Development Level

Tbio 594 | 10,625
Tchem 204 | 1,890
Tdark 152 | 7,003
Tclin 78 | 602

Collection

Ion Channel: IDG Consortium (Targets) 10 | 102
Kinase: IDG Consortium (Targets) 7 | 125
Kinase: IDG Consortium (Complete/Control) 3 | 37

IMPC Phenotype

preweaning lethality, complete... 50 | 633
decreased body weight 17 | 174
decreased total body fat amoun... 15 | 186
embryonic lethality prior to t... 15 | 187
abnormal bone structure 14 | 131
preweaning lethality, incomple... 14 | 260
decreased bone mineral content 13 | 157
decreased lean body mass 11 | 195
abnormal embryo size 10 | 112
abnormal retina morphology 9 | 100
abnormal behavior 8 | 226
abnormal retinal pigmentation 8 | 61
decreased circulating triglyce... 8 | 83
decreased lumbar vertebrae num... 8 | 62
increased circulating alkaline... 8 | 119
male infertility 8 | 62
decreased body length 7 | 108
decreased bone mineral density 7 | 126
decreased circulating serum al... 7 | 79
decreased rib number 7 | 59
increased mean corpuscular hem... 7 | 93
increased or absent threshold ... 7 | 128
decreased circulating choleste... 6 | 85
decreased circulating fructosa... 6 | 31
decreased grip strength 6 | 123
abnormal coat-hair pigmentatio... 5 | 54
abnormal cornea morphology 5 | 24
decreased circulating alanine ... 5 | 53
decreased circulating total pr... 5 | 41
embryonic lethality prior to o... 5 | 148
enlarged heart 5 | 111
female infertility 5 | 34
impaired righting response 5 | 19
increased body weight 5 | 42
increased sacral vertebrae num... 5 | 62
persistence of hyaloid vascula... 5 | 22
prenatal lethality prior to he... 5 | 64
short tibia 5 | 82
abnormal bone mineralization 4 | 55
abnormal lens morphology 4 | 73
abnormal spleen morphology 4 | 36
corneal opacity 4 | 25
decreased caudal vertebrae num... 4 | 49
decreased circulating HDL chol... 4 | 77
decreased circulating glucose ... 4 | 121
decreased circulating sodium l... 4 | 18
decreased heart weight 4 | 44
decreased hemoglobin content 4 | 53
decreased kidney weight 4 | 7
decreased leukocyte cell numbe... 4 | 54
impaired glucose tolerance 4 | 52
increased bone mineral content 4 | 92
increased circulating free fat... 4 | 17
increased circulating phosphat... 4 | 24
increased circulating triglyce... 4 | 24
increased fasted circulating g... 4 | 68
increased lean body mass 4 | 107
increased mean corpuscular vol... 4 | 91
increased respiratory quotient 4 | 12
thrombocytopenia 4 | 46
abnormal coat appearance 3 | 25
abnormal femur morphology 3 | 14
abnormal gait 3 | 51
abnormal locomotor activation 3 | 26
abnormal respiratory quotient 3 | 9
abnormal seminal vesicle morph... 3 | 47
abnormal tooth morphology 3 | 24
cataract 3 | 26
decreased circulating LDL chol... 3 | 37
decreased circulating amylase ... 3 | 24
decreased circulating calcium ... 3 | 33
decreased circulating creatini... 3 | 31
decreased circulating insulin ... 3 | 75
decreased circulating iron lev... 3 | 25
decreased mean corpuscular hem... 3 | 19
decreased mean corpuscular vol... 3 | 50
decreased startle reflex 3 | 48
decreased threshold for audito... 3 | 32
edema 3 | 11
hyperactivity 3 | 108
hypoactivity 3 | 89
impaired pupillary reflex 3 | 14
improved glucose tolerance 3 | 56
increased blood urea nitrogen ... 3 | 44
increased circulating HDL chol... 3 | 63
increased circulating choleste... 3 | 53
increased hemoglobin content 3 | 45
increased startle reflex 3 | 38
increased total body fat amoun... 3 | 57
irregularly shaped pupil 3 | 7
small testis 3 | 37
abnormal head morphology 2 | 10
decreased circulating potassiu... 2 | 17
decreased neutrophil cell numb... 2 | 37
decreased vertical activity 2 | 22
enlarged spleen 2 | 26
increased circulating iron lev... 2 | 25
increased grip strength 2 | 83
tremors 2 | 34
vertebral fusion 2 | 23

