Development Level

Tbio 193 | 11,651
Tchem 38 | 1,388
Tdark 34 | 6,593
Tclin 11 | 612

IMPC Phenotype

preweaning lethality, complete... 30 | 979
decreased body weight 6 | 161
embryonic lethality prior to t... 6 | 278
preweaning lethality, incomple... 6 | 499
abnormal behavior 5 | 298
decreased total body fat amoun... 5 | 207
hypoactivity 5 | 132
decreased circulating choleste... 4 | 93
embryonic lethality prior to o... 4 | 239
increased mean corpuscular hem... 4 | 96
increased startle reflex 4 | 112
male infertility 4 | 123
thrombocytopenia 4 | 56
corneal opacity 3 | 32
decreased body length 3 | 101
decreased hemoglobin content 3 | 68
decreased lean body mass 3 | 135
decreased leukocyte cell numbe... 3 | 73
increased circulating HDL chol... 3 | 80
increased circulating alkaline... 3 | 122
increased circulating choleste... 3 | 66
increased lean body mass 3 | 172
increased mean corpuscular vol... 3 | 92
thrombocytosis 3 | 27
abnormal cornea morphology 2 | 31
abnormal cranium morphology 2 | 36
abnormal embryo size 2 | 220
abnormal facial morphology 2 | 17
abnormal head shape 2 | 10
abnormal heart morphology 2 | 162
abnormal limb morphology 2 | 13
abnormal tail morphology 2 | 25
abnormal vocalization 2 | 21
anophthalmia 2 | 33
decreased caudal vertebrae num... 2 | 53
decreased circulating glucose ... 2 | 126
decreased circulating total pr... 2 | 49
decreased mean corpuscular hem... 2 | 50
decreased red blood cell distr... 2 | 41
enlarged heart 2 | 210
female infertility 2 | 60
hyperactivity 2 | 148
increased body weight 2 | 25
increased circulating glucose ... 2 | 24
increased circulating phosphat... 2 | 26
increased heart weight 2 | 62
increased mean platelet volume 2 | 45
long tibia 2 | 25
microphthalmia 2 | 26
narrow eye opening 2 | 12
prenatal lethality prior to he... 2 | 87
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
vertebral fusion 2 | 23
abnormal behavioral response t... 1 | 66
abnormal body wall morphology 1 | 9
abnormal coat- hair morphology 1 | 19
abnormal craniofacial morpholo... 1 | 33
abnormal eyelid morphology 1 | 7
abnormal gait 1 | 69
abnormal head size 1 | 6
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal pelvic girdle bone mo... 1 | 12
abnormal seminal vesicle morph... 1 | 114
abnormal spine curvature 1 | 9
abnormal vertebrae morphology 1 | 18
cleft palate 1 | 8
decreased KLRG1+ CD8 alpha bet... 1 | 2
decreased blood urea nitrogen ... 1 | 51
decreased circulating calcium ... 1 | 36
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fluid intake 1 | 3
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
edema 1 | 59
impaired pupillary reflex 1 | 26
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased blood uric acid leve... 1 | 5
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating magnesiu... 1 | 10
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased red blood cell distr... 1 | 34
increased total body fat amoun... 1 | 134
persistence of hyaloid vascula... 1 | 33
shortened RR interval 1 | 17
syndactyly 1 | 23
thin ventricular wall 1 | 24

