Development Level

Tbio 701 | 11,651
Tdark 146 | 6,593
Tchem 123 | 1,388
Tclin 56 | 612

Collection

RFA-RM-18-021 17 | 328
Ion Channel: IDG Consortium (T... 10 | 99
Kinase: IDG Consortium (Target... 7 | 125
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 73 | 979
preweaning lethality, incomple... 29 | 499
embryonic lethality prior to t... 24 | 278
abnormal embryo size 18 | 220
abnormal bone structure 16 | 187
decreased total body fat amoun... 15 | 207
decreased vertical activity 15 | 208
decreased body weight 13 | 161
embryonic lethality prior to o... 13 | 239
embryonic growth retardation 11 | 106
abnormal behavior 10 | 298
abnormal retina morphology 10 | 71
increased circulating alkaline... 9 | 122
prenatal lethality prior to he... 9 | 87
decreased bone mineral content 8 | 151
decreased bone mineral density 8 | 126
increased lean body mass 8 | 172
increased startle reflex 8 | 112
short tibia 8 | 97
abnormal cornea morphology 7 | 31
abnormal heart morphology 7 | 162
decreased circulating triglyce... 7 | 79
edema 7 | 59
hyperactivity 7 | 148
increased circulating triglyce... 7 | 42
increased mean corpuscular hem... 7 | 96
increased total body fat amoun... 7 | 134
persistence of hyaloid vascula... 7 | 33
abnormal gait 6 | 69
decreased circulating glucose ... 6 | 126
decreased lean body mass 6 | 135
decreased startle reflex 6 | 75
hypoactivity 6 | 132
impaired glucose tolerance 6 | 75
increased or absent threshold ... 6 | 101
pale yolk sac 6 | 25
abnormal kidney morphology 5 | 65
abnormal spleen morphology 5 | 55
cataract 5 | 92
decreased body length 5 | 101
decreased caudal vertebrae num... 5 | 53
decreased circulating amylase ... 5 | 28
decreased circulating choleste... 5 | 93
decreased circulating insulin ... 5 | 76
decreased circulating serum al... 5 | 82
decreased circulating total pr... 5 | 49
enlarged heart 5 | 210
male infertility 5 | 123
pallor 5 | 34
prolonged QT interval 5 | 38
abnormal coat appearance 4 | 31
abnormal eye morphology 4 | 68
abnormal lens morphology 4 | 81
abnormal neural tube closure 4 | 46
abnormal pericardium morpholog... 4 | 26
abnormal placenta size 4 | 20
corneal opacity 4 | 32
decreased circulating HDL chol... 4 | 68
decreased leukocyte cell numbe... 4 | 73
decreased lymphocyte cell numb... 4 | 83
decreased mean corpuscular vol... 4 | 79
decreased prepulse inhibition 4 | 82
hydrometra 4 | 53
impaired pupillary reflex 4 | 26
increased bone mineral density 4 | 72
increased mean corpuscular vol... 4 | 92
increased monocyte cell number 4 | 63
increased neutrophil cell numb... 4 | 46
prenatal lethality 4 | 28
small superior vagus ganglion 4 | 74
abnormal bone mineralization 3 | 38
abnormal coat-hair pigmentatio... 3 | 64
abnormal locomotor activation 3 | 16
abnormal retinal vasculature m... 3 | 27
abnormal seminal vesicle morph... 3 | 114
abnormal skin morphology 3 | 50
abnormal tooth morphology 3 | 24
decreased circulating LDL chol... 3 | 38
decreased circulating calcium ... 3 | 36
decreased circulating creatini... 3 | 39
decreased circulating fructosa... 3 | 30
decreased erythrocyte cell num... 3 | 62
decreased fasted circulating g... 3 | 65
decreased grip strength 3 | 116
decreased hematocrit 3 | 46
decreased hemoglobin content 3 | 68
decreased neutrophil cell numb... 3 | 42
enlarged uterus 3 | 11
female infertility 3 | 60
hemorrhage 3 | 23
increased blood urea nitrogen ... 3 | 48
increased bone mineral content 3 | 108
increased circulating choleste... 3 | 66
increased circulating free fat... 3 | 20
increased fasted circulating g... 3 | 76
increased hematocrit 3 | 46
increased hemoglobin content 3 | 45
increased red blood cell distr... 3 | 34
prolonged ST segment 3 | 36
small testis 3 | 58

