Development Level

Tbio 69 | 10,625
Tchem 9 | 1,890
Tdark 8 | 7,003

IMPC Term

enlarged heart 3 | 111
preweaning lethality, complete... 3 | 633
abnormal heart morphology 2 | 51
decreased circulating glucose ... 2 | 121
decreased circulating insulin ... 2 | 75
increased mean corpuscular vol... 2 | 91
preweaning lethality, incomple... 2 | 260
abnormal QRS complex 1 | 25
abnormal behavior 1 | 226
abnormal coat/hair pigmentatio... 1 | 54
abnormal lens morphology 1 | 73
abnormal liver morphology 1 | 5
abnormal lung morphology 1 | 15
abnormal lymph node morphology 1 | 3
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal seminal vesicle morph... 1 | 47
abnormal tail morphology 1 | 17
cataract 1 | 26
decreased CD11b-low dendritic ... 1 | 3
decreased CD4-positive, CD25-p... 1 | 24
decreased T cell number 1 | 31
decreased body length 1 | 108
decreased circulating HDL chol... 1 | 77
decreased circulating alanine ... 1 | 53
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating phosphat... 1 | 15
decreased circulating serum al... 1 | 79
decreased circulating triglyce... 1 | 83
decreased leukocyte cell numbe... 1 | 54
decreased prepulse inhibition 1 | 52
decreased total body fat amoun... 1 | 186
enlarged kidney 1 | 7
herniated abdominal wall 1 | 4
improved glucose tolerance 1 | 56
increased CD11b-high dendritic... 1 | 5
increased bone mineral content 1 | 92
increased circulating bilirubi... 1 | 16
increased exploration in new e... 1 | 56
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased or absent threshold ... 1 | 128
mydriasis 1 | 9
short tibia 1 | 82
small adrenal glands 1 | 15
small kidney 1 | 10

