Development Level

Tbio 48 | 11,445
Tchem 6 | 1,598
Tclin 5 | 613
Tdark 3 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal behavioral response t... 1 | 66
abnormal kidney morphology 1 | 65
cardiovascular system phenotyp... 1 | 36
decreased caudal vertebrae num... 1 | 53
decreased circulating choleste... 1 | 93
decreased circulating total pr... 1 | 49
decreased lean body mass 1 | 135
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

ovarian cancer 40 | 8,520
Multiple myeloma 31 | 1,332
lung cancer 26 | 4,740
psoriasis 25 | 6,694
Carcinoma 24 | 11,493
osteosarcoma 20 | 7,950
glioblastoma 19 | 5,792
Cancer 15 | 2,499
HIV Infections 15 | 102
dermatomyositis 13 | 966
Waldenstrons macroglobulinemia 10 | 765
Breast cancer 9 | 3,578
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
astrocytoma 8 | 1,146
atypical teratoid / rhabdoid tumor 8 | 5,112
ependymoma 8 | 4,679
malignant mesothelioma 8 | 3,232
medulloblastoma, large-cell 8 | 6,241
Mantle cell lymphoma 7 | 23
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
non-small cell lung cancer 7 | 2,890
oligodendroglioma 7 | 2,850
tuberculosis 7 | 2,010
adult high grade glioma 6 | 3,801
subependymal giant cell astrocytoma 6 | 2,287
Liver Cirrhosis, Experimental 5 | 769
Pick disease 5 | 1,894
diabetes mellitus 5 | 1,728
group 3 medulloblastoma 5 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
invasive ductal carcinoma 5 | 2,951
non primary Sjogren syndrome sicca 5 | 891
Astrocytoma, Pilocytic 4 | 3,081
Atopic dermatitis 4 | 952
Osteoporosis 4 | 363
astrocytic glioma 4 | 2,597
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
juvenile dermatomyositis 4 | 1,187
lung carcinoma 4 | 2,843
pancreatic cancer 4 | 2,398
primary Sjogren syndrome 4 | 735
Anemia 3 | 365
Asthma 3 | 385
Heat Stroke 3 | 13
Kidney cancer 3 | 2,613
Pneumonia 3 | 174
acute myeloid leukemia 3 | 783
esophageal adenocarcinoma 3 | 737
group 4 medulloblastoma 3 | 1,855
lung adenocarcinoma 3 | 2,716
primary pancreatic ductal adenocarcinoma 3 | 1,109
progressive supranuclear palsy 3 | 676
ulcerative colitis 3 | 1,819
Allergic hypersensitivity disease 2 | 126
Alzheimer's disease 2 | 658
Animal Mammary Neoplasms 2 | 136
Autosomal recessive predisposition 2 | 1,442
Cleft Palate 2 | 271
Congestive heart failure 2 | 113
Contact Dermatitis 2 | 81
Dermatitis, Atopic 2 | 37
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Elevated hepatic transaminases 2 | 81
Esophageal Squamous Cell Carcinoma 2 | 77
Hepatic enzyme increased 2 | 81
Hypereosinophilic syndrome 2 | 71
Liver Dysfunction 2 | 99
Liver enzymes abnormal 2 | 81
Liver function test increased 2 | 81
Liver function tests abnormal finding 2 | 81
Lymphadenopathy 2 | 62
Mammary Neoplasms, Animal 2 | 136
Mammary Neoplasms, Experimental 2 | 154
Myofibrillar myopathy 1 2 | 6
Myofibrillar myopathy 3 2 | 5
Parkinson's disease 2 | 392
Pick's disease 2 | 15
Rheumatoid arthritis 2 | 1,191
Splenomegaly 2 | 190
Squamous cell carcinoma of esophagus 2 | 77
Stevens-Johnson syndrome 2 | 92
Subclinical abnormal liver function tests 2 | 81
Transaminases increased 2 | 81
active Crohn's disease 2 | 922
acute quadriplegic myopathy 2 | 1,158
chronic kidney disease 2 | 90
colon cancer 2 | 1,478
cutaneous lupus erythematosus 2 | 1,057
hepatocellular carcinoma 2 | 547
primitive neuroectodermal tumor 2 | 3,035
Alveolar soft part sarcoma 1 | 10
Heart Diseases 1 | 43
Kidney Failure, Chronic 1 | 46
Mild Mental Retardation 1 | 70
Neoplasms, Experimental 1 | 40
Respiratory Distress Syndrome, Adult 1 | 40
Skin Neoplasms 1 | 69
Thymoma 1 | 16

Tissue

Endocrine System 61 | 18,159
Blood and immune system 60 | 16,909
Digestive Tract 60 | 17,369
Female tissues 60 | 17,400
Male tissues 60 | 17,142
Nervous System 60 | 16,725
Respiratory system 60 | 16,393
Urinary Tract 60 | 16,678
Cardiovascular System 59 | 15,192
Liver and Pancreas 59 | 16,750
Skin and soft tissues 59 | 17,230

Target Family

Enzyme 40 | 4,145
Non-IDG 17 | 12,091
Transcription Factor 3 | 1,400
Kinase 2 | 634

Reactome Pathway

Dectin-1 mediated noncanonical... 62 | 62
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Proteasome activator complex subunit 4 PSME4 Tdark Non-IDG -1.60128 39.3 43
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139
Putative protein SEM1, isoform 2 SEM1 Tbio Non-IDG 0.30 0.49 109
26S proteasome regulatory subunit 10B PSMC6 Tbio Enzyme -2.65165 339.0 214
Proteasome subunit alpha type-7 PSMA7 Tbio Enzyme -2.71627 496.7 288