Development Level

Tbio 174 | 10,625
Tchem 57 | 1,890
Tdark 36 | 7,003
Tclin 11 | 602

IMPC Term

preweaning lethality, complete... 23 | 633
decreased lean body mass 7 | 195
decreased body weight 6 | 174
increased circulating alkaline... 6 | 119
abnormal behavior 5 | 226
embryonic lethality prior to t... 5 | 187
decreased body length 4 | 108
decreased total body fat amoun... 4 | 186
embryonic lethality prior to o... 4 | 148
increased mean corpuscular vol... 4 | 91
increased sacral vertebrae num... 4 | 62
preweaning lethality, incomple... 4 | 260
thrombocytopenia 4 | 46
decreased B cell number 3 | 30
decreased circulating choleste... 3 | 85
decreased circulating total pr... 3 | 41
decreased circulating triglyce... 3 | 83
decreased hemoglobin content 3 | 53
decreased leukocyte cell numbe... 3 | 54
decreased lumbar vertebrae num... 3 | 62
increased heart weight 3 | 37
increased mean corpuscular hem... 3 | 93
thrombocytosis 3 | 23
abnormal bone mineralization 2 | 55
abnormal coping response 2 | 12
abnormal cornea morphology 2 | 24
abnormal cranium morphology 2 | 32
abnormal gait 2 | 51
abnormal vocalization 2 | 21
corneal opacity 2 | 25
decreased CD4-positive, CD25-p... 2 | 24
decreased Ly6C low monocyte nu... 2 | 23
decreased circulating aspartat... 2 | 27
decreased circulating glucose ... 2 | 121
decreased gamma-delta T cell n... 2 | 18
decreased mean corpuscular hem... 2 | 34
decreased mean corpuscular vol... 2 | 50
decreased neutrophil cell numb... 2 | 37
hyperactivity 2 | 108
hypoactivity 2 | 89
increased CD4-positive, alpha ... 2 | 15
increased NK cell number 2 | 19
increased T cell number 2 | 15
increased alpha-beta T cell nu... 2 | 9
increased circulating HDL chol... 2 | 63
increased circulating aspartat... 2 | 17
increased circulating choleste... 2 | 53
increased circulating glucose ... 2 | 16
increased circulating phosphat... 2 | 24
increased effector memory CD4-... 2 | 15
increased granulocyte number 2 | 8
increased grip strength 2 | 83
increased mean corpuscular hem... 2 | 25
increased monocyte cell number 2 | 27
narrow eye opening 2 | 15
polydactyly 2 | 22
prenatal lethality prior to he... 2 | 64
vertebral fusion 2 | 23
abnormal QRS complex 1 | 25
abnormal coat/ hair morphology 1 | 18
abnormal eyelid morphology 1 | 6
abnormal femur morphology 1 | 14
abnormal lip morphology 1 | 2
abnormal locomotor activation 1 | 26
abnormal rib morphology 1 | 28
abnormal tail morphology 1 | 17
abnormal vertebrae morphology 1 | 14
abnormal vertebral arch morpho... 1 | 9
decreased KLRG1-positive NK ce... 1 | 9
decreased Ly6C high monocyte n... 1 | 18
decreased blood urea nitrogen ... 1 | 31
decreased caudal vertebrae num... 1 | 49
decreased cervical vertebrae n... 1 | 12
decreased circulating calcium ... 1 | 33
decreased circulating creatini... 1 | 31
decreased circulating serum al... 1 | 79
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased mature B cell number 1 | 25
decreased monocyte cell number 1 | 28
increased NK T cell number 1 | 11
increased blood uric acid leve... 1 | 5
increased body length 1 | 20
increased body weight 1 | 42
increased bone mineral density 1 | 52
increased circulating amylase ... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating iron lev... 1 | 25
increased circulating magnesiu... 1 | 10
increased circulating potassiu... 1 | 31
increased circulating serum al... 1 | 25
increased leukocyte cell numbe... 1 | 37
increased lymphocyte cell numb... 1 | 9
increased mature B cell number 1 | 12
increased rib number 1 | 41
pale yolk sac 1 | 12
persistence of hyaloid vascula... 1 | 22
short tibia 1 | 82
straub tail 1 | 26