Disease

Carcinoma 614 | 11,493
ovarian cancer 481 | 8,520
psoriasis 476 | 6,694
osteosarcoma 405 | 7,950
glioblastoma 359 | 5,792
medulloblastoma, large-cell 342 | 6,241
lung cancer 324 | 4,740
atypical teratoid / rhabdoid tumor 305 | 5,112
Cancer 263 | 2,499
Breast cancer 258 | 3,578
ependymoma 248 | 4,679
group 3 medulloblastoma 220 | 4,104
adult high grade glioma 219 | 3,801
Kidney cancer 213 | 2,613
malignant mesothelioma 213 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 202 | 3,291
diabetes mellitus 194 | 1,728
Astrocytoma, Pilocytic 192 | 3,081
oligodendroglioma 192 | 2,850
invasive ductal carcinoma 181 | 2,951
primitive neuroectodermal tumor 180 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 170 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 169 | 2,955
non-small cell lung cancer 163 | 2,890
lung carcinoma 158 | 2,843
pancreatic cancer 158 | 2,398
lung adenocarcinoma 153 | 2,716
astrocytic glioma 152 | 2,597
subependymal giant cell astrocytoma 143 | 2,287
cystic fibrosis 133 | 1,696
interstitial cystitis 131 | 2,312
pituitary cancer 129 | 1,972
breast carcinoma 124 | 1,638
Pick disease 118 | 1,894
Schizophrenia 111 | 1,160
ductal carcinoma in situ 110 | 1,745
Multiple myeloma 108 | 1,332
group 4 medulloblastoma 104 | 1,855
ulcerative colitis 102 | 1,819
colon cancer 97 | 1,478
astrocytoma 95 | 1,146
Atopic dermatitis 90 | 952
acute quadriplegic myopathy 86 | 1,158
Intellectual disability 85 | 1,016
Autosomal recessive predisposition 82 | 1,442
tuberculosis 81 | 2,010
Epilepsy 80 | 792
pancreatic ductal adenocarcinoma liver metastasis 74 | 1,962
primary pancreatic ductal adenocarcinoma 74 | 1,109
spina bifida 74 | 1,074
Waldenstrons macroglobulinemia 72 | 765
Alzheimer's disease 70 | 658
dermatomyositis 70 | 966
Liver cancer 69 | 604
Breast Neoplasms 68 | 445
Rheumatoid arthritis 68 | 1,191
juvenile dermatomyositis 68 | 1,187
Mammary Neoplasms 66 | 425
Melanoma 64 | 711
adrenocortical carcinoma 64 | 1,428
cutaneous lupus erythematosus 64 | 1,057
esophageal adenocarcinoma 63 | 737
nasopharyngeal carcinoma 63 | 1,058
pediatric high grade glioma 61 | 1,064
Seizures 60 | 596
Bipolar Disorder 59 | 666
Liver Cirrhosis, Experimental 57 | 769
Dull intelligence 54 | 645
Low intelligence 54 | 645
Mental Retardation 54 | 645
Mental deficiency 54 | 645
Poor school performance 54 | 645
Prostatic Neoplasms 54 | 495
Skin cancer 54 | 469
Cognitive delay 51 | 608
Global developmental delay 51 | 608
Mental and motor retardation 51 | 608
Muscle hypotonia 51 | 571
acute myeloid leukemia 51 | 783
Obesity 47 | 678
medulloblastoma 47 | 720
Short stature 46 | 531
Stomach Neoplasms 46 | 300
Cleft Palate 45 | 271
gastric carcinoma 45 | 807
Autistic Disorder 44 | 364
Down syndrome 43 | 499
Parkinson's disease 43 | 392
Duchenne muscular dystrophy 42 | 601
autosomal dominant Emery-Dreifuss muscular dystrophy 41 | 510
Anemia 39 | 365
Endometrial cancer 39 | 311
Heart disease 39 | 306
non primary Sjogren syndrome sicca 39 | 891
primary Sjogren syndrome 39 | 735
Carcinoma, Squamous Cell 38 | 110
Endometriosis 38 | 540
Osteoporosis 37 | 363
Squamous cell carcinoma 37 | 129
fibroadenoma 37 | 559

Tissue

Endocrine System 913 | 18,159
Skin and soft tissues 909 | 17,230
Female tissues 902 | 17,400
Digestive Tract 901 | 17,369
Blood and immune system 867 | 16,909
Male tissues 850 | 17,142
Liver and Pancreas 841 | 16,750
Nervous System 839 | 16,725
Urinary Tract 821 | 16,678
Respiratory system 805 | 16,393
Cardiovascular System 762 | 15,192

Target Family

Non-IDG 616 | 12,091
Enzyme 165 | 4,145
Transcription Factor 93 | 1,400
Kinase 84 | 634
Ion Channel 38 | 344
Nuclear Receptor 15 | 48
Epigenetic 11 | 242
Transporter 2 | 473
GPCR 1 | 408
TF/Epigenetic 1 | 38

Reactome Pathway

Developmental Biology 1,026 | 1,026
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Kallikrein-12 KLK12 Tbio Enzyme -0.99694 11.0 111
Integrin alpha-2 ITGA2 Tbio Non-IDG -2.58423 335.9 895
Filaggrin FLG Tbio Non-IDG -3.03594 1055.2 253
Ras GTPase-activating protein 1 RASA1 Tbio Enzyme -2.61637 404.4 402
Transcription factor HES-1 HES1 Tbio Transcription Factor -1.77409 55.5 444
Proprotein convertase subtilisin/kexin type 6 PCSK6 Tchem Enzyme -2.33983 216.4 239
60S ribosomal protein L17 RPL17 Tbio Non-IDG -1.22337 16.5 217
Desmoglein-3 DSG3 Tbio Non-IDG -2.57795 402.0 381
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Ephrin type-A receptor 6 EPHA6 Tchem Kinase -1.34848 21.8 266