Development Level

Tbio 57 | 11,445
Tchem 41 | 1,598
Tdark 8 | 6,588
Tclin 5 | 613

IMPC Phenotype

preweaning lethality, incomple... 5 | 499
preweaning lethality, complete... 4 | 979
decreased vertical activity 3 | 208
enlarged heart 3 | 210
short tibia 3 | 97
abnormal eye morphology 2 | 68
abnormal femur morphology 2 | 14
abnormal heart morphology 2 | 162
abnormal humerus morphology 2 | 11
abnormal seminal vesicle morph... 2 | 114
abnormal skin coloration 2 | 25
abnormal tail morphology 2 | 25
abnormal vibrissa morphology 2 | 25
cataract 2 | 92
decreased total body fat amoun... 2 | 207
impaired glucose tolerance 2 | 75
increased body weight 2 | 25
increased bone mineral content 2 | 108
abnormal behavior 1 | 298
abnormal digit morphology 1 | 10
abnormal ear morphology 1 | 9
abnormal esophagus morphology 1 | 5
abnormal gait 1 | 69
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal limb position 1 | 3
abnormal lymph node morphology 1 | 3
abnormal nail morphology 1 | 8
abnormal pancreas morphology 1 | 13
abnormal pelvic girdle bone mo... 1 | 12
abnormal radius morphology 1 | 8
abnormal skin morphology 1 | 50
abnormal thyroid gland morphol... 1 | 3
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
abnormal trachea morphology 1 | 3
abnormal ulna morphology 1 | 8
absent lymph nodes 1 | 3
anophthalmia 1 | 33
athymia 1 | 2
brachydactyly 1 | 19
cyanosis 1 | 7
decreased T cell number 1 | 15
decreased basophil cell number 1 | 16
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating chloride... 1 | 30
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating phosphat... 1 | 27
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
edema 1 | 59
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
hemorrhage 1 | 23
hyperactivity 1 | 148
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased fasted circulating g... 1 | 76
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased vertical activity 1 | 24
premature death 1 | 5
respiratory system phenotype 1 | 2
small superior vagus ganglion 1 | 74

