Development Level

Tbio 45 | 11,651
Tchem 6 | 1,388
Tclin 6 | 612
Tdark 3 | 6,593

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal behavioral response t... 1 | 66
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal kidney morphology 1 | 65
abnormal limb bud morphology 1 | 17
abnormal liver size 1 | 5
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal stomach morphology 1 | 10
decreased caudal vertebrae num... 1 | 53
decreased circulating choleste... 1 | 93
decreased circulating total pr... 1 | 49
decreased mean corpuscular vol... 1 | 79
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
increased circulating triglyce... 1 | 42
increased mean corpuscular hem... 1 | 36
pale liver 1 | 6
pale yolk sac 1 | 25
pallor 1 | 34
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

ovarian cancer 43 | 8,520
Multiple myeloma 27 | 1,332
Carcinoma 26 | 11,493
psoriasis 25 | 6,694
lung cancer 24 | 4,740
osteosarcoma 21 | 7,950
glioblastoma 20 | 5,792
HIV Infections 15 | 102
Cancer 13 | 2,499
Breast cancer 10 | 3,578
Waldenstrons macroglobulinemia 10 | 765
dermatomyositis 10 | 966
medulloblastoma, large-cell 10 | 6,241
atypical teratoid / rhabdoid tumor 9 | 5,112
ependymoma 9 | 4,679
adult high grade glioma 8 | 3,801
astrocytoma 8 | 1,146
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
malignant mesothelioma 8 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
diabetes mellitus 7 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
subependymal giant cell astrocytoma 7 | 2,287
Pick disease 6 | 1,894
group 3 medulloblastoma 6 | 4,104
non primary Sjogren syndrome sicca 6 | 891
non-small cell lung cancer 6 | 2,890
oligodendroglioma 6 | 2,850
pancreatic cancer 6 | 2,398
Mantle cell lymphoma 5 | 23
Osteoporosis 5 | 363
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
invasive ductal carcinoma 5 | 2,951
lung carcinoma 5 | 2,843
primary pancreatic ductal adenocarcinoma 5 | 1,109
tuberculosis 5 | 2,010
Anemia 4 | 365
Astrocytoma, Pilocytic 4 | 3,081
Liver Cirrhosis, Experimental 4 | 769
Parkinson's disease 4 | 392
acute myeloid leukemia 4 | 783
astrocytic glioma 4 | 2,597
medulloblastoma 4 | 720
primary Sjogren syndrome 4 | 735
Alzheimer's disease 3 | 658
Generalized osteopenia 3 | 99
Osteopenia 3 | 99
Stevens-Johnson syndrome 3 | 92
cutaneous lupus erythematosus 3 | 1,057
esophageal adenocarcinoma 3 | 737
juvenile dermatomyositis 3 | 1,187
lung adenocarcinoma 3 | 2,716
primitive neuroectodermal tumor 3 | 3,035
progressive supranuclear palsy 3 | 676
ulcerative colitis 3 | 1,819
Animal Mammary Neoplasms 2 | 136
Cardiomegaly 2 | 116
Cholangiocarcinoma 2 | 35
Cockayne syndrome 2 | 60
Congestive heart failure 2 | 113
Crohn's disease 2 | 321
Depressive disorder 2 | 409
Duchenne muscular dystrophy 2 | 601
Epilepsy 2 | 792
Esophageal Squamous Cell Carcinoma 2 | 77
Fatigue 2 | 182
Heart failure 2 | 162
Highly variable severity 2 | 157
Kidney cancer 2 | 2,613
Large auricle 2 | 87
Large dysplastic ears 2 | 87
Large pinnae 2 | 87
Large prominent ears 2 | 87
Large protruding ears 2 | 87
Large, floppy ears 2 | 87
Macrotia 2 | 87
Major Depressive Disorder 2 | 301
Mammary Neoplasms, Animal 2 | 136
Mammary Neoplasms, Experimental 2 | 154
Muscle Weakness 2 | 170
Myocardial Infarction 2 | 151
Neurogenic Muscular Atrophy 2 | 139
Neurogenic muscle atrophy, especially in the lower limbs 2 | 139
Nevoid basal cell carcinoma syndrome 2 | 16
Osteoarthritis 2 | 184
Prostatic Neoplasms 2 | 495
Rheumatoid arthritis 2 | 1,191
Seizures 2 | 596
Skeletal muscle atrophy 2 | 139
Squamous cell carcinoma of esophagus 2 | 77
Variable expressivity 2 | 157
Vascular disease 2 | 319
active Crohn's disease 2 | 922
acute quadriplegic myopathy 2 | 1,158
colon cancer 2 | 1,478
hepatocellular carcinoma 2 | 547
interstitial cystitis 2 | 2,312
muscle degeneration 2 | 139
sarcoidosis 2 | 370
spina bifida 2 | 1,074

Tissue

Endocrine System 59 | 18,159
Male tissues 58 | 17,142
Blood and immune system 57 | 16,909
Digestive Tract 57 | 17,369
Female tissues 57 | 17,400
Nervous System 57 | 16,725
Respiratory system 57 | 16,393
Urinary Tract 57 | 16,678
Cardiovascular System 56 | 15,192
Liver and Pancreas 56 | 16,750
Skin and soft tissues 56 | 17,230

Target Family

Enzyme 41 | 4,145
Non-IDG 13 | 12,091
Kinase 5 | 634
Transcription Factor 1 | 1,400

Reactome Pathway

Degradation of GLI2 by the pro... 60 | 60
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
26S proteasome regulatory subunit 6A PSMC3 Tbio Enzyme -1.29086 19.3 302
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.09531 11.7 331
S-phase kinase-associated protein 1 SKP1 Tbio Enzyme -2.57150 310.1 381
Suppressor of fused homolog SUFU Tbio Non-IDG -2.33544 208.6 168
26S proteasome non-ATPase regulatory subunit 13 PSMD13 Tbio Enzyme -1.09295 11.9 110
26S proteasome non-ATPase regulatory subunit 3 PSMD3 Tbio Enzyme -1.22269 15.9 168
Proteasome activator complex subunit 3 PSME3 Tbio Non-IDG -1.87037 83.7 245
Cullin-1 CUL1 Tbio Non-IDG -2.37931 182.6 416
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -3.00390 610.8 955