdoid tumor 6 | 4,369
colon cancer 6 | 1,475
Adenoma 5 | 165
Anemia 5 | 252
Congenital adrenal hyperplasia 5 | 74
Pulmonary alveolar proteinosis 5 | 13
adult high grade glioma 5 | 2,148
ulcerative colitis 5 | 2,087
Breast cancer 4 | 3,094
Carcinoma 4 | 2,147
Congenital adrenal insufficiency 4 | 7
Hyperhomocysteinemia 4 | 34
Pneumonia 4 | 133
Propionic acidemia 4 | 20
adrenocortical carcinoma 4 | 1,427
atypical teratoid/rhabdoid tumor 4 | 1,095
breast carcinoma 4 | 1,614
group 4 medulloblastoma 4 | 1,875
invasive ductal carcinoma 4 | 2,950
pancreatic cancer 4 | 2,300
pilocytic astrocytoma 4 | 3,086
Adverse reaction to drug 3 | 54
Cleft Lip 3 | 91
Cushing's syndrome 3 | 47
Epilepsy 3 | 346
Glycogen storage disease 3 | 37
Hypoglycemia 3 | 81
Idiopathic pulmonary fibrosis 3 | 21
Lafora disease 3 | 9
Lung disease 3 | 132
Megaloblastic anemia 3 | 16
Myopathy 3 | 128
Obesity 3 | 616
Polycystic Ovary Syndrome 3 | 332
Proteinuria 3 | 63
Respiratory failure 3 | 30
Surfactant Metabolism Dysfunction, Pulmonary, 1 3 | 3
Waldenstrons macroglobulinemia 3 | 765
active Crohn's disease 3 | 918
cutaneous lupus erythematosus 3 | 1,056
diabetes mellitus 3 | 1,663
interstitial lung disease 3 | 291
non primary Sjogren syndrome sicca 3 | 840
posterior fossa group A ependymoma 3 | 1,511
posterior fossa group B ependymoma 3 | 1,530
primary pancreatic ductal adenocarcinoma 3 | 1,271
primitive neuroectodermal tumor 3 | 3,031
progressive supranuclear palsy 3 | 674
spina bifida 3 | 1,064
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis 3 | 1,557
3-Methylcrotonyl-CoA carboxylase deficiency 2 | 11
Alzheimer's disease 2 | 644
Autistic Disorder 2 | 320
Cholangiocarcinoma 2 | 32
Chronic obstructive pulmonary disease 2 | 146
Colorectal Neoplasms 2 | 217
Disease of metabolism 2 | 15
Down syndrome 2 | 548
Gastrointestinal Diseases 2 | 12
Hyperandrogenism 2 | 32
Hypersensitivity reaction type II disease 2 | 235
Hypertensive disease 2 | 193
Infertility 2 | 163
Kidney disease 2 | 396
Leukoencephalopathies 2 | 7
Liver carcinoma 2 | 217
Lung Neoplasms 2 | 171
Male infertility 2 | 170
Myocardial Ischemia 2 | 169
Neural tube defect, folate-sensitive 2 | 4
Neurodegenerative disease 2 | 383
Neuropathy 2 | 210
Seizures 2 | 95
West Syndrome 2 | 23
acute quadriplegic myopathy 2 | 1,157
dermatomyositis 2 | 933
esophageal adenocarcinoma 2 | 737

Tissue

Cardiovascular System 45 | 17,958
Digestive Tract 45 | 18,473
Endocrine System 45 | 18,512
Female tissues 45 | 18,647
Male tissues 45 | 17,969
Nervous System 45 | 18,561
Urinary Tract 45 | 18,444
Blood and immune system 44 | 17,995
Liver and Pancreas 44 | 18,136
Respiratory system 44 | 17,484
Skin and soft tissues 43 | 18,115

Target Family

Non-IDG 25 | 11,971
Enzyme 18 | 4,146
GPCR 1 | 406
Transcription Factor 1 | 1,400

Reactome Pathway

Diseases of metabolism 45 | 45
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein phosphatase 1 regulatory subunit 3C PPP1R3C Tbio Enzyme -2.41843 288.0 78
Pulmonary surfactant-associated protein A2 SFTPA2 Tbio Non-IDG -2.31137 207.3 90
Pulmonary surfactant-associated protein A1 SFTPA1 Tbio Non-IDG -2.01123 102.6 195
Glycogenin-2 GYG2 Tbio Enzyme -1.91838 86.9 114
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Methylmalonyl-CoA mutase, mitochondrial MUT Tbio Enzyme -2.48654 293.0 56
Pulmonary surfactant-associated protein D SFTPD Tbio Non-IDG -2.76722 653.0 266
Glycogen [starch] synthase, muscle GYS1 Tchem Enzyme -2.17524 150.6 211
Ferredoxin-2, mitochondrial FDX2 Tdark Non-IDG -0.73450 5.89 3