Development Level

Tbio 71 | 11,651
Tchem 7 | 1,388
Tdark 7 | 6,593

IMPC Phenotype

decreased vertical activity 3 | 208
enlarged heart 3 | 210
preweaning lethality, complete... 3 | 979
preweaning lethality, incomple... 3 | 499
abnormal heart morphology 2 | 162
cataract 2 | 92
increased lean body mass 2 | 172
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal eye morphology 1 | 68
abnormal kidney morphology 1 | 65
abnormal liver morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal lymph node morphology 1 | 3
abnormal seminal vesicle morph... 1 | 114
abnormal tail morphology 1 | 25
abnormal vertebrae morphology 1 | 18
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased exploration in new e... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased total body fat amoun... 1 | 207
enlarged kidney 1 | 14
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased circulating bilirubi... 1 | 16
increased circulating triglyce... 1 | 42
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased total body fat amoun... 1 | 134
mydriasis 1 | 6
short tibia 1 | 97
small adrenal glands 1 | 16
small kidney 1 | 16

Disease

Carcinoma 73 | 11,493
psoriasis 43 | 6,694
Breast cancer 40 | 3,578
ovarian cancer 40 | 8,520
lung cancer 36 | 4,740
osteosarcoma 36 | 7,950
Kidney cancer 32 | 2,613
glioblastoma 32 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 31 | 2,955
pancreatic cancer 30 | 2,398
intraductal papillary-mucinous neoplasm (IPMN) 29 | 3,291
lung adenocarcinoma 29 | 2,716
invasive ductal carcinoma 28 | 2,951
medulloblastoma, large-cell 28 | 6,241
atypical teratoid / rhabdoid tumor 26 | 5,112
intraductal papillary-mucinous carcinoma (IPMC) 26 | 2,989
non-small cell lung cancer 25 | 2,890
ependymoma 24 | 4,679
lung carcinoma 24 | 2,843
cystic fibrosis 22 | 1,696
interstitial cystitis 22 | 2,312
pituitary cancer 22 | 1,972
Astrocytoma, Pilocytic 20 | 3,081
Cancer 20 | 2,499
ductal carcinoma in situ 20 | 1,745
group 3 medulloblastoma 20 | 4,104
malignant mesothelioma 20 | 3,232
adult high grade glioma 19 | 3,801
adrenocortical carcinoma 18 | 1,428
breast carcinoma 17 | 1,638
Liver cancer 16 | 604
colon cancer 15 | 1,478
oligodendroglioma 15 | 2,850
primary pancreatic ductal adenocarcinoma 15 | 1,109
ulcerative colitis 15 | 1,819
gastric carcinoma 14 | 807
astrocytic glioma 13 | 2,597
primitive neuroectodermal tumor 13 | 3,035
Melanoma 12 | 711
diabetes mellitus 12 | 1,728
nasopharyngeal carcinoma 12 | 1,058
group 4 medulloblastoma 11 | 1,855
sonic hedgehog group medulloblastoma 11 | 467
Skin cancer 10 | 469
active ulcerative colitis 10 | 764
autosomal dominant Emery-Dreifuss muscular dystrophy 10 | 510
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
pediatric high grade glioma 10 | 1,064
Atopic dermatitis 9 | 952
Duchenne muscular dystrophy 9 | 601
Large intestine cancer 9 | 126
Myopia 9 | 176
Schizophrenia 9 | 1,160
esophageal adenocarcinoma 9 | 737
Acquired metabolic disease 8 | 336
Autosomal recessive predisposition 8 | 1,442
active Crohn's disease 8 | 922
fibroadenoma 8 | 559
juvenile dermatomyositis 8 | 1,187
posterior fossa group A ependymoma 8 | 468
subependymal giant cell astrocytoma 8 | 2,287
Osteoarthritis 7 | 184
Short neck 7 | 140
Umbilical hernia 7 | 93
Weill-Marchesani syndrome 7 | 14
adrenocortical adenoma 7 | 131
astrocytoma 7 | 1,146
cutaneous lupus erythematosus 7 | 1,057
interstitial lung disease 7 | 298
Acquired scoliosis 6 | 281
Alzheimer's disease 6 | 658
Breast Neoplasms 6 | 445
Congenital Epicanthus 6 | 177
Crohn's disease 6 | 321
Cryptorchidism 6 | 296
Curvature of spine 6 | 282
Degenerative disc disease 6 | 35
Downward slant of palpebral fissure 6 | 158
Hernia, Inguinal 6 | 89
Hydrolethalus syndrome 6 | 128
Kidney disease 6 | 430
Mammary Neoplasms 6 | 425
Short stature 6 | 531
atypical teratoid/rhabdoid tumor 6 | 357
limb girdle muscular dystrophy 2A 6 | 213
Arthritis 5 | 290
Broad flat nasal bridge 5 | 236
Down syndrome 5 | 499
Endometriosis 5 | 540
Hepatomegaly 5 | 285
Hypoplastic mandible condyle 5 | 275
Immune system cancer 5 | 140
Lens Opacities 5 | 231
Nasal bridge wide 5 | 236
Pick disease 5 | 1,894
aldosterone-producing adenoma 5 | 665
non diabetic and post-ischemic heart failure 5 | 200
spina bifida 5 | 1,074
tuberculosis 5 | 2,010
urothelial carcinoma 5 | 318

Tissue

Digestive Tract 79 | 17,369
Female tissues 78 | 17,400
Skin and soft tissues 78 | 17,230
Endocrine System 77 | 18,159
Respiratory system 74 | 16,393
Urinary Tract 74 | 16,678
Blood and immune system 73 | 16,909
Liver and Pancreas 73 | 16,750
Male tissues 73 | 17,142
Nervous System 72 | 16,725
Cardiovascular System 65 | 15,192

Target Family

Non-IDG 64 | 12,091
Enzyme 21 | 4,145

Reactome Pathway

Diseases of glycosylation 85 | 85
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
A disintegrin and metalloproteinase with thrombospondin motifs 6 ADAMTS6 Tdark Enzyme -0.67364 4.37 40
Thrombospondin-1 THBS1 Tbio Non-IDG -3.06622 1281.6 504
A disintegrin and metalloproteinase with thrombospondin motifs 2 ADAMTS2 Tbio Enzyme -2.51717 1472.5 133
Syndecan-4 SDC4 Tbio Non-IDG -2.39649 274.8 297
Osteomodulin OMD Tbio Non-IDG -2.36749 234.5 121
Spondin-1 SPON1 Tbio Non-IDG 0.00000 112
Neurogenic locus notch homolog protein 3 NOTCH3 Tchem Non-IDG -2.67185 458.4 499
Thrombospondin type-1 domain-containing protein 4 THSD4 Tdark Non-IDG -0.62904 3.69 5
Glypican-6 GPC6 Tbio Non-IDG -1.33560 21.9 125
A disintegrin and metalloproteinase with thrombospondin motifs 7 ADAMTS7 Tbio Enzyme -1.43732 33.7 98