Disease

psoriasis 505 | 6,685
ovarian cancer 494 | 8,491
osteosarcoma 447 | 7,933
glioblastoma 380 | 5,572
medulloblastoma, large-cell 366 | 6,234
lung cancer 311 | 4,473
Cancer 308 | 2,346
atypical teratoid / rhabdoid tumor 300 | 4,369
Breast cancer 236 | 3,098
malignant mesothelioma 233 | 3,163
pilocytic astrocytoma 221 | 3,086
Carcinoma 215 | 2,147
intraductal papillary-mucinous neoplasm (IPMN) 210 | 3,289
oligodendroglioma 207 | 2,849
invasive ductal carcinoma 199 | 2,950
pediatric high grade glioma 199 | 2,712
primitive neuroectodermal tumor 192 | 3,031
lung adenocarcinoma 181 | 2,714
lung carcinoma 181 | 2,844
diabetes mellitus 180 | 1,663
intraductal papillary-mucinous carcinoma (IPMC) 177 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 173 | 2,956
non-small cell lung cancer 170 | 2,798
pancreatic cancer 170 | 2,300
interstitial cystitis 161 | 2,299
ependymoma 155 | 2,514
subependymal giant cell astrocytoma 155 | 2,287
astrocytic glioma 147 | 2,241
pituitary cancer 145 | 1,972
cystic fibrosis 144 | 1,670
ulcerative colitis 140 | 2,087
group 4 medulloblastoma 131 | 1,875
breast carcinoma 126 | 1,614
ductal carcinoma in situ 124 | 1,745
Pick disease 123 | 1,893
astrocytoma 117 | 1,493
adult high grade glioma 113 | 2,148
group 3 medulloblastoma 109 | 2,254
colon cancer 105 | 1,475
posterior fossa group A ependymoma 102 | 1,511
primary pancreatic ductal adenocarcinoma 101 | 1,271
Multiple myeloma 95 | 1,327
medulloblastoma 95 | 1,524
Atopic dermatitis 94 | 944
sonic hedgehog group medulloblastoma 86 | 1,482
tuberculosis 86 | 1,563
Rheumatoid Arthritis 83 | 1,170
posterior fossa group B ependymoma 83 | 1,530
spina bifida 80 | 1,064
acute quadriplegic myopathy 75 | 1,157
cutaneous lupus erythematosus 73 | 1,056
dermatomyositis 71 | 966
Alzheimer's disease 70 | 644
esophageal adenocarcinoma 70 | 737
juvenile dermatomyositis 70 | 1,189
adrenocortical carcinoma 69 | 1,427
Mammary Neoplasms 68 | 410
nasopharyngeal carcinoma 68 | 1,056
pancreatic ductal adenocarcinoma liver metastasis 68 | 1,795
Waldenstrons macroglobulinemia 62 | 764
Intellectual disability 61 | 573
Obesity 59 | 616
gastric carcinoma 58 | 832
Prostatic Neoplasms 56 | 471
atypical teratoid/rhabdoid tumor 56 | 1,095
Schizophrenia 54 | 503
non-small cell lung carcinoma 49 | 413
Down syndrome 47 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 46 | 499
acute myeloid leukemia 45 | 785
Duchenne muscular dystrophy 44 | 602
Parkinson's disease 44 | 364
non primary Sjogren syndrome sicca 44 | 840
primary Sjogren syndrome 44 | 788
Endometriosis 43 | 535
Epilepsy 42 | 346
fibroadenoma 42 | 557
pancreatic carcinoma 42 | 567
Heart disease 40 | 279
Autistic Disorder 39 | 320
Kidney disease 38 | 397
Liver carcinoma 37 | 217
Osteoporosis 36 | 259
Vascular disease 36 | 281
Multiple Sclerosis 35 | 498
Stomach Neoplasms 35 | 282
mucosa-associated lymphoid tissue lymphoma 35 | 480
tuberculosis and treatment for 6 months 34 | 686
Diabetes Mellitus, Non-Insulin-Dependent 33 | 161
Lung Neoplasms 33 | 171
Squamous cell carcinoma 33 | 96
Neoplasm Invasiveness 32 | 127
active Crohn's disease 32 | 918
Hypertension 31 | 293
gastric cancer 31 | 436
Amyotrophic Lateral Sclerosis 30 | 432
Asthma 30 | 349
Melanoma 30 | 261
Renal Cell Carcinoma 30 | 199
aldosterone-producing adenoma 30 | 664

Tissue

Female tissues 1,001 | 18,646
Digestive Tract 994 | 18,472
Nervous System 990 | 18,560
Skin and soft tissues 984 | 18,114
Endocrine System 979 | 18,511
Urinary Tract 976 | 18,443
Liver and Pancreas 961 | 18,135
Cardiovascular System 950 | 17,957
Blood and immune system 940 | 17,994
Male tissues 934 | 17,968
Respiratory system 898 | 17,483

Target Family

Non-IDG 580 | 11,969
Enzyme 185 | 4,146
Kinase 108 | 634
Transcription Factor 88 | 1,400
Ion Channel 41 | 341
Nuclear Receptor 12 | 48
Epigenetic 11 | 242
Transporter 2 | 473
TF/Epigenetic 1 | 38

Reactome Pathway

Developmental Biology 1,028 | 1,028
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.47495 286.5 135
Short transient receptor potential channel 5 TRPC5 Tchem Ion Channel -2.22055 159.7 209
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.25806 19000.3 3336
Proto-oncogene Wnt-1 WNT1 Tbio Non-IDG -2.73870 492.7 294
Alternative prion protein PRNP Tbio Non-IDG -3.44085 5471.9 0
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.13212 1.19 10
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.16 0.33 20
Ribosomal protein S6 kinase alpha-6 RPS6KA6 Tchem Kinase -1.24881 21.2 139
Calpain small subunit 1 CAPNS1 Tbio Non-IDG -2.88291 736.0 131