Development Level

Tbio 39 | 11,178
Tdark 11 | 6,569
Tchem 1 | 1,885

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal embryo size 1 | 220
abnormal maxilla morphology 1 | 17
abnormal tail morphology 1 | 25
abnormal tooth morphology 1 | 24
decreased body weight 1 | 161
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating iron lev... 1 | 32
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16

Disease

psoriasis 27 | 6,514
Breast cancer 24 | 3,469
ovarian cancer 24 | 8,297
Carcinoma 23 | 11,192
group 3 medulloblastoma 22 | 4,002
non-small cell lung cancer 22 | 2,799
glioblastoma 21 | 5,635
lung cancer 21 | 4,607
invasive ductal carcinoma 20 | 2,867
medulloblastoma, large-cell 20 | 6,086
atypical teratoid / rhabdoid tumor 19 | 4,971
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,204
ductal carcinoma in situ 18 | 1,686
lung adenocarcinoma 18 | 2,627
osteosarcoma 17 | 7,766
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,902
primitive neuroectodermal tumor 16 | 2,957
adrenocortical carcinoma 15 | 1,385
breast carcinoma 12 | 1,589
malignant mesothelioma 12 | 3,135
colon cancer 11 | 1,428
Endometriosis 10 | 521
ependymoma 10 | 4,559
pancreatic cancer 10 | 2,322
Multiple myeloma 9 | 1,296
adult high grade glioma 9 | 3,701
nasopharyngeal carcinoma 9 | 1,024
Cancer 7 | 2,388
pituitary cancer 7 | 1,915
Waldenstrons macroglobulinemia 6 | 742
cystic fibrosis 6 | 1,629
pediatric high grade glioma 6 | 1,035
Atopic dermatitis 5 | 915
Kidney cancer 5 | 2,548
cutaneous lupus erythematosus 5 | 1,016
interstitial cystitis 4 | 2,237
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,872
non-small cell lung carcinoma 4 | 302
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,911
Astrocytoma, Pilocytic 3 | 3,006
Breast Neoplasms 3 | 423
Cleft Palate 3 | 265
Connective tissue disease 3 | 59
Lupus erythematosus 3 | 56
Mammary Neoplasms 3 | 403
Pick disease 3 | 1,856
acute myeloid leukemia 3 | 760
group 4 medulloblastoma 3 | 1,806
lung carcinoma 3 | 2,755
oligodendroglioma 3 | 2,768
subependymal giant cell astrocytoma 3 | 2,230
Acquired metabolic disease 2 | 329
Adenocarcinoma of lung 2 | 140
CREST Syndrome 2 | 16
Clinical Deterioration 2 | 6
Disease Models, Animal 2 | 148
Retinitis pigmentosa 11 2 | 58
Retinitis pigmentosa 20 2 | 5
Retinoblastoma 2 | 18
Rheumatoid arthritis 2 | 1,156
Schizophrenia 2 | 1,136
Systemic scleroderma 2 | 57
Thyroiditis 2 | 28
Type 1 diabetes mellitus 2 | 106
active Crohn's disease 2 | 882
acute quadriplegic myopathy 2 | 1,133
aldosterone-producing adenoma 2 | 646
diabetes mellitus 2 | 1,683
gastric cancer 2 | 445
hepatocellular carcinoma 2 | 536
pancreatic carcinoma 2 | 555
posterior fossa group A ependymoma 2 | 456
primary pancreatic ductal adenocarcinoma 2 | 1,071
spina bifida 2 | 1,053
ulcerative colitis 2 | 1,765
Amyotrophic lateral sclerosis 1 | 437
Ankylosing spondylitis 1 | 134
Brachydactyly 1 | 154
Down syndrome 1 | 480
Esophageal Squamous Cell Carcinoma 1 | 72
Fanconi anemia 1 | 56
Gastric antral vascular ectasia 1 | 10
Hypoglycemia 1 | 146
Influenza 1 | 136
Malaria 1 | 155
Male infertility 1 | 199
Microcephaly 1 | 166
Omphalocele 1 | 24
Seckel syndrome 1 | 34
Squamous cell carcinoma of esophagus 1 | 72
Stomach Neoplasms 1 | 287
Testicular cancer 1 | 25
Vaccinia 1 | 32
active ulcerative colitis 1 | 736
astrocytoma 1 | 1,113
atypical teratoid/rhabdoid tumor 1 | 349
cystic fibrosis and chronic rhinosinusitis 1 | 211
medulloblastoma 1 | 702
tuberculosis and treatment for 3 months 1 | 175
tuberculosis and treatment for 6 months 1 | 399

Tissue

Endocrine System 51 | 18,159
Blood and immune system 50 | 16,909
Digestive Tract 50 | 17,369
Female tissues 50 | 17,400
Skin and soft tissues 50 | 17,230
Liver and Pancreas 49 | 16,750
Male tissues 49 | 17,142
Nervous System 49 | 16,725
Respiratory system 49 | 16,393
Urinary Tract 49 | 16,678
Cardiovascular System 48 | 15,192

Target Family

Non-IDG 50 | 12,091
Epigenetic 1 | 242

Reactome Pathway

Deposition of new CENPA-contai... 51 | 51
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Histone H2A type 2-C HIST2H2AC Tbio Non-IDG -3.03938 994.7 101
Histone H2B type 2-E HIST2H2BE Tbio Non-IDG -3.48425 2920.0 135
Centromere protein N CENPN Tbio Non-IDG -0.88756 6.97 80
Histone H2B type 3-B HIST3H2BB Tbio Non-IDG -0.72238 5.02 53
Histone H2A type 1-D HIST1H2AD Tdark Non-IDG 0.17 0.32 11
Centromere protein Q CENPQ Tbio Non-IDG -0.47122 2.25 73
Histone H2B type 1-K HIST1H2BK Tbio Non-IDG -0.50219 4.04 29
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.13212 1.19 16
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.17 0.33 21