Development Level

Tbio 9 | 10,625

IMPC Term

abnormal behavior 2 | 226
hyperactivity 2 | 108
abnormal epididymis morphology 1 | 31
abnormal retina morphology 1 | 100
abnormal seminal vesicle morph... 1 | 47
abnormal testis morphology 1 | 30
enlarged epididymis 1 | 27
hypoactivity 1 | 89
preweaning lethality, incomple... 1 | 260
small testis 1 | 37

Disease

ovarian cancer 6 | 8,484
psoriasis 5 | 6,685
medulloblastoma, large-cell 4 | 6,234
colon cancer 3 | 1,475
cystic fibrosis 3 | 1,665
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
malignant mesothelioma 3 | 3,162
osteosarcoma 3 | 7,933
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
pituitary cancer 3 | 1,972
Atopic dermatitis 2 | 944
Brain disease 2 | 83
Liver Cirrhosis, Experimental 2 | 108
Pick disease 2 | 1,893
adrenocortical carcinoma 2 | 1,427
atypical teratoid/rhabdoid tumor 2 | 1,095
group 4 medulloblastoma 2 | 1,875
interstitial cystitis 2 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,988
invasive ductal carcinoma 2 | 2,950
lung cancer 2 | 4,466
oligodendroglioma 2 | 2,849
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 1,557
ulcerative colitis 2 | 2,087
Alopecia areata 1 | 37
Animal Mammary Neoplasms 1 | 136
Argininosuccinic aciduria 1 | 17
Arterial calcification of infancy 1 | 4
Breast cancer 1 | 3,094
Chronic obstructive pulmonary disease 1 | 146
Colitis 1 | 46
Cystathioninuria 1 | 1
Diabetes Mellitus, Non-Insulin-Dependent 1 | 157
Diarrhea 1 | 155
Disuse amblyopia 1 | 3
Ethylmalonic encephalopathy 1 | 1
Exostosis 1 | 15
Gamma-cystathionase deficiency 1 | 1
Glycine encephalopathy 1 | 28
Hereditary fructose intolerance syndrome 1 | 4
Histidinemia 1 | 9
Homocystinuria 1 | 23
Hyperhomocysteinemia 1 | 34
Hypermethioninemia 1 | 12
Hypertension 1 | 287
Lens subluxation 1 | 9
Liver carcinoma 1 | 217
Long QT syndrome 1 | 52
MYELODYSPLASTIC SYNDROME 1 | 36
Mammary Neoplasms, Experimental 1 | 150
Mastitis 1 | 48
Metabolic syndrome X 1 | 155
Methylmalonic acidemia 1 | 39
Microcephaly 1 | 149
Multiple myeloma 1 | 1,327
Osteopetrosis 1 | 40
Patent ductus arteriosus 1 | 23
Polycystic Ovary Syndrome 1 | 332
Prostate cancer 1 | 172
Prostatic Neoplasms 1 | 471
Pulmonary edema 1 | 14
Pyruvate decarboxylase deficiency 1 | 15
Rheumatoid Arthritis 1 | 1,160
Serine deficiency 1 | 9
Staphyloenterotoxemia 1 | 20
Sulfite oxidase deficiency 1 | 1
Sulfocysteinuria 1 | 1
Toxic shock syndrome 1 | 28
Tricuspid valve insufficiency 1 | 11
Vascular disease 1 | 281
Ventricular septal defect 1 | 15
Vitiligo 1 | 71
X-linked cerebral adrenoleukodystrophy 1 | 115
adult high grade glioma 1 | 2,148
autosomal dominant Emery-Dreifuss muscular dystrophy 1 | 499
breast carcinoma 1 | 1,614
ductal carcinoma in situ 1 | 1,745
fibroadenoma 1 | 557
gastric carcinoma 1 | 832
glioblastoma 1 | 5,572
group 3 medulloblastoma 1 | 2,254
interstitial lung disease 1 | 291
lung adenocarcinoma 1 | 2,713
lung carcinoma 1 | 2,844
non-inflammatory breast cancer 1 | 208
non-small cell lung cancer 1 | 2,798
pancreatic cancer 1 | 2,300
pediatric high grade glioma 1 | 2,712
pilocytic astrocytoma 1 | 3,086
progressive supranuclear palsy 1 | 674
tuberculosis and treatment for 3 months 1 | 327

Tissue

Blood and immune system 9 | 17,995
Cardiovascular System 9 | 17,958
Digestive Tract 9 | 18,473
Endocrine System 9 | 18,512
Female tissues 9 | 18,647
Liver and Pancreas 9 | 18,136
Male tissues 9 | 17,969
Nervous System 9 | 18,561
Respiratory system 9 | 17,484
Skin and soft tissues 9 | 18,115
Urinary Tract 9 | 18,444

Target Family

Enzyme 8 | 4,146
Transporter 1 | 473

Reactome Pathway

Degradation of cysteine and ho... 9 | 9
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sulfide:quinone oxidoreductase, mitochondrial SQRDL Tbio Enzyme -1.04064 12.9 74
Sulfite oxidase, mitochondrial SUOX Tbio Enzyme -1.99744 106.9 229
Cysteine sulfinic acid decarboxylase CSAD Tbio Enzyme -2.12492 135.4 119
2-aminoethanethiol dioxygenase ADO Tbio Enzyme -2.71830 571.2 112
Mitochondrial dicarboxylate carrier SLC25A10 Tbio Transporter -1.22503 15.9 66
Cysteine dioxygenase type 1 CDO1 Tbio Enzyme -1.49742 31.4 82
Thiosulfate sulfurtransferase TST Tbio Enzyme -2.37820 231.7 65
Persulfide dioxygenase ETHE1, mitochondrial ETHE1 Tbio Enzyme -1.91585 85.0 109
Cystathionine gamma-lyase CTH Tbio Enzyme -2.68585 450.1 217