Development Level

Tbio 174 | 10,625
Tchem 56 | 1,890
Tdark 36 | 7,003
Tclin 11 | 602

IMPC Phenotype

preweaning lethality, complete... 23 | 633
decreased lean body mass 7 | 195
decreased body weight 6 | 174
increased circulating alkaline... 6 | 119
abnormal behavior 5 | 226
embryonic lethality prior to t... 5 | 187
decreased body length 4 | 108
decreased total body fat amoun... 4 | 186
embryonic lethality prior to o... 4 | 148
increased mean corpuscular vol... 4 | 91
increased sacral vertebrae num... 4 | 62
preweaning lethality, incomple... 4 | 260
thrombocytopenia 4 | 46
decreased B cell number 3 | 30
decreased circulating choleste... 3 | 85
decreased circulating total pr... 3 | 41
decreased circulating triglyce... 3 | 83
decreased hemoglobin content 3 | 53
decreased leukocyte cell numbe... 3 | 54
decreased lumbar vertebrae num... 3 | 62
increased heart weight 3 | 37
increased mean corpuscular hem... 3 | 93
thrombocytosis 3 | 23
abnormal bone mineralization 2 | 55
abnormal coping response 2 | 12
abnormal cornea morphology 2 | 24
abnormal cranium morphology 2 | 32
abnormal gait 2 | 51
abnormal vocalization 2 | 21
corneal opacity 2 | 25
decreased CD4-positive, CD25-p... 2 | 24
decreased Ly6C low monocyte nu... 2 | 23
decreased circulating aspartat... 2 | 27
decreased circulating glucose ... 2 | 121
decreased gamma-delta T cell n... 2 | 18
decreased mean corpuscular hem... 2 | 34
decreased mean corpuscular vol... 2 | 50
decreased neutrophil cell numb... 2 | 37
hyperactivity 2 | 108
hypoactivity 2 | 89
increased CD4-positive, alpha ... 2 | 15
increased NK cell number 2 | 19
increased T cell number 2 | 15
increased alpha-beta T cell nu... 2 | 9
increased circulating HDL chol... 2 | 63
increased circulating aspartat... 2 | 17
increased circulating choleste... 2 | 53
increased circulating glucose ... 2 | 16
increased circulating phosphat... 2 | 24
increased effector memory CD4-... 2 | 15
increased granulocyte number 2 | 8
increased grip strength 2 | 83
increased mean corpuscular hem... 2 | 25
increased monocyte cell number 2 | 27
narrow eye opening 2 | 15
polydactyly 2 | 22
prenatal lethality prior to he... 2 | 64
vertebral fusion 2 | 23
abnormal QRS complex 1 | 25
abnormal coat- hair morphology 1 | 18
abnormal eyelid morphology 1 | 6
abnormal femur morphology 1 | 14
abnormal lip morphology 1 | 2
abnormal locomotor activation 1 | 26
abnormal rib morphology 1 | 28
abnormal tail morphology 1 | 17
abnormal vertebrae morphology 1 | 14
abnormal vertebral arch morpho... 1 | 9
decreased KLRG1-positive NK ce... 1 | 9
decreased Ly6C high monocyte n... 1 | 18
decreased blood urea nitrogen ... 1 | 31
decreased caudal vertebrae num... 1 | 49
decreased cervical vertebrae n... 1 | 12
decreased circulating calcium ... 1 | 33
decreased circulating creatini... 1 | 31
decreased circulating serum al... 1 | 79
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased mature B cell number 1 | 25
decreased monocyte cell number 1 | 28
increased NK T cell number 1 | 11
increased blood uric acid leve... 1 | 5
increased body length 1 | 20
increased body weight 1 | 42
increased bone mineral density 1 | 52
increased circulating amylase ... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating iron lev... 1 | 25
increased circulating magnesiu... 1 | 10
increased circulating potassiu... 1 | 31
increased circulating serum al... 1 | 25
increased leukocyte cell numbe... 1 | 37
increased lymphocyte cell numb... 1 | 9
increased mature B cell number 1 | 12
increased rib number 1 | 41
pale yolk sac 1 | 12
persistence of hyaloid vascula... 1 | 22
short tibia 1 | 82
straub tail 1 | 26