Disease

Carcinoma 88 | 11,493
ovarian cancer 60 | 8,520
osteosarcoma 52 | 7,950
glioblastoma 45 | 5,792
psoriasis 44 | 6,694
Cancer 41 | 2,499
malignant mesothelioma 41 | 3,232
pancreatic cancer 39 | 2,398
Breast cancer 38 | 3,578
Astrocytoma, Pilocytic 37 | 3,081
atypical teratoid / rhabdoid tumor 37 | 5,112
invasive ductal carcinoma 37 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 36 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 35 | 3,291
lung cancer 35 | 4,740
medulloblastoma, large-cell 32 | 6,241
non-small cell lung cancer 32 | 2,890
lung adenocarcinoma 30 | 2,716
Kidney cancer 29 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 29 | 2,989
ulcerative colitis 29 | 1,819
lung carcinoma 27 | 2,843
cystic fibrosis 26 | 1,696
ependymoma 26 | 4,679
Autosomal recessive predisposition 25 | 1,442
interstitial cystitis 25 | 2,312
diabetes mellitus 24 | 1,728
adult high grade glioma 22 | 3,801
breast carcinoma 20 | 1,638
primary pancreatic ductal adenocarcinoma 20 | 1,109
Arthritis 19 | 290
ductal carcinoma in situ 19 | 1,745
Duchenne muscular dystrophy 18 | 601
acute quadriplegic myopathy 17 | 1,158
gastric carcinoma 17 | 807
oligodendroglioma 17 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,962
pituitary cancer 17 | 1,972
subependymal giant cell astrocytoma 17 | 2,287
Alzheimer's disease 16 | 658
Atopic dermatitis 16 | 952
primitive neuroectodermal tumor 16 | 3,035
Vascular disease 15 | 319
cutaneous lupus erythematosus 15 | 1,057
astrocytic glioma 14 | 2,597
group 3 medulloblastoma 14 | 4,104
group 4 medulloblastoma 14 | 1,855
Kidney disease 13 | 430
Liver Cirrhosis, Experimental 13 | 769
Rheumatoid arthritis 13 | 1,191
pediatric high grade glioma 13 | 1,064
periodontitis 13 | 293
tuberculosis 13 | 2,010
Degenerative disc disease 12 | 35
Heart disease 12 | 306
Neoplasm Invasiveness 12 | 161
autosomal dominant Emery-Dreifuss muscular dystrophy 12 | 510
colon cancer 12 | 1,478
esophageal adenocarcinoma 12 | 737
Endometriosis 11 | 540
active Crohn's disease 11 | 922
juvenile dermatomyositis 11 | 1,187
nasopharyngeal carcinoma 11 | 1,058
Lung disease 10 | 142
active ulcerative colitis 10 | 764
adrenocortical carcinoma 10 | 1,428
dermatomyositis 10 | 966
Atherosclerosis 9 | 291
Breast Neoplasms 9 | 445
Dental caries 9 | 164
Hypertension 9 | 396
Mammary Neoplasms 9 | 425
Melanoma 9 | 711
Multiple Sclerosis 9 | 540
Neoplasm Metastasis 9 | 168
Osteoarthritis 9 | 184
Osteoporosis 9 | 363
Prostatic Neoplasms 9 | 495
Short stature 9 | 531
interstitial lung disease 9 | 298
Abnormality of epiphysis morphology 8 | 39
Abortion, Spontaneous 8 | 109
Gait abnormality 8 | 135
Liver disease 8 | 237
Multiple myeloma 8 | 1,332
Obesity 8 | 678
Pick disease 8 | 1,894
Schizophrenia 8 | 1,160
Spontaneous abortion 8 | 113
astrocytoma 8 | 1,146
Asthma 7 | 385
Becker muscular dystrophy 7 | 191
Down syndrome 7 | 499
Hypersensitivity reaction type II disease 7 | 253
Hypoplastic mandible condyle 7 | 275
Inflammatory bowel disease 7 | 151
Skin cancer 7 | 469
fibroadenoma 7 | 559
medulloblastoma 7 | 720
non diabetic and post-ischemic heart failure 7 | 200

Tissue

Digestive Tract 110 | 17,369
Female tissues 110 | 17,400
Endocrine System 109 | 18,159
Blood and immune system 108 | 16,909
Skin and soft tissues 108 | 17,230
Urinary Tract 108 | 16,678
Male tissues 107 | 17,142
Liver and Pancreas 105 | 16,750
Respiratory system 105 | 16,393
Nervous System 101 | 16,725
Cardiovascular System 93 | 15,192

Target Family

Non-IDG 56 | 12,091
Enzyme 55 | 4,145

Reactome Pathway

Degradation of the extracellul... 111 | 111
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Collagen alpha-1(XXIII) chain COL23A1 Tbio Non-IDG -0.49550 1.85 112
Matrix metalloproteinase-24 MMP24 Tbio Enzyme -1.38282 25.8 147
Calpain-14 CAPN14 Tdark Non-IDG -0.55232 4.56 19
Calpain-10 CAPN10 Tbio Non-IDG -2.27096 197.8 112
Collagen alpha-1(XII) chain COL12A1 Tbio Non-IDG -1.36571 21.4 38
Disintegrin and metalloproteinase domain-containing protein 15 ADAM15 Tbio Enzyme -1.87408 84.1 301
Disintegrin and metalloproteinase domain-containing protein 9 ADAM9 Tchem Enzyme -2.08807 122.3 258
Collagen alpha-1(XV) chain COL15A1 Tbio Non-IDG -1.18716 15.5 74
A disintegrin and metalloproteinase with thrombospondin motifs 1 ADAMTS1 Tchem Enzyme -2.44459 279.8 227
Collagen alpha-1(XVIII) chain COL18A1 Tbio Non-IDG -3.18339 1561.4 433