Development Level

Tbio 34 | 10,625
Tchem 17 | 1,890
Tclin 6 | 602
Tdark 1 | 7,003

Collection

Kinase: IDG Consortium (Targets) 2 | 125

IMPC Phenotype

preweaning lethality, complete... 3 | 633
abnormal bone structure 1 | 131
abnormal embryo size 1 | 112
abnormal eye morphology 1 | 38
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal limb bud morphology 1 | 15
abnormal liver size 1 | 4
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal placenta size 1 | 10
abnormal spinal cord morpholog... 1 | 8
abnormal stomach morphology 1 | 4
absent heartbeat 1 | 6
anophthalmia 1 | 20
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased lean body mass 1 | 195
decreased mean corpuscular vol... 1 | 50
embryonic lethality prior to t... 1 | 187
enlarged lymph nodes 1 | 27
increased mean corpuscular vol... 1 | 91
pale liver 1 | 5
pale yolk sac 1 | 12
pallor 1 | 13

Disease

ovarian cancer 43 | 8,491
Multiple myeloma 26 | 1,327
psoriasis 26 | 6,685
lung cancer 23 | 4,473
osteosarcoma 22 | 7,933
glioblastoma 21 | 5,572
HIV Infections 14 | 99
Cancer 13 | 2,346
medulloblastoma, large-cell 11 | 6,234
atypical teratoid / rhabdoid tumor 10 | 4,369
Breast cancer 9 | 3,098
Waldenstrons macroglobulinemia 9 | 764
astrocytoma 9 | 1,493
dermatomyositis 9 | 966
malignant mesothelioma 9 | 3,163
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,988
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
pediatric high grade glioma 7 | 2,712
Pick disease 6 | 1,893
diabetes mellitus 6 | 1,663
ependymoma 6 | 2,514
non primary Sjogren syndrome sicca 6 | 840
oligodendroglioma 6 | 2,849
pancreatic cancer 6 | 2,300
primary pancreatic ductal adenocarcinoma 6 | 1,271
subependymal giant cell astrocytoma 6 | 2,287
Mantle cell lymphoma 5 | 20
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
invasive ductal carcinoma 5 | 2,950
lung carcinoma 5 | 2,844
non-small cell lung cancer 5 | 2,798
Parkinson's disease 4 | 364
acute myeloid leukemia 4 | 785
group 3 medulloblastoma 4 | 2,254
medulloblastoma 4 | 1,524
pilocytic astrocytoma 4 | 3,086
tuberculosis 4 | 1,563
ulcerative colitis 4 | 2,087
Alzheimer's disease 3 | 644
Stevens-Johnson syndrome 3 | 91
astrocytic glioma 3 | 2,241
cutaneous lupus erythematosus 3 | 1,056
esophageal adenocarcinoma 3 | 737
juvenile dermatomyositis 3 | 1,189
lung adenocarcinoma 3 | 2,714
posterior fossa group A ependymoma 3 | 1,511
primary Sjogren syndrome 3 | 788
primitive neuroectodermal tumor 3 | 3,031
progressive supranuclear palsy 3 | 674
sonic hedgehog group medulloblastoma 3 | 1,482
Basal Cell Nevus Syndrome 2 | 4
Basal cell carcinoma 2 | 31
Carney complex 2 | 23
Cholangiocarcinoma 2 | 32
Crohn's disease 2 | 304
Duchenne muscular dystrophy 2 | 602
IGA Glomerulonephritis 2 | 454
Myocardial Infarction 2 | 126
Myofibrillar myopathy 1 2 | 6
Myofibrillar myopathy 3 2 | 5
Nevoid basal cell carcinoma syndrome 2 | 9
Osteoporosis 2 | 259
Peripheral Neuropathy 2 | 303
Pick's disease 2 | 14
Polydactyly 2 | 93
Prostatic Neoplasms 2 | 471
Squamous cell carcinoma of esophagus 2 | 82
Vascular disease 2 | 281
active Crohn's disease 2 | 918
acute quadriplegic myopathy 2 | 1,157
adult high grade glioma 2 | 2,148
chronic kidney disease 2 | 90
colon cancer 2 | 1,475
group 4 medulloblastoma 2 | 1,875
hepatocellular carcinoma 2 | 550
interstitial cystitis 2 | 2,299
sarcoidosis 2 | 368
tuberculosis and treatment for 6 months 2 | 686
Acute kidney injury 1 | 65
Adult T-Cell Lymphoma/Leukemia 1 | 30
Anemia 1 | 252
Animal Mammary Neoplasms 1 | 135
Ankylosing spondylitis 1 | 138
Barrett's esophagus 1 | 185
Bipolar Disorder 1 | 266
COPD 1 | 116
Cleft Lip 1 | 91
Craniofacial Abnormalities 1 | 147
Depressive disorder 1 | 48
Heart failure 1 | 80
Hypertensive retinopathy 1 | 9
Kidney Diseases 1 | 86
Mammary Neoplasms, Experimental 1 | 149
Melancholia 1 | 12
Muscular atrophy 1 | 67
Narcolepsy 1 | 69
Osteoarthritis 1 | 96
hand, foot and mouth disease 1 | 11
interstitial lung disease 1 | 292

Tissue

Blood and immune system 58 | 17,994
Digestive Tract 58 | 18,472
Endocrine System 58 | 18,511
Female tissues 58 | 18,646
Liver and Pancreas 58 | 18,135
Male tissues 58 | 17,968
Nervous System 58 | 18,560
Urinary Tract 58 | 18,443
Cardiovascular System 57 | 17,957
Respiratory system 57 | 17,483
Skin and soft tissues 57 | 18,114

Target Family

Enzyme 40 | 4,146
Non-IDG 12 | 11,969
Kinase 5 | 634
Transcription Factor 1 | 1,400

Reactome Pathway

Degradation of GLI2 by the pro... 58 | 58
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
26S proteasome non-ATPase regulatory subunit 13 PSMD13 Tchem Enzyme -1.05639 9.70 94
S-phase kinase-associated protein 1 SKP1 Tbio Enzyme -2.54884 305.8 337
Suppressor of fused homolog SUFU Tbio Non-IDG -2.28664 185.5 162
26S proteasome non-ATPase regulatory subunit 3 PSMD3 Tbio Enzyme -1.21151 15.4 162
Proteasome activator complex subunit 1 PSME1 Tbio Non-IDG -1.72065 54.6 204
Casein kinase I isoform alpha CSNK1A1 Tchem Kinase -1.81545 66.1 375
Zinc finger protein GLI2 GLI2 Tchem Transcription Factor -2.54628 325.2 174
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.10500 124.2 150
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.62947 56.7 150
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -2.96407 567.7 767