Development Level

Tbio 660 | 11,651
Tchem 118 | 1,388
Tclin 68 | 612
Tdark 33 | 6,593

Collection

Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Comple... 1 | 37
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 72 | 979
preweaning lethality, incomple... 20 | 499
embryonic lethality prior to t... 19 | 278
abnormal embryo size 14 | 220
embryonic lethality prior to o... 14 | 239
enlarged heart 13 | 210
abnormal heart morphology 11 | 162
decreased body weight 11 | 161
increased total body fat amoun... 11 | 134
decreased vertical activity 10 | 208
abnormal bone structure 9 | 187
hypoactivity 9 | 132
cataract 8 | 92
decreased bone mineral content 8 | 151
decreased total body fat amoun... 8 | 207
increased mean corpuscular hem... 8 | 96
abnormal retina morphology 7 | 71
decreased lean body mass 7 | 135
increased circulating alkaline... 7 | 122
increased startle reflex 7 | 112
abnormal behavior 6 | 298
decreased bone mineral density 6 | 126
increased circulating HDL chol... 6 | 80
increased lean body mass 6 | 172
short tibia 6 | 97
abnormal seminal vesicle morph... 5 | 114
decreased prepulse inhibition 5 | 82
increased circulating choleste... 5 | 66
increased leukocyte cell numbe... 5 | 47
increased mean corpuscular vol... 5 | 92
male infertility 5 | 123
abnormal epididymis morphology 4 | 42
abnormal eye morphology 4 | 68
abnormal lens morphology 4 | 81
abnormal retinal vasculature m... 4 | 27
abnormal skin morphology 4 | 50
abnormal vibrissa morphology 4 | 25
decreased caudal vertebrae num... 4 | 53
decreased circulating choleste... 4 | 93
decreased fasted circulating g... 4 | 65
hemorrhage 4 | 23
increased blood urea nitrogen ... 4 | 48
increased circulating total pr... 4 | 28
increased neutrophil cell numb... 4 | 46
prenatal lethality prior to he... 4 | 87
small superior vagus ganglion 4 | 74
abnormal body wall morphology 3 | 9
abnormal craniofacial morpholo... 3 | 33
abnormal gait 3 | 69
abnormal kidney morphology 3 | 65
abnormal lung morphology 3 | 26
abnormal retinal blood vessel ... 3 | 26
abnormal tail morphology 3 | 25
decreased body length 3 | 101
decreased circulating LDL chol... 3 | 38
decreased circulating creatini... 3 | 39
decreased circulating insulin ... 3 | 76
decreased leukocyte cell numbe... 3 | 73
decreased lymphocyte cell numb... 3 | 83
decreased mean corpuscular vol... 3 | 79
decreased neutrophil cell numb... 3 | 42
decreased startle reflex 3 | 75
edema 3 | 59
embryonic growth retardation 3 | 106
enlarged lymph nodes 3 | 37
hydrometra 3 | 53
impaired righting response 3 | 26
increased circulating LDL chol... 3 | 13
increased circulating free fat... 3 | 20
increased grip strength 3 | 41
increased hemoglobin content 3 | 45
increased lymphocyte cell numb... 3 | 32
increased or absent threshold ... 3 | 101
pallor 3 | 34
prolonged QT interval 3 | 38
thrombocytopenia 3 | 56
abnormal cornea morphology 2 | 31
abnormal head morphology 2 | 10
abnormal placenta size 2 | 20
absent startle reflex 2 | 24
anophthalmia 2 | 33
cardiovascular system phenotyp... 2 | 36
decreased circulating calcium ... 2 | 36
decreased circulating iron lev... 2 | 32
decreased circulating serum al... 2 | 82
decreased mean corpuscular hem... 2 | 31
enlarged spleen 2 | 41
hyperactivity 2 | 148
impaired glucose tolerance 2 | 75
impaired pupillary reflex 2 | 26
increased anti-nuclear antigen... 2 | 19
increased body weight 2 | 25
increased bone mineral content 2 | 108
increased circulating calcium ... 2 | 34
increased circulating phosphat... 2 | 26
increased circulating potassiu... 2 | 29
increased fasted circulating g... 2 | 76
increased monocyte cell number 2 | 63
pale yolk sac 2 | 25
small testis 2 | 58

