Development Level

Tbio 594 | 10,625
Tchem 205 | 1,890
Tdark 152 | 7,003
Tclin 78 | 602

Collection

Eligible Ion Channel Proteins 10 | 117
Eligible Kinase Proteins 7 | 134

IMPC Term

preweaning lethality, complete... 50 | 633
decreased body weight 17 | 174
decreased total body fat amoun... 15 | 186
embryonic lethality prior to t... 15 | 187
abnormal bone structure 14 | 131
preweaning lethality, incomple... 14 | 260
decreased bone mineral content 13 | 157
decreased lean body mass 11 | 195
abnormal embryo size 10 | 112
abnormal retina morphology 9 | 100
abnormal behavior 8 | 226
abnormal retinal pigmentation 8 | 61
decreased circulating triglyce... 8 | 83
decreased lumbar vertebrae num... 8 | 62
increased circulating alkaline... 8 | 119
male infertility 8 | 62
decreased body length 7 | 108
decreased bone mineral density 7 | 126
decreased circulating serum al... 7 | 79
decreased rib number 7 | 59
increased mean corpuscular hem... 7 | 93
increased or absent threshold ... 7 | 128
decreased circulating choleste... 6 | 85
decreased circulating fructosa... 6 | 31
decreased grip strength 6 | 123
abnormal coat/hair pigmentatio... 5 | 54
abnormal cornea morphology 5 | 24
decreased circulating alanine ... 5 | 53
decreased circulating total pr... 5 | 41
embryonic lethality prior to o... 5 | 148
enlarged heart 5 | 111
female infertility 5 | 34
impaired righting response 5 | 19
increased body weight 5 | 42
increased sacral vertebrae num... 5 | 62
persistence of hyaloid vascula... 5 | 22
prenatal lethality prior to he... 5 | 64
short tibia 5 | 82
abnormal bone mineralization 4 | 55
abnormal lens morphology 4 | 73
abnormal spleen morphology 4 | 36
corneal opacity 4 | 25
decreased caudal vertebrae num... 4 | 49
decreased circulating HDL chol... 4 | 77
decreased circulating glucose ... 4 | 121
decreased circulating sodium l... 4 | 18
decreased heart weight 4 | 44
decreased hemoglobin content 4 | 53
decreased kidney weight 4 | 7
decreased leukocyte cell numbe... 4 | 54
impaired glucose tolerance 4 | 52
increased bone mineral content 4 | 92
increased circulating free fat... 4 | 17
increased circulating phosphat... 4 | 24
increased circulating triglyce... 4 | 24
increased fasted circulating g... 4 | 68
increased lean body mass 4 | 107
increased mean corpuscular vol... 4 | 91
increased respiratory quotient 4 | 12
thrombocytopenia 4 | 46
abnormal coat appearance 3 | 25
abnormal femur morphology 3 | 14
abnormal gait 3 | 51
abnormal locomotor activation 3 | 26
abnormal respiratory quotient 3 | 9
abnormal seminal vesicle morph... 3 | 47
abnormal tooth morphology 3 | 24
cataract 3 | 26
decreased circulating LDL chol... 3 | 37
decreased circulating amylase ... 3 | 24
decreased circulating calcium ... 3 | 33
decreased circulating creatini... 3 | 31
decreased circulating insulin ... 3 | 75
decreased circulating iron lev... 3 | 25
decreased mean corpuscular hem... 3 | 19
decreased mean corpuscular vol... 3 | 50
decreased startle reflex 3 | 48
decreased threshold for audito... 3 | 32
edema 3 | 11
hyperactivity 3 | 108
hypoactivity 3 | 89
impaired pupillary reflex 3 | 14
improved glucose tolerance 3 | 56
increased blood urea nitrogen ... 3 | 44
increased circulating HDL chol... 3 | 63
increased circulating choleste... 3 | 53
increased hemoglobin content 3 | 45
increased startle reflex 3 | 38
increased total body fat amoun... 3 | 57
irregularly shaped pupil 3 | 7
small testis 3 | 37
abnormal head morphology 2 | 10
decreased circulating potassiu... 2 | 17
decreased neutrophil cell numb... 2 | 37
decreased vertical activity 2 | 22
enlarged spleen 2 | 26
increased circulating iron lev... 2 | 25
increased grip strength 2 | 83
tremors 2 | 34
vertebral fusion 2 | 23

