Development Level

Tbio 9 | 11,445
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, incomple... 2 | 499
abnormal QT variability 1 | 10
absent startle reflex 1 | 24
hypoactivity 1 | 132
increased lean body mass 1 | 172

Disease

Carcinoma 9 | 11,493
Astrocytoma, Pilocytic 7 | 3,081
glioblastoma 7 | 5,792
ovarian cancer 7 | 8,520
adult high grade glioma 6 | 3,801
ependymoma 6 | 4,679
group 3 medulloblastoma 6 | 4,104
invasive ductal carcinoma 6 | 2,951
lung cancer 6 | 4,740
psoriasis 6 | 6,694
Ehlers-Danlos syndrome 5 | 43
atypical teratoid / rhabdoid tumor 5 | 5,112
diabetes mellitus 5 | 1,728
ductal carcinoma in situ 5 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
malignant mesothelioma 5 | 3,232
medulloblastoma, large-cell 5 | 6,241
osteosarcoma 5 | 7,950
pituitary cancer 5 | 1,972
Breast cancer 4 | 3,578
colon cancer 4 | 1,478
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
lung adenocarcinoma 4 | 2,716
lung carcinoma 4 | 2,843
oligodendroglioma 4 | 2,850
pancreatic cancer 4 | 2,398
Atherosclerosis 3 | 291
Atopic dermatitis 3 | 952
Duchenne muscular dystrophy 3 | 601
Myopia 3 | 176
Pick disease 3 | 1,894
adrenocortical carcinoma 3 | 1,428
aldosterone-producing adenoma 3 | 665
breast carcinoma 3 | 1,638
cutaneous lupus erythematosus 3 | 1,057
gastric carcinoma 3 | 807
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
limb girdle muscular dystrophy 2A 3 | 213
primitive neuroectodermal tumor 3 | 3,035
ulcerative colitis 3 | 1,819
Cancer 2 | 2,499
Congenital clubfoot 2 | 109
Degenerative disc disease 2 | 35
Down syndrome 2 | 499
EHLERS-DANLOS SYNDROME, MUSCULOCONTRACTURAL TYPE 1 2 | 2
Ehlers-Danlos syndrome, musculocontractural type 2 | 2
Endometriosis 2 | 540
Kidney cancer 2 | 2,613
Melanoma 2 | 711
Mental Depression 2 | 333
Osteoarthritis 2 | 184
Rheumatoid arthritis 2 | 1,191
Schizophrenia 2 | 1,160
astrocytic glioma 2 | 2,597
astrocytoma 2 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
cystic fibrosis 2 | 1,696
esophageal adenocarcinoma 2 | 737
non-small cell lung cancer 2 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
posterior fossa group A ependymoma 2 | 468
primary pancreatic ductal adenocarcinoma 2 | 1,109
pterygium 2 | 76
sonic hedgehog group medulloblastoma 2 | 467
tuberculosis 2 | 2,010
Abnormal vision 1 | 52
Aortic aneurysm 1 | 38
Arachnodactyly 1 | 49
Blue sclera 1 | 32
Coxa valga 1 | 22
Coxa valga deformity 1 | 22
Decreased projection of maxilla 1 | 66
Decreased visual acuity, progressive 1 | 36
Deficiency of upper jaw bones 1 | 66
Dengue disease 1 | 23
Dentinogenesis imperfecta 1 | 25
EHLERS-DANLOS SYNDROME, MUSCULOCONTRACTURAL TYPE 2 1 | 1
Ehlers-Danlos Syndrome, Musculocontractural Type, 2 1 | 1
Fatty liver disease 1 | 103
Fibrosis 1 | 44
Foramen Ovale, Patent 1 | 10
Gross motor development delay 1 | 21
Hypoplasia of the maxilla 1 | 66
Hypoplastic feet 1 | 66
Hypotrophic maxilla 1 | 66
Inadequate arch length for tooth size 1 | 45
Limited elbow extension 1 | 19
Maxillary retrognathia 1 | 66
Neoplasm Recurrence, Local 1 | 37
Progressive visual loss 1 | 36
Retrusion of upper jaw bones 1 | 66
Salivary Gland Neoplasms 1 | 46
Short-trunked dwarfism 1 | 13
Tooth Crowding 1 | 45
Tooth mass arch size discrepancy 1 | 45
Tooth size discrepancy 1 | 45
Vitreoretinal degeneration 1 | 9
X- linked recessive 1 | 110
chronic kidney disease 1 | 90

Tissue

Endocrine System 10 | 18,159
Nervous System 10 | 16,725
Blood and immune system 9 | 16,909
Cardiovascular System 9 | 15,192
Digestive Tract 9 | 17,369
Female tissues 9 | 17,400
Liver and Pancreas 9 | 16,750
Male tissues 9 | 17,142
Respiratory system 9 | 16,393
Skin and soft tissues 9 | 17,230
Urinary Tract 9 | 16,678

Target Family

Non-IDG 6 | 12,091
Enzyme 4 | 4,145

Reactome Pathway

Dermatan sulfate biosynthesis 10 | 10
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dermatan-sulfate epimerase DSE Tbio Enzyme -2.57112 360.0 44
Dermatan-sulfate epimerase-like protein DSEL Tdark Enzyme -0.86717 7.99 3
Versican core protein VCAN Tbio Non-IDG -2.88501 795.4 190
Chondroitin sulfate proteoglycan 5 CSPG5 Tbio Non-IDG -2.55925 360.8 181
Chondroitin sulfate proteoglycan 4 CSPG4 Tbio Non-IDG -2.20166 186.1 395
Carbohydrate sulfotransferase 14 CHST14 Tbio Enzyme -2.28079 185.3 75
Neurocan core protein NCAN Tbio Non-IDG -2.19768 158.4 127
Uronyl 2-sulfotransferase UST Tbio Enzyme -2.27096 184.4 86
Decorin DCN Tbio Non-IDG -3.05208 1155.4 480
Biglycan BGN Tbio Non-IDG -2.73039 529.9 267