Disease

ovarian cancer 171 | 8,484
osteosarcoma 129 | 7,933
psoriasis 106 | 6,685
glioblastoma 93 | 5,572
lung cancer 91 | 4,466
medulloblastoma, large-cell 79 | 6,234
Cancer 72 | 2,346
atypical teratoid / rhabdoid tumor 70 | 4,369
Breast cancer 61 | 3,094
malignant mesothelioma 55 | 3,162
Multiple myeloma 48 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 45 | 3,289
lung adenocarcinoma 44 | 2,713
non-small cell lung cancer 43 | 2,798
oligodendroglioma 42 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 38 | 2,988
Carcinoma 36 | 2,147
invasive ductal carcinoma 36 | 2,950
subependymal giant cell astrocytoma 36 | 2,287
primitive neuroectodermal tumor 35 | 3,031
astrocytic glioma 32 | 2,241
intraductal papillary-mucinous adenoma (IPMA) 32 | 2,956
pancreatic cancer 32 | 2,300
pediatric high grade glioma 32 | 2,712
pilocytic astrocytoma 32 | 3,086
dermatomyositis 31 | 933
ependymoma 31 | 2,514
lung carcinoma 31 | 2,844
group 3 medulloblastoma 30 | 2,254
juvenile dermatomyositis 30 | 1,189
pancreatic ductal adenocarcinoma liver metastasis 30 | 1,795
diabetes mellitus 29 | 1,663
Pick disease 27 | 1,893
adult high grade glioma 26 | 2,148
astrocytoma 26 | 1,493
ulcerative colitis 26 | 2,087
cystic fibrosis 24 | 1,665
group 4 medulloblastoma 24 | 1,875
tuberculosis 24 | 1,557
Rheumatoid Arthritis 22 | 1,160
Waldenstrons macroglobulinemia 22 | 765
medulloblastoma 22 | 1,524
posterior fossa group A ependymoma 22 | 1,511
acute myeloid leukemia 21 | 780
ductal carcinoma in situ 21 | 1,745
acute quadriplegic myopathy 20 | 1,157
adrenocortical carcinoma 20 | 1,427
breast carcinoma 20 | 1,614
colon cancer 20 | 1,475
HIV Infections 19 | 100
cutaneous lupus erythematosus 19 | 1,056
interstitial cystitis 17 | 2,299
spina bifida 17 | 1,064
Prostatic Neoplasms 16 | 471
Atopic dermatitis 15 | 944
pituitary cancer 15 | 1,972
tuberculosis and treatment for 6 months 15 | 686
Alzheimer's disease 14 | 644
Liver carcinoma 14 | 217
Mammary Neoplasms 14 | 410
non-small cell lung carcinoma 14 | 413
gastric cancer 13 | 430
hepatocellular carcinoma 13 | 532
primary Sjogren syndrome 13 | 789
primary pancreatic ductal adenocarcinoma 13 | 1,271
active Crohn's disease 12 | 918
posterior fossa group B ependymoma 12 | 1,530
Crohn's disease 11 | 304
Lung Neoplasms 11 | 171
Parkinson's disease 11 | 364
Vascular disease 11 | 281
pancreatic carcinoma 11 | 567
sonic hedgehog group medulloblastoma 11 | 1,482
Bladder Neoplasm 10 | 109
Neurodegenerative disease 10 | 383
Peripheral Neuropathy 10 | 303
glioblastoma multiforme 10 | 347
nasopharyngeal carcinoma 10 | 1,056
non primary Sjogren syndrome sicca 10 | 840
Adenoma 9 | 165
Amyotrophic Lateral Sclerosis 9 | 431
Colorectal Neoplasms 9 | 217
Endometriosis 9 | 535
IGA Glomerulonephritis 9 | 454
Intellectual disability 9 | 573
Kidney disease 9 | 396
esophageal adenocarcinoma 9 | 737
progressive supranuclear palsy 9 | 674
Asthma 8 | 349
Craniofacial Abnormalities 8 | 147
Male infertility 8 | 170
Malignant neoplasm of breast 8 | 63
Melanoma 8 | 261
Neoplastic Cell Transformation 8 | 81
Neoplastic Syndromes, Hereditary 8 | 48
Prostate cancer 8 | 172
Stomach Neoplasms 8 | 282
aldosterone-producing adenoma 8 | 664
inflammatory breast cancer 8 | 404
Lung disease 7 | 132

Tissue

Nervous System 277 | 18,561
Female tissues 276 | 18,647
Blood and immune system 274 | 17,995
Urinary Tract 267 | 18,444
Endocrine System 265 | 18,512
Digestive Tract 264 | 18,473
Liver and Pancreas 263 | 18,136
Male tissues 262 | 17,969
Cardiovascular System 260 | 17,958
Respiratory system 259 | 17,484
Skin and soft tissues 255 | 18,115

Target Family

Enzyme 130 | 4,146
Non-IDG 115 | 11,971
Transcription Factor 15 | 1,400
Epigenetic 7 | 242
Kinase 7 | 634
Nuclear Receptor 2 | 48
GPCR 1 | 406
Ion Channel 1 | 341

Reactome Pathway

Deubiquitination 278 | 278
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin carboxyl-terminal hydrolase 24 USP24 Tbio Enzyme -1.53939 36.4 61
Ubiquitin carboxyl-terminal hydrolase 22 USP22 Tbio Enzyme -1.59877 51.0 199
Ubiquitin carboxyl-terminal hydrolase 17-like protein 1 USP17L1 Tdark Enzyme 10.9 3
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
TNF receptor-associated factor 2 TRAF2 Tbio Non-IDG -1.85843 68.9 516
Host cell factor 1 HCFC1 Tbio Non-IDG -2.50024 341.6 160
Lysine-specific histone demethylase 1B KDM1B Tbio Epigenetic -1.39308 24.2 69
Ubiquitin carboxyl-terminal hydrolase 11 USP11 Tbio Enzyme -1.06624 14.9 210
Transcriptional repressor protein YY1 YY1 Tbio Transcription Factor -2.75991 594.0 437
Beta-arrestin-1 ARRB1 Tchem Non-IDG -2.54226 366.3 416