Development Level

Tbio 11 | 11,445
Tchem 6 | 1,598
Tclin 6 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 2 | 979
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
enlarged heart 1 | 210
hydrometra 1 | 53
small superior vagus ganglion 1 | 74

Disease

Carcinoma 16 | 11,493
diabetes mellitus 10 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
psoriasis 8 | 6,694
Autosomal recessive predisposition 7 | 1,442
Diarrhea 7 | 253
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
lung cancer 7 | 4,740
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
Obesity 5 | 678
active Crohn's disease 5 | 922
active ulcerative colitis 5 | 764
lung carcinoma 5 | 2,843
non-small cell lung cancer 5 | 2,890
ovarian cancer 5 | 8,520
pancreatic cancer 5 | 2,398
Diabetes mellitus type 2 4 | 69
Kidney cancer 4 | 2,613
cystic fibrosis 4 | 1,696
malignant mesothelioma 4 | 3,232
osteosarcoma 4 | 7,950
Atherosclerosis 3 | 291
Breast cancer 3 | 3,578
Lactose intolerance 3 | 7
Metabolic acidosis 3 | 90
Pancreatitis 3 | 123
Steatorrhea 3 | 34
colon cancer 3 | 1,478
gastric carcinoma 3 | 807
interstitial cystitis 3 | 2,312
lung adenocarcinoma 3 | 2,716
Abdomen distended 2 | 43
Acrodermatitis enteropathica 2 | 18
Breast Neoplasms 2 | 445
Cancer 2 | 2,499
Cholesterol ester storage disease 2 | 6
Chronic diarrhea 2 | 29
Coronary artery disease 2 | 268
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Failure to gain weight 2 | 365
Gaucher's disease 2 | 26
Glycosuria 2 | 29
Hyperglycemia 2 | 137
Hypoglycemia 2 | 152
Hypokalemia 2 | 52
Hypophosphatemia 2 | 40
Irritable bowel syndrome 2 | 60
Kidney disease 2 | 430
Large intestine cancer 2 | 126
Lipid metabolism disorder 2 | 114
Liver cancer 2 | 604
Malabsorption 2 | 82
Mammary Neoplasms 2 | 425
Melanoma 2 | 711
Pediatric failure to thrive 2 | 365
Personality disorder 2 | 25
Primary cutaneous amyloidosis 2 | 29
Short bowel syndrome 2 | 16
Skin cancer 2 | 469
Type 2 diabetes mellitus 2 | 272
facioscapulohumeral dystrophy 2 | 288
group 3 medulloblastoma 2 | 4,104
head and neck cancer and chronic obstructive pulmonary disease 2 | 239
maturity-onset diabetes of the young 2 | 32
medulloblastoma, large-cell 2 | 6,241
mucosa-associated lymphoid tissue lymphoma 2 | 484
nephrosclerosis 2 | 333
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
tuberculosis 2 | 2,010
ulcerative colitis 2 | 1,819
Acrocallosal syndrome 1 | 12
Acromesomelic dysplasia 1 | 10
Anemia, Megaloblastic 1 | 16
Calcinosis 1 | 70
Celiac disease 1 | 116
Choledocholithiasis 1 | 11
Chromosome 1p36 deletion syndrome 1 | 23
Chronic idiopathic constipation 1 | 3
Colorectal cancer 1 | 25
Dehydration 1 | 40
Diabetes Mellitus, Noninsulin-Dependent 1 | 31
Dysthymic Disorder 1 | 17
Eating disorder 1 | 26
Esophagitis 1 | 35
Exocrine pancreatic insufficiency 1 | 32
Fanconi syndrome 1 | 14
Galactosemia 1 | 19
Hypoparathyroidism 1 | 41
Insulinoma 1 | 24
Irritable bowel syndrome characterized by constipation 1 | 3
Kidney Failure, Chronic 1 | 46
Nephrotic Syndrome 1 | 78
Orofaciodigital syndrome 1 | 21
Pancreatic Insufficiency 1 | 13
Pancreatitis, Chronic 1 | 9
Primary hypomagnesemia 1 | 7
Respiratory Distress Syndrome, Adult 1 | 40
Space motion sickness 1 | 3
Spinocerebellar ataxia type 17 1 | 7
Tetanus 1 | 68

Tissue

Digestive Tract 23 | 17,369
Endocrine System 22 | 18,159
Female tissues 22 | 17,400
Skin and soft tissues 21 | 17,230
Blood and immune system 20 | 16,909
Liver and Pancreas 19 | 16,750
Male tissues 19 | 17,142
Urinary Tract 18 | 16,678
Nervous System 17 | 16,725
Respiratory system 16 | 16,393
Cardiovascular System 13 | 15,192

Target Family

Enzyme 16 | 4,145
Non-IDG 4 | 12,091
Transporter 3 | 473
Kinase 1 | 634

Reactome Pathway

Digestion and absorption 24 | 24
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Guanylin GUCA2A Tbio Non-IDG -1.92667 79.2 137
Maltase-glucoamylase, intestinal MGAM Tclin Enzyme -4.52158 32564.4 32
Heat-stable enterotoxin receptor GUCY2C Tclin Kinase -2.33494 214.5 228
Niemann-Pick C1-like protein 1 NPC1L1 Tclin Non-IDG -2.33312 222.7 139
Sucrase-isomaltase, intestinal SI Tchem Enzyme -1.84903 67.8 62
Regulatory solute carrier protein family 1 member 1 RSC1A1 Tbio Non-IDG -0.66823 5.31 39
Sodium/glucose cotransporter 1 SLC5A1 Tchem Transporter -2.86201 723.3 244
Pancreatic lipase-related protein 3 PNLIPRP3 Tdark Enzyme 0.30 0.50 88
Lactase-phlorizin hydrolase LCT Tbio Enzyme -2.65148 430.9 148
Guanylate cyclase activator 2B GUCA2B Tbio Enzyme -1.30745 23.3 137