Disease

psoriasis 43 | 6,685
ovarian cancer 40 | 8,484
osteosarcoma 37 | 7,933
Carcinoma 33 | 2,147
intraductal papillary-mucinous adenoma (IPMA) 31 | 2,956
lung cancer 31 | 4,466
glioblastoma 30 | 5,572
intraductal papillary-mucinous neoplasm (IPMN) 29 | 3,289
lung adenocarcinoma 29 | 2,713
medulloblastoma, large-cell 29 | 6,234
invasive ductal carcinoma 28 | 2,950
pancreatic cancer 27 | 2,300
Breast cancer 26 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 26 | 2,988
lung carcinoma 24 | 2,844
non-small cell lung cancer 24 | 2,798
interstitial cystitis 23 | 2,299
atypical teratoid / rhabdoid tumor 22 | 4,369
pituitary cancer 22 | 1,972
Cancer 21 | 2,346
cystic fibrosis 21 | 1,665
pilocytic astrocytoma 21 | 3,086
sonic hedgehog group medulloblastoma 21 | 1,482
ductal carcinoma in situ 20 | 1,745
pediatric high grade glioma 20 | 2,712
malignant mesothelioma 19 | 3,162
adrenocortical carcinoma 18 | 1,427
primary pancreatic ductal adenocarcinoma 18 | 1,271
breast carcinoma 17 | 1,614
oligodendroglioma 16 | 2,849
ulcerative colitis 16 | 2,087
colon cancer 15 | 1,475
posterior fossa group A ependymoma 15 | 1,511
gastric carcinoma 14 | 832
group 4 medulloblastoma 13 | 1,875
primitive neuroectodermal tumor 13 | 3,031
astrocytic glioma 12 | 2,241
diabetes mellitus 12 | 1,663
group 3 medulloblastoma 12 | 2,254
nasopharyngeal carcinoma 12 | 1,056
adult high grade glioma 10 | 2,148
atypical teratoid/rhabdoid tumor 10 | 1,095
autosomal dominant Emery-Dreifuss muscular dystrophy 10 | 499
ependymoma 10 | 2,514
posterior fossa group B ependymoma 10 | 1,530
Atopic dermatitis 9 | 944
Duchenne muscular dystrophy 9 | 602
esophageal adenocarcinoma 9 | 737
Alzheimer's disease 8 | 644
Osteoarthritis 8 | 96
active Crohn's disease 8 | 918
active ulcerative colitis 8 | 477
fibroadenoma 8 | 557
juvenile dermatomyositis 8 | 1,189
subependymal giant cell astrocytoma 8 | 2,287
Acquired metabolic disease 7 | 267
Weill-Marchesani syndrome 7 | 14
adrenocortical adenoma 7 | 134
astrocytoma 7 | 1,493
cutaneous lupus erythematosus 7 | 1,056
inflammatory breast cancer 7 | 404
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
Degenerative disc disease 6 | 28
Down syndrome 6 | 548
Hydrolethalus syndrome 6 | 128
Kidney disease 6 | 396
Mammary Neoplasms 6 | 410
Obesity 6 | 616
Schizophrenia 6 | 501
interstitial lung disease 6 | 291
limb girdle muscular dystrophy 2A 6 | 156
tuberculosis 6 | 1,557
Adenoma 5 | 165
Arthritis 5 | 248
Cerebrovascular disease 5 | 231
Ehlers-Danlos syndrome 5 | 42
Endometriosis 5 | 535
Multiple Sclerosis 5 | 498
Myopia 5 | 99
Pick disease 5 | 1,893
Rheumatoid Arthritis 5 | 1,160
Simpson-Golabi-Behmel syndrome 5 | 17
aldosterone-producing adenoma 5 | 664
head and neck cancer and chronic obstructive pulmonary disease 5 | 237
non diabetic and post-ischemic heart failure 5 | 200
non primary Sjogren syndrome sicca 5 | 840
non-small cell lung carcinoma 5 | 413
spina bifida 5 | 1,064
urothelial carcinoma 5 | 318
Asthma 4 | 349
Atherosclerosis 4 | 275
Biliary papillomatosis 4 | 4
Chronic obstructive pulmonary disease 4 | 146
Craniofacial Abnormalities 4 | 147
Crohn's disease 4 | 304
Otitis media 4 | 32
Polycystic Ovary Syndrome 4 | 332
acute quadriplegic myopathy 4 | 1,157
cystic fibrosis and chronic rhinosinusitis 4 | 213
primary Sjogren syndrome 4 | 789

Tissue

Liver and Pancreas 84 | 18,136
Male tissues 84 | 17,969
Urinary Tract 84 | 18,444
Cardiovascular System 83 | 17,958
Digestive Tract 83 | 18,473
Blood and immune system 82 | 17,995
Endocrine System 82 | 18,512
Female tissues 82 | 18,647
Nervous System 82 | 18,561
Respiratory system 82 | 17,484
Skin and soft tissues 80 | 18,115

Target Family

Non-IDG 65 | 11,971
Enzyme 21 | 4,146

Reactome Pathway

Diseases of glycosylation 86 | 86
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Properdin CFP Tbio Non-IDG -3.16935 1491.5 297
Glypican-3 GPC3 Tbio Non-IDG -2.85848 794.8 523
Thrombospondin type-1 domain-containing protein 7A THSD7A Tbio Non-IDG -1.12816 15.9 11
A disintegrin and metalloproteinase with thrombospondin motifs 3 ADAMTS3 Tbio Enzyme -0.45918 3.20 40
A disintegrin and metalloproteinase with thrombospondin motifs 4 ADAMTS4 Tchem Enzyme -1.59386 46.6 337
Glypican-1 GPC1 Tbio Non-IDG -2.34418 224.6 160
Versican core protein VCAN Tbio Non-IDG -2.85549 756.2 159
Mucin-3B MUC3B Tdark Non-IDG -0.48407 3.54 0