Development Level

Tbio 603 | 10,625
Tchem 156 | 1,890
Tclin 65 | 602
Tdark 32 | 7,003

Collection

Eligible Ion Channel Proteins 1 | 117
Eligible non-olfactory GPCR Proteins 1 | 145

IMPC Term

preweaning lethality, complete... 48 | 633
decreased lean body mass 12 | 195
embryonic lethality prior to t... 12 | 187
decreased bone mineral content 11 | 157
decreased body weight 10 | 174
decreased total body fat amoun... 9 | 186
enlarged heart 9 | 111
preweaning lethality, incomple... 9 | 260
abnormal retina morphology 8 | 100
increased mean corpuscular hem... 8 | 93
abnormal embryo size 7 | 112
decreased body length 7 | 108
embryonic lethality prior to o... 7 | 148
increased circulating alkaline... 7 | 119
increased leukocyte cell numbe... 7 | 37
abnormal behavior 6 | 226
decreased bone mineral density 6 | 126
hypoactivity 6 | 89
abnormal bone structure 5 | 131
abnormal heart morphology 5 | 51
decreased caudal vertebrae num... 5 | 49
decreased circulating insulin ... 5 | 75
decreased grip strength 5 | 123
decreased lumbar vertebrae num... 5 | 62
decreased prepulse inhibition 5 | 52
increased body weight 5 | 42
increased mean corpuscular vol... 5 | 91
increased or absent threshold ... 5 | 128
abnormal lens morphology 4 | 73
decreased circulating LDL chol... 4 | 37
decreased circulating glucose ... 4 | 121
decreased fasted circulating g... 4 | 49
increased blood urea nitrogen ... 4 | 44
increased circulating HDL chol... 4 | 63
increased circulating LDL chol... 4 | 15
increased grip strength 4 | 83
increased lean body mass 4 | 107
prenatal lethality prior to he... 4 | 64
abnormal QRS complex 3 | 25
abnormal body wall morphology 3 | 7
abnormal coping response 3 | 12
abnormal epididymis morphology 3 | 31
abnormal eye morphology 3 | 38
abnormal retinal pigmentation 3 | 61
abnormal seminal vesicle morph... 3 | 47
abnormal vibrissa morphology 3 | 17
cataract 3 | 26
decreased blood urea nitrogen ... 3 | 31
decreased circulating calcium ... 3 | 33
decreased circulating choleste... 3 | 85
decreased circulating creatini... 3 | 31
decreased circulating fructosa... 3 | 31
decreased circulating glycerol... 3 | 19
decreased circulating serum al... 3 | 79
decreased circulating triglyce... 3 | 83
decreased kidney weight 3 | 7
decreased leukocyte cell numbe... 3 | 54
decreased mean corpuscular vol... 3 | 50
decreased startle reflex 3 | 48
enlarged lymph nodes 3 | 27
impaired glucose tolerance 3 | 52
improved glucose tolerance 3 | 56
increased circulating calcium ... 3 | 32
increased circulating free fat... 3 | 17
increased circulating phosphat... 3 | 24
increased sacral vertebrae num... 3 | 62
thrombocytopenia 3 | 46
vertebral transformation 3 | 12
abnormal cornea morphology 2 | 24
abnormal gait 2 | 51
abnormal hair growth 2 | 8
abnormal head morphology 2 | 10
abnormal lung morphology 2 | 15
abnormal respiratory quotient 2 | 9
abnormal skin morphology 2 | 23
abnormal sleep behavior 2 | 63
abnormal testis morphology 2 | 30
absent pinna reflex 2 | 21
absent startle reflex 2 | 15
anophthalmia 2 | 20
decreased T cell number 2 | 31
decreased circulating HDL chol... 2 | 77
decreased circulating free fat... 2 | 39
decreased circulating iron lev... 2 | 25
decreased circulating sodium l... 2 | 18
decreased mean corpuscular hem... 2 | 34
decreased total retina thickne... 2 | 20
enlarged spleen 2 | 26
impaired righting response 2 | 19
increased bone mineral content 2 | 92
increased bone mineral density 2 | 52
increased circulating choleste... 2 | 53
increased circulating potassiu... 2 | 31
increased erythrocyte cell num... 2 | 26
increased exploration in new e... 2 | 56
increased heart weight 2 | 37
increased total body fat amoun... 2 | 57
limb grasping 2 | 35
short tibia 2 | 82
vertebral fusion 2 | 23

