Development Level

Tbio 25 | 11,651

IMPC Phenotype

abnormal coat-hair pigmentatio... 1 | 64
abnormal tail morphology 1 | 25
cataract 1 | 92
decreased circulating serum al... 1 | 82
decreased exploration in new e... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased red blood cell distr... 1 | 41
increased circulating bilirubi... 1 | 16
increased circulating triglyce... 1 | 42
increased lean body mass 1 | 172
increased neutrophil cell numb... 1 | 46
mydriasis 1 | 6
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
small adrenal glands 1 | 16
small kidney 1 | 16

Disease

Carcinoma 21 | 11,493
psoriasis 21 | 6,694
ovarian cancer 16 | 8,520
glioblastoma 15 | 5,792
Breast cancer 13 | 3,578
invasive ductal carcinoma 13 | 2,951
osteosarcoma 13 | 7,950
atypical teratoid / rhabdoid tumor 12 | 5,112
ductal carcinoma in situ 12 | 1,745
ependymoma 12 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
lung cancer 12 | 4,740
Astrocytoma, Pilocytic 11 | 3,081
medulloblastoma, large-cell 11 | 6,241
pituitary cancer 11 | 1,972
lung carcinoma 10 | 2,843
pancreatic cancer 10 | 2,398
adrenocortical carcinoma 9 | 1,428
adult high grade glioma 9 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
sonic hedgehog group medulloblastoma 9 | 467
breast carcinoma 8 | 1,638
lung adenocarcinoma 8 | 2,716
malignant mesothelioma 8 | 3,232
non-small cell lung cancer 8 | 2,890
primitive neuroectodermal tumor 8 | 3,035
Cancer 7 | 2,499
Duchenne muscular dystrophy 7 | 601
cutaneous lupus erythematosus 7 | 1,057
diabetes mellitus 7 | 1,728
group 3 medulloblastoma 7 | 4,104
interstitial cystitis 7 | 2,312
oligodendroglioma 7 | 2,850
primary pancreatic ductal adenocarcinoma 7 | 1,109
Atopic dermatitis 6 | 952
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
colon cancer 6 | 1,478
cystic fibrosis 6 | 1,696
limb girdle muscular dystrophy 2A 6 | 213
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
ulcerative colitis 6 | 1,819
Kidney cancer 5 | 2,613
Myopia 5 | 176
Simpson-Golabi-Behmel syndrome 5 | 19
juvenile dermatomyositis 5 | 1,187
Atrial Septal Defects 4 | 85
Broad flat nasal bridge 4 | 236
Cryptorchidism 4 | 296
Nasal bridge wide 4 | 236
Pick disease 4 | 1,894
Short neck 4 | 140
Umbilical hernia 4 | 93
adrenocortical adenoma 4 | 131
aldosterone-producing adenoma 4 | 665
astrocytic glioma 4 | 2,597
astrocytoma 4 | 1,146
esophageal adenocarcinoma 4 | 737
gastric carcinoma 4 | 807
group 4 medulloblastoma 4 | 1,855
subependymal giant cell astrocytoma 4 | 2,287
Acquired scoliosis 3 | 281
Atherosclerosis 3 | 291
Autosomal recessive predisposition 3 | 1,442
Cleft Palate 3 | 271
Concave bridge of nose 3 | 195
Congenital Epicanthus 3 | 177
Congenital clubfoot 3 | 109
Congenital stromal corneal dystrophy 3 | 5
Craniofacial Abnormalities 3 | 151
Curvature of spine 3 | 282
Degenerative disc disease 3 | 35
Depressed nasal bridge 3 | 195
Depressed nasal root/bridge 3 | 195
Down syndrome 3 | 499
Ehlers-Danlos syndrome 3 | 43
Gaucher disease type 1 3 | 180
Hernia, Inguinal 3 | 89
Hypoplastic feet 3 | 66
Low-set, posteriorly rotated ears 3 | 110
Melanoma 3 | 711
Osteoarthritis 3 | 184
Schizophrenia 3 | 1,160
Short hands 3 | 50
Short nose 3 | 132
Small nose 3 | 132
Uranostaphyloschisis 3 | 167
Ventricular Septal Defects 3 | 119
X- linked recessive 3 | 110
fascioscapulohumeral muscular dystrophy 3 | 100
fibroadenoma 3 | 559
medulloblastoma 3 | 720
nasopharyngeal carcinoma 3 | 1,058
non primary Sjogren syndrome sicca 3 | 891
pediatric high grade glioma 3 | 1,064
posterior fossa group A ependymoma 3 | 468
primary Sjogren syndrome 3 | 735
spina bifida 3 | 1,074
tuberculosis 3 | 2,010
Conduction disorder of the heart 2 | 79

Tissue

Endocrine System 25 | 18,159
Nervous System 25 | 16,725
Blood and immune system 24 | 16,909
Digestive Tract 24 | 17,369
Female tissues 24 | 17,400
Liver and Pancreas 24 | 16,750
Male tissues 24 | 17,142
Respiratory system 24 | 16,393
Skin and soft tissues 24 | 17,230
Urinary Tract 24 | 16,678
Cardiovascular System 22 | 15,192

Target Family

Non-IDG 24 | 12,091
Enzyme 1 | 4,145

Reactome Pathway

Diseases associated with glyco... 25 | 25
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Syndecan-4 SDC4 Tbio Non-IDG -2.39649 274.8 297
Osteomodulin OMD Tbio Non-IDG -2.36749 234.5 121
Glypican-6 GPC6 Tbio Non-IDG -1.33560 21.9 125
Basement membrane-specific heparan sulfate proteoglycan core protein HSPG2 Tbio Enzyme -2.99264 1021.1 225
Lumican LUM Tbio Non-IDG -2.72477 535.8 237
Glypican-3 GPC3 Tbio Non-IDG -2.92699 862.1 768
Prolargin PRELP Tbio Non-IDG -1.55880 36.1 124
Glypican-1 GPC1 Tbio Non-IDG -2.38207 232.3 202
Neurocan core protein NCAN Tbio Non-IDG -2.19768 158.4 127
Glypican-4 GPC4 Tbio Non-IDG -1.59066 43.7 257