Disease

psoriasis 505 | 6,685
ovarian cancer 492 | 8,484
osteosarcoma 447 | 7,933
glioblastoma 380 | 5,572
medulloblastoma, large-cell 366 | 6,234
lung cancer 311 | 4,466
Cancer 308 | 2,346
atypical teratoid / rhabdoid tumor 300 | 4,369
Breast cancer 237 | 3,094
malignant mesothelioma 233 | 3,162
pilocytic astrocytoma 221 | 3,086
Carcinoma 215 | 2,147
intraductal papillary-mucinous neoplasm (IPMN) 210 | 3,289
oligodendroglioma 207 | 2,849
invasive ductal carcinoma 199 | 2,950
pediatric high grade glioma 199 | 2,712
primitive neuroectodermal tumor 192 | 3,031
lung adenocarcinoma 181 | 2,713
lung carcinoma 181 | 2,844
diabetes mellitus 180 | 1,663
intraductal papillary-mucinous carcinoma (IPMC) 177 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 173 | 2,956
non-small cell lung cancer 170 | 2,798
pancreatic cancer 170 | 2,300
interstitial cystitis 161 | 2,299
ependymoma 155 | 2,514
subependymal giant cell astrocytoma 155 | 2,287
astrocytic glioma 147 | 2,241
pituitary cancer 145 | 1,972
cystic fibrosis 144 | 1,665
ulcerative colitis 140 | 2,087
group 4 medulloblastoma 131 | 1,875
breast carcinoma 126 | 1,614
ductal carcinoma in situ 124 | 1,745
Pick disease 123 | 1,893
astrocytoma 117 | 1,493
adult high grade glioma 113 | 2,148
group 3 medulloblastoma 109 | 2,254
colon cancer 105 | 1,475
posterior fossa group A ependymoma 102 | 1,511
primary pancreatic ductal adenocarcinoma 101 | 1,271
Multiple myeloma 96 | 1,327
medulloblastoma 95 | 1,524
Atopic dermatitis 94 | 944
sonic hedgehog group medulloblastoma 86 | 1,482
tuberculosis 86 | 1,557
Rheumatoid Arthritis 84 | 1,160
posterior fossa group B ependymoma 83 | 1,530
spina bifida 80 | 1,064
acute quadriplegic myopathy 75 | 1,157
cutaneous lupus erythematosus 73 | 1,056
dermatomyositis 72 | 933
Alzheimer's disease 70 | 644
esophageal adenocarcinoma 70 | 737
juvenile dermatomyositis 70 | 1,189
adrenocortical carcinoma 69 | 1,427
Mammary Neoplasms 68 | 410
nasopharyngeal carcinoma 68 | 1,056
pancreatic ductal adenocarcinoma liver metastasis 68 | 1,795
Waldenstrons macroglobulinemia 63 | 765
Intellectual disability 61 | 573
Obesity 59 | 616
gastric carcinoma 58 | 832
Prostatic Neoplasms 56 | 471
atypical teratoid/rhabdoid tumor 56 | 1,095
Schizophrenia 54 | 501
non-small cell lung carcinoma 49 | 413
Down syndrome 47 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 46 | 499
acute myeloid leukemia 45 | 780
primary Sjogren syndrome 45 | 789
Duchenne muscular dystrophy 44 | 602
Parkinson's disease 44 | 364
non primary Sjogren syndrome sicca 44 | 840
Endometriosis 43 | 535
Epilepsy 42 | 346
fibroadenoma 42 | 557
pancreatic carcinoma 42 | 567
Heart disease 40 | 279
Autistic Disorder 39 | 320
Kidney disease 38 | 396
Liver carcinoma 37 | 217
Osteoporosis 36 | 257
Vascular disease 36 | 281
Multiple Sclerosis 35 | 498
Stomach Neoplasms 35 | 282
mucosa-associated lymphoid tissue lymphoma 35 | 480
tuberculosis and treatment for 6 months 34 | 686
Diabetes Mellitus, Non-Insulin-Dependent 33 | 157
Lung Neoplasms 33 | 171
Squamous cell carcinoma 33 | 94
Neoplasm Invasiveness 32 | 127
active Crohn's disease 32 | 918
Hypertension 31 | 287
Amyotrophic Lateral Sclerosis 30 | 431
Asthma 30 | 349
Mammary Neoplasms, Experimental 30 | 150
Melanoma 30 | 261
aldosterone-producing adenoma 30 | 664
gastric cancer 30 | 430

Tissue

Female tissues 1,002 | 18,647
Digestive Tract 995 | 18,473
Nervous System 991 | 18,561
Skin and soft tissues 985 | 18,115
Endocrine System 980 | 18,512
Urinary Tract 977 | 18,444
Liver and Pancreas 962 | 18,136
Cardiovascular System 951 | 17,958
Blood and immune system 941 | 17,995
Male tissues 935 | 17,969
Respiratory system 899 | 17,484

Target Family

Non-IDG 580 | 11,971
Enzyme 186 | 4,146
Kinase 108 | 634
Transcription Factor 88 | 1,400
Ion Channel 41 | 341
Nuclear Receptor 12 | 48
Epigenetic 11 | 242
Transporter 2 | 473
TF/Epigenetic 1 | 38

Reactome Pathway

Developmental Biology 1,029 | 1,029
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Teratocarcinoma-derived growth factor 1 TDGF1 Tbio Non-IDG 156.3 371
Cyclin-dependent kinase 8 CDK8 Tchem Kinase -1.96301 102.7 307
Keratin, type II cytoskeletal 3 KRT3 Tbio Non-IDG -2.12849 126.8 100
Fibroblast growth factor 5 FGF5 Tbio Non-IDG -2.00731 99.9 143
Solute carrier family 2, facilitated glucose transporter member 4 SLC2A4 Tchem Transporter -3.30074 2066.8 474
Desmoplakin DSP Tbio Non-IDG -2.90088 786.5 167
Transcription factor E2-alpha TCF3 Tbio Transcription Factor -2.76637 577.9 373