Disease

ovarian cancer 463 | 8,492
osteosarcoma 393 | 7,933
psoriasis 331 | 6,685
lung cancer 312 | 4,473
Cancer 299 | 2,346
glioblastoma 286 | 5,572
medulloblastoma, large-cell 281 | 6,234
atypical teratoid / rhabdoid tumor 214 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 197 | 3,289
Breast cancer 176 | 3,099
malignant mesothelioma 176 | 3,163
Multiple myeloma 157 | 1,328
diabetes mellitus 157 | 1,663
pilocytic astrocytoma 157 | 3,086
invasive ductal carcinoma 153 | 2,950
oligodendroglioma 152 | 2,849
pediatric high grade glioma 151 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 148 | 2,956
Carcinoma 146 | 2,147
lung adenocarcinoma 146 | 2,714
intraductal papillary-mucinous carcinoma (IPMC) 142 | 2,988
non-small cell lung cancer 138 | 2,798
interstitial cystitis 133 | 2,299
primitive neuroectodermal tumor 131 | 3,031
ependymoma 129 | 2,514
lung carcinoma 128 | 2,844
subependymal giant cell astrocytoma 127 | 2,287
pancreatic cancer 123 | 2,300
ulcerative colitis 113 | 2,087
astrocytoma 109 | 1,493
group 3 medulloblastoma 106 | 2,254
pancreatic ductal adenocarcinoma liver metastasis 102 | 1,795
pituitary cancer 96 | 1,972
astrocytic glioma 95 | 2,241
adult high grade glioma 94 | 2,148
Pick disease 93 | 1,893
group 4 medulloblastoma 93 | 1,875
cystic fibrosis 89 | 1,670
breast carcinoma 87 | 1,614
tuberculosis 87 | 1,563
acute quadriplegic myopathy 84 | 1,157
ductal carcinoma in situ 84 | 1,745
Waldenstrons macroglobulinemia 82 | 765
juvenile dermatomyositis 81 | 1,189
Rheumatoid Arthritis 80 | 1,171
colon cancer 79 | 1,475
primary pancreatic ductal adenocarcinoma 79 | 1,271
adrenocortical carcinoma 76 | 1,427
dermatomyositis 75 | 967
sonic hedgehog group medulloblastoma 73 | 1,482
medulloblastoma 70 | 1,524
Mammary Neoplasms 63 | 410
Kidney disease 62 | 397
cutaneous lupus erythematosus 62 | 1,056
posterior fossa group A ependymoma 59 | 1,511
Prostatic Neoplasms 56 | 471
posterior fossa group B ependymoma 56 | 1,530
gastric carcinoma 54 | 832
Alzheimer's disease 53 | 644
Anemia 53 | 252
atypical teratoid/rhabdoid tumor 52 | 1,095
Arthritis 51 | 248
Multiple Sclerosis 51 | 498
Hypersensitivity reaction type II disease 46 | 235
acute myeloid leukemia 45 | 785
Atopic dermatitis 44 | 944
Obesity 44 | 616
primary Sjogren syndrome 44 | 789
Liver disease 42 | 219
Stomach Neoplasms 41 | 282
nasopharyngeal carcinoma 41 | 1,056
spina bifida 41 | 1,064
Lung Neoplasms 38 | 171
esophageal adenocarcinoma 38 | 737
non primary Sjogren syndrome sicca 37 | 840
Intellectual disability 36 | 573
Schizophrenia 36 | 503
hepatocellular carcinoma 36 | 550
inflammatory breast cancer 36 | 404
Duchenne muscular dystrophy 35 | 602
Acquired immunodeficiency syndrome 34 | 164
Asthma 34 | 349
IGA Glomerulonephritis 34 | 454
Liver carcinoma 34 | 217
Vascular disease 34 | 281
pancreatic carcinoma 34 | 567
fibroadenoma 33 | 557
non-small cell lung carcinoma 33 | 413
Colorectal Neoplasms 32 | 217
Osteoporosis 32 | 259
aldosterone-producing adenoma 32 | 664
autosomal dominant Emery-Dreifuss muscular dystrophy 32 | 499
tuberculosis and treatment for 6 months 32 | 686
active Crohn's disease 31 | 918
progressive supranuclear palsy 30 | 674
Adenoma 29 | 165
Down syndrome 29 | 548
Hepatitis B 29 | 103
Amyotrophic Lateral Sclerosis 28 | 432
mucosa-associated lymphoid tissue lymphoma 28 | 480

Tissue

Endocrine System 834 | 18,512
Female tissues 834 | 18,647
Nervous System 834 | 18,561
Digestive Tract 833 | 18,473
Liver and Pancreas 833 | 18,136
Urinary Tract 833 | 18,444
Cardiovascular System 831 | 17,958
Male tissues 831 | 17,969
Blood and immune system 830 | 17,995
Respiratory system 823 | 17,484
Skin and soft tissues 821 | 18,115

Target Family

Non-IDG 535 | 11,969
Enzyme 189 | 4,146
Kinase 62 | 634
Transcription Factor 29 | 1,400
Epigenetic 21 | 242
GPCR 12 | 408
Transporter 4 | 473
Ion Channel 3 | 341
Nuclear Receptor 1 | 48

Reactome Pathway

Disease 856 | 856
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 Tbio Enzyme -1.23140 15.5 156
Myeloid differentiation primary response protein MyD88 MYD88 Tbio Non-IDG -3.22244 1606.1 561
60S ribosomal protein L6 RPL6 Tbio Non-IDG -1.54952 37.8 65
Tumor susceptibility gene 101 protein TSG101 Tbio Non-IDG -2.44656 282.1 289
Na(+)/H(+) exchange regulatory cofactor NHE-RF4 PDZD3 Tbio Non-IDG -0.76581 6.10 107
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.64327 44.9 16
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.00824 98.4 170
Talin-1 TLN1 Tbio Non-IDG -1.88948 80.4 340
Spondin-1 SPON1 Tbio Non-IDG 0.00000 97
Insulin receptor substrate 2 IRS2 Tbio Non-IDG -2.62322 398.1 207