Development Level

Tbio 9 | 10,625

IMPC Phenotype

abnormal behavior 2 | 226
hyperactivity 2 | 108
abnormal epididymis morphology 1 | 31
abnormal retina morphology 1 | 100
abnormal seminal vesicle morph... 1 | 47
abnormal testis morphology 1 | 30
enlarged epididymis 1 | 27
hypoactivity 1 | 89
preweaning lethality, incomple... 1 | 260
small testis 1 | 37

Disease

ovarian cancer 6 | 8,491
psoriasis 5 | 6,685
medulloblastoma, large-cell 4 | 6,234
colon cancer 3 | 1,475
cystic fibrosis 3 | 1,670
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
malignant mesothelioma 3 | 3,163
osteosarcoma 3 | 7,933
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
pituitary cancer 3 | 1,972
Atopic dermatitis 2 | 944
Brain disease 2 | 84
Liver Cirrhosis, Experimental 2 | 108
Pick disease 2 | 1,893
adrenocortical carcinoma 2 | 1,427
atypical teratoid/rhabdoid tumor 2 | 1,095
group 4 medulloblastoma 2 | 1,875
interstitial cystitis 2 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,988
invasive ductal carcinoma 2 | 2,950
lung cancer 2 | 4,473
oligodendroglioma 2 | 2,849
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 1,563
ulcerative colitis 2 | 2,087
Alopecia areata 1 | 37
Animal Mammary Neoplasms 1 | 135
Argininosuccinic aciduria 1 | 17
Arterial calcification of infancy 1 | 4
Breast cancer 1 | 3,098
Chronic obstructive pulmonary disease 1 | 147
Colitis 1 | 46
Common variable immunodeficiency 1 | 98
Cystathioninuria 1 | 1
Diabetes Mellitus, Non-Insulin-Dependent 1 | 161
Diarrhea 1 | 155
Disuse amblyopia 1 | 3
Encephalopathy, Ethylmalonic 1 | 1
Ethylmalonic encephalopathy 1 | 1
Exostosis 1 | 15
Gamma-cystathionase deficiency 1 | 1
Glycine encephalopathy 1 | 28
Hereditary fructose intolerance syndrome 1 | 4
Histidinemia 1 | 9
Homocystinuria 1 | 23
Hyperhomocysteinemia 1 | 34
Hypermethioninemia 1 | 12
Hypertension 1 | 293
Isolated sulfite oxidase deficiency 1 | 1
Lens subluxation 1 | 9
Liver carcinoma 1 | 217
Long QT syndrome 1 | 53
MYELODYSPLASTIC SYNDROME 1 | 39
Mammary Neoplasms, Experimental 1 | 149
Mastitis 1 | 48
Metabolic syndrome X 1 | 155
Methylmalonic acidemia 1 | 39
Microcephaly 1 | 149
Multiple myeloma 1 | 1,327
Osteopetrosis 1 | 40
Patent ductus arteriosus 1 | 23
Polycystic Ovary Syndrome 1 | 334
Prostate cancer 1 | 172
Prostatic Neoplasms 1 | 471
Pulmonary edema 1 | 14
Pyruvate decarboxylase deficiency 1 | 15
Rheumatoid Arthritis 1 | 1,170
Serine deficiency 1 | 9
Staphyloenterotoxemia 1 | 20
Sulfite oxidase deficiency 1 | 1
Sulfocysteinuria 1 | 1
Toxic shock syndrome 1 | 28
Tricuspid valve insufficiency 1 | 11
Vascular disease 1 | 281
Vitiligo 1 | 71
X-linked cerebral adrenoleukodystrophy 1 | 115
adult high grade glioma 1 | 2,148
autosomal dominant Emery-Dreifuss muscular dystrophy 1 | 499
breast carcinoma 1 | 1,614
ductal carcinoma in situ 1 | 1,745
fibroadenoma 1 | 557
gastric carcinoma 1 | 832
glioblastoma 1 | 5,572
group 3 medulloblastoma 1 | 2,254
interstitial lung disease 1 | 292
lung adenocarcinoma 1 | 2,714
lung carcinoma 1 | 2,844
non-inflammatory breast cancer 1 | 208
non-small cell lung cancer 1 | 2,798
pancreatic cancer 1 | 2,300
pediatric high grade glioma 1 | 2,712
pilocytic astrocytoma 1 | 3,086
progressive supranuclear palsy 1 | 674
tuberculosis and treatment for 3 months 1 | 327
ventricular septal defect 1 | 20

Tissue

Blood and immune system 9 | 17,994
Cardiovascular System 9 | 17,957
Digestive Tract 9 | 18,472
Endocrine System 9 | 18,511
Female tissues 9 | 18,646
Liver and Pancreas 9 | 18,135
Male tissues 9 | 17,968
Nervous System 9 | 18,560
Respiratory system 9 | 17,483
Skin and soft tissues 9 | 18,114
Urinary Tract 9 | 18,443

Target Family

Enzyme 8 | 4,146
Transporter 1 | 473

Reactome Pathway

Degradation of cysteine and ho... 9 | 9
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
2-aminoethanethiol dioxygenase ADO Tbio Enzyme -2.73980 571.2 112
Cystathionine gamma-lyase CTH Tbio Enzyme -2.68605 450.1 217
Sulfite oxidase, mitochondrial SUOX Tbio Enzyme -2.00597 106.9 229
Mitochondrial dicarboxylate carrier SLC25A10 Tbio Transporter -1.23039 15.9 66
Cysteine dioxygenase type 1 CDO1 Tbio Enzyme -1.52478 31.4 82
Thiosulfate sulfurtransferase TST Tbio Enzyme -2.33502 231.7 65
Persulfide dioxygenase ETHE1, mitochondrial ETHE1 Tbio Enzyme -1.83850 85.0 109
Sulfide:quinone oxidoreductase, mitochondrial SQRDL Tbio Enzyme -1.07641 12.9 74
Cysteine sulfinic acid decarboxylase CSAD Tbio Enzyme -2.14830 135.4 119