Disease

Carcinoma 176 | 11,493
ovarian cancer 169 | 8,520
osteosarcoma 127 | 7,950
psoriasis 105 | 6,694
glioblastoma 98 | 5,792
lung cancer 97 | 4,740
medulloblastoma, large-cell 79 | 6,241
Cancer 76 | 2,499
atypical teratoid / rhabdoid tumor 75 | 5,112
Breast cancer 66 | 3,578
malignant mesothelioma 57 | 3,232
ependymoma 52 | 4,679
adult high grade glioma 51 | 3,801
group 3 medulloblastoma 49 | 4,104
Multiple myeloma 47 | 1,332
non-small cell lung cancer 46 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 45 | 3,291
lung adenocarcinoma 45 | 2,716
oligodendroglioma 43 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,989
Kidney cancer 38 | 2,613
astrocytic glioma 38 | 2,597
invasive ductal carcinoma 37 | 2,951
subependymal giant cell astrocytoma 37 | 2,287
pancreatic cancer 34 | 2,398
primitive neuroectodermal tumor 34 | 3,035
Astrocytoma, Pilocytic 31 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 31 | 2,955
lung carcinoma 31 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 31 | 1,962
dermatomyositis 30 | 966
diabetes mellitus 30 | 1,728
juvenile dermatomyositis 30 | 1,187
Pick disease 27 | 1,894
tuberculosis 27 | 2,010
group 4 medulloblastoma 26 | 1,855
breast carcinoma 25 | 1,638
cystic fibrosis 24 | 1,696
Waldenstrons macroglobulinemia 23 | 765
ulcerative colitis 23 | 1,819
ductal carcinoma in situ 22 | 1,745
acute myeloid leukemia 21 | 783
adrenocortical carcinoma 21 | 1,428
astrocytoma 21 | 1,146
colon cancer 21 | 1,478
HIV Infections 20 | 102
Rheumatoid arthritis 20 | 1,191
acute quadriplegic myopathy 20 | 1,158
cutaneous lupus erythematosus 19 | 1,057
interstitial cystitis 18 | 2,312
Intellectual disability 17 | 1,016
Prostatic Neoplasms 17 | 495
spina bifida 17 | 1,074
Atopic dermatitis 16 | 952
Breast Neoplasms 16 | 445
Liver Cirrhosis, Experimental 16 | 769
Mammary Neoplasms 16 | 425
Schizophrenia 16 | 1,160
hepatocellular carcinoma 16 | 547
Carcinoma, Hepatocellular 14 | 228
Liver carcinoma 14 | 240
pituitary cancer 14 | 1,972
primary Sjogren syndrome 14 | 735
Bipolar Disorder 13 | 666
Melanoma 13 | 711
gastric cancer 13 | 459
non-small cell lung carcinoma 13 | 317
Asthma 12 | 385
Vascular disease 12 | 319
active Crohn's disease 12 | 922
Alzheimer's disease 11 | 658
Bladder Neoplasm 11 | 112
Crohn's disease 11 | 321
Lung Neoplasms 11 | 232
Parkinson's disease 11 | 392
Stomach Neoplasms 11 | 300
Urinary Bladder Neoplasms 11 | 114
nasopharyngeal carcinoma 11 | 1,058
tuberculosis and treatment for 6 months 11 | 409
Cleft Palate 10 | 271
Epilepsy 10 | 792
Hypertensive disease 10 | 292
Neurodegenerative disease 10 | 414
Osteoporosis 10 | 363
Pancreatic Neoplasm 10 | 85
esophageal adenocarcinoma 10 | 737
non primary Sjogren syndrome sicca 10 | 891
primary pancreatic ductal adenocarcinoma 10 | 1,109
Amyotrophic lateral sclerosis 9 | 451
Autosomal recessive predisposition 9 | 1,442
Colonic Neoplasms 9 | 142
Depressive disorder 9 | 409
Endometrial cancer 9 | 311
Endometriosis 9 | 540
Failure to gain weight 9 | 365
Liver cancer 9 | 604
Pancreatic Neoplasms 9 | 85
Pediatric failure to thrive 9 | 365
Prostate cancer 9 | 175
pancreatic carcinoma 9 | 562

Tissue

Endocrine System 259 | 18,159
Female tissues 257 | 17,400
Blood and immune system 255 | 16,909
Male tissues 255 | 17,142
Digestive Tract 254 | 17,369
Liver and Pancreas 254 | 16,750
Nervous System 254 | 16,725
Respiratory system 254 | 16,393
Skin and soft tissues 254 | 17,230
Urinary Tract 254 | 16,678
Cardiovascular System 249 | 15,192

Target Family

Enzyme 129 | 4,145
Non-IDG 113 | 12,091
Transcription Factor 15 | 1,400
Kinase 8 | 634
Epigenetic 7 | 242
Nuclear Receptor 2 | 48
GPCR 1 | 408
Ion Channel 1 | 344

Reactome Pathway

Deubiquitination 276 | 276
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
INO80 complex subunit B INO80B Tbio Non-IDG -1.16370 15.1 53
Estrogen receptor ESR1 Tclin Nuclear Receptor -4.00480 8421.6 2610
Ubiquitin carboxyl-terminal hydrolase 3 USP3 Tbio Enzyme -1.16770 14.5 246
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879