Disease

Carcinoma 581 | 11,493
ovarian cancer 478 | 8,520
osteosarcoma 399 | 7,950
lung cancer 339 | 4,740
psoriasis 337 | 6,694
Cancer 316 | 2,499
glioblastoma 312 | 5,792
medulloblastoma, large-cell 287 | 6,241
atypical teratoid / rhabdoid tumor 254 | 5,112
Breast cancer 226 | 3,578
ependymoma 214 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 198 | 3,291
malignant mesothelioma 190 | 3,232
group 3 medulloblastoma 186 | 4,104
adult high grade glioma 183 | 3,801
Kidney cancer 174 | 2,613
diabetes mellitus 166 | 1,728
Multiple myeloma 161 | 1,332
Astrocytoma, Pilocytic 155 | 3,081
invasive ductal carcinoma 155 | 2,951
oligodendroglioma 153 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 150 | 2,955
lung adenocarcinoma 148 | 2,716
non-small cell lung cancer 145 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 143 | 2,989
interstitial cystitis 136 | 2,312
pancreatic cancer 135 | 2,398
primitive neuroectodermal tumor 134 | 3,035
tuberculosis 132 | 2,010
subependymal giant cell astrocytoma 131 | 2,287
lung carcinoma 129 | 2,843
astrocytic glioma 125 | 2,597
pancreatic ductal adenocarcinoma liver metastasis 114 | 1,962
Schizophrenia 105 | 1,160
ulcerative colitis 105 | 1,819
Autosomal recessive predisposition 103 | 1,442
pituitary cancer 98 | 1,972
breast carcinoma 97 | 1,638
Pick disease 94 | 1,894
cystic fibrosis 92 | 1,696
astrocytoma 91 | 1,146
group 4 medulloblastoma 86 | 1,855
ductal carcinoma in situ 85 | 1,745
Waldenstrons macroglobulinemia 83 | 765
acute quadriplegic myopathy 83 | 1,158
Rheumatoid arthritis 82 | 1,191
juvenile dermatomyositis 82 | 1,187
colon cancer 79 | 1,478
adrenocortical carcinoma 77 | 1,428
dermatomyositis 77 | 966
Intellectual disability 71 | 1,016
Anemia 69 | 365
Breast Neoplasms 69 | 445
Mammary Neoplasms 68 | 425
pediatric high grade glioma 68 | 1,064
primary pancreatic ductal adenocarcinoma 67 | 1,109
Epilepsy 66 | 792
Kidney disease 64 | 430
cutaneous lupus erythematosus 63 | 1,057
Prostatic Neoplasms 60 | 495
Seizures 60 | 596
Multiple Sclerosis 57 | 540
Cognitive delay 55 | 608
Global developmental delay 55 | 608
Mental and motor retardation 55 | 608
Short stature 55 | 531
gastric carcinoma 55 | 807
Arthritis 54 | 290
Dull intelligence 54 | 645
Low intelligence 54 | 645
Mental Retardation 54 | 645
Mental deficiency 54 | 645
Poor school performance 54 | 645
Stomach Neoplasms 53 | 300
Bipolar Disorder 52 | 666
Alzheimer's disease 51 | 658
Liver Cirrhosis, Experimental 51 | 769
Hypersensitivity reaction type II disease 50 | 253
Melanoma 49 | 711
Osteoporosis 49 | 363
acute myeloid leukemia 49 | 783
Failure to gain weight 48 | 365
Liver cancer 48 | 604
Pediatric failure to thrive 48 | 365
Muscle hypotonia 46 | 571
Obesity 46 | 678
Atopic dermatitis 45 | 952
Cleft Palate 45 | 271
Lung Neoplasms 45 | 232
Orbital separation excessive 45 | 244
Depressive disorder 44 | 409
Liver disease 43 | 237
medulloblastoma 43 | 720
nasopharyngeal carcinoma 43 | 1,058
primary Sjogren syndrome 43 | 735
spina bifida 43 | 1,074
Vascular disease 41 | 319
Hypoplastic mandible condyle 40 | 275
Mandibular hypoplasia 40 | 275
Micrognathism 40 | 275

Tissue

Digestive Tract 836 | 17,369
Endocrine System 836 | 18,159
Skin and soft tissues 830 | 17,230
Female tissues 829 | 17,400
Male tissues 823 | 17,142
Urinary Tract 822 | 16,678
Blood and immune system 820 | 16,909
Liver and Pancreas 817 | 16,750
Respiratory system 817 | 16,393
Nervous System 814 | 16,725
Cardiovascular System 785 | 15,192

Target Family

Non-IDG 547 | 12,091
Enzyme 195 | 4,145
Kinase 62 | 634
Transcription Factor 30 | 1,400
Epigenetic 22 | 242
GPCR 13 | 408
Transporter 4 | 473
Ion Channel 3 | 344
Nuclear Receptor 3 | 48

Reactome Pathway

Disease 879 | 879
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
A disintegrin and metalloproteinase with thrombospondin motifs 6 ADAMTS6 Tdark Enzyme -0.67364 4.37 40
Ras GTPase-activating protein 1 RASA1 Tbio Enzyme -2.61637 404.4 402
HLA class I histocompatibility antigen, A-25 alpha chain HLA-A Tbio Non-IDG -2.41667 4123.8 0
Transcription factor HES-1 HES1 Tbio Transcription Factor -1.77409 55.5 444
Long-wave-sensitive opsin 1 OPN1LW Tbio GPCR -2.37983 238.7 47
Medium-wave-sensitive opsin 1 OPN1MW Tbio GPCR -0.97721 8.41 18
Thrombospondin-1 THBS1 Tbio Non-IDG -3.06622 1281.6 504
T-cell surface glycoprotein CD3 zeta chain CD247 Tbio Non-IDG -2.61157 386.3 882
60S ribosomal protein L17 RPL17 Tbio Non-IDG -1.22337 16.5 217
A disintegrin and metalloproteinase with thrombospondin motifs 2 ADAMTS2 Tbio Enzyme -2.51717 1472.5 133