Disease

ovarian cancer 172 | 8,491
osteosarcoma 129 | 7,933
psoriasis 106 | 6,685
glioblastoma 93 | 5,572
lung cancer 92 | 4,473
medulloblastoma, large-cell 79 | 6,234
Cancer 72 | 2,346
atypical teratoid / rhabdoid tumor 70 | 4,369
Breast cancer 60 | 3,098
malignant mesothelioma 55 | 3,163
Multiple myeloma 47 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 45 | 3,289
lung adenocarcinoma 45 | 2,714
non-small cell lung cancer 43 | 2,798
oligodendroglioma 42 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 38 | 2,988
Carcinoma 36 | 2,147
invasive ductal carcinoma 36 | 2,950
subependymal giant cell astrocytoma 36 | 2,287
primitive neuroectodermal tumor 35 | 3,031
astrocytic glioma 32 | 2,241
intraductal papillary-mucinous adenoma (IPMA) 32 | 2,956
pancreatic cancer 32 | 2,300
pediatric high grade glioma 32 | 2,712
pilocytic astrocytoma 32 | 3,086
ependymoma 31 | 2,514
lung carcinoma 31 | 2,844
dermatomyositis 30 | 966
group 3 medulloblastoma 30 | 2,254
juvenile dermatomyositis 30 | 1,189
pancreatic ductal adenocarcinoma liver metastasis 30 | 1,795
diabetes mellitus 29 | 1,663
Pick disease 27 | 1,893
adult high grade glioma 26 | 2,148
astrocytoma 26 | 1,493
ulcerative colitis 26 | 2,087
cystic fibrosis 24 | 1,670
group 4 medulloblastoma 24 | 1,875
tuberculosis 24 | 1,563
acute myeloid leukemia 22 | 785
medulloblastoma 22 | 1,524
posterior fossa group A ependymoma 22 | 1,511
Rheumatoid Arthritis 21 | 1,170
Waldenstrons macroglobulinemia 21 | 764
ductal carcinoma in situ 21 | 1,745
acute quadriplegic myopathy 20 | 1,157
adrenocortical carcinoma 20 | 1,427
breast carcinoma 20 | 1,614
colon cancer 20 | 1,475
cutaneous lupus erythematosus 19 | 1,056
HIV Infections 18 | 99
interstitial cystitis 17 | 2,299
spina bifida 17 | 1,064
Prostatic Neoplasms 16 | 471
hepatocellular carcinoma 16 | 550
Atopic dermatitis 15 | 944
pituitary cancer 15 | 1,972
tuberculosis and treatment for 6 months 15 | 686
Alzheimer's disease 14 | 644
Liver carcinoma 14 | 217
Mammary Neoplasms 14 | 410
gastric cancer 14 | 436
non-small cell lung carcinoma 14 | 413
primary pancreatic ductal adenocarcinoma 13 | 1,271
active Crohn's disease 12 | 918
posterior fossa group B ependymoma 12 | 1,530
primary Sjogren syndrome 12 | 788
Crohn's disease 11 | 304
Lung Neoplasms 11 | 171
Parkinson's disease 11 | 364
Vascular disease 11 | 281
pancreatic carcinoma 11 | 567
sonic hedgehog group medulloblastoma 11 | 1,482
Bladder Neoplasm 10 | 109
Neurodegenerative disease 10 | 383
Peripheral Neuropathy 10 | 303
glioblastoma multiforme 10 | 347
nasopharyngeal carcinoma 10 | 1,056
non primary Sjogren syndrome sicca 10 | 840
Adenoma 9 | 165
Amyotrophic Lateral Sclerosis 9 | 432
Colorectal Neoplasms 9 | 217
Endometriosis 9 | 535
IGA Glomerulonephritis 9 | 454
Intellectual disability 9 | 573
Kidney disease 9 | 397
esophageal adenocarcinoma 9 | 737
progressive supranuclear palsy 9 | 674
Asthma 8 | 349
Craniofacial Abnormalities 8 | 147
Male infertility 8 | 170
Malignant neoplasm of breast 8 | 63
Melanoma 8 | 261
Neoplastic Cell Transformation 8 | 81
Neoplastic Syndromes, Hereditary 8 | 48
Prostate cancer 8 | 172
Stomach Neoplasms 8 | 282
aldosterone-producing adenoma 8 | 664
inflammatory breast cancer 8 | 404
Lung disease 7 | 136

Tissue

Nervous System 276 | 18,560
Female tissues 275 | 18,646
Blood and immune system 273 | 17,994
Urinary Tract 266 | 18,443
Endocrine System 264 | 18,511
Digestive Tract 263 | 18,472
Liver and Pancreas 262 | 18,135
Male tissues 261 | 17,968
Cardiovascular System 259 | 17,957
Respiratory system 258 | 17,483
Skin and soft tissues 254 | 18,114

Target Family

Enzyme 129 | 4,146
Non-IDG 115 | 11,969
Transcription Factor 15 | 1,400
Epigenetic 7 | 242
Kinase 7 | 634
Nuclear Receptor 2 | 48
GPCR 1 | 408
Ion Channel 1 | 341

Reactome Pathway

Deubiquitination 277 | 277
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.13212 1.19 10
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.16 0.33 20
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 42
Histone H2B type 1-N HIST1H2BN Tdark Non-IDG -1.51554 30.2 48
Breast cancer type 1 susceptibility protein BRCA1 Tchem Non-IDG -3.74239 5756.8 1322
E3 ubiquitin-protein ligase RNF146 RNF146 Tbio Enzyme -0.92024 8.53 46
Histone H2A type 1-B/E HIST1H2AB Tbio Non-IDG -1.26707 18.9 109
Interferon-induced helicase C domain-containing protein 1 IFIH1 Tbio Enzyme -2.60557 384.3 296
Ubiquitin carboxyl-terminal hydrolase 17-like protein 20 USP17L20 Tdark Enzyme 0.00000 0
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.09050 11730.8 2241