Development Level

Tbio 8 | 11,445
Tchem 2 | 1,598

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
decreased bone mineral content 1 | 151
decreased circulating insulin ... 1 | 76
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
small superior vagus ganglion 1 | 74

Disease

Cancer 9 | 2,499
ovarian cancer 7 | 8,520
psoriasis 7 | 6,694
glioblastoma 6 | 5,792
lung cancer 6 | 4,740
Carcinoma 5 | 11,493
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
malignant mesothelioma 5 | 3,232
Astrocytoma, Pilocytic 4 | 3,081
Hypersensitivity reaction type II disease 4 | 253
Multiple Sclerosis 4 | 540
atypical teratoid / rhabdoid tumor 4 | 5,112
colon cancer 4 | 1,478
cutaneous lupus erythematosus 4 | 1,057
ependymoma 4 | 4,679
lung carcinoma 4 | 2,843
osteosarcoma 4 | 7,950
pituitary cancer 4 | 1,972
Arthritis 3 | 290
Autoimmune lymphoproliferative syndrome 3 | 11
Pancreatic Neoplasm 3 | 85
Pancreatic Neoplasms 3 | 85
Prostatic Neoplasms 3 | 495
Rheumatoid arthritis 3 | 1,191
Vasculitis 3 | 80
adult high grade glioma 3 | 3,801
gastric carcinoma 3 | 807
pancreatic cancer 3 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
subependymal giant cell astrocytoma 3 | 2,287
ulcerative colitis 3 | 1,819
Acute Lung Injury 2 | 22
Anti-nuclear factor positive 2 | 18
Antiphospholipid antibody positivity 2 | 4
Autoimmune hemolytic anemia 2 | 31
Autoimmune neutropenia 2 | 5
Autoimmune thrombocytopenia 2 | 22
Autosomal recessive predisposition 2 | 1,442
Breast cancer 2 | 3,578
Cardiomyopathies 2 | 110
Cardiomyopathy, Dilated 2 | 83
Chronic noninfectious lymphadenopathy 2 | 6
Colonic Neoplasms 2 | 142
Coombs positive hemolytic anemia 2 | 4
Defective lymphocyte apoptosis 2 | 4
Drug Hypersensitivity 2 | 34
Drug allergy 2 | 36
Elevated serum IgA 2 | 5
Eosinophilia 2 | 28
Fatigue 2 | 182
Follicular hyperplasia 2 | 4
Gaucher disease type 3 2 | 67
Hepatomegaly 2 | 285
Human immunodeficiency virus infectious disease 2 | 138
Idiopathic thrombocytopenia 2 | 22
Immune thrombocytopenic purpura 2 | 24
Increased IgM levels 2 | 16
Increased levels of IgG 2 | 4
Increased number of CD4-/CD8- T cells expressing alpha/beta T-cell receptors 2 | 3
Increased number of peripheral CD3+ T cells 2 | 3
Increased proportion of HLA DR+ and CD57+ T cells 2 | 3
Iridocyclitis 2 | 19
Iron deficiency anemia 2 | 12
Leukemia 2 | 104
Leukemia, Myelocytic, Acute 2 | 120
Leukemia, Myeloid, Acute 2 | 105
Liver Failure, Acute 2 | 29
Liver disease 2 | 237
Lung Neoplasms 2 | 232
Lymphoproliferative syndrome 2 | 58
Neoplasm Metastasis 2 | 168
Neutrophil antibody positive 2 | 3
Platelet antibody positive 2 | 4
Reduced delayed hypersensitivity 2 | 4
Rheumatoid factor positive (finding) 2 | 3
Sensorineural Hearing Loss (disorder) 2 | 284
Smooth muscle antibodies positive 2 | 3
Splenomegaly 2 | 190
Systemic lupus erythematosus 2 | 194
Urticaria 2 | 67
acute myeloid leukemia 2 | 783
acute quadriplegic myopathy 2 | 1,158
adrenocortical carcinoma 2 | 1,428
aldosterone-producing adenoma 2 | 665
dermatomyositis 2 | 966
diabetes mellitus 2 | 1,728
hepatocellular carcinoma 2 | 547
interstitial cystitis 2 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
juvenile dermatomyositis 2 | 1,187
non-small cell lung cancer 2 | 2,890
oligodendroglioma 2 | 2,850
primary pancreatic ductal adenocarcinoma 2 | 1,109
primitive neuroectodermal tumor 2 | 3,035
tuberculosis 2 | 2,010
Confusion 1 | 21
Juvenile rheumatoid arthritis 1 | 111
Liver Neoplasms, Experimental 1 | 59
Ventricular Dysfunction, Left 1 | 22

Tissue

Blood and immune system 10 | 16,909
Cardiovascular System 10 | 15,192
Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Male tissues 10 | 17,142
Nervous System 10 | 16,725
Respiratory system 10 | 16,393
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678

Target Family

Non-IDG 9 | 12,091
Kinase 1 | 634

Reactome Pathway

Dimerization of procaspase-8 10 | 10
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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