Development Level

Tclin 1 | 613

Disease

Abnormal behavior 1 | 52
Abnormal ocular motility 1 | 19
Abnormality of metabolism/homeostasis 1 | 134
Absence Epilepsy 1 | 22
Absence seizure 1 | 12
Aggressive behavior 1 | 75
Aggressive reaction 1 | 75
Anxiety 1 | 136
Anxiety disease 1 | 113
Autistic Disorder 1 | 364
Autosomal recessive predisposition 1 | 1,442
Bipolar affective disorder, current episode manic 1 | 13
Brain Diseases, Metabolic 1 | 2
Carcinoma 1 | 11,493
Cardiovascular system disease 1 | 246
Cerebellar Ataxia 1 | 304
Chronic Lymphocytic Leukemia 1 | 262
Cognitive delay 1 | 608
Decreased tendon reflex 1 | 122
Delayed speech and language development 1 | 112
Dull intelligence 1 | 645
Dystonia Disorders 1 | 6
Dystonic Disorders 1 | 7
Electroencephalogram abnormal 1 | 101
Epilepsies, Myoclonic 1 | 32
Epilepsy 1 | 792
Epilepsy characterized by intractable complex partial seizures 1 | 28
Generalized myoclonic seizures 1 | 30
Global developmental delay 1 | 608
Hallucinations 1 | 34
Hallucinations, Sensory 1 | 33
Highly variable clinical phenotype 1 | 150
Highly variable phenotype and severity 1 | 150
Highly variable phenotype, even within families 1 | 150
Hyperactive behavior 1 | 91
Infantile onset 1 | 238
Intellectual disability 1 | 1,016
Language Delay 1 | 112
Low intelligence 1 | 645
Mental Retardation 1 | 645
Mental and motor retardation 1 | 608
Mental deficiency 1 | 645
Migraine Prevention 1 | 23
Motor delay 1 | 147
Muscle hypotonia 1 | 571
Myoclonic Epilepsies, Progressive 1 | 44
No development of motor milestones 1 | 147
Paraplegia 1 | 74
Peroneal nerve paralysis 1 | 11
Phenotypic variability 1 | 150
Physical aggression 1 | 76
Poor school performance 1 | 645
Psychotic Disorders 1 | 151
Self-Injurious Behavior 1 | 12
Spasm 1 | 6
Speech Delay 1 | 112
Speech impairment 1 | 112
Status Epilepticus 1 | 98
Succinic semialdehyde dehydrogenase deficiency 1 | 16
Tonic - clonic seizures 1 | 44
Waldenstrons macroglobulinemia 1 | 765
active ulcerative colitis 1 | 764
adrenocortical carcinoma 1 | 1,428
adult high grade glioma 1 | 3,801
astrocytic glioma 1 | 2,597
atypical teratoid / rhabdoid tumor 1 | 5,112
cystic fibrosis 1 | 1,696
gastric cancer 1 | 459
glioblastoma 1 | 5,792
interstitial cystitis 1 | 2,312
medulloblastoma 1 | 720
medulloblastoma, large-cell 1 | 6,241
oligodendroglioma 1 | 2,850
osteosarcoma 1 | 7,950
ovarian cancer 1 | 8,520
pancreatic ductal adenocarcinoma liver metastasis 1 | 1,962
pituitary cancer 1 | 1,972
primary Sjogren syndrome 1 | 735

Tissue

Blood and immune system 1 | 16,909
Cardiovascular System 1 | 15,192
Digestive Tract 1 | 17,369
Endocrine System 1 | 18,159
Female tissues 1 | 17,400
Liver and Pancreas 1 | 16,750
Male tissues 1 | 17,142
Nervous System 1 | 16,725
Respiratory system 1 | 16,393
Skin and soft tissues 1 | 17,230
Urinary Tract 1 | 16,678

Target Family

Enzyme 1 | 4,145

Reactome Pathway

Degradation of GABA 1 | 1
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Succinate-semialdehyde dehydrogenase, mitochondrial ALDH5A1 Tclin Enzyme -2.23586 168.4 347