Development Level

Tbio 21 | 11,445
Tchem 7 | 1,598
Tclin 1 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
increased mean corpuscular vol... 2 | 92
preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal locomotor behavior 1 | 24
abnormal startle reflex 1 | 15
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased total retina thickne... 1 | 17
decreased vertical activity 1 | 208
enlarged heart 1 | 210
hydrometra 1 | 53
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased bone mineral density 1 | 72
increased circulating insulin ... 1 | 3
increased hematocrit 1 | 46
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
male infertility 1 | 123
mammalian phenotype 1 | 17
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
small superior vagus ganglion 1 | 74
thrombocytosis 1 | 27

Disease

Carcinoma 23 | 11,493
ovarian cancer 18 | 8,520
osteosarcoma 16 | 7,950
psoriasis 16 | 6,694
Cancer 15 | 2,499
glioblastoma 15 | 5,792
medulloblastoma, large-cell 15 | 6,241
atypical teratoid / rhabdoid tumor 13 | 5,112
adult high grade glioma 10 | 3,801
ependymoma 9 | 4,679
Breast cancer 8 | 3,578
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
lung cancer 8 | 4,740
group 3 medulloblastoma 7 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
Intellectual disability 6 | 1,016
Kidney cancer 6 | 2,613
Osteoporosis 6 | 363
adrenocortical carcinoma 6 | 1,428
primitive neuroectodermal tumor 6 | 3,035
Cognitive delay 5 | 608
Dull intelligence 5 | 645
Global developmental delay 5 | 608
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental and motor retardation 5 | 608
Mental deficiency 5 | 645
Orbital separation excessive 5 | 244
Poor school performance 5 | 645
Rheumatoid arthritis 5 | 1,191
astrocytic glioma 5 | 2,597
breast carcinoma 5 | 1,638
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
lung adenocarcinoma 5 | 2,716
malignant mesothelioma 5 | 3,232
oligodendroglioma 5 | 2,850
pituitary cancer 5 | 1,972
tuberculosis 5 | 2,010
Astrocytoma, Pilocytic 4 | 3,081
Autosomal recessive predisposition 4 | 1,442
Endometrial cancer 4 | 311
Liver cancer 4 | 604
Pick disease 4 | 1,894
Prostatic Neoplasms 4 | 495
Schizophrenia 4 | 1,160
Stomach Neoplasms 4 | 300
diabetes mellitus 4 | 1,728
ductal carcinoma in situ 4 | 1,745
group 4 medulloblastoma 4 | 1,855
interstitial cystitis 4 | 2,312
invasive ductal carcinoma 4 | 2,951
medulloblastoma 4 | 720
non-small cell lung cancer 4 | 2,890
osteoporosis-pseudoglioma syndrome 4 | 9
pancreatic cancer 4 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
subependymal giant cell astrocytoma 4 | 2,287
Big calvaria 3 | 147
Carcinoma, Hepatocellular 3 | 228
Colonic Neoplasms 3 | 142
Downward slant of palpebral fissure 3 | 158
Familial adenomatous polyposis 3 | 32
Increased head circumference 3 | 147
Increased hepatocellular carcinoma risk 3 | 27
Increased incidence of hepatocellular carcinoma 3 | 27
Increased size of cranium 3 | 147
Increased size of skull 3 | 147
Juvenile osteoporosis 3 | 4
Liver carcinoma 3 | 240
Long philtrum 3 | 137
Lung Neoplasms 3 | 232
Lymphoid leukemia 3 | 160
Malabsorption 3 | 82
Micronodular cirrhosis 3 | 12
Muscle hypotonia 3 | 571
Osteoarthritis 3 | 184
Osteoporosis, Juvenile 3 | 4
Parkinson's disease 3 | 392
Robinow syndrome 3 | 11
Short stature 3 | 531
Somatic mutation 3 | 61
Subacute progressive viral hepatitis 3 | 9
astrocytoma 3 | 1,146
fibroadenoma 3 | 559
gastric carcinoma 3 | 807
hepatocellular carcinoma 3 | 547
ulcerative colitis 3 | 1,819
Abnormality of retinal pigmentation 2 | 111
Autistic Disorder 2 | 364
Dilated ventricles (finding) 2 | 121
Frontal bossing 2 | 157
Heart conduction disease 2 | 83
High forehead 2 | 102
Highly variable severity 2 | 157
Hypoplasia of corpus callosum 2 | 90
Large intestine cancer 2 | 126
Range of joint movement increased 2 | 32
Retinal pigment epithelial abnormality 2 | 111
Variable expressivity 2 | 157
posterior fossa group A ependymoma 2 | 468

Tissue

Female tissues 29 | 17,400
Digestive Tract 28 | 17,369
Endocrine System 28 | 18,159
Nervous System 28 | 16,725
Blood and immune system 27 | 16,909
Male tissues 27 | 17,142
Respiratory system 27 | 16,393
Skin and soft tissues 27 | 17,230
Urinary Tract 27 | 16,678
Liver and Pancreas 26 | 16,750
Cardiovascular System 25 | 15,192

Target Family

Non-IDG 15 | 12,091
Enzyme 9 | 4,145
GPCR 3 | 408
Kinase 3 | 634

Reactome Pathway

Disassembly of the destruction... 30 | 30
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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